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Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, ACID
Papers on Properdin
Reach out and touch someone: anticipatory sensorimotor processes of active interpersonal touch.
New
Gallese et al., Chieti, Italy. In J Cogn Neurosci, 30 Sep 2014
The results showed weaker deactivation in primary somatosensory cortex and medial pFC and stronger activation in cerebellum for the animate target, compared with the inanimate target, when intending to touch it with one's own hand.
The face of negative affect: trial-by-trial corrugator responses to negative pictures are positively associated with amygdala and negatively associated with ventromedial prefrontal cortex activity.
New
Davidson et al., Madison, United States. In J Cogn Neurosci, 30 Sep 2014
Trial-by-trial increases in corrugator EMG activity to negative pictures were associated with greater amygdala activity and a concurrent decrease in ventromedial PFC activity.
Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder.
New
Francis et al., Baton Rouge, United States. In Behav Brain Res, Aug 2014
The rats were then euthanized and their brains were dissected to remove the hippocampus and prefrontal cortex (PFC).
A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior.
Review
New
Gorzalka et al., Montréal, Canada. In Neurosci Biobehav Rev, May 2014
The prefrontal cortex (PFC) provides executive control of the brain in humans and rodents, coordinating cognitive, emotional, and behavioral responses to threatening stimuli and subsequent feedback inhibition of the hypothalamic-pituitary-adrenal (HPA) axis.
Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity.
New
Mandyam et al., Los Angeles, United States. In Brain Struct Funct, Apr 2014
In sum, our results not only provide evidence that alcohol dependence leads to pathological changes in the mPFC, which may in part define a cellular basis for cognitive impairments associated with alcoholism, but also show dependence-associated morphological changes in the PFC at the single neuron level.
Benefits of physical exercise on basic visuo-motor functions across age.
New
Di Russo et al., Roma, Italy. In Front Aging Neurosci, Dec 2013
The results indicates that: (a) the brain of older adults needs the PFC engagement also to perform elementary task, such as the SRT, while this activity is not necessary in younger adults, (b) physical exercise could reduce this age-related reliance on extra cognitive control also during the performance of a SRT, and (c) the activity of the PFC is a sensitive index of the benefits of physical exercise on sensorimotor decline.
Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine.
Review
New
Mansvelder et al., Amsterdam, Netherlands. In Biochem Pharmacol, Nov 2013
The prefrontal cortex (PFC) is the main link in integrating emotional and motivational state of an animal to regulate top-down attentional processes.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
NIRS as a tool for assaying emotional function in the prefrontal cortex.
Review
Shinohara et al., Nagasaki, Japan. In Front Hum Neurosci, 2012
For instance, the unique characteristics of NIRS give it potential as a tool for investigating the role of the prefrontal cortex (PFC) in emotion processing.
Role of nucleus accumbens glutamatergic plasticity in drug addiction.
Review
Quintero, Panamá, Panama. In Neuropsychiatr Dis Treat, 2012
The glutamate homeostasis hypothesis centers around the dynamics of synaptic and extrasynaptic levels of glutamate, and their impact on circuitry from the prefrontal cortex (PFC) to the NAc.
[Neural basis of maternal behavior].
Review
Kikuchi et al., Tokyo, Japan. In Seishin Shinkeigaku Zasshi, 2012
The differential neural activation pattern was found in the dorsal region of OFC, caudate nucleus, right inferior frontal gyrus, dorsomedial prefrontal cortex (PFC), anterior cingulate, posterior cingulate, posterior superior temporal sulcus, and dorsolateral PFC.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
Review
Impact
Volkow et al., New York City, United States. In Nat Rev Neurosci, 2011
However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness).
Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention.
Impact
Mansvelder et al., Amsterdam, Netherlands. In Science, 2011
The prefrontal cortex (PFC) is involved in a range of cognitive functions and is thought to mediate attentional focus.
The role of the human prefrontal cortex in social cognition and moral judgment.
Review
Impact
Grafman et al., Bethesda, United States. In Annu Rev Neurosci, 2009
Results from functional magnetic resonance imaging and lesion studies indicate that the prefrontal cortex (PFC) is essential for successful navigation through a complex social world inundated with intricate norms and moral values.
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