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Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, ACID
Papers on Properdin
Different stress-related gene expression in depression and suicide.
New
Swaab et al., Amsterdam, Netherlands. In J Psychiatr Res, 30 Sep 2015
The prefrontal cortex (PFC) is involved in, among other things, impulse control and inhibitory behavior and plays an important role in both suicide and depression.
Genetic deletion of monoacylglycerol lipase (MAGL) leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior.
New
Cristino et al., Pozzuoli, Italy. In J Neurochem, 30 Aug 2015
We employed the MAGL knock-out mice (MAGL-/-), a genetic model of congenital and sustained elevation of 2-AG levels in the brain, to provide morphological and biochemical evidence for β-arrestin2-mediated CB1R desensitization in brain regions involved in the control of emotional states, that is, the prefrontal cortex (PFC), amygdala, hippocampus and cerebellar cortex.
Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine.
New
Macêdo et al., Fortaleza, Brazil. In Dev Neurobiol, 27 Aug 2015
The changes in the hippocampus were in contrast to those in the PFC in which only increased levels of nitrite in all groups studied were observed.
Modulation of schizophrenia-related genes in the forebrain of adolescent and adult rats exposed to maternal immune activation.
New
Seroogy et al., Cincinnati, United States. In Schizophr Res, 20 Aug 2015
ErbB4 expression was also elevated in the prefrontal cortex (PFC) at P14.
Effect of a socıal defeat experıence on prefrontal actıvıty ın schızophrenıa.
New
Özel-Kızıl et al., Ankara, Turkey. In Psychiatry Res, 15 Aug 2015
We measured prefrontal cortex (PFC) activity in subjects with schizophrenia and healthy controls during exposure to a single SD experience with functional near infrared spectroscopy.
NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders.
Review
New
Gao et al., Philadelphia, United States. In Neurosci Biobehav Rev, 01 Aug 2015
UNASSIGNED: The prefrontal cortex (PFC) is a brain region featured with working memory function.
Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.
Review
New
Impact
Paspalas et al., New Haven, United States. In Pharmacol Rev, 31 Jul 2015
The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical dopamine (DA).
Molecular aspects of age-related cognitive decline: the role of GABA signaling.
Review
New
Bizon et al., Gainesville, United States. In Trends Mol Med, 31 Jul 2015
This review highlights basic science demonstrating that inhibitory signaling is altered in aging, and discusses the impact of age-related shifts in inhibition on different forms of memory function, including hippocampus-dependent spatial reference memory and prefrontal cortex (PFC)-dependent working memory.
Nicotine attenuates the effect of HIV-1 proteins on the neural circuits of working and contextual memories.
New
Li et al., Charlottesville, United States. In Mol Brain, Dec 2014
METHODS: We investigated the effects of nicotine on synaptic plasticity and hippocampus-prefrontal cortex (PFC)-amygdala-dependent memory formation in the HIV-1 transgenic (Tg) and F344 control rats.
Hippocampal-prefrontal circuit and disrupted functional connectivity in psychiatric and neurodegenerative disorders.
Review
New
Yang et al., Guangzhou, China. In Biomed Res Int, Dec 2014
In rodents, the hippocampus has been studied extensively as part of a brain system responsible for learning and memory, and the prefrontal cortex (PFC) participates in numerous cognitive functions including working memory, flexibility, decision making, and rewarding learning.
Molecular and functional imaging of internet addiction.
Review
New
Tian et al., Hangzhou, China. In Biomed Res Int, Dec 2014
Abnormal dopamine regulation of the prefrontal cortex (PFC) could underlie the enhanced motivational value and uncontrolled behavior over Internet overuse in addicted subjects.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
New
Impact
Koechlin et al., Paris, France. In Science, Jul 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
New
Impact
Duman et al., New Haven, United States. In Nat Med, May 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
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