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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, V1a
Papers on Properdin
The IFNγ-PKR Pathway in the Prefrontal Cortex Reactions to Chronic Excessive Alcohol Use.
New
Wang et al., Jackson, United States. In Alcohol Clin Exp Res, 19 Mar 2015
METHODS: Using Western blot and double immunofluorescence, we examined the expression of interferon (IFN)-induced protein kinase R (PKR), phosphorylated-PKR (p-PKR), and IFN gamma (IFNγ) in the prefrontal cortex (PFC) of postmortem brains from subjects with alcohol use disorders (AUD).
Depression of Excitatory Synapses onto Parvalbumin Interneurons in the Medial Prefrontal Cortex in Susceptibility to Stress.
New
Li et al., New York City, United States. In J Neurosci, 18 Mar 2015
The prefrontal cortex (PFC) is required for coping with stress, and PFC dysfunction has been implicated in stress-related mental disorders, including depression.
Functional mapping of dynamic happy and fearful facial expressions in young adults with familial risk for psychosis - Oulu Brain and Mind Study.
New
Veijola et al., Oulu, Finland. In Schizophr Res, 18 Mar 2015
Failure to deactivate PFC structures may imply error in the default mode network.
Indirect association of DAT1 genotype with executive function through white matter volume in orbitofrontal cortex.
New
Clark et al., Pittsburgh, United States. In Psychiatry Res, 04 Mar 2015
This study tested an indirect effect model in which DAT1 genotype (9-repeat (9R) carriers vs 10-repeat (10R) homozygotes) is linked to phenotypes representing impulsivity and executive function (planning behavior) through effects on white matter (WM) volumes in prefrontal cortex (PFC), particularly orbitofrontal cortex (OFC).
The neurobiology of thalamic amnesia: Contributions of medial thalamus and prefrontal cortex to delayed conditional discrimination.
Review
New
Gibson et al., Durham, United Kingdom. In Neurosci Biobehav Rev, 20 Feb 2015
Here we focus on MD and the adjacent M and IL nuclei, structures identified in animal studies as critical nodes in prefrontal cortex (PFC)-related pathways that are necessary for delayed conditional discrimination.
Properdin levels in human sepsis.
New
Thompson et al., Leicester, United Kingdom. In Front Immunol, Dec 2014
Properdin is a normal serum protein that increases the production of complement activation products by binding C3b integral to convertase complexes and amplifying their activity at the site of activation.
Catechol-O-methyltransferase, dopamine, and sleep-wake regulation.
Review
New
Landolt et al., Montpellier, France. In Sleep Med Rev, Nov 2014
Individuals homozygous for the Val allele show higher COMT activity, and lower dopaminergic signaling in prefrontal cortex (PFC) than subjects homozygous for the Met allele.
Learning robust cortico-cortical associations with the basal ganglia: An integrative review.
Review
New
Ashby et al., United States. In Cortex, Nov 2014
This article focuses on the interaction between the basal ganglia (BG) and prefrontal cortex (PFC).
The Cognition-Enhancing Effects of Psychostimulants Involve Direct Action in the Prefrontal Cortex.
Review
New
Berridge et al., Madison, United States. In Biol Psychiatry, Oct 2014
The clinical efficacy of these drugs is strongly linked to their ability to improve cognition dependent on the prefrontal cortex (PFC) and extended frontostriatal circuit.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
New
Impact
Koechlin et al., Paris, France. In Science, Jul 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
New
Impact
Duman et al., New Haven, United States. In Nat Med, May 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
Hierarchical processing in the prefrontal cortex in a variety of cognitive domains.
Review
Jeon, Leipzig, Germany. In Front Syst Neurosci, 2013
This review scrutinizes several findings on human hierarchical processing within the prefrontal cortex (PFC) in diverse cognitive domains.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
Review
Impact
Volkow et al., New York City, United States. In Nat Rev Neurosci, 2011
However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness).
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