Properdin levels in human sepsis.
Leicester, United Kingdom. In Front Immunol, Dec 2014
Properdin is a normal serum protein that increases the production of complement activation products by binding C3b integral to convertase complexes and amplifying their activity at the site of activation.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.