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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, ACID
Papers on Properdin
Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
New
Szumlinski et al., Santa Barbara, United States. In Addict Biol, Feb 2016
This effect was more robust within the ventromedial versus dorsomedial PFC, was not observed in comparable cocaine-experienced rats not tested for drug-seeking behavior and was distinct from the rise in phosphorylated extracellular signal-regulated kinase observed in cocaine-seeking rats.
Variants of contextual fear conditioning induce differential patterns of Egr-1 activity within the young adult prefrontal cortex.
New
Rosen et al., Newark, United States. In Behav Brain Res, Feb 2016
Neural activity within CA1 of the dorsal hippocampus (CA1), amygdala (LA), and prefrontal cortex (PFC) may play a critical role when animals learn to associate a context with a footshock (i.e., training).
Cortical activation changes and sub-threshold affective symptoms are associated with social functioning in a non-clinical population: A multi-channel near-infrared spectroscopy study.
New
Morinobu et al., Mihara, Japan. In Psychiatry Res, Feb 2016
Eighty healthy volunteers performed a serial arithmetic task according to the Uchida-Kraepelin performance test while hemoglobin concentration changes were assessed on the surface of the prefrontal cortex (PFC) using 32-channel near-infrared spectroscopy.
Relationships Between Gum-Chewing and Stress.
New
Sakatani et al., Tokyo, Japan. In Adv Exp Med Biol, Dec 2015
On the other hand, studies have suggested that the right prefrontal cortex (PFC) dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (HPA) axis.
Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects.
New
Sakatani et al., Tokyo, Japan. In Adv Exp Med Biol, Dec 2015
The prefrontal cortex (PFC) plays an important role in emotion and emotional regulation.
Differential cognitive actions of norepinephrine a2 and a1 receptor signaling in the prefrontal cortex.
Review
New
Spencer et al., Madison, United States. In Brain Res, Dec 2015
UNASSIGNED: The prefrontal cortex (PFC) supports cognitive and behavioral processes that guide goal directed behavior.
Stress weakens prefrontal networks: molecular insults to higher cognition.
Review
New
Arnsten, New Haven, United States. In Nat Neurosci, Oct 2015
A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of the newly evolved prefrontal cortex (PFC).
Estrogen in prefrontal cortex blocks stress-induced cognitive impairments in female rats.
Review
New
Yan et al., Buffalo, United States. In J Steroid Biochem Mol Biol, Sep 2015
Repeated stress has been found to impair cognitive behaviors via suppressing glutamatergic transmission and glutamate receptor surface expression in pyramidal neurons of prefrontal cortex (PFC) in male rats.
Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.
Review
New
Impact
Paspalas et al., New Haven, United States. In Pharmacol Rev, Jul 2015
The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical dopamine (DA).
Précis on The Cognitive-Emotional Brain.
Impact
Pessoa, College Park, United States. In Behav Brain Sci, 2015
(2) Cognitive-emotional interactions in the human prefrontal cortex (PFC) assume diverse forms and are not limited to mutual suppression.
Molecular and neuronal plasticity mechanisms in the amygdala-prefrontal cortical circuit: implications for opiate addiction memory formation.
Review
Laviolette et al., London, Canada. In Front Neurosci, 2014
The mammalian prefrontal cortex (PFC) and basolateral nucleus of the amygdala (BLA) share important functional and anatomical connections that are involved importantly in the processing of associative memories linked to drug reward.
The Regulation of Task Performance: A Trans-Disciplinary Review.
Review
Dumas et al., Nagoya, Japan. In Front Psychol, 2014
We will rigorously explore research that addresses the pivotal role of the prefrontal cortex (PFC) in controlling the meta-cognitive processes that underpin the self-regulated learning (SRL) strategies learners employ to regulate task performance.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
Impact
Koechlin et al., Paris, France. In Science, 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
Impact
Duman et al., New Haven, United States. In Nat Med, 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
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