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Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, ACID
Papers on Properdin
Association of periventricular nodular heterotopia with posterior fossa cyst: a prenatal case series.
New
GRRIF (Groupe de Recherche Radiopédiatrique en Imagerie Fœtale)-SFIPP (Société Francophone d'Imagerie Pédiatrique et Prénatale) et al., Paris, France. In Prenat Diagn, 04 Jan 2015
OBJECTIVE: The association of periventricular nodular heterotopia (PVNH) with posterior fossa cyst (PFC) is documented after birth.
Possible involvement of activated locus coeruleus-noradrenergic neurons in pain-related sleep disorders.
New
Narita et al., Tokyo, Japan. In Neurosci Lett, 03 Jan 2015
In the present study, sciatic nerve ligation, which produced significant thermal hyperalgesia, significantly increased the levels of noradrenaline released in the prefrontal cortex (PFC) by the weak electrical stimulation of neurons in the LC.
Dopamine Receptors Differentially Enhance Rule Coding in Primate Prefrontal Cortex Neurons.
New
Nieder et al., Tübingen, Germany. In Neuron, 03 Jan 2015
UNLABELLED: Flexibly applying abstract rules is a hallmark feature of executive functioning represented by prefrontal cortex (PFC) neurons.
Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain.
New
Stylianopoulou et al., Athens, Greece. In Psychoneuroendocrinology, 24 Dec 2014
Increased maternal behavior was experimentally induced by a brief 15-min separation between the mother and the pups during postnatal days 1 to 22. On postnatal days (PND) 12 and 22, we determined in experimental and control dams levels of anxiety in the elevated plus maze (EPM) as well as the levels of receptors for estrogens (ERα, ERβ), oxytocin (OTR) and serotonin (5-HT1AR) in areas of the limbic system (prefrontal cortex-PFC, hippocampus, lateral septum-SL, medial preoptic area-MPOA, shell of nucleus accumbens-nAc-Sh, central-CeA and basolateral-BLA amygdala), involved in the regulation of maternal behavior.
Learning robust cortico-cortical associations with the basal ganglia: An integrative review.
Review
New
Ashby et al., United States. In Cortex, 27 Nov 2014
UNLABELLED: This article focuses on the interaction between the basal ganglia (BG) and prefrontal cortex (PFC).
Catechol-O-methyltransferase, dopamine, and sleep-wake regulation.
Review
New
Landolt et al., Montpellier, France. In Sleep Med Rev, 27 Nov 2014
Individuals homozygous for the Val allele show higher COMT activity, and lower dopaminergic signaling in prefrontal cortex (PFC) than subjects homozygous for the Met allele.
A rostro-caudal axis for language in the frontal lobe: The role of executive control in speech production.
Review
New
Bourguignon, Montréal, Canada. In Neurosci Biobehav Rev, 08 Nov 2014
UNLABELLED: The present article promotes a formal executive model of frontal functions underlying speech production, bringing together hierarchical theories of adaptive behavior in the (pre-)frontal cortex (pFC) and psycho- and neurolinguistic approaches to spoken language within an information-theoretic framework.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
New
Impact
Koechlin et al., Paris, France. In Science, Jul 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
New
Impact
Duman et al., New Haven, United States. In Nat Med, May 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia.
Review
New
Laviolette et al., London, Canada. In Front Psychiatry, Dec 2013
Two neural regions in particular, the medial prefrontal cortex (PFC) and the basolateral nucleus of the amygdala (BLA), play important roles in emotional regulation and contain high levels of cannabinoid receptors.
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.
Review
New
Luckhart et al., Ottawa, Canada. In Front Behav Neurosci, Dec 2013
In addition, 5-HT1A heteroreceptors are abundantly expressed post-synaptically in the prefrontal cortex (PFC), amygdala, and hippocampus to mediate serotonin actions on fear, anxiety, stress, and cognition.
Remoteness modulates the effects of emotional valence on the neural network of autobiographical memory in older females.
New
Long et al., In Int J Aging Hum Dev, Dec 2013
Within the network, increased activation of a prefrontal cortex/anterior cingulate cortex (PFC/ACC) control system was found when processing negative recent AMs compared with positive recent AMs; increased activation of the somatosensory area was found with positive remote AMs compared with negative remote AMs.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
Review
Impact
Volkow et al., New York City, United States. In Nat Rev Neurosci, 2011
However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness).
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