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Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, ACID
Papers on Properdin
Cocaine craving during protracted withdrawal requires PKCε priming within vmPFC.
Szumlinski et al., Santa Barbara, United States. In Addict Biol, 14 Feb 2016
This effect was more robust within the ventromedial versus dorsomedial PFC, was not observed in comparable cocaine-experienced rats not tested for drug-seeking behavior and was distinct from the rise in phosphorylated extracellular signal-regulated kinase observed in cocaine-seeking rats.
Control your anger! The neural basis of aggression regulation in response to negative social feedback.
Crone et al., Leiden, Netherlands. In Soc Cogn Affect Neurosci, 10 Feb 2016
In addition, more activation in the right dorsal lateral PFC (dlPFC) during negative feedback versus neutral feedback was associated with shorter noise blasts in response to negative social feedback, suggesting a potential role of dlPFC in aggression regulation, or top-down control over affective impulsive actions.
Variants of contextual fear conditioning induce differential patterns of Egr-1 activity within the young adult prefrontal cortex.
Rosen et al., Newark, United States. In Behav Brain Res, 08 Feb 2016
Neural activity within CA1 of the dorsal hippocampus (CA1), amygdala (LA), and prefrontal cortex (PFC) may play a critical role when animals learn to associate a context with a footshock (i.e., training).
Prefrontal glutamate correlates of methamphetamine sensitization and preference.
Szumlinski et al., Santa Barbara, United States. In Eur J Neurosci, 06 Feb 2016
UNASSIGNED: Methamphetamine (MA) is a widely abused, highly addictive, psychostimulant that elicits pronounced deficits in neurocognitive function related to hypo-functioning of the prefrontal cortex (PFC).
Cortical activation changes and sub-threshold affective symptoms are associated with social functioning in a non-clinical population: A multi-channel near-infrared spectroscopy study.
Morinobu et al., Mihara, Japan. In Psychiatry Res, 04 Feb 2016
Eighty healthy volunteers performed a serial arithmetic task according to the Uchida-Kraepelin performance test while hemoglobin concentration changes were assessed on the surface of the prefrontal cortex (PFC) using 32-channel near-infrared spectroscopy.
Relationships Between Gum-Chewing and Stress.
Sakatani et al., Tokyo, Japan. In Adv Exp Med Biol, 31 Dec 2015
On the other hand, studies have suggested that the right prefrontal cortex (PFC) dominates the regulation of the stress response system, including the hypothalamic-pituitary-adrenal (HPA) axis.
Influence of Pleasant and Unpleasant Auditory Stimuli on Cerebral Blood Flow and Physiological Changes in Normal Subjects.
Sakatani et al., Tokyo, Japan. In Adv Exp Med Biol, 31 Dec 2015
The prefrontal cortex (PFC) plays an important role in emotion and emotional regulation.
Serum KIBRA mRNA and Protein Expression and Cognitive Functions in Depression.
Gałecki et al., Łódź, Poland. In Med Sci Monit, 31 Dec 2015
BACKGROUND Genes participating in synaptic signalling or plasticity in brain regions such as the prefrontal cortex (PFC) and the hippocampus have been implicated in cognition.
DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders.
Zhang et al., New Haven, United States. In Sci Rep, 31 Dec 2015
DNA methylome alterations in the prefrontal cortex (PFC) may contribute to risk for alcohol use disorders (AUDs).
Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders.
Paspalas et al., New Haven, United States. In Pharmacol Rev, Jul 2015
The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical dopamine (DA).
The Regulation of Task Performance: A Trans-Disciplinary Review.
Dumas et al., Nagoya, Japan. In Front Psychol, 2014
We will rigorously explore research that addresses the pivotal role of the prefrontal cortex (PFC) in controlling the meta-cognitive processes that underpin the self-regulated learning (SRL) strategies learners employ to regulate task performance.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
Koechlin et al., Paris, France. In Science, 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
Duman et al., New Haven, United States. In Nat Med, 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
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