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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Nov 2014.

Complement factor properdin

Properdin, PFC
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, ACID, V1a
Papers on Properdin
Effects of disrupting medial prefrontal cortex GABA transmission on decision-making in a rodent gambling task.
New
Lowes et al., United States. In Psychopharmacology (berl), 26 Dec 2014
RATIONALE: Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC).
Sex dependent reduction by prenatal stress of the expression of 5HT1A receptors in the prefrontal cortex and CRF type 2 receptors in the raphe nucleus in rats: reversal by citalopram.
New
Weinstock et al., Jerusalem, Israel. In Psychopharmacology (berl), 26 Dec 2014
OBJECTIVES: The objective of the current study is to determine whether the increased anxiety of prenatally stressed (PS) rats of both sexes is associated with changes in 5HT1A and CRF type 2 receptors (5HT1AR and CRFR2) in the prefrontal cortex (PFC)-dorsal raphe nuclei (DRN) axis, and how these are affected by chronic treatment with citalopram (10 mg/kg/day).
Dissociable Deficits of Executive Function Caused by Gestational Adversity are Linked to Specific Transcriptional Changes in the Prefrontal Cortex.
New
Reyes et al., Philadelphia, United States. In Neuropsychopharmacology, 24 Dec 2014
These dissociable executive function deficits are known to be mediated by the medial prefrontal cortex (PFC), which displays markers of epigenetic dysregulation in neurodevelopmental disorders.
Functional compensation in the ventromedial prefrontal cortex improves memory-dependent decisions in older adults.
New
Cabeza et al., Durham, United States. In J Neurosci, 19 Dec 2014
Extending these results, we observed evidence for compensation in connectivity between vmPFC and the dorsolateral PFC during memory-dependent choice.
Markers of apoptosis induction and proliferation in the orbitofrontal cortex in alcohol dependence.
New
Miguel-Hidalgo et al., Jackson, United States. In Alcohol Clin Exp Res, 30 Nov 2014
BACKGROUND: Alcohol-dependent (ALC) subjects exhibit glial and neuronal pathology in the prefrontal cortex (PFC).
A rostro-caudal axis for language in the frontal lobe: The role of executive control in speech production.
Review
New
Bourguignon, Montréal, Canada. In Neurosci Biobehav Rev, 08 Nov 2014
UNLABELLED: The present article promotes a formal executive model of frontal functions underlying speech production, bringing together hierarchical theories of adaptive behavior in the (pre-)frontal cortex (pFC) and psycho- and neurolinguistic approaches to spoken language within an information-theoretic framework.
Human cognition. Foundations of human reasoning in the prefrontal cortex.
New
Impact
Koechlin et al., Paris, France. In Science, Jul 2014
The prefrontal cortex (PFC) subserves reasoning in the service of adaptive behavior.
REDD1 is essential for stress-induced synaptic loss and depressive behavior.
New
Impact
Duman et al., New Haven, United States. In Nat Med, May 2014
Here, we show that stress increases levels of REDD1 (regulated in development and DNA damage responses-1), an inhibitor of mTORC1 (mammalian target of rapamycin complex-1; ref. 10), in rat prefrontal cortex (PFC).
The role of cannabinoid transmission in emotional memory formation: implications for addiction and schizophrenia.
Review
New
Laviolette et al., London, Canada. In Front Psychiatry, Dec 2013
Two neural regions in particular, the medial prefrontal cortex (PFC) and the basolateral nucleus of the amygdala (BLA), play important roles in emotional regulation and contain high levels of cannabinoid receptors.
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.
Review
New
Luckhart et al., Ottawa, Canada. In Front Behav Neurosci, Dec 2013
In addition, 5-HT1A heteroreceptors are abundantly expressed post-synaptically in the prefrontal cortex (PFC), amygdala, and hippocampus to mediate serotonin actions on fear, anxiety, stress, and cognition.
New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons.
Review
New
Gao et al., Philadelphia, United States. In Front Neural Circuits, Dec 2013
Cognitive functions associated with prefrontal cortex (PFC), such as working memory and attention, are strongly influenced by catecholamine [dopamine (DA) and norepinephrine (NE)] release.
A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge.
Impact
Deisseroth et al., Stanford, United States. In Nature, 2013
The prefrontal cortex (PFC) is thought to participate in high-level control of the generation of behaviours (including the decision to execute actions); indeed, imaging and lesion studies in human beings have revealed that PFC dysfunction can lead to either impulsive states with increased tendency to initiate action, or to amotivational states characterized by symptoms such as reduced activity, hopelessness and depressed mood.
Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems.
Review
Bugajski et al., Kraków, Poland. In Pharmacol Rep, 2012
During chronic stress-induced inhibition of systemic feedback, cytosolic glucocorticoid receptor (GR) levels were significantly changed in the prefrontal cortex (PFC) and hippocampus, both structures known to be deeply involved in the pathogenesis of depression.
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
GeneRIF
van den Born et al., Groningen, Netherlands. In J Biol Chem, 2012
Factor h and properdin recognize different epitopes on renal tubular epithelial heparan sulfate.
The role of properdin in zymosan- and Escherichia coli-induced complement activation.
GeneRIF
Mollnes et al., Oslo, Norway. In J Immunol, 2012
Properdin released from human polymorphonuclear cells does not bind to zymosan or E. coli, but when incubated in properdin-depleted serum this form of properdin binds efficiently to both substrates in a strictly complement C3-dependent manner.
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder.
Impact
Duman et al., New Haven, United States. In Nat Med, 2012
We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD and that, when expressed in PFC neurons, is sufficient to decrease the expression of synapse-related genes, cause loss of dendritic spines and dendrites, and produce depressive behavior in rat models of depression.
A new effector of lipid metabolism: complement factor properdin.
GeneRIF
Cianflone et al., Québec, Canada. In Mol Immunol, 2012
properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue
Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein.
GeneRIF
Ram et al., Worcester, United States. In J Immunol, 2012
Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains.
Elevated properdin and enhanced complement activation in first-degree relatives of South Asian subjects with type 2 diabetes.
GeneRIF
Carter et al., Leeds, United Kingdom. In Diabetes Care, 2012
Properdin and SC5b-9 may be novel biomarkers for future risk of type 2 diabetes in this high-risk population and warrant further investigation.
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications.
Review
Impact
Volkow et al., New York City, United States. In Nat Rev Neurosci, 2011
However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order executive function (for example, self-control, salience attribution and awareness).
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