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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Proopiomelanocortin

proopiomelanocortin, alpha-MSH, Adrenocorticotropic Hormone
Top mentioned proteins: Neuropeptide, leptin, V1a, CAN, neuropeptide Y
Papers on proopiomelanocortin
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.
New
Wagner et al., Pomona, United States. In Neuroendocrinology, Feb 2016
UNASSIGNED: Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis.
60 YEARS OF POMC: From the prohormone theory to proopiomelanocortin and to proprotein convertases (PCSK1 to PCSK9).
Review
New
Mbikay et al., Montréal, Canada. In J Mol Endocrinol, Feb 2016
UNASSIGNED: POMC, pro-opio-melano-cortin, is a polyprotein expressed in the pituitary and the brain where it is proteolytically processed into peptide hormones and neuropeptides with distinct biological activities.
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.
New
Impact
Singh et al., United States. In Cell Metab, Feb 2016
Here, we show that cold induces autophagy in proopiomelanocortin (POMC) neurons and activates lipophagy in brown adipose tissue (BAT) and liver in mice.
Role of the neural pathway from hindbrain to hypothalamus in the regulation of energy homeostasis in rats.
New
Date et al., Miyazaki, Japan. In Neurosci Lett, Feb 2016
Furthermore, the hypothalamic mRNA levels of anorectic proopiomelanocortin and cocaine- and amphetamine-related transcript were significantly lower in midbrain-transected rats than in sham-operated rats.
Appetite-enhancing Effects of trans-Cinnamaldehyde, Benzylacetone and 1-Phenyl-2-butanone by Inhalation.
New
Ito et al., Kyoto, Japan. In Planta Med, Jan 2016
In this study, food intake and the expression of neuropeptide Y and proopiomelanocortin in the hypothalamus after inhalation of fragrant compounds or essential oils were investigated in mice.
The brain in bone and fuel metabolism.
Review
New
Baldock et al., Sydney, Australia. In Bone, Jan 2016
Two main neuronal populations within the arcuate nucleus of the hypothalamus regulate energy homeostasis: The orexigenic, appetite-stimulating neurons that co-express neuropeptide Y and agouti-related peptide and the anorexigenic, appetite-suppressing neurons that co-express proopiomelanocortin and cocaine- and amphetamine related transcript.
60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.
Review
New
Clark, London, United Kingdom. In J Mol Endocrinol, Jan 2016
With this work they instantly confirmed the single precursor hypothesis for ACTH-β-lipotropin, as it was then known, and in so doing revealed the existence of additional, largely unpredicted, N-terminal peptides that together formed the proopiomelanocortin (POMC) precursor peptide.
Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats.
New
Chowen et al., Madrid, Spain. In Biol Sex Differ, Dec 2015
CONCLUSIONS: These findings indicate that some of the long-term changes in metabolic and reproductive parameters induced by MD, such as advanced pubertal onset and increased hypothalamic proopiomelanocortin (POMC) expression, hyperinsulinemia, and hypertriglyceridemia in adult males and decreased serum triglyceride and estradiol levels in females, are most likely due to the decrease in leptin levels during the period of MD.
Intermittent Moderate Energy Restriction Improves Weight Loss Efficiency in Diet-Induced Obese Mice.
New
Sainsbury et al., Sydney, Australia. In Plos One, Dec 2015
Mice on the CD exhibited significantly greater hypothalamic mRNA expression of proopiomelanocortin (POMC) relative to ID and control mice, with no differences in neuropeptide Y or agouti-related peptide mRNA expression between energy-restricted groups.
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis.
Review
New
Wagner et al., Pomona, United States. In J Steroid Biochem Mol Biol, Aug 2015
This occurs via the hypothalamic feeding circuitry, where estradiol rapidly attenuates the cannabinoid CB1 receptor-mediated presynaptic inhibition of glutamatergic input onto anorexigenic proopiomelanocortin (POMC) neurons in the arcuate nucleus.
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease.
New
Impact
Paez-Pereda et al., München, Germany. In Nat Med, Mar 2015
One function of the glucocorticoid receptor (GR) in corticotroph cells is to suppress the transcription of the gene encoding proopiomelanocortin (POMC), the precursor of the stress hormone adrenocorticotropin (ACTH).
Leptin and insulin act on POMC neurons to promote the browning of white fat.
New
Impact
Tiganis et al., Australia. In Cell, Feb 2015
Deletion of the phosphatases PTP1B and TCPTP enhanced insulin and leptin signaling in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and energy expenditure.
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
Impact
Komada et al., München, Germany. In Nat Genet, 2015
USP8 mutants enhanced promoter activity of the gene encoding proopiomelanocortin.
Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake.
Review
Benani et al., Dijon, France. In Front Endocrinol (lausanne), 2014
Agouti-related peptide (AgRP) and proopiomelanocortin (POMC) expressing neurons located in the arcuate nucleus of the hypothalamus are the key elements of this system.
Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.
Impact
Cai et al., New York City, United States. In Nat Med, 2014
Further, using cell-specific genetic analyses in vivo, we found that astrocytes and proopiomelanocortin neurons are responsible for the production and prodiabetic effect of central TGF-β, respectively.
AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.
Impact
GeneRIF
Cone et al., Nashville, United States. In Cell Metab, 2012
Hypothalamic pro-opiomelanocortin and AgRP neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
ERK-regulated double cortin-like kinase (DCLK)-short phosphorylation and nuclear translocation stimulate POMC gene expression in endocrine melanotrope cells.
GeneRIF
Scheenen et al., Nijmegen, Netherlands. In Endocrinology, 2011
DCLK phosphorylation and nuclear translocation stimulate POMC gene expression in endocrine melanotrope cells.
Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells.
GeneRIF
Jenks et al., Nijmegen, Netherlands. In J Neuroendocrinol, 2011
Extracellular-signal regulated kinase regulates production of pro-opiomelanocortin in pituitary melanotroph cells.
V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cells.
GeneRIF
Martens et al., Nijmegen, Netherlands. In Mol Biol Cell, 2010
The V-ATPase accessory subunit Ac45 represents the first regulator of the proton pump and controls V-ATPase-mediated granular acidification that is necessary for efficient prohormone processing.
COP-binding sites in p24delta2 are necessary for proper secretory cargo biosynthesis.
GeneRIF
Martens et al., Nijmegen, Netherlands. In Int J Biochem Cell Biol, 2009
The p24 proteins fulfil their role in secretory protein biosynthesis via COPI- or COPII-coated transport vesicles.
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