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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Prolyl endopeptidase

prolyl endopeptidase, Prep, prolyl oligopeptidase
The protein encoded by this gene is a cytosolic prolyl endopeptidase that cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Prolyl endopeptidases have been reported to be involved in the maturation and degradation of peptide hormones and neuropeptides. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, fibrillin-1, aminopeptidase
Papers using prolyl endopeptidase antibodies
Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.
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Uversky Vladimir N., In PLoS ONE, 2009
... clone was cultured to prepare supercoiled recombinant plasmid DNA using a Mini Prep kit (QIAGEN).
Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction.
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Holowka David, In PLoS ONE, 2008
... Library plasmids from positive colonies were isolated using Fast Prep (Thermo Scientific), rescued into E ...
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus
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Black Margaret E. et al., In Cancer gene therapy, 2007
... The Wizard PCR prep kit (Promega, Madison, WI), HiSpeed Plasmid Midi Kit (Qiagen, Valencia, CA) and StrataPrep ...
Zebrafish dax1 is required for development of the interrenal organ, the adrenal cortex equivalent
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McCabe Edward R. B. et al., In Development Genes and Evolution, 2005
... DNA was isolated using the Mini-Prep Kit and protocol as supplied by Qiagen.
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
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Blagosklonny Mikhail V., In PLoS ONE, 2004
... at the National Institutes of Health and NCI-Frederick Blood Banks were collected in 8-mL Cell Prep Tubes (Becton Dickinson, Rockville, MD); PBMCs were ...
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Papers on prolyl endopeptidase
Transport of a Prolyl Endopeptidase Inhibitory Peptide across the Blood-Brain Barrier Demonstrated Using the hCMEC/D3 Cell Line Transcytosis Assay.
New
Lea et al., Dublin, Ireland. In J Agric Food Chem, Feb 2016
A prolyl endopeptidase (PEP) inhibitory peptide with the amino acid sequence proline-proline-leucine (PPL) was chemically synthesized labeled with 5-FAM and assessed using a transcytosis assay for its ability to cross the BBB.
Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from corydalis cava (fumariaceae) as Alzheimer's disease targets.
New
Andrisano et al., Hradec Králové, Czech Republic. In Fitoterapia, Feb 2016
On the basis of the reported results, we found that some Corydalis cava alkaloids have multifunctional activity against AD targets (prolyl oligopeptidase, cholinesterases and BACE1).
Acylpeptidyl Oligopeptidase: Porphyromonas gingivalis Periplasmic Novel Exopeptidase Releases N-Acylated Di- and Tri-peptides from Oligopeptides.
New
Kimura et al., Nagasaki, Japan. In J Biol Chem, Feb 2016
AOP is currently listed as an unassigned S9-family peptidase or prolyl oligopeptidase.
Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease.
New
Cahlíková et al., Hradec Králové, Czech Republic. In Chem Biodivers, Jan 2016
Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase-3β inhibitory activities.
(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity.
New
Cahlíková et al., In Nat Prod Commun, Oct 2015
The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase.
The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis.
Review
De Meester et al., Antwerp, Belgium. In Front Immunol, 2014
In this review, we provide a comprehensive discussion on the role of prolyl-specific peptidases DPPIV, FAP, DPP8, DPP9, dipeptidyl peptidase II, prolyl carboxypeptidase, and prolyl oligopeptidase in the immune system and its diseases.
Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation.
Impact
Meisinger et al., Freiburg, Germany. In Cell Metab, 2014
Upon import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (Aβ).
Mitochondrial import and degradation of amyloid-β peptide.
Review
Glaser et al., Stockholm, Sweden. In Biochim Biophys Acta, 2014
The mitochondrial presequence protease (PreP) is responsible for Aβ degradation reducing toxic effects of Aβ on mitochondrial functions.
Hox regulation of transcription: more complex(es).
Review
Sagerström et al., Worcester, United States. In Dev Dyn, 2014
The first such "cofactors" were members of the Extradenticle/Pbx and Homothorax/Meis/Prep families.
Parasite prolyl oligopeptidases and the challenge of designing chemotherapeuticals for Chagas disease, leishmaniasis and African trypanosomiasis.
Review
Santana et al., Brasília, Brazil. In Curr Med Chem, 2012
In this regard, prolyl oligopeptidase and oligopeptidase B, both members of the S9 serine protease family, have been shown to play important roles in the interactions of pathogenic protozoa with their mammalian hosts and may thus be considered targets for drug design.
Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors.
GeneRIF
Carpen et al., Helsinki, Finland. In J Histochem Cytochem, 2012
PREP may be associated with secretory processes as well as in reproduction. A more abundant expression of PREP in malignant than benign tumors suggests that PREP may be associated with expansion and metastasis of tumors.
Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes.
Review
Rustgi et al., Pullman, United States. In Funct Integr Genomics, 2012
In view of the above, we evaluated the capacity of cereal grains to synthesize and store the enzymes prolyl endopeptidase from Flavobacterium meningosepticum and the barley cysteine endoprotease B2, which in combination are capable of detoxifying immunogenic gluten peptides in a novel treatment of celiac disease.
Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein α.
GeneRIF
Galande et al., Harrisonburg, United States. In Febs Lett, 2012
analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha
Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.
GeneRIF
Forsberg et al., Kuopio, Finland. In Neurosci Lett, 2011
PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin.
Prolyl oligopeptidase participates in cell cycle progression in a human neuroblastoma cell line.
GeneRIF
Takaoka et al., Takatsuki, Japan. In Biochem Biophys Res Commun, 2011
These results indicate that POP is a part of the machinery that controls the cell cycle.
Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding.
GeneRIF
Sowdhamini et al., Bengaluru, India. In Plos One, 2010
Molecular modeling and docking based approaches were used to unravel questions like differences in ligand binding affinities in three POP species (porcine, human and A. thaliana).
Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.
Impact
Ma et al., New York City, United States. In Immunity, 2007
This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system.
Structural basis for gluten intolerance in celiac sprue.
Impact
Khosla et al., Stanford, United States. In Science, 2002
The peptide could be detoxified in in vitro and in vivo assays by exposure to a bacterial prolyl endopeptidase, suggesting a strategy for oral peptidase supplement therapy for Celiac Sprue.
A common mechanism of action for three mood-stabilizing drugs.
Impact
Harwood et al., London, United Kingdom. In Nature, 2002
Moreover, the development of Dictyostelium is sensitive to lithium and to valproic acid, but resistance to both is conferred by deletion of the gene that codes for prolyl oligopeptidase, which also regulates inositol metabolism.
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.
Impact
Polgár et al., Oxford, United Kingdom. In Cell, 1998
Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases.
More papers using prolyl endopeptidase antibodies
Very fast empirical prediction and interpretation of protein pKa values.
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Kobe Bostjan, In PLoS ONE, 2004
... , 10 mM imidazole, pH 7.5, using the FAST Prep matrix (MP Biomedicals).
Integrin activation by R-ras
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Shattil Sanford J. et al., In The Journal of Cell Biology, 1995
... Plasmids with inserts in the correct orientation were amplified and purified for CHO cell transfections (Maxi-Prep; QIAGEN Inc., Chatsworth, CA) ...
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