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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peptidase D

prolidase, PEPD
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, aminopeptidase, AGE
Papers on prolidase
Diagnostic performance of increased prolidase activity in schizophrenia.
Sir et al., Diyarbakır, Turkey. In Neurosci Lett, Jan 2016
UNASSIGNED: We investigated whether prolidase activity has a diagnostic test value in schizophrenia and assessed the relation between prolidase activity and sociodemographic-clinical characteristics of patients with schizophrenia.
Effect of Chronic Periodontitis on Oxidative Status in Patients With Psoriasis and Psoriatic Arthritis.
Onat et al., İstanbul, Turkey. In J Periodontol, Jan 2016
Also measured were the levels of prolidase and the total sulfhydryl groups.
The Value of Serum Prolidase Activity in Progression of Microalbuminuria in Patients With Type 2 Diabetes Mellitus.
Aksoy et al., Şanlıurfa, Turkey. In J Clin Lab Anal, Jan 2016
BACKGROUND: Prolidase is a cytosolic exopeptidase that plays a pivotal role in collagen turnover.
Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions.
Tanyeri et al., İstanbul, Turkey. In J Oral Pathol Med, Jan 2016
OBJECTIVE: The aim of this study was to evaluate prolidase activity and oxidative stress in patients with oral lichen planus (OLP) and oral lichenoid contact reactions (OLCR) using serum and salivary samples and to compare these biomarkers with each other as well as with a group of healthy subjects in order to be able to opine their role in the estimation of OLP and OLCR.
A Rare Cause of Lower Extremity Ulcers: Prolidase Deficiency.
Gürer et al., Ankara, Turkey. In Int J Low Extrem Wounds, Jan 2016
UNASSIGNED: Prolidase deficiency is an autosomal recessive disorder, which is associated with chronic skin ulcers, a characteristic facial appearance, mental retardation, and recurrent infections.
Differential Diagnosis of Genetic Disorders Associated with Moderate to Severe Refractory Eczema and Elevated Immunoglobulin E.
Tercedor Sánchez et al., Cadiz, Spain. In Actas Dermosifiliogr, Jan 2016
UNASSIGNED: The association of moderate to severe eczema and elevated plasma levels of immunoglobulin E is a characteristic not only of atopic dermatitis but also of various genodermatoses: hyperimmunoglobulin E syndromes, Omenn syndrome, Netherton syndrome, peeling skin syndrome type B, severe dermatitis, multiple allergies, and metabolic wasting syndrome, Wiskott-Aldrich syndrome, prolidase deficiency, Loeys-Dietz syndrome, IPEX syndrome, STAT5B deficiency, and pentasomy X.
Protective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury.
Yavuz et al., Diyarbakır, Turkey. In Cardiovasc J Afr, Nov 2015
After reperfusion was initiated, cardiac and renal tissues and blood samples were obtained from each rat with subsequent analysis of nitrogen oxide (NOx), malondialdehyde (MDA), paraoxonase 1 (PON1) and prolidase.
Prolidase Deficiency
Wang et al., Seattle, United States. In Unknown Journal, Jul 2015
DIAGNOSIS/TESTING: The diagnosis of prolidase deficiency is established by detection of either biallelic PEPD pathogenic variants or reduced prolidase enzyme activity in a proband who has characteristic clinical findings and imidodipeptiduria.
Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts.
Surazynski et al., Białystok, Poland. In Drug Des Devel Ther, 2014
MATERIALS AND METHODS: Collagen biosynthesis, activity of prolidase, DNA biosynthesis, and cytotoxicity were measured in confluent human skin fibroblast cultures that have been treated with 25, 50, and 100 mM ethanol and with ethanol and 500 µg/mL HA.
Evaluation of serum prolidase activity in patients with slow coronary flow.
Sezen et al., Adıyaman, Turkey. In Postepy Kardiol Interwencyjnej, 2014
It has been shown that increased serum prolidase activity (SPA) correlates with collagen turnover.
Progress in the development of enzyme-based nerve agent bioscavengers.
Masson et al., France. In Chem Biol Interact, 2014
Human prolidase appears to be another promising human enzyme.
Prolidase function in proline metabolism and its medical and biotechnological applications.
Grunden et al., Raleigh, United States. In J Appl Microbiol, 2012
Prolidase deficiency (PD), a rare autosomal recessive disorder in which mutations in the PEPD gene affect prolidase functionality, tends to have serious and sometimes life-threatening clinical symptoms.
Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer.
Ceylan et al., Van, Turkey. In J Cancer Res Clin Oncol, 2012
Increased prolidase seems to be associated with increased NO levels and oxidative stress along with decreased antioxidant levels in bladder cancer.
The retinoic acid-induced up-regulation of insulin-like growth factor 1 and 2 is associated with prolidase-dependent collagen synthesis in UVA-irradiated human dermal equivalents.
Noh et al., South Korea. In J Dermatol Sci, 2012
Relinoic acid regulates prolidase activity in human dermal cells via IGF receptor signaling in photoaged cells.
Oxidative stress and prolidase activity in women with uterine fibroids.
Aksoy et al., Şanlıurfa, Turkey. In J Obstet Gynaecol, 2012
elevated in submucosal uterine fibroids
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
Seielstad et al., South Korea. In Nat Genet, 2012
The combined analysis identified eight new T2D loci reaching genome-wide significance, which mapped in or near GLIS3, PEPD, FITM2-R3HDML-HNF4A, KCNK16, MAEA, GCC1-PAX4, PSMD6 and ZFAND3.
Serum prolidase activity in patients with pulmonary tuberculosis.
Bilgic et al., Ankara, Turkey. In Scand J Clin Lab Invest, 2011
Serum prolidase activity is elevated in patients with pulmonary tuberculosis
A photographic essay of prolidase deficiency.
Winship et al., Melbourne, Australia. In Clin Dysmorphol, 2011
Prolidase deficiency is a rare inherited connective tissue disorder characterised by intractable skin ulceration, lymphoedema, recurrent infections and mild intellectual impairment.
Developmental cardiac hypertrophy in a mouse model of prolidase deficiency.
Gunn et al., Ithaca, United States. In Birth Defects Res A Clin Mol Teratol, 2011
The dark-like mutation causes cardiomyocyte hypertrophy due to loss-of-function of peptidase d (Pepd).
Current Insights into the role of HIF-1 in cutaneous wound healing.
Harmon et al., Baltimore, United States. In Curr Mol Med, 2011
Studies on the effect of HIF-1 on the expression and activity of extracellular cell matrix modifying enzymes, such as MMPs and prolidase, have been conducted in the context of tumor angiogenesis and metastasis, and have resulted in controversial findings.
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