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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Prolactin

Prolactin, PRL
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, fibrillin-1, Insulin
Papers using Prolactin antibodies
The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.
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Korach Kenneth S. et al., In Environmental Health Perspectives, 2009
... including 0.2 μg of expression plasmid, 0.2 μg of reporter plasmid, and 0.1 μg of pRL-TK plasmid, were transfected overnight using Effectene Transfection Reagent (QIAGEN, Valencia, CA) according to ...
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
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Ratner Adam J., In PLoS ONE, 2007
... Plasmids pCRE-Luc and pRL-TK were obtained from Clontech and Promega, respectively ...
Cell dynamics and immune response to BLV infection: a unifying model.
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Kehn-Hall Kylene, In PLoS ONE, 2006
... The plasmid expressing the Renilla luciferase via the enhancerless promoter pRL-null (pRL-renilla) was purchased from Promega Corporation (Madison WI, USA) ...
Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective open-label pilot study
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Nanes Mark S et al., In Journal of Bone and Mineral Research, 2004
... ) The Dual Luciferase Assay System, TNF T7 Coupled Reticulocyte Lysate System, and pRL-TK control vector were purchased from Promega Corporation (Madison, WI, USA) ...
A statistical model for identifying proteins by tandem mass spectrometry
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Zhu Jianhong et al., In Proteome Science, 2002
... Tris-Buffered Saline (TBS) for 4 min and then incubated at 1:300 dilution of primary anti-rabbit polyclonal prolactin antibody (Dako Cytomation, Copenhagen, Denmark) in ...
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Papers on Prolactin
Immunohistochemistry of ductal adenocarcinoma of the prostate and adenocarcinomas of non-prostatic origin: a comparative study.
New
Egevad et al., Stockholm, Sweden. In Apmis, Feb 2016
Slides were stained for estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-Myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, and PAX-8.
Dopaminergic drugs in type 2 diabetes and glucose homeostasis.
Review
New
Becu-Villalobos et al., Buenos Aires, Argentina. In Pharmacol Res, Jan 2016
On the other hand, dopamine inhibits prolactin, which has metabolic functions; and, at the pancreatic beta cell dopamine D2 receptors inhibit insulin secretion.
Biomarkers in the diagnosis and study of psychogenic nonepileptic seizures: A systematic review.
Review
New
Jimenez et al., Cleveland, United States. In Seizure, Jan 2016
RESULTS: A total of 49 studies were examined, including neuroimaging, autonomic nervous system, prolactin, other (non-prolactin) hormonal, enzyme, and miscellaneous marker studies.
The pituitary TGFβ1 system as a novel target for the treatment of resistant prolactinomas.
Review
New
Diaz-Torga et al., Buenos Aires, Argentina. In J Endocrinol, Jan 2016
TGFβ1 is a known inhibitor of lactotroph cell proliferation and prolactin secretion, and it partly mediates dopamine inhibitory action.
Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.
New
Ishige et al., Yotsukaidō, Japan. In Oncol Lett, Dec 2015
Compared with the control treatment, treatment with 10 µm niclosamide suppressed the proliferation of the HLF and PRL/PRF/5 cells to 49.9±3.7 and 17.9±11.5%
Placental Barrier and Autism Spectrum Disorders: The Role of Prolactin and Dopamine on the Developing Fetal Brain.
Review
New
Clayton et al., Stockholm, Sweden. In Innov Clin Neurosci, Sep 2015
Dopamine and prolactin exhibit opposite effects on lactation.
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Impact
Schraenen et al., Leuven, Belgium. In Cell Metab, 2015
Locally secreted hGH binds to prolactin receptors on β cells, activates STAT5 signaling, and induces pregnancy-like changes in gene expression, thereby augmenting pancreatic β cell mass and insulin content.
Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus.
Li et al., Shanghai, China. In Int J Clin Exp Med, 2014
AIMS AND OBJECTIVES: We determined the expression levels of human growth hormone (GH), prolactin (PRL), and their receptors in subjects presenting with SLE, and modulation of disease severity.
Dopamine and Somatostatin Analogues Resistance of Pituitary Tumors: Focus on Cytoskeleton Involvement.
Review
Mantovani et al., Milano, Italy. In Front Endocrinol (lausanne), 2014
Although long-acting DA and SS analogs are currently used in the treatment of prolactin (PRL)- and growth hormone (GH)-secreting pituitary tumors, respectively, clinical practice indicates a great variability in the frequency and entity of favorable responses.
Effect of transcription factor ZBTB20 on mouse pituitary development.
Li et al., Tai'an, China. In Genet Mol Res, 2014
Real-time polymerase chain reaction and western blotting assays were used to detect the levels of five hormones: growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH).
Identification of SNPs within the PRLR gene and effects on maternal behavior in sheep.
Sun et al., Yancheng, China. In Genet Mol Res, 2014
The prolactin receptor gene (PRLR) plays an essential role in maternal behavior.
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Impact
Luckman et al., Ann Arbor, United States. In Cell Metab, 2014
Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure.
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
Impact
Hankinson et al., Boston, United States. In J Clin Oncol, 2014
Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasive breast cancer (n = 437 patient cases and n = 775 controls not using postmenopausal hormones) in the Nurses' Health Study.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Impact
Struman et al., Liège, Belgium. In Nat Med, 2014
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown.
Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial.
Impact
Stroup et al., New York City, United States. In Jama, 2014
Patients taking paliperidone palmitate had significantly higher maximum mean levels of serum prolactin (men, 34.56 µg/L [95% CI, 29.75-39.37]
Transformation of a transposon into a derived prolactin promoter with function during human pregnancy.
GeneRIF
Wagner et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
analysis of transformation of a transposon into a derived prolactin promoter with function during human pregnancy
Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells.
GeneRIF
Sarkar et al., New Brunswick, United States. In J Endocrinol, 2012
Results suggest that the suppression of Dopamine-2 (D2) receptor short (D2S)-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling estradiol (E(2)-activated prolactin (PRL) synthesis and cell proliferation in lactotropes.
Serum prolactin and macroprolactin levels in diabetic nephropathy.
GeneRIF
Cetinkaya et al., Antalya, Turkey. In Clin Nephrol, 2012
Serum prolactin/macroprolactin levels increased especially in moderate to severe renal failure which was due to decreased glomerular filtration and renal parenchymal function.
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.
GeneRIF
Wang et al., Baltimore, United States. In Plos One, 2011
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers.
The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.
GeneRIF
Simon et al., Trento, Italy. In Neural Dev, 2011
In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer, is down-regulated.
More papers using Prolactin antibodies
Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader
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Alpini Gianfranco et al., In BMC Physiology, 2001
... polyclonal (ab35349) antibody recognizing the prolactin receptor (used for the immunohistochemical and immunofluorescent evaluation of prolactin receptor in liver sections) was purchased from Abcam (Cambridge, UK) ...
Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury
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Levy Andy et al., In The Journal of Endocrinology, 1998
... and 1·7 kb of 3′ PRL sequence driving Cre recombinase expression was used to generate the PRL-Cre transgenic mice ...
Internalization is required for proper Wingless signaling in Drosophila melanogaster
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Bellen Hugo J. et al., In The Journal of Cell Biology, 1995
... ), and 2 ng pRL-CMV (Promega) in 100 μL were sequentially combined with 3.2 μL Effectene Enhancer (QIAGEN), 10 μL Effectene (QIAGEN), ...
Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene
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Kondaiah Paturu et al., In BMC Genomics, 1985
... 200 ng of pSBE-luc plasmid and 1.25 ng of pRL-CMV construct (Renilla luciferase, for transfection normalization) were transfected using Effectene reagent (Qiagen GmbH, Germany) in serum ...
Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion
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Holly J M P et al., In British Journal of Cancer, 1978
... The prolactin monoclonal antibody was bought from QED Bioscience Inc., San Diego, CA, ...
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