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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 09 Oct 2015.


Prolactin, PRL
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, fibrillin-1, Insulin
Papers using Prolactin antibodies
The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.
Korach Kenneth S. et al., In Environmental Health Perspectives, 2009
... including 0.2 μg of expression plasmid, 0.2 μg of reporter plasmid, and 0.1 μg of pRL-TK plasmid, were transfected overnight using Effectene Transfection Reagent (QIAGEN, Valencia, CA) according to ...
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
Ratner Adam J., In PLoS ONE, 2007
... Plasmids pCRE-Luc and pRL-TK were obtained from Clontech and Promega, respectively ...
Cell dynamics and immune response to BLV infection: a unifying model.
Kehn-Hall Kylene, In PLoS ONE, 2006
... The plasmid expressing the Renilla luciferase via the enhancerless promoter pRL-null (pRL-renilla) was purchased from Promega Corporation (Madison WI, USA) ...
Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective open-label pilot study
Nanes Mark S et al., In Journal of Bone and Mineral Research, 2004
... ) The Dual Luciferase Assay System, TNF T7 Coupled Reticulocyte Lysate System, and pRL-TK control vector were purchased from Promega Corporation (Madison, WI, USA) ...
A statistical model for identifying proteins by tandem mass spectrometry
Zhu Jianhong et al., In Proteome Science, 2002
... Tris-Buffered Saline (TBS) for 4 min and then incubated at 1:300 dilution of primary anti-rabbit polyclonal prolactin antibody (Dako Cytomation, Copenhagen, Denmark) in ...
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Papers on Prolactin
Rapid modulation of hypothalamic Kiss1 levels by the suckling stimulus in the lactating rat.
Ozawa et al., Tokyo, Japan. In J Endocrinol, 30 Nov 2015
We also examined the possible involvement of prolactin (PRL).
An autoregulatory enhancer controls mammary-specific STAT5 functions.
Hennighausen et al., Bethesda, United States. In Nucleic Acids Res, 07 Nov 2015
Although STAT5A is expressed in most tissues it remains to be understood why its premier, non-redundant functions are restricted to prolactin-induced mammary gland development and function.
Exercise augments the nocturnal prolactin rise in exercise-trained men.
Lane et al., Chapel Hill, United States. In Ther Adv Endocrinol Metab, 31 Oct 2015
OBJECTIVE: The objective of this study was to profile over a 24 h period the prolactin responses of exercise-trained men on a day involving rest with no exercise in comparison to a day involving exercise training sessions.
Update on prolactinomas. Part 1: Clinical manifestations and diagnostic challenges.
Liu et al., Newark, United States. In J Clin Neurosci, 31 Oct 2015
Dopamine agonist therapy remains the first line of treatment for prolactinomas, as it is effective in normalizing serum prolactin levels and reducing tumor size.
Update on prolactinomas. Part 2: Treatment and management strategies.
Liu et al., Newark, United States. In J Clin Neurosci, 31 Oct 2015
Dopamine agonist therapy is the first line of treatment for prolactinomas because of its effectiveness in normalizing serum prolactin levels and shrinking tumor size.
ITI-007 for the Treatment of Schizophrenia: A 4-Week Randomized, Double-Blind, Controlled Trial.
Vanover et al., New York City, United States. In Biol Psychiatry, 01 Oct 2015
However, both doses of ITI-007 were well tolerated in this patient population, as evidenced by low discontinuation and adverse event rates, and were associated with a benign metabolic profile as evidenced by significantly lower levels of prolactin, fasting glucose, total cholesterol, and triglycerides than risperidone.
[Hyperprolactinaemia and bone mineral density].
Męczekalski et al., Poznań, Poland. In Pol Merkur Lekarski, Aug 2015
Prolactin is produced by the anterior lobe of the pituitary.The main role of prolactin is associated with mamotrophic action and lactogenesis.
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Schraenen et al., Leuven, Belgium. In Cell Metab, Jan 2015
Locally secreted hGH binds to prolactin receptors on β cells, activates STAT5 signaling, and induces pregnancy-like changes in gene expression, thereby augmenting pancreatic β cell mass and insulin content.
The influence of atypical antipsychotic drugs on sexual function.
Just, Piekary Śląskie, Poland. In Neuropsychiatr Dis Treat, Dec 2014
The relationship between atypical antipsychotic drugs and sexual dysfunction is mediated in part by antipsychotic blockade of pituitary dopamine D2 receptors increasing prolactin secretion, although direct correlations have not been established between raised prolactin levels and clinical symptoms.
Adjunctive Aripiprazole Treatment for Risperidone-Induced Hyperprolactinemia: An 8-Week Randomized, Open-Label, Comparative Clinical Trial.
Lv et al., Xinxiang, China. In Plos One, Dec 2014
Rating scales and safety assessments (RSESE, BARS, UKU) were performed at baseline and at weeks 4 and 8. Serum levels of prolactin were determined at baseline and at weeks 2, 4, 6 and 8. Metabolic parameters were determined at baseline and again at weeks 4 and 8. RESULTS: One hundred and thirteen patients were enrolled in this study, and 107 patients completed the study (54 in the aripiprazole group, and 53 in the control group).
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Luckman et al., Ann Arbor, United States. In Cell Metab, Nov 2014
Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure.
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
Hankinson et al., Boston, United States. In J Clin Oncol, Nov 2014
Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasive breast cancer (n = 437 patient cases and n = 775 controls not using postmenopausal hormones) in the Nurses' Health Study.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Struman et al., Liège, Belgium. In Nat Med, Jul 2014
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown.
Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial.
Stroup et al., New York City, United States. In Jama, Jun 2014
Patients taking paliperidone palmitate had significantly higher maximum mean levels of serum prolactin (men, 34.56 µg/L [95% CI, 29.75-39.37]
Tuka et al., In Ideggyogy Sz, Apr 2014
The antioxidant PAN, formulated besides the CysA, has similar effects: it attenuates the levels of SST and prolactin in the cerebral cortex and hypothalamus through the accumulation of CysA within cells throughout the body.
Transformation of a transposon into a derived prolactin promoter with function during human pregnancy.
Wagner et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
analysis of transformation of a transposon into a derived prolactin promoter with function during human pregnancy
Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells.
Sarkar et al., New Brunswick, United States. In J Endocrinol, 2012
Results suggest that the suppression of Dopamine-2 (D2) receptor short (D2S)-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling estradiol (E(2)-activated prolactin (PRL) synthesis and cell proliferation in lactotropes.
Serum prolactin and macroprolactin levels in diabetic nephropathy.
Cetinkaya et al., Antalya, Turkey. In Clin Nephrol, 2012
Serum prolactin/macroprolactin levels increased especially in moderate to severe renal failure which was due to decreased glomerular filtration and renal parenchymal function.
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.
Wang et al., Baltimore, United States. In Plos One, 2011
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers.
The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.
Simon et al., Trento, Italy. In Neural Dev, 2011
In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer, is down-regulated.
More papers using Prolactin antibodies
Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader
Alpini Gianfranco et al., In BMC Physiology, 2001
... polyclonal (ab35349) antibody recognizing the prolactin receptor (used for the immunohistochemical and immunofluorescent evaluation of prolactin receptor in liver sections) was purchased from Abcam (Cambridge, UK) ...
Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury
Levy Andy et al., In The Journal of Endocrinology, 1998
... and 1·7 kb of 3′ PRL sequence driving Cre recombinase expression was used to generate the PRL-Cre transgenic mice ...
Internalization is required for proper Wingless signaling in Drosophila melanogaster
Bellen Hugo J. et al., In The Journal of Cell Biology, 1995
... ), and 2 ng pRL-CMV (Promega) in 100 μL were sequentially combined with 3.2 μL Effectene Enhancer (QIAGEN), 10 μL Effectene (QIAGEN), ...
Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene
Kondaiah Paturu et al., In BMC Genomics, 1985
... 200 ng of pSBE-luc plasmid and 1.25 ng of pRL-CMV construct (Renilla luciferase, for transfection normalization) were transfected using Effectene reagent (Qiagen GmbH, Germany) in serum ...
Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion
Holly J M P et al., In British Journal of Cancer, 1978
... The prolactin monoclonal antibody was bought from QED Bioscience Inc., San Diego, CA, ...
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