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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.


Prolactin, PRL
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, Insulin, fibrillin-1
Papers using Prolactin antibodies
The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.
Korach Kenneth S. et al., In Environmental Health Perspectives, 2009
... including 0.2 μg of expression plasmid, 0.2 μg of reporter plasmid, and 0.1 μg of pRL-TK plasmid, were transfected overnight using Effectene Transfection Reagent (QIAGEN, Valencia, CA) according to ...
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
Ratner Adam J., In PLoS ONE, 2007
... Plasmids pCRE-Luc and pRL-TK were obtained from Clontech and Promega, respectively ...
Cell dynamics and immune response to BLV infection: a unifying model.
Kehn-Hall Kylene, In PLoS ONE, 2006
... The plasmid expressing the Renilla luciferase via the enhancerless promoter pRL-null (pRL-renilla) was purchased from Promega Corporation (Madison WI, USA) ...
Increase in bone mineral density of patients with rheumatoid arthritis treated with anti-TNF-alpha antibody: a prospective open-label pilot study
Nanes Mark S et al., In Journal of Bone and Mineral Research, 2004
... ) The Dual Luciferase Assay System, TNF T7 Coupled Reticulocyte Lysate System, and pRL-TK control vector were purchased from Promega Corporation (Madison, WI, USA) ...
A statistical model for identifying proteins by tandem mass spectrometry
Zhu Jianhong et al., In Proteome Science, 2002
... Tris-Buffered Saline (TBS) for 4 min and then incubated at 1:300 dilution of primary anti-rabbit polyclonal prolactin antibody (Dako Cytomation, Copenhagen, Denmark) in ...
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Papers on Prolactin
A Patient with a Thyrotropin-secreting Microadenoma and Resistance to Thyroid Hormone (P453T).
Shan et al., Shenyang, China. In J Clin Endocrinol Metab, 13 May 2015
Histologically, the tumor stained positively for TSH-β ,α-GSU, GH, PRL and ACTH.
Effect of estrogen receptor subtype specific ligands on fertility in adult male rats.
Balasinor et al., Mumbai, India. In J Endocrinol, 13 May 2015
Our results indicate that ERα is mainly involved in negative feedback regulation of gonadotropin hormones, whereas both the ERs are involved in regulation of prolactin and testosterone production.
Behavioral and endocrine evaluation of the stressfulness of single-pen housing compared to group-housing and social isolation conditions.
Chaillou et al., Lille, France. In Physiol Behav, 09 May 2015
The highest plasma prolactin levels were observed in Isol and Free animals, which might result from stress and physical activity, respectively.
New insights in prolactin: pathological implications.
Binart et al., Le Kremlin-Bicêtre, France. In Nat Rev Endocrinol, 17 Apr 2015
The major isoform, 23 kDa prolactin, acts via its membrane receptor, the prolactin receptor (PRL-R), which is a member of the haematopoietic cytokine superfamily and for which the mechanism of activation has been deciphered.
Outcomes of Endoscopic Transsphenoidal Pituitary Surgery.
Jane et al., Charlottesville, United States. In Endocrinol Metab Clin North Am, 31 Mar 2015
This article discusses some of the recent studies reporting outcomes from endoscopic series for Cushing disease, acromegaly, prolactin-secreting tumors, and nonfunctioning macroadenomas.
Bronstein et al., São Paulo, Brazil. In Endocrinol Metab Clin North Am, 31 Mar 2015
Dopamine agonists are efficacious in about 80% to 90% of patients with prolactinoma, leading to reduction of serum prolactin levels and tumor dimensions.
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Schraenen et al., Leuven, Belgium. In Cell Metab, Jan 2015
Locally secreted hGH binds to prolactin receptors on β cells, activates STAT5 signaling, and induces pregnancy-like changes in gene expression, thereby augmenting pancreatic β cell mass and insulin content.
Molecular Mechanisms of Taste Recognition: Considerations about the Role of Saliva.
Fábián et al., Denmark. In Int J Mol Sci, Dec 2014
Other proteins like glucagon-like peptide-1, salivary immunoglobulin-A, zinc-α-2-glycoprotein, salivary lactoperoxidase, salivary prolactin-inducible protein and salivary molecular chaperone HSP70/HSPAs were also expected to play an important role.
Bisphenol A and phthalate endocrine disruption of parental and social behaviors.
Rosenfeld, Columbia, United States. In Front Neurosci, Dec 2014
These behavioral disturbances may originate by altering the fetal or adult gonadal production of testosterone or estrogen, expression of ESR1, ESR2, and AR in the brain regions governing these behaviors, neuropeptide/protein hormone (oxytocin, vasopressin, and prolactin) and their cognate neural receptors, and/or through epimutations.
[Our experience with hormonal therapy in transsexual patients].
Fifková et al., In Vnitr Lek, Dec 2014
In MtF during hormonal therapy average prolactin level increased from 350.1 to 570.5 mU/l without clinical significance.
The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus.
Luckman et al., Ann Arbor, United States. In Cell Metab, Nov 2014
Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure.
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
Hankinson et al., Boston, United States. In J Clin Oncol, Nov 2014
Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasive breast cancer (n = 437 patient cases and n = 775 controls not using postmenopausal hormones) in the Nurses' Health Study.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Struman et al., Liège, Belgium. In Nat Med, Jul 2014
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown.
Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial.
Stroup et al., New York City, United States. In Jama, Jun 2014
Patients taking paliperidone palmitate had significantly higher maximum mean levels of serum prolactin (men, 34.56 µg/L [95% CI, 29.75-39.37]
Colocalization methods in pituitary tumorigenesis aged-related in MEN1 KO and wild type mice.
Coculescu et al., Bucureşti, Romania. In J Med Life, 2013
METHODS: Pituitary samples from nine Men1+/- mice, 29-34 days old male mice (n=8) and one year old (n=1) and control group, four new born (1,5 days old) wild type (mus musculus) mice were analyzed by immunofluorescence immunohistochemistry (GH, PRL, gonadotrophs) to find hormonal colocalization in pituitary cell.
Transformation of a transposon into a derived prolactin promoter with function during human pregnancy.
Wagner et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
analysis of transformation of a transposon into a derived prolactin promoter with function during human pregnancy
Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells.
Sarkar et al., New Brunswick, United States. In J Endocrinol, 2012
Results suggest that the suppression of Dopamine-2 (D2) receptor short (D2S)-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling estradiol (E(2)-activated prolactin (PRL) synthesis and cell proliferation in lactotropes.
Serum prolactin and macroprolactin levels in diabetic nephropathy.
Cetinkaya et al., Antalya, Turkey. In Clin Nephrol, 2012
Serum prolactin/macroprolactin levels increased especially in moderate to severe renal failure which was due to decreased glomerular filtration and renal parenchymal function.
Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites.
Wang et al., Baltimore, United States. In Plos One, 2011
The results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers.
The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons.
Simon et al., Trento, Italy. In Neural Dev, 2011
In Pbx1-deficient dopaminergic neurons, the high affinity netrin-1 receptor, deleted in colon cancer, is down-regulated.
More papers using Prolactin antibodies
Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader
Alpini Gianfranco et al., In BMC Physiology, 2001
... polyclonal (ab35349) antibody recognizing the prolactin receptor (used for the immunohistochemical and immunofluorescent evaluation of prolactin receptor in liver sections) was purchased from Abcam (Cambridge, UK) ...
Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury
Levy Andy et al., In The Journal of Endocrinology, 1998
... and 1·7 kb of 3′ PRL sequence driving Cre recombinase expression was used to generate the PRL-Cre transgenic mice ...
Internalization is required for proper Wingless signaling in Drosophila melanogaster
Bellen Hugo J. et al., In The Journal of Cell Biology, 1995
... ), and 2 ng pRL-CMV (Promega) in 100 μL were sequentially combined with 3.2 μL Effectene Enhancer (QIAGEN), 10 μL Effectene (QIAGEN), ...
Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene
Kondaiah Paturu et al., In BMC Genomics, 1985
... 200 ng of pSBE-luc plasmid and 1.25 ng of pRL-CMV construct (Renilla luciferase, for transfection normalization) were transfected using Effectene reagent (Qiagen GmbH, Germany) in serum ...
Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion
Holly J M P et al., In British Journal of Cancer, 1978
... The prolactin monoclonal antibody was bought from QED Bioscience Inc., San Diego, CA, ...
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