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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Prokineticin 1

PROK1, prokineticin 1
may act as an endothelial cell mitogen; may be involved in G-protein coupled receptor signaling via regulation of intracellular calcium [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: vascular endothelial growth factor, PK2, PKR2, PKR1, V1a
Papers on PROK1
miRNA and target gene expression in menstrual endometria and early pregnancy decidua.
New
Wang et al., Hohhot, China. In Eur J Obstet Gynecol Reprod Biol, Dec 2015
In addition, the decidua had significantly lower levels of expression of LIF, IL6, MMP2, MMP10, and IGF2R and higher levels of expression of SGK1, LEPR, PROK1, and STAT3 than the menstrual endometria group.
Prokineticins in central and peripheral control of human reproduction.
New
Alfaidy et al., In Horm Mol Biol Clin Investig, Dec 2015
Prokineticin 1 (PROK1) and (PROK2), are two closely related proteins that were identified as the mammalian homologs of their two amphibian homologs, mamba intestinal toxin (MIT-1) and Bv8.
Cimetidine-induced Leydig cell apoptosis and reduced EG-VEGF (PK-1) immunoexpression in rats: Evidence for the testicular vasculature atrophy.
New
Sasso-Cerri et al., São Paulo, Brazil. In Reprod Toxicol, Nov 2015
Since Leydig cells (LCs) produce the pro-angiogenic factor, EG-VEGF (endocrine gland-derived vascular endothelial growth factor), also known as prokineticin 1 (PK-1), this study examined the effect that cimetidine might have on LCs in testes with damaged vasculature.
The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1 (No correlation coefficient between VEGF and PROK1).
New
Yamaguchi et al., Fukui, Japan. In Oncotarget, Nov 2015
The angiogenic proteins vascular endothelial growth factor (VEGF) and prokineticin1 (PROK1) proteins are considered important in colorectal cancer, the relationship between their simultaneous expression and prognosis was investigated in the present study.
PROK1 level in the follicular microenvironment: a new non-invasive predictive biomarker of embryo implantation.
New
Brouillet et al., Grenoble, France. In J Clin Endocrinol Metab, Oct 2015
CONTEXT: Prokineticin 1 (PROK1), also called EG-VEGF (Endocrine Gland-derived Vascular Endothelial Growth Factor), is a well-established regulator of endometrial receptivity and placental development.
Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.
New
Anderson et al., Belfast, United Kingdom. In J Clin Endocrinol Metab, Sep 2015
RESULTS: Expression of PROK1 and PROKR1 was significantly higher in mid-gestation ovaries (17-20 wk) than at earlier gestations (8-11 and 14-16 wk).
Prokineticin 1 protein expression is a useful new prognostic factor for human sporadic colorectal cancer.
New
Yamaguchi et al., Fukui, Japan. In Ann Surg Oncol, May 2015
The angiogenic growth factor prokineticin 1 (PROK1) has been cloned from endocrine cells.
The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer.
New
Yamaguchi et al., Fukui, Japan. In Oncotarget, Apr 2015
Two angiogenic growth factors, in particular, Vascular endothelial growth factor (VEGF) and Prokineticin1(PROK1), are considered to have an important role in hematogenous metastasis of colorectal cancer.
The multiple roles of EG-VEGF/PROK1 in normal and pathological placental angiogenesis.
Review
Brouillet et al., Grenoble, France. In Biomed Res Int, 2013
In the last decade, endocrine gland derived vascular endothelial growth factor (EG-VEGF), also called prokineticin 1 (PROK1), has emerged as specific placental angiogenic factor that controls many aspects of normal and pathological placental angiogenesis such as recurrent pregnancy loss (RPL), gestational trophoblastic diseases (GTD), fetal growth restriction (FGR), and preeclampsia (PE).
EG-VEGF: a key endocrine factor in placental development.
Review
Alfaidy et al., Grenoble, France. In Trends Endocrinol Metab, 2012
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), also named prokineticin 1, is the canonical member of the prokineticin family.
Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity.
Wang et al., Shanghai, China. In Neural Regen Res, 2012
Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia.
The puzzles of the prokineticin 2 pathway in human reproduction.
Review
Crowley et al., Boston, United States. In Mol Cell Endocrinol, 2011
In particular, PROK1 acts as a potent angiogenic mitogen on endocrine vascular epithelium, thus earning its other name, Endocrine gland-vascular endothelial factor (EG-VEGF) (LeCouter et al., 2002).
Prokineticins in angiogenesis and cancer.
Review
Samson et al., Rennes, France. In Cancer Lett, 2010
The mammalian orthologs consist of two prokineticin peptides, prokineticin 1 (PROK1) and prokineticin 2 (PROK2) that signal through two G-protein coupled receptors: prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2).
The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism.
Review
Latronico et al., São Paulo, Brazil. In Neuroendocrinology, 2009
The prokineticin system comprises two multifunctional secreted proteins, prokineticin-1 (PROK1) and prokineticin-2 (PROK2), and their cognate G protein-coupled receptors.
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Impact
Ferrara et al., San Francisco, United States. In Nature, 2008
We have previously shown that the related EG-VEGF and Bv8 proteins, also known as prokineticin 1 (Prok1) and prokineticin 2 (Prok2), promote both tissue-specific angiogenesis and haematopoietic cell mobilization.
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