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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


prohibitin, PHB, PHB1
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, fibrillin-1, V1a, HAD
Papers using prohibitin antibodies
Phosphorylation of histones by tissue transglutaminase.
Kobe Bostjan, In PLoS ONE, 2005
... The pCMV6-XL5 vector containing human PHB clone (Reference sequence XM_056688) was obtained from Origene technologies, USA ...
The uptake of lipids by rat liver cells.
Kursula Petri, In PLoS ONE, 1965
... (Brea, CA); HEL cells were obtained from the American Type Culture Collection (Rockville, MD); prohibitin1 (PHB1) antibody was from Cell Signaling Technology, Inc ...
Papers on prohibitin
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
Langer et al., Köln, Germany. In J Cell Biol, Feb 2016
Using mice lacking prohibitin membrane scaffolds as a model of neurodegeneration, we demonstrate that additional ablation of Oma1 delays neuronal loss and prolongs lifespan.
Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked tumor development in insulin resistance-dependent manner.
Mishra et al., Winnipeg, Canada. In Oncogene, Feb 2016
Prohibitin (PHB) is a pleiotropic protein that has a role in adipose and immune functions.
Obesity-related abnormalities couple environmental triggers with genetic susceptibility in adult-onset T1D.
Mishra et al., Winnipeg, Canada. In Biochem Biophys Res Commun, Feb 2016
Recently, we have developed two novel transgenic obese mice models, Mito-Ob and m-Mito-Ob, by expressing a pleiotropic protein prohibitin (PHB) and a phospho mutant form of PHB (Y114F-PHB or m-PHB) from the aP2 gene promoter, respectively.
Unveiling the potential of prohibitin in cancer.
Dart et al., Cardiff, United Kingdom. In Cancer Lett, Jan 2016
Recently, research has shed new light on the role of Prohibitin (PHB) in cancer pathogenesis across an array of cancer types.
Effect of Polyhydroxybutyrate (PHB) storage on L-arginine production in recombinant Corynebacterium crenatum using coenzyme regulation.
Xu et al., Wuxi, China. In Microb Cell Fact, Dec 2015
Poly-β-hydroxybutyrate (PHB) is a kind of biopolymer stored as bacterial reserve materials for carbon and energy.
Modeling of Progesterone Release from Poly(3-Hydroxybutyrate) (PHB) Membranes.
Gonzo et al., Salta, Argentina. In Aaps Pharmscitech, Oct 2015
UNASSIGNED: Poly(3-hydroxybutyrate) (PHB) biodegradable polymeric membranes were evaluated as platform for progesterone (Prg)-controlled release.
Multifaceted role of prohibitin in cell survival and apoptosis.
Song et al., Changsha, China. In Apoptosis, Sep 2015
Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations.
Non-random distribution of macromolecules as driving forces for phenotypic variation.
Müller et al., Leipzig, Germany. In Curr Opin Microbiol, Jun 2015
Different types of segregation are described, addressing both metabolically pertinent molecules such as PHA/PHB or polyphosphates, and components that adversely affect cells by promoting aging, such as damaged protein complexes or extrachromosomal rDNA circles.
Prohibitin 2: At a communications crossroads.
Blalock et al., Bologna, Italy. In Iubmb Life, Apr 2015
The human genome encodes two PHB proteins, prohibitin 1 (PHB1) and prohibitin 2 (PHB2), which function not only as a heterodimeric complex, but also independently.
Oligopeptide complex for targeted non-viral gene delivery to adipocytes.
Kim et al., Seoul, South Korea. In Nat Mater, 2014
Here, we show that an adipocyte-targeting fusion-oligopeptide gene carrier consisting of an adipocyte-targeting sequence and 9-arginine (ATS-9R) selectively transfects mature adipocytes by binding to prohibitin.
A Review: Proteomics in Nasopharyngeal Carcinoma.
Zhu et al., Nanning, China. In Int J Mol Sci, 2014
In conclusion, identical proteins are sorted as follows: Keratin is ranked the highest followed by such proteins as annexin, heat shock protein, 14-3-3σ, nm-23 protein, cathepsin, heterogeneous nuclear ribonucleoproteins, enolase, triosephosphate isomerase, stathmin, prohibitin, and vimentin.
DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.
Langer et al., Köln, Germany. In Cell Metab, 2014
Here, we have defined the interactome of PHB2 in mitochondria and identified DNAJC19, mutated in dilated cardiomyopathy with ataxia, as binding partner of PHB complexes.
Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility?
Chen et al., Shanghai, China. In Antioxid Redox Signal, 2012
PHB expression is an indicator of sperm quality in infertile men, and that it regulates sperm motility via an alteration in mitochondrial membrane potential and increased reactive oxygen species levels.
Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation.
Agrawal et al., Omaha, United States. In Exp Mol Pathol, 2012
These results suggest that under inflammatory conditions there is decreased expression of vitamin D receptor resulting in decreased expression of prohibitin. Vitamin D deficiency decreased the expression of vitamin D receptor and prohibitin.
Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.
CIMBA et al., Szczecin, Poland. In Br J Cancer, 2012
The PHB 1630TT genotype may modify breast and ovarian cancer risks in BRCA1 mutation carriers.
Prohibitin 1 modulates mitochondrial stress-related autophagy in human colonic epithelial cells.
Theiss et al., Dallas, United States. In Plos One, 2011
Decreased PHB levels coupled with dysfunctional autophagy renders intestinal epithelial cells susceptible to mitochondrial damage and cytotoxicity.
Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells.
Thompson et al., Atlanta, United States. In Plos One, 2011
PHB1 and PHB2 are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies
Prohibitin couples diapause signalling to mitochondrial metabolism during ageing in C. elegans.
Tavernarakis et al., Irákleion, Greece. In Nature, 2009
Here, we show that the mitochondrial prohibitin complex promotes longevity by modulating mitochondrial function and fat metabolism in the nematode Caenorhabditis elegans.
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly.
Anderson et al., Boston, United States. In Nat Cell Biol, 2008
O-GlcNAc-modified proteins are prominent components of SGs but not PBs, and include RACK1 (receptor for activated C kinase 1), prohibitin-2, glyceraldehyde-3-phosphate dehydrogenase and numerous ribosomal proteins.
Reduced cytosolic protein synthesis suppresses mitochondrial degeneration.
Chen et al., Syracuse, United States. In Nat Cell Biol, 2008
These longevity interventions also independently suppressed ageing-related mitochondrial degeneration in the pro-ageing prohibitin mutants.
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