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Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

Progesterone Reductase, HSD3B2, HSD3B
The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: P450scc, P450c17, HAD, CAN, AGE
Papers on Progesterone Reductase
High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells.
New
Martin et al., Durham, United States. In Toxicol Sci, Feb 2016
Clustering of the concentration-dependent chemical-mediated steroid hormone effects grouped chemical samples into five distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition.
Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro.
New
Bollwein et al., Bern, Switzerland. In Reproduction, Jan 2016
Punch biopsies of the CL were collected every 60 min and used for RT-qPCR to evaluate mRNA expression of receptors for LPS (TLR2, -4) and LH (LHCGR); the cytokine TNFA; steroidogenic (STAR, HSD3B), angiogenic (VEGFA121, FGF2), and vasoactive (EDN1) factors; and factors of prostaglandin synthesis (PGES, PGFS, PTGFR) and apoptosis (CASP3, -8, -9).
A Dietary Medium-Chain Fatty Acid, Decanoic Acid, Inhibits Recruitment of Nur77 to the HSD3B2 Promoter In Vitro and Reverses Endocrine and Metabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
New
Yong et al., Singapore, Singapore. In Endocrinology, Jan 2016
Here, we report for the first time that DA, like metformin, inhibits androgen biosynthesis in NCI-H295R steroidogenic cells by regulating the enzyme 3β-hydroxysteroid dehydrogenase/Δ5-Δ4-isomerase type 2 (HSD3B2).
Preliminary evidence of altered steroidogenesis in women with Alzheimer's disease: Have the patients "OLDER" adrenal zona reticularis?
New
Stárka et al., Praha, Czech Republic. In J Steroid Biochem Mol Biol, Jan 2016
The patients showed diminished HSD3B2 activity for C21 steroids, abated conversion of 17-hydroxyprogesterone to cortisol, and significantly elevated cortisol.
Morphological characterization of adult mouse Leydig cells in culture.
New
Cao et al., Beijing, China. In Biochem Biophys Res Commun, Jan 2016
The Leydig cells were identified by HSD3B staining and RT-PCR.
Calcium-dependent NR4A1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements.
New
Tremblay et al., Québec, Canada. In J Mol Endocrinol, Jan 2016
UNASSIGNED: The nuclear receptor NR4A1 is expressed in steroidogenic Leydig cells where it plays pivotal roles by regulating the expression of several genes involved in steroidogenesis and male sex differentiation including Star, HSD3B2, and Insl3.
Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.
New
Li et al., Chongqing, China. In Int J Mol Sci, Dec 2015
Mechanistic studies revealed that Prl7d1 transgenic mice have defects in the testicular expression of steroidogenic acute regulatory protein (STAR) and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase cluster (HSD3B).
Human 3β-hydroxysteroid dehydrogenase deficiency seems to affect fertility but may not harbor a tumor risk: lesson from an experiment of nature.
Review
New
Flück et al., Bern, Switzerland. In Eur J Endocrinol, Nov 2015
There are two isozymes of 3βHSD, HSD3B1 and HSD3B2.
Autoantibodies against Cytochrome P450 Side-Chain Cleavage Enzyme in Dogs (Canis lupus familiaris) Affected with Hypoadrenocorticism (Addison's Disease).
Catchpole et al., Edinburgh, United Kingdom. In Plos One, 2014
Coding regions of canine CYP21A2 (21-hydroxylase; 21-OH), CYP17A1 (17-hydroxylase; 17-OH), CYP11A1 (P450 side-chain cleavage enzyme; P450scc) and HSD3B2 (3β hydroxysteroid dehydrogenase; 3βHSD) were amplified, cloned and expressed as 35S-methionine radiolabelled recombinant protein.
Dynamic Changes in the Follicular Transcriptome and Promoter DNA Methylation Pattern of Steroidogenic Genes in Chicken Follicles throughout the Ovulation Cycle.
Jiang et al., Taishan, China. In Plos One, 2014
We further investigated the transcriptional regulation of follicular steroidogenesis by examining the follicle-specific methylation profiles of Star (steroidogenic acute regulatory protein), Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1) and Hsd3b (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1), genes encoding the key enzymes for progesterone synthesis.
Steroidogenesis of the testis -- new genes and pathways.
Review
Pandey et al., Bern, Switzerland. In Ann Endocrinol (paris), 2014
The classic androgen biosynthesis defects with AI are lipoid CAH, CYP11A1 and HSD3B2 deficiencies.
Luteal regression vs. prepartum luteolysis: regulatory mechanisms governing canine corpus luteum function.
Review
Kowalewski, Zürich, Switzerland. In Reprod Biol, 2014
Most recently, evidence has been provided for an autocrine/paracrine role of prostaglandin E2 (PGE2) as a luteotrophic factor in the canine CL acting at the level of steroidogenic acute regulatory (STAR)-protein mediated supply of steroidogenic substrate, without having a significant impact on the enzymatic activity of the respective steroidogenic enzymes, 3β-hydroxysteroid-dehydrogenase (3βHSD, HSD3B2) and cytochrome P450 side-chain cleavage enzyme (P450scc, CYP11A1).
Aetiology of hypospadias: a systematic review of genes and environment.
Review
Roeleveld et al., Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
Mitochondrial 3β-hydroxysteroid dehydrogenase enzyme activity requires reversible pH-dependent conformational change at the intermembrane space.
GeneRIF
Bose et al., Savannah, United States. In J Biol Chem, 2012
Mitochondrial HSD3B2 activity requires reversible pH-dependent conformational change at the intermembrane space.
Lipid-mediated unfolding of 3β-hydroxysteroid dehydrogenase 2 is essential for steroidogenic activity.
GeneRIF
Bose et al., Savannah, United States. In Biochemistry, 2012
Data suggest that HSD3B2 interacts/unfolds in presence of specific liposomes (unilamellar liposomes of DPPG/DPPC). This lipid-mediated unfolding completely supports model in which cavity forms between alpha-helix and beta-sheet to activate enzyme.
Inner mitochondrial translocase Tim50 interacts with 3β-hydroxysteroid dehydrogenase type 2 to regulate adrenal and gonadal steroidogenesis.
GeneRIF
Bose et al., Savannah, United States. In J Biol Chem, 2011
3beta-hydroxysteroid dehydrogenase type 2
Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production.
GeneRIF
Rainey et al., Sendai, Japan. In J Steroid Biochem Mol Biol, 2011
Human adrenal cells that express both 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
GeneRIF
Matsumoto et al., Tokyo, Japan. In Eur J Endocrinol, 2010
SNPs located within the HSD3B2 gene were not associated with essential hypertension.
Pituitary-adrenal axis during human development.
Review
Goto, Tokyo, Japan. In Clin Pediatr Endocrinol, 2006
Fluctuation of 3beta-hydroxysteroid dehydrogenase (HSD3B2) in human fetal adrenal has several significant meanings.
Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family.
Review
Impact
Melner et al., Québec, Canada. In Endocr Rev, 2005
Recent studies indicate that HSD3B2 gene regulation involves the orphan nuclear receptors steroidogenic factor-1 and dosage-sensitive sex reversal adrenal hypoplasia congenita critical region on the X chromosome gene 1 (DAX-1).
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