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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Platelet-derived growth factor receptor-like

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, p22, POLYMERASE, TSG, PTEN
Papers on PRLTS
Identification and characterisation of alternative transcriptional variants of PDGFRL in two lines of commercial poultry.
Dunn et al., Edinburgh, United Kingdom. In Anim Genet, Oct 2015
A putative member of the family, platelet-derived growth factor receptor-like (PDGFRL), has been implicated in steroid-based feedback mechanisms within the chicken reproductive system.
Exome analysis identified a novel missense mutation in the CLPP gene in a consanguineous Saudi family expanding the clinical spectrum of Perrault Syndrome type-3.
Al-Aama et al., Jiddah, Saudi Arabia. In J Neurol Sci, 2014
Perrault syndrome (PRLTS) is a clinically and genetically heterogeneous disorder.
Genetic variant on PDGFRL associated with Beh├žet disease in Chinese Han populations.
Yang et al., Chongqing, China. In Hum Mutat, 2013
This study aimed to explore the predisposition of PDGFRL at the 8p21.3
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Yan et al., Cardiff, United Kingdom. In Hum Mutat, 2012
CNAs involving the ITGB8, PDGFA, Ras-related C3 botulinum toxin substrate 1 (RAC1) (7p21-p22), PDGFRL (8p22-p21.3),
Identification of novel candidate genes for follicle selection in the broiler breeder ovary.
Hocking et al., Edinburgh, United Kingdom. In Bmc Genomics, 2011
Three candidate genes were confirmed by QPCR as showing significant differential expression between restricted and ad libitum feeding: FSHR, GDF9 and PDGFRL.
Expression and functional characterization of platelet-derived growth factor receptor-like gene.
Li et al., Changsha, China. In World J Gastroenterol, 2010
Results indicate that PDGFRL functions as a tumor suppressor, inhibiting the growth of colorectal cancer cells.
An integrative approach to characterize disease-specific pathways and their coordination: a case study in cancer.
Zhou et al., Los Angeles, United States. In Bmc Genomics, 2007
Here by adopting a network perspective, we have identified their interrelationships and, particularly, a hub gene PDGFRL that may play an important role in this tumor suppressor network.
The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.
Matta et al., Mobile, United States. In Bmc Med Genomics, 2007
Several putative tumor oncogenes (SPP-1, MITF, CITED-1, GDF-15, c-Met, HOX loci) and suppressor genes (PITX-1, CST-6, PDGFRL, DSC-3, POU2F3, CLCA2, ST7L), were identified and validated by quantitative PCR as changing expression during this transition period.
Genetic background of different cancer cell lines influences the gene set involved in chromosome 8 mediated breast tumor suppression.
Scherneck et al., Berlin, Germany. In Genes Chromosomes Cancer, 2006
The expression patterns of seven genes highly expressed in the hybrids but down-regulated in the tumors and metastases (MYH11, CRYAB, C11ORF8, PDGFRL, PLAGL1, SH3BP5, and KIAA1026) were confirmed by RT-PCR and tissue microarray analyses.
Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival.
Krainer et al., Vienna, Austria. In Cancer, 2006
METHODS: On the basis of publicly available expression data in ovarian tissues, the authors selected the eight most noteworthy genes from 8p22 (DLC1, N33, ZDHHC2, FLJ32642, PDGFRL, MTSG1, PCM1, and EFA6R) for a detailed expression analysis in 58 primary ovarian carcinoma tissues and in 38 ovarian cancer cell lines by using quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR).
Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis.
Kawanami et al., Japan. In J Nihon Med Sch, 2004
The common upregulated genes in well and poorly differentiated cell types at both irradiation doses included SCYA5, CYP51, SMARCD2, COX6C, MAPK8, FOS, UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6.
Loss of heterozygosity of chromosome 8p and 11p in the dysplastic nodule and hepatocellular carcinoma.
Kang et al., Seoul, South Korea. In J Gastroenterol Hepatol, 2003
Platelet-derived growth factor-receptor beta-like tumor suppressor gene (PRLTS) and deletion in liver cancer-1 tumor suppressor gene are located at 8p21.3-p22.
Deletion of tumor suppressor genes in Chinese non-small cell lung cancer.
Cheng et al., Beijing, China. In Cancer Lett, 2002
The studied TSGs comprised FHIT, VHL, APC, PRLTS, p16, IFNA, PTEN, p57, ATM, p53, BRCA1, DPC4 and DCC.
[Comparison of tumor suppressor gene deletion between squamous cell carcinoma and adenocarcinoma lung cancer in Chinese].
Huang et al., Beijing, China. In Zhonghua Zhong Liu Za Zhi, 2001
Three genes, PRLTS, PTEN and p57, showed statistically significant differences in the LOH frequency between SCC and ADC.
Sequence analysis of a total of three megabases of DNA in two regions of chromosome 8p.
Nakamura et al., Tokyo, Japan. In Dna Res, 2000
region, six known genes (PRLTS, PCM1, MTAMR7, HCAT2, HFREP-1 and PHP) and three novel genes.
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