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Protein tyrosine phosphatase type IVA, member 3

PRL-3, PTP4A3
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Prolactin, CAN, HAD, PRL-1, OV-1
Papers on PRL-3
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
New
Li et al., Guangzhou, China. In Cancer Res, Feb 2016
Importantly, we found that phosphatase of regenerating liver-3 (PRL-3) is indispensable for USP4-mediated oncogenic activity in colorectal cancer.
Genomic gain of the PRL-3 gene may represent poor prognosis of primary colorectal cancer, and associate with liver metastasis.
New
Watanabe et al., Sagamihara, Japan. In Clin Exp Metastasis, Dec 2015
UNASSIGNED: PRL-3 genomic copy number is increased in colorectal cancer (CRC), and PRL-3 expression is closely associated with lymph node and liver metastasis of CRC.
PRL-3 promotes gastric cancer migration and invasion through a NF-κB-HIF-1α-miR-210 axis.
New
Shou et al., Beijing, China. In J Mol Med (berl), Dec 2015
UNASSIGNED: Phosphatase of regenerating liver-3 (PRL-3) has been implicated in controlling cancer cell invasiveness.
Prognostic importance of RASSF2 expression in patients with gastric cancer who had undergone radical gastrectomy.
New
Aliustaoglu et al., İstanbul, Turkey. In Clin Transl Oncol, Nov 2015
Low PRL-3 expression was closely correlated with lymph node metastasis (p = 0.001), advanced pT stage (p = 0.021), advanced TNM stage (p < 0.001), the presence of vascular invasion (p < 0.001), perineural invasion (p = 0.018) and high prevalence of recurrence (p = 0.003) compared with high RASSF2 expression.
Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer.
New
Wu et al., Kao-hsiung, Taiwan. In World J Urol, Nov 2015
From a published BC transcriptome, we identified that PTP IVA3 (PTP4A3) was the most significantly upregulated gene implicated in tumor progression among genes related to prenylated PTPs.
Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver.
Köhn et al., Heidelberg, Germany. In Plos One, 2014
Remarkably, the tested procyanidins showed selectivity in vitro when compared to other PPs, and over 10-fold selectivity toward PRL-1 over PRL-2 and PRL-3.
PRL-3 activates mTORC1 in Cancer Progression.
Zeng et al., Singapore, Singapore. In Sci Rep, 2014
PRL-3, a metastasis-associated phosphatase, is known to exert its oncogenic functions through activation of PI3K/Akt, which is a key regulator of the rapamycin-sensitive mTOR complex 1 (mTORC1), but a coherent link between PRL-3 and activation of mTOR has not yet been formally demonstrated.
Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents.
Review
Lazo et al., Charlottesville, United States. In Expert Opin Investig Drugs, 2014
AREAS COVERED: This review examines the investigational challenges in identifying Tyr phosphatase inhibitors using the oncogenic phosphatase PTP4A3 as a prototype.
miR-495 and miR-551a inhibit the migration and invasion of human gastric cancer cells by directly interacting with PRL-3.
GeneRIF
Park et al., Nanchang, China. In Cancer Lett, 2012
our findings suggest that miR-495 and miR-551a both act as tumor suppressors by targeting the PRL-3 oncogene and inhibiting gastric cancer cell migration and invasion.
miR-21, miR-17 and miR-19a induced by phosphatase of regenerating liver-3 promote the proliferation and metastasis of colon cancer.
GeneRIF
Wang et al., Guangzhou, China. In Br J Cancer, 2012
The overexpression of PRL-3 in colon cancer cells induced the expression of miR-21, miR-17 and miR-19a by activating STAT3.
Prognostic significance of high phosphatase of regenerating liver-3 expression in patients with gastric cancer who underwent curative gastrectomy.
GeneRIF
Gumus et al., İstanbul, Turkey. In Dig Dis Sci, 2012
PRL-3 gene expression, may have prognostic significance in gastric cancer, treated with radical gastrectomy.
Downregulating PRL-3 inhibit migration and invasion of lung cancer cell via RhoA and mDia1.
GeneRIF
Enhua et al., Shenyang, China. In Tumori, 2012
Data indicate that downregulating PRL-3 inhibit cell migration and invasion by inactivating RhoA to downregulate mDia1 to reorganizate cytoskeleton of lung cancer cells.
Genetic determinants of uveal melanoma.
Review
Saule et al., Paris, France. In Dev Ophthalmol, 2011
Among other discriminant genes identified from genome-wide expression profiling, PTP4A3, mapping to 8q24.3, coding for a protein promoting cell migration, is highly overexpressed in class 2 tumors.
Proteomic analysis identifies translationally controlled tumor protein as a mediator of phosphatase of regenerating liver-3-promoted proliferation, migration and invasion in human colon cancer cells.
GeneRIF
Guan et al., Guangzhou, China. In Chin Med J (engl), 2011
Results imply that TCTP might be a mediator of PRL-3-promoted proliferation, migration and invasion of human colon cancer cells.
PRL-3, an emerging marker of carcinogenesis, is strongly associated with poor prognosis.
Review
GeneRIF
Pryczynicz et al., Białystok, Poland. In Anticancer Agents Med Chem, 2011
REVIEW: role of this protein in the process of cancer angiogenesis and metastasis, and poor prognosis
Genomic and epigenetic profiles of gastric cancer: potential diagnostic and therapeutic applications.
Review
Watanabe et al., Sagamihara, Japan. In Surg Today, 2011
On the other hand, the prometastatic oncogene PRL-3 is commonly activated in both types of advanced gastric cancer, and might represent a relevant therapeutic target for gastric cancer with lymph node metastasis or peritoneal dissemination.
PRL-3 phosphatase and cancer metastasis.
Review
Zeng et al., Singapore, Singapore. In J Cell Biochem, 2011
Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression.
PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase.
Impact
GeneRIF
Zeng et al., Singapore, Singapore. In Cancer Cell, 2010
Overexpression of PRL-3 is associated with cancer.
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.
Impact
Sikic et al., Stanford, United States. In J Clin Oncol, 2007
This set of 271 differentially expressed genes (including GAB1, CIITA, XBP1, CD83, SERPINB9, PTP4A3, NOV, LOX, CTNND1, BAALC, and RAB21) is enriched for genes involved in cell death, cellular growth and proliferation, and hematologic system development and function.
A phosphatase associated with metastasis of colorectal cancer.
Impact
GeneRIF
Vogelstein et al., Baltimore, United States. In Science, 2001
Data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.
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