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Protein kinase, Y-linked, pseudogene

This gene is similar to the protein kinase, X-linked gene in the pseudoautosomal region of the X chromosome. The gene is classified as a transcribed pseudogene because it has lost a coding exon that results in all transcripts being candidates for nonsense-mediated decay (NMD) and unlikely to express a protein. Abnormal recombination between this gene and a related gene on chromosome X is a frequent cause of XX males and XY females. [provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: PRKX, AMELY, SRY, POLYMERASE, USP9Y
Papers on PRKY
Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies.
Tomaszewski et al., Leicester, United Kingdom. In Arterioscler Thromb Vasc Biol, 2013
When compared with men with other haplogroups, carriers of haplogroup I had ≈ 0.61- and 0.64-fold lower expression of ubiquitously transcribed tetratricopeptide repeat, Y-linked gene (UTY) and protein kinase, Y-linked, pseudogene (PRKY) in macrophages (P=0.0001 and P=0.002, respectively).
The nuts and bolts of AGC protein kinases.
Alessi et al., Dundee, United Kingdom. In Nat Rev Mol Cell Biol, 2010
The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST).
Gene conversion between the X chromosome and the male-specific region of the Y chromosome at a translocation hotspot.
Jobling et al., Leicester, United Kingdom. In Am J Hum Genet, 2009
We resequenced X and Y copies of a translocation hotspot adjacent to the PRKX and PRKY genes and found evidence of historical exchange between the male-specific region of the human Y and the X in patchy flanking gene-conversion tracts on both chromosomes.
Constitutional duplication of a region of chromosome Yp encoding AMELY, PRKY, and TBL1Y: implications for sex chromosome analysis and bone marrow engraftment analysis.
Griffin et al., Baltimore, United States. In J Mol Diagn, 2007
The amplified region contains the genes AMELY, transducin (beta)-like 1 protein Y (TBL1Y), and protein kinase Y (PRKY).
Structural variation on the short arm of the human Y chromosome: recurrent multigene deletions encompassing Amelogenin Y.
Parkin et al., Leicester, United Kingdom. In Hum Mol Genet, 2007
In addition to AMELY, deletion males all lack the genes PRKY and TBL1Y, and the rarer deletion classes also lack PCDH11Y.
Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma.
Kuo et al., Tainan City, Taiwan. In Gynecol Oncol, 2006
We tested transcripts of 14 Y chromosomal genes by RT-PCR (TSPY, DAZ, BPY1 and BPY2, PRY, XKRY, CDY1 and CDY2, TTY1 and TTY2, PRKY, RBMY1, DBY and USP9Y), and only transcript of TSPY was detectable in the tumor tissue.
Olfactory receptor-gene clusters, genomic-inversion polymorphisms, and common chromosome rearrangements.
Zuffardi et al., Chicago, United States. In Am J Hum Genet, 2001
After the Yp inversion polymorphism, which is the preferential background for the PRKX/PRKY translocation in XX males and XY females, the OR-8p inversion is the second genomic polymorphism that confers susceptibility to the formation of common chromosome rearrangements.
Expression analysis of Y chromosome genes in human prostate cancer.
Dahiya et al., San Francisco, United States. In J Urol, 2001
RESULTS: Of the 19 genes analyzed in cell lines BPH-1 cells expressed the RPS4Y, USP9Y, TMSB4Y and DBY genes; DUPro expressed RPS4Y, USP9Y, TMSB4Y, DBY and UTY; DU145 expressed DAZ, RPS4Y, USP9Y, TMSB4Y, DBY, EIAFIY, PRKY and SMCY; LNCaP expressed TSPY, SRY, BPY1, PRY, DAZ, RBMIH, RPS4Y, DBY, EIAFIY, PRKY and SMCY; ND1 expressed DAZ, RPS4Y, USP9Y, TMSB4Y, DBY, EIAFIY, PRKY and SMCY; and PC3 expressed RPS4Y, USP9Y and DBY.
Expression analysis of thirty one Y chromosome genes in human prostate cancer.
Zhang et al., San Francisco, United States. In Mol Carcinog, 2000
The last group includes X-Y homologous (e.g., ZFY, PRKY, DFFRY, TB4Y, EIF1AY, and UTY) and Y-specific genes (e.g., SRY, TSPY, PRY, and XKRY).
An SRY-negative 47,XXY mother and daughter.
Scherer et al., Freiburg, Germany. In Cytogenet Cell Genet, 1999
PCR and FISH analysis revealed that the mother carries a structurally altered Y chromosome that most likely resulted from an aberrant X-Y interchange between the closely related genomic regions surrounding the gene pair PRKX and PRKY on Xp22.3 and Yp11.2, respectively.
Clinical, cytogenetic and molecular analysis of three 46,XX males.
Schiebel et al., Salzburg, Austria. In J Pediatr Endocrinol Metab, 1999
Two of these patients show a breakpoint within a protein kinase gene, PRKY, previously described as a hotspot of ectopic recombination between homologous regions on X and Y chromosomes during male meiosis.
Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.
Rappold et al., Heidelberg, Germany. In Hum Mol Genet, 1997
We have isolated and characterized a novel gene on the Y chromosome, PRKY.
High-resolution fluorescence in situ hybridization of human Y-linked genes on released chromatin.
Schempp et al., Freiburg, Germany. In Chromosome Res, 1997
We have, therefore, made use of the fluorescence in situ hybridization technique as an alternative strategy for physically mapping the PRKY and AMELY genes as well as the TSPY, RBM and DAZ gene families to human Y chromosomes in prometaphase and to extended Y chromatin in interphase.
FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12-->q13.
Rappold et al., Heidelberg, Germany. In Cytogenet Cell Genet, 1996
Sequencing and FISH mapping of all 4 members now reveals that the Y-homolog (PRKY) of the previously mapped PRKX gene (Xp22.3) is located in Yp11.2, in close vicinity to AMELY.
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