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Protein kinase, X-linked

PRKX, PKX1
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: PRKY, CAN, Akt, SGK1, BAG3
Papers on PRKX
PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development.
New
Li et al., Chengdu, China. In J Cell Biochem, Sep 2015
UNASSIGNED: The human protein kinase X gene (PRKX) and cAMP-dependent protein kinase (PKA) are both c-AMP-dependent serine/threonine protein kinases within the protein kinase AGC subgroup.
Gene expression profiling of taxol-resistant nasopharyngeal carcinoma cells with siRNA-mediated FOLR1 downregulation.
Tan et al., Changsha, China. In Int J Clin Exp Pathol, 2014
There was a significant deregulation of expression in the apoptosis-related genes such as BIRC3, PRKX, TNFRSF10A and involved in Viral carcinogenesis, MAPK signaling pathways after FOLR1 was downregulated.
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX).
Xia et al., Hangzhou, China. In J Biol Chem, 2014
In vitro kinase and shRNA-based knockdown assays reveal that TAK1 Ser-412 phosphorylation is regulated by cAMP-dependent protein kinase catalytic subunit α (PKACα) and X-linked protein kinase (PRKX), which is essential for proper signaling and proinflammatory cytokine induction by TLR/IL-1R activation.
PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.
GeneRIF
Ullrich et al., Martinsried, Germany. In Int J Cancer, 2012
findings reveals a major role of PRKX, TTBK2 and RSK4 in triggering Sunitinib resistance formation; data suggest transcriptional regulation of these kinases together with other proteins might play an important role in formation of Sunitinib resistance by affecting transcription factors
MBD 4--a potential substrate for protein kinase X.
GeneRIF
Li et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2011
MBD 4--a potential substrate for protein kinase X
PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation.
GeneRIF
Wilson et al., New York City, United States. In Dev Biol, 2011
The interaction of PRKX with Pin-1, Magi-1 and Bag-3 could contribute to the stimulating role of PRKX in angiogenesis.
The nuts and bolts of AGC protein kinases.
Review
Impact
Alessi et al., Dundee, United Kingdom. In Nat Rev Mol Cell Biol, 2010
The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, SGK494, PRKX, PRKY and MAST).
Gene conversion between the X chromosome and the male-specific region of the Y chromosome at a translocation hotspot.
Jobling et al., Leicester, United Kingdom. In Am J Hum Genet, 2009
We resequenced X and Y copies of a translocation hotspot adjacent to the PRKX and PRKY genes and found evidence of historical exchange between the male-specific region of the human Y and the X in patchy flanking gene-conversion tracts on both chromosomes.
Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development.
Wilson et al., New York City, United States. In Kidney Int, 2009
We previously identified protein kinase-X (PRKX), a cAMP-dependent kinase, as a regulator of epithelial morphogenesis during kidney development and found that it binds to and phosphorylates Polycystin-1.
Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency.
GeneRIF
Wilson et al., New York City, United States. In Biochim Biophys Acta, 2008
PRKX can restore normal function to PKD1-deficient kidneys and have implications for the development of preventative therapy for autosomal dominant polycystic kidney disease
Protein kinase X activates ureteric bud branching morphogenesis in developing mouse metanephric kidney.
Burrow et al., New York City, United States. In J Am Soc Nephrol, 2005
The human protein kinase X (PRKX) gene was identified previously as a cAMP-dependent serine/threonine kinase that is aberrantly expressed in autosomal dominant polycystic disease kidneys and normally expressed in fetal kidneys.
M-CSF induced differentiation of myeloid precursor cells involves activation of PKC-delta and expression of Pkare.
Silvennoinen et al., Tampere, Finland. In J Leukoc Biol, 2003
A cyclic adenosine monophosphate-regulated Ser/Thr kinase gene, protein kinase X (PRKX), has been associated with macrophage differentiation in human cells.
FG syndrome: linkage analysis in two families supporting a new gene localization at Xp22.3 [FGS3].
Review
Briault et al., Tours, France. In Am J Med Genet, 2002
In this region, two potential candidate genes, VCX-A and PRKX, were excluded by sequence analysis of the coding region in patients of the two reported FG families.
PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis.
GeneRIF
Burrow et al., New York City, United States. In Proc Natl Acad Sci U S A, 2002
PRKX kinase may regulate epithelial morphogenesis during mammalian kidney development.
Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: fine mapping and analysis of mechanism.
Kotin et al., Bethesda, United States. In J Virol, 2002
Adeno-associated virus type 2 (AAV-2) nonstructural protein Rep78 inhibits members of the cAMP signal transduction pathway, the protein kinases PKA and PRKX.
Antibody binding to endothelial and epithelial antigens triggers pig-to-rabbit xenograft rejection and its absence results in atypical complement deposition.
Musiani et al., Pittsburgh, United States. In Transpl Int, 1991
In pig-to-rabbit kidney xenograft (PRKX), endothelial antigen determinants (EAD) are immediately recognized by IgG and IgA, while IgM does not react with them.
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