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Protein kinase C, eta

PRKCH, protein kinase C-eta, PKC-L
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: endothelin receptor, AGE, HAD, V1a, OUT
Papers on PRKCH
PRKCH 1425G/A Polymorphism Predicts Recurrence of Ischemic Stroke in a Chinese Population.
Liu et al., Nanjing, China. In Mol Neurobiol, Dec 2015
A recent genome-wide association study (GWAS) identified a nonsynonymous SNP (1425G/A) in PRKCH which was associated with increased risk of ischemic stroke.
G-protein genomic association with normal variation in gray matter density.
Liu et al., Albuquerque, United States. In Hum Brain Mapp, Nov 2015
The SNP component was enriched in genes with neuronal functions, including synaptic plasticity, axon guidance, molecular signal transduction via PKA and CREB, highlighting the GRM1, PRKCH, GNA12, and CAMK2B genes.
Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges.
Ratnam et al., Detroit, United States. In Oncotarget, Nov 2015
Among estrogen-regulated genes, progestin/PR-A counter-regulated a distinctive subset, including breast tumor progression genes (e.g., HES1, PRKCH, ELF5, TM4SF1), leading to invasiveness.
Protein kinase Cη polymorphism and the susceptibility to ischemic stroke in the Taiwan population.
Chen et al., Taipei, Taiwan. In Biomed J, Sep 2015
BACKGROUND: Prior studies suggested that protein kinase Cη (PRKCH) 1425G/A polymorphism was associated with lacunar infarction.
A quantitative assessment of the association between 1425G/A polymorphism in PRKCH and risk of stroke.
Liu et al., Nanjing, China. In Neuromolecular Med, 2014
UNLABELLED: Previous studies suggested an association between 1425G/A polymorphism in PRKCH and stroke risk, but the results were inconsistent.
Integrated Analyses of Gene Expression Profiles Digs out Common Markers for Rheumatic Diseases.
Deng et al., Suzhou, China. In Plos One, 2014
RESULTS: We identified a total of eight differentially expressed genes (TNFSF10, CX3CR1, LY96, TLR5, TXN, TIA1, PRKCH, PRF1), each associated with at least 3 of the 4 studied rheumatic diseases.
A therapeutically targetable mechanism of BCR-ABL-independent imatinib resistance in chronic myeloid leukemia.
Green et al., Worcester, United States. In Sci Transl Med, 2014
In these IMSG knockdown cells, RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling is sustained after IM treatment because of up-regulation of PRKCH, which encodes the protein kinase C (PKC) family member PKCη, an activator of CRAF.
PKCη Regulates the TGFβ3-induced Chondevrepogenic Differentiation of Human Mesenchymal Stem Cell.
Kang et al., Chinju, South Korea. In Dev Reprod, 2013
Among 145 C2 domains, C2 domain of protein kinase C eta (PKCη) was selected as a possible chondevrepogenic differentiation factor for hMSC.
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Farooqi et al., Cambridge, United Kingdom. In Nat Genet, 2013
Evaluation of 29 SNPs (P < 1 × 10(-5)) in an additional 971 severely obese children and 1,990 controls identified 4 new loci associated with severe obesity (LEPR, PRKCH, PACS1 and RMST).
PKCη is a negative regulator of AKT inhibiting the IGF-I induced proliferation.
Livneh et al., Beersheba, Israel. In Exp Cell Res, 2012
It was shown that the PKCeta isoform is a negative regulator of the AKT signaling pathway. The IGF-I induced phosphorylation on Ser473 of AKT was inhibited by the PKCeta-induced expression in MCF-7 breast adenocarcinoma cancer cells.
The role of PRKCH gene variants in coronary artery disease in a Chinese population.
Wang et al., Nanjing, China. In Mol Biol Rep, 2012
A remarkable association of minor alleles (1425G/A and _15) in the PRKCH gene with an elevated risk of coronary artery disease and increased levels of LDL-C in a Chinese population.
Association between 1425G/A SNP in PRKCH and ischemic stroke among Chinese and Japanese populations: a meta-analysis including 3686 cases and 4589 controls.
Sheng et al., Guangzhou, China. In Neurosci Lett, 2012
The present meta-analyses suggested that 1425G/A SNP in PRKCH was associated with ischemic stroke, particularly lacunar infarction, in Chinese and Japanese populations.
Contribution of 1425G/A polymorphism in protein kinase C-Eta (PRKCH) gene and brain white matter lesions to the risk of sudden sensorineural hearing loss in a Japanese nested case-control study.
Shimokata et al., Ōbu, Japan. In J Neurogenet, 2011
In the present study, a significant association between the PRKCH 1425G/A polymorphism and SSNHL risk was observed through a nested case-control analysis within the population-based study.
Protein kinase Cη activates NF-κB in response to camptothecin-induced DNA damage.
Livneh et al., Israel. In Biochem Biophys Res Commun, 2011
study suggests that PKCeta is involved in NF-kappaB signaling leading to drug resistance.
[Genome-wide association study for ischemic stroke based on the Hisayama study].
Kiyohara et al., Fukuoka, Japan. In Nihon Eiseigaku Zasshi, 2011
After comparison of allele frequencies between 1,112 patients with ischemic stroke and the same number of age- and sex-matched control subjects, who were selected from among the residents of the town of Hisayama, Japan, we identified three novel candidate genes for ischemic stroke: PRKCH (protein kinase C eta (PKCη)), AGTRL1 (apelin receptor), and ARHGEF10 (Rho guanine nucleotide exchange factor 10).
Metallothioneins and cancer.
Kizek et al., Brno, Czech Republic. In Curr Protein Pept Sci, 2009
p53, NF-kappaB, PKCl, and GTPase Rab3A.
[Molecular epidemiology of cerebrovascular diseases; the Hisayama study and the Fukuoka Stroke Registry (FSR)].
Iida et al., In Rinsho Shinkeigaku, 2008
We performed a genome-wide case-control study and found that a nonsynonymous SNP in PRKCH encoding a member of protein kinase C (PKCC eta) was significantly associated with brain infarction.
[Genetic risk factors of ischemic stroke identified by a genome-wide association study].
Kubo, Yokohama, Japan. In Brain Nerve, 2008
We used a two-stage screening method and identified 2 genes related to the susceptibility of ischemic stroke: PRKCH and AGTRL1.
ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation.
Hanash et al., New Orleans, United States. In Autoimmunity, 2008
In microarray experiments and real-time RT-PCR assays, we observed significant differences in RNA levels from ICF vs. control lymphoblasts for pro- and anti-apoptotic genes (BCL2L10, CASP1, and PTPN13); nitrous oxide, carbon monoxide, NF-kappaB, and TNFalpha signalling pathway genes (PRKCH, GUCY1A3, GUCY1B3, MAPK13; HMOX1, and MAP4K4); and transcription control genes (NR2F2 and SMARCA2).
A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
Kiyohara et al., Fukuoka, Japan. In Nat Genet, 2007
We report that a nonsynonymous SNP in PRKCH increases the risk of cerebral infarction in the general Japanese population. We also found that PKCeta was expressed in vascular endothelial cells and foamy macrophages in human atherosclerotic lesions.
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