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Protein kinase, AMP-activated, gamma 3 non-catalytic subunit

PRKAG3, AMPKgamma3
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AMPK, HAD, ACID, Insulin, hAM
Papers on PRKAG3
AMPKγ3 is Dispensable for Skeletal Muscle Hypertrophy Induced by Functional Overload.
Zierath et al., Dublin, Ireland. In Am J Physiol Endocrinol Metab, Feb 2016
Using AMPKγ3 mutant-overexpressing transgenic Tg-Prkag3(225Q) and AMPKγ3 knockout (Prkag3(-/-)) mice, we investigated the requirement for the AMPKγ3 isoform in functional overload-induced muscle hypertrophy.
Hypoxia-Induced Upregulation of miR-132 Promotes Schwann Cell Migration After Sciatic Nerve Injury by Targeting PRKAG3.
Yu et al., Nantong, China. In Mol Neurobiol, Oct 2015
miR-132 downregulated PRKAG3 through binding to its 3'-UTR, and PRKAG3 knockdown compromised the reducing effect of miR-132 inhibition on SC migration under normal or hypoxia condition.
Variation in the ovine PRKAG3 gene.
Hickford et al., Lanzhou, China. In Gene, Sep 2015
The PRKAG3 gene (PRKAG3) encodes the γ3 subunit of the AMPK.
A retrospective analysis of allele frequency changes of major genes during 20 years of selection in the Italian Large White pig breed.
Buttazzoni et al., Bologna, Italy. In J Anim Breed Genet, Jun 2015
MC4R p.D298N, VRTN PRE1 insertion, PRKAG3 p.I199V and FTO g.276T>G).
Polymorphisms in epigenetic and meat quality related genes in fourteen cattle breeds and association with beef quality and carcass traits.
Yu et al., Beijing, China. In Asian-australas J Anim Sci, Apr 2015
The present study was designed to analyze the genetic effect of single nucleotide polymorphisms (SNPs) in seven epigenetic-related genes (DNMT1, DNMT3a, DNMT3b, DNMT3L, Ago1, Ago2, and HDAC5) and two meat quality candidate genes (CAPN1 and PRKAG3) on fourteen carcass traits related to beef quality in a Snow Dragon beef population, and also to identify SNPs in a total of fourteen cattle populations.
Genome-wide association analysis reveals genetic loci and candidate genes for meat quality traits in Chinese Laiwu pigs.
Huang et al., Nanchang, China. In Mamm Genome, Apr 2015
In addition, this study revealed at least five novel QTLs and several candidate genes including 4-linked MYH genes (MYH1, MYH2, MYH3, and MYH13), MAL2, LPAR1, and PRKAG3 at four significant loci.
Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs.
Plastow et al., Edmonton, Canada. In Bmc Genet, 2014
ASGA0070625 is located in intron 2 of ZNF142, and the other two markers are close to PRKAG3, STK36, TTLL7 and CDK5R2.
Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone.
Højlund et al., Odense, Denmark. In Eur J Endocrinol, 2014
testosterone therapy had no effect on insulin sensitivity or mRNA levels of genes involved in mitochondrial biogenesis (PPARGC1A, PRKAA2, and PRKAG3), OxPhos (NDUFS1, ETFA, SDHA, UQCRC1, and COX5B), or lipid metabolism (ACADVL, CD36, CPT1B, HADH, and PDK4).
Joint analysis of additive, dominant and first-order epistatic effects of four genes (IGF2, MC4R, PRKAG3 and LEPR) with known effects on fat content and fat distribution in pigs.
Varona et al., Zaragoza, Spain. In Anim Genet, 2014
LEPR, MC4R, IGF2 and PRKAG3 are genes with known effects on fat content and distribution in pig carcass and pork.
A combination of two variants in PRKAG3 is needed for a positive effect on meat quality in pigs.
Sironen et al., Finland. In Bmc Genet, 2013
Several amino acid substitutions in PRKAG3 have been associated with various meat quality traits.
Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma.
Lu et al., Shanghai, China. In Chin Med J (engl), 2013
Ten target genes (ACSL1, AXIN2, CACNA2D2, FOXO3, PPP1R3A, PRKAG3, RUNX1, SMAD4, STK3 and TBL1XR1) were significantly down-regulated in SQ and had a strong negative correlation with miR-205, while one target gene (CDH3) was up-regulated in SQ and exhibited a strong positive correlation with miR-205.
Allelic frequencies of PRKAG3 in several pig breeds and its technological consequences on a Duroc × Landrace-Large White cross.
López-Buesa et al., Zaragoza, Spain. In J Anim Breed Genet, 2013
The allelic frequencies of PRKAG3 gene (the RN gene) have been investigated in several pig breeds.
PPARbeta activation induces rapid changes of both AMPK subunit expression and AMPK activation in mouse skeletal muscle.
Lopez et al., Nice, France. In Mol Endocrinol, 2011
gamma3-AMPK down-regulation is a rapid physiological muscle response observed in mouse after running exercise or fasting, two situations leading to PPARbeta activation.
Association between polymorphism in bovine PRKAG3 gene and milk production traits.
Kulig et al., Szczecin, Poland. In Genetika, 2011
Association between polymorphism in bovine PRKAG3 gene and milk production traits.
Naturally occurring R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3) results in increased oxidative capacity and glucose uptake in human primary myotubes.
Harper et al., Ottawa, Canada. In Diabetologia, 2010
Through the enhancement of skeletal muscle glucose uptake and increased mitochondrial content, the R225W mutation of the gene encoding AMP-activated protein kinase (AMPK)gamma(3)may significantly enhance exercise performance.
Mouse AMP-activated protein kinase gamma3 subunit R225Q mutation affecting mouse growth performance when fed a high-energy diet.
Du et al., Laramie, United States. In J Anim Sci, 2010
subunit R225Q mutation effect on growth performance with normal or high-energy diet
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
Auwerx et al., Lausanne, Switzerland. In Cell Metab, 2010
AMPK acts as the primordial trigger for fasting- and exercise-induced adaptations in skeletal muscle and that activation of SIRT1 and its downstream signaling pathways are improperly triggered in AMPK-deficient states.
Role of AMP--activated protein kinase in the control of glucose homeostasis.
Zierath et al., Stockholm, Sweden. In Curr Mol Med, 2005
Furthermore, mutations in the AMPK gamma3-isoform may provide protection from diet-induced insulin resistance by increasing lipid oxidation in the presence of increased lipid supply.
Identification and characterization of AMPK gamma 3 mutations in the pig.
Andersson, Uppsala, Sweden. In Biochem Soc Trans, 2003
The protein kinase AMP-activated gamma 3 subunit gene, PRKAG3, which encodes the gamma 3 isoform of AMP-activated protein kinase (AMPK), was identified as the causative gene for this phenotype by a pure positional cloning approach.
A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle.
Andersson et al., France. In Science, 2000
Functional analysis of the pig counterpart.
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