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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Proteoglycan 4

PRG4, proteoglycan 4, Lubricin, SZP, megakaryocyte stimulating factor
The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, CD45, ACID, POLYMERASE
Papers on PRG4
Collagen Membranes Adsorb the Transforming Growth Factor-β Receptor I Kinase-dependent Activity of Enamel Matrix Derivative.
New
Gruber et al., Bern, Switzerland. In J Periodontol, Feb 2016
The expression of the TGF-β target genes interleukin 11 and proteoglycan 4 was evaluated by real time PCR.
Increased lubricin/proteoglycan 4 gene expression and decreased modulus in medial collateral ligaments following ovariohysterectomy in the adult rabbit: Evidence consistent with aging.
New
Thornton et al., Calgary, Canada. In J Biomech, Jan 2016
UNASSIGNED: This study investigated whether ovariohysterectomy (OVH) surgery to induce menopause resulted in changes to modulus, failure strain and lubricin/proteoglycan 4 (PRG4) gene expression in rabbit medial collateral ligaments (MCLs), similar to aging (Thornton et al., 2015a).
Effects of Electromagnetic Fields on the Metabolism of Lubricin of Rat Chondrocytes.
New
Wu et al., Wuhan, China. In Connect Tissue Res, Jan 2016
In the present study, we investigated the effects of exposure for different durations with 75 Hz, 2.3mT sinusoidal EMFs (SEMFs) on the metabolism of lubricin of rat chondrocytes cultured in vitro.
Effect of disulfide bonding and multimerisation on Proteoglycan 4's cartilage boundary lubricating ability and adsorption.
New
Schmidt et al., Calgary, Canada. In Connect Tissue Res, Jan 2016
PURPOSE: The objectives of this study were to assess the cartilage boundary lubricating ability of (1) non reduced (NR) disulfide-bonded proteoglycan 4 (PRG4) multimers versus PRG4 monomers, (2) NR versus reduced and alkylated (R/A) PRG4 monomers, and (3) assess the ability of NR PRG4 multimers versus monomers to adsorb to an articular cartilage surface.
Genetic association of marbling score with intragenic nucleotide variants at selection signals of the bovine genome.
New
Lee et al., Seoul, South Korea. In Animal, Jan 2016
Genetic associations of MS were found (P<3.88×10-4) with six intragenic nucleotide variants on bovine autosomes 3 (cache domain containing 1, CACHD1), 5 (like-glycosyltransferase, LARGE), 16 (cell division cycle 42 binding protein kinase alpha, CDC42BPA) and 21 (snurportin 1, SNUPN; protein tyrosine phosphatase, non-receptor type 9, PTPN9; chondroitin sulfate proteoglycan 4, CSPG4).
Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro.
New
Krawetz et al., Calgary, Canada. In Sci Rep, Dec 2015
Proteoglycan 4 (PRG4/lubricin) is secreted by cells that reside in articular cartilage and line the synovial joint.
Elastoviscous Transitions of Articular Cartilage Reveal a Mechanism of Synergy between Lubricin and Hyaluronic Acid.
Bonassar et al., Ithaca, United States. In Plos One, 2014
While it is known that macromolecular constituents of synovial fluid provide it with its lubricating ability, it is not fully understood how two of the main molecules, lubricin and hyaluronic acid, lubricate and interact with one another.
Chondroitin sulfate proteoglycan 4 as a target for chimeric antigen receptor-based T-cell immunotherapy of solid tumors.
Review
Dotti et al., Bethesda, United States. In Expert Opin Ther Targets, 2014
In particular, chondroitin sulfate proteoglycan 4 (CSPG4) is recognized as an attractive target for antibody-based approaches because of its high expression on cancer cells in several types of human malignancies and its restricted distribution in normal tissues.
Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure.
Schmidt et al., Calgary, Canada. In Bmc Musculoskelet Disord, 2014
BACKGROUND: Proteoglycan 4 (PRG4) and hyaluronan (HA) are key synovial fluid constituents that contribute synergistically to cartilage boundary lubrication; however, the effects of their concentrations as well as their structure, both of which can be altered in osteoarthritis, on this functional synergism are unknown.
The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.
Elsaid et al., Boston, United States. In Arthritis Res Ther, 2014
BACKGROUND: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes.
The biology of lubricin: near frictionless joint motion.
Review
Waller et al., Warren, United States. In Matrix Biol, 2014
Recent studies in lubricin null joints indicate that lubricin (Prg4) plays a role in preventing damage to the superficial zone and preservation of chondrocytes.
Chondroitin sulfate-cell membrane effectors as regulators of growth factor-mediated vascular and cancer cell migration.
Review
Papadimitriou et al., Pátrai, Greece. In Biochim Biophys Acta, 2014
SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase β/ζ, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.
Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model.
Impact
Sheffield et al., Iowa City, United States. In Nat Med, 2012
We found that hydrocephalus in this mouse model is caused by aberrant platelet-derived growth factor receptor α (PDGFR-α) signaling, resulting in increased apoptosis and impaired proliferation of chondroitin sulfate proteoglycan 4 (also known as neuron-glial antigen 2 or NG2)(+)PDGFR-α(+) neural progenitors.
Defects in tendon, ligament, and enthesis in response to genetic alterations in key proteoglycans and glycoproteins: a review.
Review
Veillette et al., Toronto, Canada. In Arthritis, 2012
The genes reviewed are for small leucine-rich proteoglycans (lumican, fibromodulin, biglycan, decorin, and asporin); dermatan sulfate epimerase (Dse) that alters structure of glycosaminoglycan and hence the function of small leucine-rich proteoglycans by converting glucuronic to iduronic acid; matricellular proteins (thrombospondin 2, secreted phosphoprotein 1 (Spp1), secreted protein acidic and rich in cysteine (Sparc), periostin, and tenascin X) including human tenascin C variants; and others, such as tenomodulin, leukocyte cell derived chemotaxin 1 (chondromodulin-I, ChM-I), CD44 antigen (Cd44), lubricin (Prg4), and aggrecan degrading gene, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (Adamts5).
Melanoma biomolecules: independently identified but functionally intertwined.
Review
Coombe et al., Perth, Australia. In Front Oncol, 2012
This review focuses on five putative biomarkers - melanoma cell adhesion molecule (MCAM), galectin-3 (gal-3), matrix metalloproteinase 2 (MMP-2), chondroitin sulfate proteoglycan 4 (CSPG4), and paired box 3 (PAX3).
Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc.
GeneRIF
Musumeci et al., Catania, Italy. In Acta Histochem, 2012
lubricin is expressed in the TMJ disc bilaminar zone; lubricin may have a role in normal disc posterior attachment physiology through the prevention of cellular adhesion as well as providing lubrication during normal bilaminar zone function
Lubricin distribution in the torn human anterior cruciate ligament and meniscus.
GeneRIF
Spector et al., Boston, United States. In J Orthop Res, 2011
The surface layer of lubricin coating torn edges of anterior cruciate ligaments and menisci may interfere with the integrative healing process needed for repair.
The mechanical properties of tail tendon fascicles from lubricin knockout, wild type and heterozygous mice.
GeneRIF
Amadio et al., Rochester, United States. In J Struct Biol, 2011
lubricin expression has an effect on the viscoelastic properties of tendon fascicles
A novel deletion mutation in proteoglycan-4 underlies camptodactyly-arthropathy-coxa-vara-pericarditis syndrome in a consanguineous pakistani family.
GeneRIF
Ahmad et al., Islamabad, Pakistan. In Arch Med Res, 2011
We described a 2-bp novel deletion mutation in PRG4 gene in a Pakistani family with camptodactyly-arthropathy-coxa-vara-pericarditis syndrome
Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold.
GeneRIF
Leonardi et al., Catania, Italy. In Eur J Histochem, 2010
Lubricin is expressed in chondrocytes derived from osteoarthritic cartilage encapsulated in poly (ethylene glycol) diacrylate scaffold.
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