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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 May 2015.

Presenilin 1

Presenilin-1, FAD, PS1, presenilin, PSI
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: APP, CAN, AGE, ACID, V1a
Papers using Presenilin-1 antibodies
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
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Smith Mark A., In PLoS ONE, 2009
... APP-NT, APP-CT and β-actin (Sigma, St Louis, MS); antibodies for B94, ADAM9, ADAM10, BACE1 and PS1 (Santa Cruz Biotechnology, Santa Cruz, CA); antibodies ...
Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
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Zhao Li-Ru et al., In Alzheimer's Research & Therapy, 2008
... The mouse model of AD used for the present study is an amyloid precursor protein/presenilin 1 (APP/PS1) transgenic strain ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
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Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... APP695SWE/co + PS1/ΔE9 transgenic ( ...
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
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Combs Colin, In PLoS ONE, 2006
... APP/PS1 transgenic mice of C57BL/6J background ...
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
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Rivest Serge et al., In Molecular Neurodegeneration, 2006
... /PS1 transgenic mice harbouring the human ...
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Papers on Presenilin-1
Thiacremonone Potentiates Anti-Oxidant Effects to Improve Memory Dysfunction in an APP/PS1 Transgenic Mice Model.
New
Hong et al., Seoul, South Korea. In Mol Neurobiol, 26 Jun 2015
Treatment of thiacremonone significantly attenuated cognitive impairments in amyloid precursor protein (APP)/presenilin 1 (PS1) double-mutant transgenic mice.
Sulfite-stress induced functional and structural changes in the complexes of photosystems I and II in a cyanobacterium, Synechococcus elongatus PCC 7942.
New
Sato et al., Hachiōji, Japan. In Plant Cell Physiol, 25 Jun 2015
Meanwhile, the PSI complex showed monomerization of its trimeric configuration with little effect on the activity.
Foldase and inhibitor functionalities of the pepsinogen prosegment are encoded within discrete segments of the 44 residue domain.
New
Yada et al., Edmonton, Canada. In Biochim Biophys Acta, 20 Jun 2015
Four PS truncations were examined, corresponding to PS residues 1p-16p (PS1-16), 1p-29p (PS1-29), 17p-44p (PS17-44) and 30p-44p (PS30-44).
High-Fat Diet-Induced Deregulation Of Hippocampal Insulin Signaling And Mitochondrial Homeostasis Deficiences Contribute To Alzheimer Disease Pathology In Rodents.
New
Camins et al., Barcelona, Spain. In Biochim Biophys Acta, 20 Jun 2015
In the current study, we have focused on the effects of a high-fat diet (HFD) on hippocampal-dependent memory in C57/Bl6 Wild-type (WT) and APPswe/PS1dE9 (APP/PS1) mice, a well-established mouse model of familial AD.
Ca(2+) dysregulation in the endoplasmic reticulum related to Alzheimer's disease: A review on experimental progress and computational modeling.
Review
New
Samarasinghe et al., Christchurch, New Zealand. In Biosystems, 18 Jun 2015
Numerous research papers have suggested that the dysregulation of ER Ca(2+) homeostasis is associated with mutations in the presenilin genes and amyloid-β oligomers.
ATP Synthase.
New
Impact
Nelson et al., Osnabrück, Germany. In Annu Rev Biochem, 23 Apr 2015
Four multisubunit membrane proteins are involved: photosystem I (PSI), photosystem II (PSII), cytochrome b6f (cyt b6f) and ATP synthase (FOF1).
Structure and Energy Transfer in Photosystems of Oxygenic Photosynthesis.
New
Impact
Junge et al., Tel Aviv-Yafo, Israel. In Annu Rev Biochem, 05 Apr 2015
The conversion of solar energy into chemical energy is catalyzed by two multisubunit membrane protein complexes, photosystem I (PSI) and photosystem II (PSII).
Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways.
Review
New
St George-Hyslop et al., Toronto, Canada. In Mol Cell Neurosci, 04 Apr 2015
Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of Aβ produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD).
Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation "in vivo" by P2X7 receptor.
Review
New
Gualix et al., Madrid, Spain. In Comput Struct Biotechnol J, Dec 2014
The in vivo approach was made possible by the use of J20 mice, a transgenic mouse model of familial Alzheimer's disease (FAD) expressing human APP mutant protein.
Predictors of mortality for nursing home-acquired pneumonia: a systematic review.
Review
New
Gupta et al., Fort Lauderdale, United States. In Biomed Res Int, Dec 2014
RESULTS: More studies supported the Pneumonia Severity Index (PSI) as a superior predictor of NHAP severity.
Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.
New
Paris et al., Sarasota, United States. In Plos One, Dec 2014
We therefore investigated the effects of a chronic oral treatment with anatabine in a transgenic mouse model (Tg PS1/APPswe) of Alzheimer's disease (AD) which displays pathological Aβ deposits, neuroinflammation and behavioral deficits.
A three-dimensional human neural cell culture model of Alzheimer's disease.
New
Impact
Kim et al., United States. In Nature, Dec 2014
Here we report that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloid-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system.
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
New
Impact
Fromme et al., Tempe, United States. In Nature, Oct 2014
Two large membrane protein complexes, photosystem I and II (PSI and PSII), act in series to catalyse the light-driven reactions in photosynthesis.
Three-dimensional structure of human γ-secretase.
New
Impact
Shi et al., Beijing, China. In Nature, Sep 2014
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage.
Oedema, solid organ transplantation and mammalian target of rapamycin inhibitor/proliferation signal inhibitors (mTOR-I/PSIs).
Review
New
Izzedine et al., Paris, France. In Clin Kidney J, Apr 2014
Mammalian target of rapamycin inhibitor (mTOR-I)/proliferation signal inhibitors (PSI) including sirolimus and everolimus represent a new class of drugs increasingly used in solid-organ transplantation as alternatives to calcineurin inhibitors for patients with renal dysfunction, transplant coronary arterial vasculopathy or malignancy.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
GeneRIF
Couch et al., Rochester, United States. In Dev Cell, 2012
A specific role for BRCA2 in the regulation of midbody structure and function is identified that is separate from DNA damage repair and is an explanation of whole-chromosomal instability in BRCA2-deficient tumors.
Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
GeneRIF
Mlodzik et al., New York City, United States. In Dev Cell, 2012
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Impact
GeneRIF
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
GeneRIF
Anand et al., Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.
Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.
GeneRIF
Hafez et al., Sūhāj, Egypt. In Egypt J Immunol, 2010
Sixty-two patients (index cases) with invasive breast cancer belonging to sixty families and their asymptomatic female first-degree relatives (300 cases) were studied for germline mutations of BRCA1 and BRCA2 genes.
More papers using Presenilin-1 antibodies
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
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Iijima Koichi M., In PLoS ONE, 2004
... AβPP/PS1 double transgenic mice (AβPP Swedish mutant ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
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Shen Jie et al., In Nature, 2001
... Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Ikezu Tsuneya, In PLoS ONE, 2000
... MEF PS1/2-/- cells were transfected with pCNA3.1/PS1
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
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Elder Gregory A et al., In Molecular Neurodegeneration, 2000
... wild type and FAD mutant PAC transgenic mice can be found ...
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
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Okazawa H. et al., In The Journal of Cell Biology, 1997
... cDNA encoding full-length PS1 was amplified from human hippocampal mRNA (Clontech) by reverse transcriptase PCR ...
Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA
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Yu Yi-Kuo et al., In Database: The Journal of Biological Databases and Curation, 1997
... Using the full PSI-MI ontology file in Open Biomedical Ontology (OBO) format ( ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
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Finkelstein David I., In PLoS ONE, 1996
... The PS1 mice were homozygous transgenic mice (Swiss Webster/B6D2; I.D ...
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
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Ikezu Tsuneya, In PLoS ONE, 1996
... /PSEN1ΔE9 (APP/PS1) transgenic mice (line 85, Stock ...
Tissue levels of S-adenosylmethionine in aging rats
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Kiliaan Amanda J. et al., In Neurological Sciences, 1976
... Male APP/PS1 transgenic mice and their wild-type ...
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