An atomic structure of human γ-secretase.
Beijing, China. In Nature, 10 Oct 2015
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1).
Alzheimer's Disease, Drosophila melanogaster and Polyphenols.
Medellín, Colombia. In Adv Exp Med Biol, Dec 2014
A large, genetically-isolated community in Antioquia, Colombia, with early-onset familial Alzheimer's disease due to a presenilin-1 mutation is ideally suited for the study of molecular mechanisms of AD, and hence accelerate the discovery of new or alternative treatment approaches.
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
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Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.