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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Presenilin 1

Presenilin-1, FAD, PS1, presenilin, PSI
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: APP, CAN, V1a, AGE, ACID
Papers using Presenilin-1 antibodies
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
Smith Mark A., In PLoS ONE, 2009
... APP-NT, APP-CT and β-actin (Sigma, St Louis, MS); antibodies for B94, ADAM9, ADAM10, BACE1 and PS1 (Santa Cruz Biotechnology, Santa Cruz, CA); antibodies ...
Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
Zhao Li-Ru et al., In Alzheimer's Research & Therapy, 2008
... The mouse model of AD used for the present study is an amyloid precursor protein/presenilin 1 (APP/PS1) transgenic strain ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... APP695SWE/co + PS1/ΔE9 transgenic ( ...
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Combs Colin, In PLoS ONE, 2006
... APP/PS1 transgenic mice of C57BL/6J background ...
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
Rivest Serge et al., In Molecular Neurodegeneration, 2006
... /PS1 transgenic mice harbouring the human ...
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Papers on Presenilin-1
DNA Triplexes That Bind Several Cofactor Molecules.
Richert et al., Stuttgart, Germany. In Chemistry, 12 Dec 2015
Oligonucleotides with up to six non-nucleotide bridges between purines were synthesized and their ability to bind ATP, cAMP or FAD was measured.
Characterization of Aβ Monomers Through the Convergence of Ensemble Properties Among Simulations with Multiple Force Fields.
Garcia et al., In J Phys Chem B, 12 Dec 2015
Further, there are mutations within Aβ that change the way the peptide aggregates and are known to cause familial AD (FAD).
Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
Tomita et al., Japan. In J Biol Chem, 11 Dec 2015
UNASSIGNED: γ-Secretase is a multisubunit membrane protein complex containing presenilin (PS1) as a catalytic subunit.
Brain regional differences in social encounter-induced Fos expression in male and female rats after post-weaning social isolation.
Bland et al., Denver, United States. In Brain Res, 09 Dec 2015
We have previously reported that the social encounter-induced increases in Fos expression in the medial prefrontal cortex observed in group-housed controls (GRP) was attenuated in rats that had experienced PSI.
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock.
Takamatsu et al., Tokyo, Japan. In Plos Biol, 30 Nov 2015
The FAD binding domain of CRY1, two C-terminal BMAL1 domains, and particularly BMAL1-Lys537 acetylation/deacetylation by CLOCK/SIRT1, were shown to be critical for CRY-mediated BMAL1-CK2β binding.
Chloroplast NDH: A different enzyme with a structure similar to that of respiratory NADH dehydrogenase.
Shikanai, Kyoto, Japan. In Biochim Biophys Acta, 28 Nov 2015
In Arabidopsis thaliana, chloroplast NDH interacts with photosystem I (PSI); this interaction is needed to stabilize NDH, especially under high light.
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways.
McCarthy et al., Cork, Ireland. In Cell Signal, 21 Nov 2015
The diversity of γ-secretase substrates highlights the importance of presenilin-dependent γ-secretase protease activities as a regulatory mechanism in a range of biological systems.
An atomic structure of human γ-secretase.
Shi et al., Beijing, China. In Nature, 10 Oct 2015
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1).
Photosynthesis. Structural basis for energy transfer pathways in the plant PSI-LHCI supercomplex.
Shen et al., Beijing, China. In Science, Jun 2015
Photosynthesis converts solar energy to chemical energy by means of two large pigment-protein complexes: photosystem I (PSI) and photosystem II (PSII).
Sofosbuvir, a Significant Paradigm Change in HCV Treatment.
Seyedkazemi et al., Norwalk, United States. In J Clin Transl Hepatol, Mar 2015
Sofosbuvir was originally discovered by Pharmasset Corporation and named PSI-7977.
Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases.
Kitteringham et al., Liverpool, United Kingdom. In Lancet, Mar 2015
Five of them predicted histopathological response to fluorouracil-based chemotherapy regimens, of which the FAD binding protein NQO1 was subsequently validated by immunohistochemistry.
Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease.
van Leeuwen et al., Maastricht, Netherlands. In Front Mol Neurosci, Dec 2014
These approaches were based upon the idea that autosomal dominant mutations in amyloid precursor protein (APP) and Presenilin 1 (PS1) genes are predictive for treatment of all AD patients.
A security network in PSI photoprotection: regulation of photosynthetic control, NPQ and O2 photoreduction by cyclic electron flow.
Johnson et al., Saint-Maur-des-Fossés, France. In Front Plant Sci, Dec 2014
Cyclic electron flow (CEF) around PSI regulates acceptor-side limitations and has multiple functions in the green alga, Chlamydomonas reinhardtii.
Structure and energy transfer in photosystems of oxygenic photosynthesis.
Junge et al., Tel Aviv-Yafo, Israel. In Annu Rev Biochem, Dec 2014
The conversion of solar energy into chemical energy is catalyzed by two multisubunit membrane protein complexes, photosystem I (PSI) and photosystem II (PSII).
A three-dimensional human neural cell culture model of Alzheimer's disease.
Kim et al., United States. In Nature, Dec 2014
Here we report that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloid-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
Couch et al., Rochester, United States. In Dev Cell, 2012
A specific role for BRCA2 in the regulation of midbody structure and function is identified that is separate from DNA damage repair and is an explanation of whole-chromosomal instability in BRCA2-deficient tumors.
Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
Mlodzik et al., New York City, United States. In Dev Cell, 2012
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
Anand et al., Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.
Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.
Hafez et al., Sūhāj, Egypt. In Egypt J Immunol, 2010
Sixty-two patients (index cases) with invasive breast cancer belonging to sixty families and their asymptomatic female first-degree relatives (300 cases) were studied for germline mutations of BRCA1 and BRCA2 genes.
More papers using Presenilin-1 antibodies
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
Iijima Koichi M., In PLoS ONE, 2004
... AβPP/PS1 double transgenic mice (AβPP Swedish mutant ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
Shen Jie et al., In Nature, 2001
... Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Ikezu Tsuneya, In PLoS ONE, 2000
... MEF PS1/2-/- cells were transfected with pCNA3.1/PS1
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Elder Gregory A et al., In Molecular Neurodegeneration, 2000
... wild type and FAD mutant PAC transgenic mice can be found ...
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Okazawa H. et al., In The Journal of Cell Biology, 1997
... cDNA encoding full-length PS1 was amplified from human hippocampal mRNA (Clontech) by reverse transcriptase PCR ...
Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA
Yu Yi-Kuo et al., In Database: The Journal of Biological Databases and Curation, 1997
... Using the full PSI-MI ontology file in Open Biomedical Ontology (OBO) format ( ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
Finkelstein David I., In PLoS ONE, 1996
... The PS1 mice were homozygous transgenic mice (Swiss Webster/B6D2; I.D ...
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
Ikezu Tsuneya, In PLoS ONE, 1996
... /PSEN1ΔE9 (APP/PS1) transgenic mice (line 85, Stock ...
Tissue levels of S-adenosylmethionine in aging rats
Kiliaan Amanda J. et al., In Neurological Sciences, 1976
... Male APP/PS1 transgenic mice and their wild-type ...
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