NDH-1 and NDH-2 Plastoquinone Reductases in Oxygenic Photosynthesis.
Marseille, France. In Annu Rev Plant Biol, Jan 2016
In addition to the major photosynthetic complexes photosystem II (PSII), cytochrome b6f, and photosystem I (PSI), chloroplasts also contain minor components, including a well-conserved type I NADH dehydrogenase (NDH-1) complex that functions in close relationship with photosynthesis and likewise originated from the endosymbiotic cyanobacterial ancestor.
An atomic structure of human γ-secretase.
Beijing, China. In Nature, Oct 2015
Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1).
A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis.
Madison, United States. In J Alzheimers Dis, 2014
Genetic mutations in AβPP, PSEN1, and PSEN2 that alter amyloid-β precursor protein and Notch processing drive reactivation of the cell cycle in EOFAD, while age-related reproductive endocrine dyscrasia that upregulates mitogenic TNF signaling and AβPP processing toward the amyloidogenic pathway drives reactivation of the cell cycle in LOSAD.
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
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Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.