Emerging roles for diverse intramembrane proteases in plant biology.
Jerusalem, Israel. In Biochim Biophys Acta, Dec 2013
Gene encoding orthologs of rhomboid proteases, site-2 proteases (S2P), presenilin/γ-secretases, and signal peptide peptidases are found in plant genomes and some of these gene products were identified in different plant cell membranes.
Structural basis of kynurenine 3-monooxygenase inhibition.
More papers using
Manchester, United Kingdom. In Nature, May 2013
KMO is a flavin adenine dinucleotide (FAD)-dependent monooxygenase and is located in the outer mitochondrial membrane where it converts l-kynurenine to 3-hydroxykynurenine. Perturbations in the levels of kynurenine pathway metabolites have been linked to the pathogenesis of a spectrum of brain disorders, as well as cancer and several peripheral inflammatory conditions.