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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Feb 2015.

Presenilin 1

Presenilin-1, FAD, PS1, presenilin, PSI
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: APP, CAN, AGE, ACID, V1a
Papers using Presenilin-1 antibodies
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
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Smith Mark A., In PLoS ONE, 2009
... APP-NT, APP-CT and β-actin (Sigma, St Louis, MS); antibodies for B94, ADAM9, ADAM10, BACE1 and PS1 (Santa Cruz Biotechnology, Santa Cruz, CA); antibodies ...
Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
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Zhao Li-Ru et al., In Alzheimer's Research & Therapy, 2008
... The mouse model of AD used for the present study is an amyloid precursor protein/presenilin 1 (APP/PS1) transgenic strain ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
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Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... APP695SWE/co + PS1/ΔE9 transgenic ( ...
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
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Combs Colin, In PLoS ONE, 2006
... APP/PS1 transgenic mice of C57BL/6J background ...
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
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Rivest Serge et al., In Molecular Neurodegeneration, 2006
... /PS1 transgenic mice harbouring the human ...
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Papers on Presenilin-1
Protective effect of Notoginsenoside R1 on an APP/PS1 mouse model of Alzheimer's disease by up-regulating insulin degrading enzyme and inhibiting Aβ accumulation.
New
Zhang et al., Beijing, China. In Cns Neurol Disord Drug Targets, 25 Mar 2015
This study was designed to explore the protective effect of NTR1 on an APP/PS1 double-transgenic mouse model of AD and investigate the possible mechanism.
Kinetic Mechanism of L-α-Glycerophosphate Oxidase from Mycoplasma pneumoniae.
New
Chaiyen et al., Hat Yai, Thailand. In Febs J, 25 Mar 2015
UNASSIGNED: L-α-glycerophosphate oxidase is an FAD-dependent enzyme that catalyzes the oxidation of L-α-glycerophosphate (Glp) by molecular oxygen to generate dihydroxyacetone phosphate (DHAP) and hydrogen peroxide (H2 O2 ).
Biofuel Cell Based Self-Powered Sensing Platform for L-Cysteine Detection.
New
Liu et al., In Anal Chem, 25 Mar 2015
In this paper, a glucose/O2 biofuel cell (BFC) was assembled by using flavin adenine dinucleotide-dependent glucose dehydrogenase (FAD-GDH)-based bioanode and laccase-based biocathode.
Photoactivation of Cryptochromes from Drosophila Melanogaster and Sylvia Borin: Insight into the Chemical Compass Mechanism by Computational Investigation.
New
Pachter et al., In J Phys Chem B, 24 Mar 2015
To assess potential feasibility of a radical-pair mechanism in DmCry1 and gwCry1a, formed by excitation and electron transfer between a Trp-triad and flavin adenine dinucleotide (FAD), further separated by electron transfer within the triad, we applied a combination of theoretical methods, including homology modeling and molecular dynamics (MD) for structure refinement, high-level ab initio theory, and MD simulations using a polarizable force-field for prediction of pKa and the electron transfer rate.
Photosystem II repair in plant chloroplasts - regulation, assisting proteins and shared components with photosystem II biogenesis.
Review
New
Aro et al., Turku, Finland. In Biochim Biophys Acta, 20 Feb 2015
UNASSIGNED: Photosystem (PS) II is a multisubunit thylakoid membrane pigment-protein complex responsible for light-driven oxidation of water and reduction of plastoquinone.
Photoprotection of photosystems in fluctuating light intensities.
Review
New
Aro et al., Turku, Finland. In J Exp Bot, Jan 2015
Recent studies with both plants and cyanobacteria have revealed that Photosystem (PS) I is the potential target of damage upon abrupt changes in light intensity.
Identifying DNA-binding proteins by combining support vector machine and PSSM distance transformation.
New
Liu et al., In Bmc Syst Biol, Dec 2014
First, the PSSM profiles are generated by using the PSI-BLAST program to search the non-redundant (NR) database.
A three-dimensional human neural cell culture model of Alzheimer's disease.
New
Impact
Kim et al., United States. In Nature, Dec 2014
Here we report that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloid-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system.
Mechanisms of resistance to BCR-ABL TKIs and the therapeutic strategies: A review.
Review
New
Fu et al., Guangzhou, China. In Crit Rev Oncol Hematol, Dec 2014
In this review, we summarized BCR-ABL inhibitors approved by Food and Drug Administration (FAD), with the same concerns focus on the resistant mechanisms of BCR-ABL inhibitors and therapeutic resistant strategies.
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
New
Impact
Fromme et al., Tempe, United States. In Nature, Oct 2014
Two large membrane protein complexes, photosystem I and II (PSI and PSII), act in series to catalyse the light-driven reactions in photosynthesis.
Three-dimensional structure of human γ-secretase.
New
Impact
Shi et al., Beijing, China. In Nature, Sep 2014
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage.
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation.
New
Impact
Wolf et al., München, Germany. In Cell, Jun 2014
mPER2 winds around the helical mCRY1 domain covering the binding sites of FBXL3 and CLOCK/BMAL1, but not the FAD binding pocket.
Complex regulation of γ-secretase: from obligatory to modulatory subunits.
Review
Li et al., New York City, United States. In Front Aging Neurosci, 2013
Regulation is also accomplished by an array of cellular events, such as presenilin (active subunit of γ-secretase) endoproteolysis and hypoxia.
The γ-secretase complex: from structure to function.
Review
Zhang et al., Xiamen, China. In Front Cell Neurosci, 2013
γ-secretase is a high molecular weight complex minimally composed of four components: presenilins (PS), nicastrin, anterior pharynx defective 1 (APH-1), and presenilin enhancer 2 (PEN-2).
Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function.
Impact
Wolf et al., München, Germany. In Cell, 2013
Drosophila cryptochrome (dCRY) is a FAD-dependent circadian photoreceptor, whereas mammalian cryptochromes (CRY1/2) are integral clock components that repress mCLOCK/mBMAL1-dependent transcription.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
GeneRIF
Couch et al., Rochester, United States. In Dev Cell, 2012
A specific role for BRCA2 in the regulation of midbody structure and function is identified that is separate from DNA damage repair and is an explanation of whole-chromosomal instability in BRCA2-deficient tumors.
Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
GeneRIF
Mlodzik et al., New York City, United States. In Dev Cell, 2012
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Impact
GeneRIF
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
GeneRIF
Anand et al., Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.
Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.
GeneRIF
Hafez et al., Sūhāj, Egypt. In Egypt J Immunol, 2010
Sixty-two patients (index cases) with invasive breast cancer belonging to sixty families and their asymptomatic female first-degree relatives (300 cases) were studied for germline mutations of BRCA1 and BRCA2 genes.
More papers using Presenilin-1 antibodies
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
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Iijima Koichi M., In PLoS ONE, 2004
... AβPP/PS1 double transgenic mice (AβPP Swedish mutant ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
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Shen Jie et al., In Nature, 2001
... Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Ikezu Tsuneya, In PLoS ONE, 2000
... MEF PS1/2-/- cells were transfected with pCNA3.1/PS1
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
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Elder Gregory A et al., In Molecular Neurodegeneration, 2000
... wild type and FAD mutant PAC transgenic mice can be found ...
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
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Okazawa H. et al., In The Journal of Cell Biology, 1997
... cDNA encoding full-length PS1 was amplified from human hippocampal mRNA (Clontech) by reverse transcriptase PCR ...
Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA
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Yu Yi-Kuo et al., In Database: The Journal of Biological Databases and Curation, 1997
... Using the full PSI-MI ontology file in Open Biomedical Ontology (OBO) format ( ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
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Finkelstein David I., In PLoS ONE, 1996
... The PS1 mice were homozygous transgenic mice (Swiss Webster/B6D2; I.D ...
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
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Ikezu Tsuneya, In PLoS ONE, 1996
... /PSEN1ΔE9 (APP/PS1) transgenic mice (line 85, Stock ...
Tissue levels of S-adenosylmethionine in aging rats
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Kiliaan Amanda J. et al., In Neurological Sciences, 1976
... Male APP/PS1 transgenic mice and their wild-type ...
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