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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Presenilin 1

Presenilin-1, FAD, PS1, presenilin, PSI
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: APP, CAN, AGE, V1a, ACID
Papers using Presenilin-1 antibodies
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
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Smith Mark A., In PLoS ONE, 2009
... APP-NT, APP-CT and β-actin (Sigma, St Louis, MS); antibodies for B94, ADAM9, ADAM10, BACE1 and PS1 (Santa Cruz Biotechnology, Santa Cruz, CA); antibodies ...
Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
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Zhao Li-Ru et al., In Alzheimer's Research & Therapy, 2008
... The mouse model of AD used for the present study is an amyloid precursor protein/presenilin 1 (APP/PS1) transgenic strain ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
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Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... APP695SWE/co + PS1/ΔE9 transgenic ( ...
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
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Combs Colin, In PLoS ONE, 2006
... APP/PS1 transgenic mice of C57BL/6J background ...
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
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Rivest Serge et al., In Molecular Neurodegeneration, 2006
... /PS1 transgenic mice harbouring the human ...
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Papers on Presenilin-1
Structure of T4moF, the toluene 4-monooxygenase ferredoxin oxidoreductase.
New
Fox et al., In Biochemistry, 26 Sep 2015
Close contacts between the C8 methyl group of FAD and [2Fe-2S] ligand Cys36-O represent a plausible pathway for electron transfer between the redox cofactors.
Closing the gaps on the viral photosystem-I psaDCAB gene organization.
New
Béjà et al., Haifa, Israel. In Environ Microbiol, 26 Sep 2015
Genes encoding for photosystem (PS) I and II reaction center proteins are found in cyanophages and are believed to increase their fitness.
Discovery of a novel fluorescent probe for the sensitive detection of β-amyloid deposits.
New
Hu et al., Shanghai, China. In Biosens Bioelectron, 18 Sep 2015
As a proof of concept, its application has been exemplified by staining Aβ plaques in slices of brain tissue from double transgenic (APP/PS1) mice of Alzheimer's disease.
An atomic structure of human γ-secretase.
New
Impact
Shi et al., Beijing, China. In Nature, 17 Sep 2015
UNASSIGNED: Dysfunction of the intramembrane protease γ-secretase is thought to cause Alzheimer's disease, with most mutations derived from Alzheimer's disease mapping to the catalytic subunit presenilin 1 (PS1).
POLYAMINE OXIDASE2 of Arabidopsis contributes to ABA mediated plant developmental processes.
New
Scherer et al., Hannover, Germany. In Plant Physiol Biochem, 10 Sep 2015
UNASSIGNED: Polyamines (PA) are catabolised by two groups of amine oxidases, the copper-binding amine oxidases (CuAOs) and the FAD-binding polyamine oxidases (PAOs).
Advances in the development of histone lysine demethylase inhibitors.
Review
New
Buesa et al., Cornellà de Llobregat, Spain. In Curr Opin Pharmacol, 31 Aug 2015
Initially thought to be an irreversible process, histone methylation is now known to be reversed by demethylases, FAD dependent amineoxidases and by iron(II)-alpha-ketoglutarate dependent deoxygenases of the Jumonji family.
Ca(2+) dysregulation in the endoplasmic reticulum related to Alzheimer's disease: A review on experimental progress and computational modeling.
Review
New
Samarasinghe et al., Christchurch, New Zealand. In Biosystems, 31 Aug 2015
Numerous research papers have suggested that the dysregulation of ER Ca(2+) homeostasis is associated with mutations in the presenilin genes and amyloid-β oligomers.
Photosynthesis. Structural basis for energy transfer pathways in the plant PSI-LHCI supercomplex.
New
Impact
Shen et al., Beijing, China. In Science, Jun 2015
Photosynthesis converts solar energy to chemical energy by means of two large pigment-protein complexes: photosystem I (PSI) and photosystem II (PSII).
Proteomic analysis to identify biomarkers in the primary tumour that predict response to neoadjuvant chemotherapy in liver metastases.
New
Impact
Kitteringham et al., Liverpool, United Kingdom. In Lancet, Mar 2015
Five of them predicted histopathological response to fluorouracil-based chemotherapy regimens, of which the FAD binding protein NQO1 was subsequently validated by immunohistochemistry.
Comparative Analysis and Distribution of Omega-3 lcPUFA Biosynthesis Genes in Marine Molluscs.
New
Pavasovic et al., Brisbane, Australia. In Plos One, Dec 2014
In this study we generated a representative list of fatty acyl desaturase (Fad) and elongation of very long-chain fatty acid (Elovl) genes from major orders of Phylum Mollusca, through the interrogation of transcriptome and genome sequences, and various publicly available databases.
Autosomal Dominant Alzheimer Disease: A Unique Resource to Study CSF Biomarker Changes in Preclinical AD.
Review
New
Fagan et al., Saint Louis, United States. In Front Neurol, Dec 2014
Mutations in the genes coding for amyloid precursor protein (APP), presenilin 1 (PSEN-1), and presenilin 2 (PSEN-2) cause over-production of the amyloid-β peptide (Aβ) leading to early deposition of Aβ in the brain, which in turn is hypothesized to initiate a cascade of processes, resulting in neuronal death, cognitive decline, and eventual dementia.
Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer's Disease.
Review
New
Sáez-Valero et al., San Juan de Alicante, Spain. In Front Neurol, Dec 2014
However, we and others recently identified soluble forms of BACE1 and APP in CSF containing the intracellular domains, as well as the multi-pass transmembrane presenilin-1 (PS1) and other subunits of γ-secretase.
Mutations in presenilin 2 and its implications in Alzheimer's disease and other dementia-associated disorders.
Review
New
Kim et al., South Korea. In Clin Interv Aging, Dec 2014
Mutations in the genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have been identified as the main genetic causes of familial AD.
Structure and energy transfer in photosystems of oxygenic photosynthesis.
New
Impact
Junge et al., Tel Aviv-Yafo, Israel. In Annu Rev Biochem, Dec 2014
The conversion of solar energy into chemical energy is catalyzed by two multisubunit membrane protein complexes, photosystem I (PSI) and photosystem II (PSII).
A three-dimensional human neural cell culture model of Alzheimer's disease.
New
Impact
Kim et al., United States. In Nature, Dec 2014
Here we report that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloid-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
GeneRIF
Couch et al., Rochester, United States. In Dev Cell, 2012
A specific role for BRCA2 in the regulation of midbody structure and function is identified that is separate from DNA damage repair and is an explanation of whole-chromosomal instability in BRCA2-deficient tumors.
Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
GeneRIF
Mlodzik et al., New York City, United States. In Dev Cell, 2012
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Impact
GeneRIF
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
GeneRIF
Anand et al., Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.
Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.
GeneRIF
Hafez et al., Sūhāj, Egypt. In Egypt J Immunol, 2010
Sixty-two patients (index cases) with invasive breast cancer belonging to sixty families and their asymptomatic female first-degree relatives (300 cases) were studied for germline mutations of BRCA1 and BRCA2 genes.
More papers using Presenilin-1 antibodies
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
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Iijima Koichi M., In PLoS ONE, 2004
... AβPP/PS1 double transgenic mice (AβPP Swedish mutant ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
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Shen Jie et al., In Nature, 2001
... Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
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Ikezu Tsuneya, In PLoS ONE, 2000
... MEF PS1/2-/- cells were transfected with pCNA3.1/PS1
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
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Elder Gregory A et al., In Molecular Neurodegeneration, 2000
... wild type and FAD mutant PAC transgenic mice can be found ...
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
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Okazawa H. et al., In The Journal of Cell Biology, 1997
... cDNA encoding full-length PS1 was amplified from human hippocampal mRNA (Clontech) by reverse transcriptase PCR ...
Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA
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Yu Yi-Kuo et al., In Database: The Journal of Biological Databases and Curation, 1997
... Using the full PSI-MI ontology file in Open Biomedical Ontology (OBO) format ( ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
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Finkelstein David I., In PLoS ONE, 1996
... The PS1 mice were homozygous transgenic mice (Swiss Webster/B6D2; I.D ...
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
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Ikezu Tsuneya, In PLoS ONE, 1996
... /PSEN1ΔE9 (APP/PS1) transgenic mice (line 85, Stock ...
Tissue levels of S-adenosylmethionine in aging rats
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Kiliaan Amanda J. et al., In Neurological Sciences, 1976
... Male APP/PS1 transgenic mice and their wild-type ...
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