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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

Presenilin 1

Presenilin-1, FAD, PS1, presenilin, PSI
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: APP, CAN, AGE, ACID, V1a
Papers using Presenilin-1 antibodies
PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis.
Smith Mark A., In PLoS ONE, 2009
... APP-NT, APP-CT and β-actin (Sigma, St Louis, MS); antibodies for B94, ADAM9, ADAM10, BACE1 and PS1 (Santa Cruz Biotechnology, Santa Cruz, CA); antibodies ...
Decreased plasma levels of granulocyte-colony stimulating factor (G-CSF) in patients with early Alzheimer's disease
Zhao Li-Ru et al., In Alzheimer's Research & Therapy, 2008
... The mouse model of AD used for the present study is an amyloid precursor protein/presenilin 1 (APP/PS1) transgenic strain ...
Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment
Liu Jian-xun et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2006
... APP695SWE/co + PS1/ΔE9 transgenic ( ...
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model.
Combs Colin, In PLoS ONE, 2006
... APP/PS1 transgenic mice of C57BL/6J background ...
Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
Rivest Serge et al., In Molecular Neurodegeneration, 2006
... /PS1 transgenic mice harbouring the human ...
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Papers on Presenilin-1
GRASP: Guided Reference-based Assembly of Short Peptides.
Yooseph et al., Los Angeles, United States. In Nucleic Acids Res, 20 Dec 2014
GRASP was compared to three commonly used protein sequence search programs (BLASTP, PSI-BLAST and FASTM).
Signaling-State Formation Mechanism of a BLUF Protein PapB from the Purple Bacterium Rhodopseudomonas palustris Studied by Femtosecond Time-resolved Absorption Spectroscopy.
Tahara et al., In J Phys Chem B, 19 Dec 2014
UNLABELLED: We studied the signaling-state formation of a BLUF (blue light using FAD) protein, PapB from the purple bacterium Rhodopseudomonas palustris, using femtosecond time-resolved absorption spectroscopy.
Pestana et al., Porto, Portugal. In Am J Physiol Renal Physiol, 19 Dec 2014
UNLABELLED: Renalase is a recently identified FAD/NADH-dependent amine oxidase mainly expressed in kidney, which is secreted into blood and urine where it was suggested to metabolize catecholamines.
Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System.
Combs et al., Grand Forks, United States. In J Alzheimers Dis, 18 Dec 2014
To test this hypothesis, ileums of the small intestine of thirteen month old AβPP/PS1 and C57BL/6 (wild type) mice were collected and analyzed using immunohistochemistry, western blot analysis, cytokine arrays, and ELISA.
Peripheral Amyloid Levels Present Gender Differences Associated with Aging in AβPP/PS1 Mice.
Wandosell et al., Madrid, Spain. In J Alzheimers Dis, 14 Dec 2014
We have analyzed whether the progression of amyloidosis differentially affects males and females along aging in AβPP/PS1 transgenic mice.
A three-dimensional human neural cell culture model of Alzheimer's disease.
Kim et al., United States. In Nature, 13 Dec 2014
Here we report that FAD mutations in β-amyloid precursor protein and presenilin 1 are able to induce robust extracellular deposition of amyloid-β, including amyloid-β plaques, in a human neural stem-cell-derived three-dimensional (3D) culture system.
Photochemistry of flavoprotein light sensors.
Crane et al., Ithaca, United States. In Nat Chem Biol, 31 Oct 2014
Three major classes of flavin photosensors, light oxygen voltage (LOV) domains, blue light sensor using FAD (BLUF) proteins and cryptochromes (CRYs), regulate diverse biological activities in response to blue light.
Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.
Fromme et al., Tempe, United States. In Nature, 11 Oct 2014
Two large membrane protein complexes, photosystem I and II (PSI and PSII), act in series to catalyse the light-driven reactions in photosynthesis.
Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.
Mitchell et al., Philadelphia, United States. In Exp Eye Res, Sep 2014
An elevated lysosomal pH with upregulation of TcFEB and vHATPase resembles the pathology in fibroblasts of patients with mutant presenilin 1 (PS1), suggesting a common link between age-related macular degeneration (AMD) and Alzheimer's disease.
Three-dimensional structure of human γ-secretase.
Shi et al., Beijing, China. In Nature, Sep 2014
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage.
Vibrational Spectroscopy of Photosystem I.
Hastings, Atlanta, United States. In Biochim Biophys Acta, Aug 2014
To fully characterize PSI particles with different quinones incorporated into the A1 binding site nanosecond to millisecond visible absorption spectroscopy has been shown to be of considerable value, especially so when undertaken using identical samples under identical conditions to that used in time-resolved step-scan FTIR measurements.
Interaction of circadian clock proteins CRY1 and PER2 is modulated by zinc binding and disulfide bond formation.
Wolf et al., München, Germany. In Cell, Jun 2014
mPER2 winds around the helical mCRY1 domain covering the binding sites of FBXL3 and CLOCK/BMAL1, but not the FAD binding pocket.
Understanding the role of Notch in osteosarcoma.
Hughes et al., Houston, United States. In Adv Exp Med Biol, Dec 2013
Most pharmacologic approaches thus far have focused on inhibition of gamma secretase, a protease of the presenilin complex.
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases.
Li et al., New York City, United States. In Front Genet, Dec 2013
Genes in which mutations are correlated with AD have counterparts in C. elegans, including an APP-related gene, apl-1, a tau homolog, ptl-1, and presenilin homologs, such as sel-12 and hop-1.
Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function.
Wolf et al., München, Germany. In Cell, Jul 2013
Drosophila cryptochrome (dCRY) is a FAD-dependent circadian photoreceptor, whereas mammalian cryptochromes (CRY1/2) are integral clock components that repress mCLOCK/mBMAL1-dependent transcription.
BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis.
Couch et al., Rochester, United States. In Dev Cell, 2012
A specific role for BRCA2 in the regulation of midbody structure and function is identified that is separate from DNA damage repair and is an explanation of whole-chromosomal instability in BRCA2-deficient tumors.
Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
Mlodzik et al., New York City, United States. In Dev Cell, 2012
Consistent with its role in Psn processing, Hbs genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.
Jasin et al., New York City, United States. In Cancer Cell, 2012
show a repair-independent requirement for FA genes, including FANCD2, and BRCA1 in protecting stalled replication forks from degradation
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
Anand et al., Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.
Detection of BRCA1 and BRCA2 gene mutation in Egyptian females with breast cancer and their relatives by PCR-SSCP method.
Hafez et al., Sūhāj, Egypt. In Egypt J Immunol, 2010
Sixty-two patients (index cases) with invasive breast cancer belonging to sixty families and their asymptomatic female first-degree relatives (300 cases) were studied for germline mutations of BRCA1 and BRCA2 genes.
More papers using Presenilin-1 antibodies
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
Iijima Koichi M., In PLoS ONE, 2004
... AβPP/PS1 double transgenic mice (AβPP Swedish mutant ...
Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons
Shen Jie et al., In Nature, 2001
... Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Ikezu Tsuneya, In PLoS ONE, 2000
... MEF PS1/2-/- cells were transfected with pCNA3.1/PS1
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
Elder Gregory A et al., In Molecular Neurodegeneration, 2000
... wild type and FAD mutant PAC transgenic mice can be found ...
Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Okazawa H. et al., In The Journal of Cell Biology, 1997
... cDNA encoding full-length PS1 was amplified from human hippocampal mRNA (Clontech) by reverse transcriptase PCR ...
Multiple transcriptional activation complexes tether the yeast activator Met4 to DNA
Yu Yi-Kuo et al., In Database: The Journal of Biological Databases and Curation, 1997
... Using the full PSI-MI ontology file in Open Biomedical Ontology (OBO) format ( ...
New software toolkits for comprehensive visualization and analysis of three-dimensional multimodal biomedical images.
Finkelstein David I., In PLoS ONE, 1996
... The PS1 mice were homozygous transgenic mice (Swiss Webster/B6D2; I.D ...
Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.
Ikezu Tsuneya, In PLoS ONE, 1996
... /PSEN1ΔE9 (APP/PS1) transgenic mice (line 85, Stock ...
Tissue levels of S-adenosylmethionine in aging rats
Kiliaan Amanda J. et al., In Neurological Sciences, 1976
... Male APP/PS1 transgenic mice and their wild-type ...
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