Advances in the development of histone lysine demethylase inhibitors.
Cornellà de Llobregat, Spain. In Curr Opin Pharmacol, 05 Jul 2015
Initially thought to be an irreversible process, histone methylation is now known to be reversed by demethylases, FAD dependent amineoxidases and by iron(II)-alpha-ketoglutarate dependent deoxygenases of the Jumonji family.
Three-dimensional structure of human γ-secretase.
Beijing, China. In Nature, Sep 2014
The γ-secretase complex, comprising presenilin 1 (PS1), PEN-2, APH-1 and nicastrin, is a membrane-embedded protease that controls a number of important cellular functions through substrate cleavage.
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
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Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.