Evidence of short-range electron transfer of a redox enzyme on graphene oxide electrodes.
Santo André, Brazil. In Phys Chem Chem Phys, 07 Oct 2014
It is postulated that GO layers decrease the distance between the flavin cofactor (FAD/FADH2) of the glucose oxidase enzyme (GOx) and the electrode surface, though experimental evidence concerning the distance dependence of the rate constant for heterogeneous electron-transfer (k(het)) has not yet been observed.
Retinoids as potential targets for Alzheimer's disease.
Patiāla, India. In Pharmacol Biochem Behav, May 2014
Ligand activation of RAR and RXR in APP/PS1 transgenic mice ameliorated the symptoms of AD and reduced amyloid accumulation and tau hyperphosphorylation. Retinoids also reduce the production of pro-inflammatory cytokines and chemokines by astrocytes and the microglia.
Structural basis of kynurenine 3-monooxygenase inhibition.
Manchester, United Kingdom. In Nature, May 2013
KMO is a flavin adenine dinucleotide (FAD)-dependent monooxygenase and is located in the outer mitochondrial membrane where it converts l-kynurenine to 3-hydroxykynurenine. Perturbations in the levels of kynurenine pathway metabolites have been linked to the pathogenesis of a spectrum of brain disorders, as well as cancer and several peripheral inflammatory conditions.
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
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Hamilton, Canada. In Bmc Med Genet, 2011
Although there was an association between two SNPs in BRCA2 and cardiovascular disease in a multi-ethnic population, these results were not replicated in two South Asian case-control studies of incident myocardial infarction.