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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2015.

Pbx/knotted 1 homeobox

Prep1, PKNOX1, AtPreP1
Zinc metalloprotease pitrilysin subfamily A. Signal peptide degrading enzyme targeted to mitochondria and chloroplasts. Expressed only in siliques and flowers (from NCBI)
Top mentioned proteins: prolyl endopeptidase, Meis1, ACID, Hoxb1, HOXA9
Papers on Prep1
Associations between DNA methylation and schizophrenia-related intermediate phenotypes - a gene set enrichment analysis.
New
Ehrlich et al., Dresden, Germany. In Prog Neuropsychopharmacol Biol Psychiatry, 03 Jul 2015
We found the predicted hsa-miR-219a-5p target gene set to be significantly enriched for genes (EPHA4, PKNOX1, ESR1, among others) whose methylation status is correlated with hippocampal volume independent of disease status.
Molecular characterization of mouse lens epithelial cell lines and their suitability to study RNA granules and cataract associated genes.
New
Lachke et al., Newark, United States. In Exp Eye Res, Feb 2015
In addition to these genes, all three LECs also express key lens- and cataract-associated genes, namely Dkk3, Epha2, Hsf4, Jag1, Mab21l1, Meis1, Pknox1, Pou2f1, Sfrp1, Sparc, Tdrd7 and Trpm3.
ChIP-Seq and RNA-Seq analyses identify components of the Wnt and Fgf signaling pathways as Prep1 target genes in mouse embryonic stem cells.
New
Penkov et al., Milano, Italy. In Plos One, Dec 2014
The Prep1 (Pknox1) homeodomain transcription factor is essential at multiple stages of embryo development.
Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.
New
Blasi et al., Milano, Italy. In Plos One, Dec 2014
Human PREP1 and PBX1 are homeodomain transcriptional factors, whose biochemical and structural characterization has not yet been fully described.
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.
New
Verde et al., Napoli, Italy. In Proc Natl Acad Sci U S A, Oct 2014
Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis.
Phenotypical consequences of expressing the dually targeted Presequence Protease, AtPreP, exclusively in mitochondria.
New
Glaser et al., Stockholm, Sweden. In Biochimie, May 2014
Mitochondrial, as well as chloroplastic peptides are degraded by Presequence Protease (PreP), which is dually targeted to mitochondrial matrix and chloroplastic stroma.
Expression characterization and promoter activity analysis of the tilapia (Oreochromis niloticus) myosin light chain 3 promoter in skeletal muscle of fish.
New
Chen et al., Kao-hsiung, Taiwan. In Transgenic Res, Feb 2014
The clone contained several putative binding sequences for transcription factors, including MEF-2, MYOG, MyoD, PKNOX1, and AREB6.
Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.
Review
Blasi et al., Milano, Italy. In Dev Dyn, 2014
Finally, recent advances in determining the genome-wide DNA-binding sites of PREP1, MEIS1, and PBX1, and their partial correspondence with the binding sites of some HOX proteins, are reviewed.
Pknox1/Prep1 regulates mitochondrial oxidative phosphorylation components in skeletal muscle.
Schürmann et al., Potsdam, Germany. In Mol Cell Biol, 2014
The homeodomain transcription factor Prep1 was previously shown to regulate insulin sensitivity.
PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice.
Beguinot et al., Napoli, Italy. In Diabetologia, 2013
AIMS/HYPOTHESIS: The aim of this study was to investigate the function of Prep1 (also known as Pknox1) in hepatic lipogenesis.
Prep1 (pKnox1) regulates mouse embryonic HSC cycling and self-renewal affecting the Stat1-Sca1 IFN-dependent pathway.
Blasi et al., Milano, Italy. In Plos One, 2013
A hypomorphic Prep1 mutation results in embryonic lethality at late gestation with a pleiotropic embryonic phenotype that includes defects in all hematopoietic lineages.
The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis.
Blasi et al., Milano, Italy. In Plos One, 2013
Prep1 and Meis1 ortholog TALE transcription factors have opposing roles in tumorigenesis: Meis1 serves as an oncogene, Prep1 as a tumor suppressor.
Nuclear actin polymerization from faster growing ends in the initial activation of Hox gene transcription are nuclear speckles involved?
Rivera-Pomar et al., In Transcription, 2013
The DNA-binding Pknox1-Pbx1 complex modulates Hox protein activity.
A novel mitochondrial and chloroplast peptidasome, PreP.
Review
Glaser et al., Stockholm, Sweden. In Physiol Plant, 2012
A novel mitochondrial and chloroplast peptidasome, the Presequence Protease (PreP) degrades organellar targeting peptides as well as other unstructured peptides up to 65 amino acid residues in length.
Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.
GeneRIF
van 't Wout et al., Amsterdam, Netherlands. In Plos One, 2011
Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
GeneRIF
Sauvageau et al., Montréal, Canada. In Blood, 2011
The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression.
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
GeneRIF
Selleri et al., New York City, United States. In Dev Cell, 2011
Loss of Pbx-Wnt-p63-Irf6 regulatory module results in clefting.
Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.
GeneRIF
Blasi et al., Milano, Italy. In Proc Natl Acad Sci U S A, 2011
The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability.
MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.
GeneRIF
Jave-Suárez et al., Guadalajara, Mexico. In J Exp Clin Cancer Res, 2010
High levels of MEIS1 and PREP1, and low levels of PBX4 expression were founded in samples of patients with ALL.
Two novel mitochondrial and chloroplastic targeting-peptide-degrading peptidasomes in A. thaliana, AtPreP1 and AtPreP2.
Review
GeneRIF
Bhushan et al., Stockholm, Sweden. In Biol Chem, 2006
AtPreP1 and AtPreP2 genes are differentially expressed in Arabidopsis
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