GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Pbx/knotted 1 homeobox
Prep1, PKNOX1, AtPreP1
Zinc metalloprotease pitrilysin subfamily A. Signal peptide degrading enzyme targeted to mitochondria and chloroplasts. Expressed only in siliques and flowers (from
NCBI)
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Papers on
Prep1
A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation.
New
College Station, United States. In Circulation, Jul 2012
In addition, we identified Pknox1 as a genuine miR-223 target gene and an essential regulator for macrophage polarization.
A novel mitochondrial and chloroplast peptidasome, PreP.
Review
New
Stockholm, Sweden. In Physiol Plant, May 2012
A novel mitochondrial and chloroplast peptidasome, the Presequence Protease (PreP) degrades organellar targeting peptides as well as other unstructured peptides up to 65 amino acid residues in length.
Non-synonymous variants in pre-B cell leukemia homeobox (PBX) genes are associated with congenital heart defects.
New
Salt Lake City, United States. In Eur J Med Genet, Apr 2012
The coding exons of PBX1-4, PKNOX1, PKNOX2, MEIS1-3, and PBXIP1 were amplified by polymerase chain reaction and the products analyzed on a lightscanner.
Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia.
Amsterdam, Netherlands. In Plos One, 2011
A significant difference in genotype distribution among all cases and controls irrespective of year of AIDS diagnosis was found only for a SNP in candidate gene PREP1 (p = 1.2 × 10(-5)).
C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein.
GeneRIF
Montréal, Canada. In Blood, 2011
The C-terminal domain of MEIS1 confers to PKNOX1 an ectopic transactivating function that promotes leukemogenesis by regulating expression of genes involved in chromatin accessibility and cell cycle progression.
A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.
GeneRIF
New York City, United States. In Dev Cell, 2011
Loss of Pbx-Wnt-p63-Irf6 regulatory module results in clefting.
Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability.
GeneRIF
Milano, Italy. In Proc Natl Acad Sci U S A, 2011
The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability.
Targeting capacity and conservation of PreP homologues localization in mitochondria of different species.
GeneRIF
Stockholm, Sweden. In J Mol Biol, 2011
Data show that the AtPreP presequence has the capacity to target GFP into the mitochondrial matrix of all three species.
SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter element.
Montréal, Canada. In Mol Endocrinol, 2011
In contrast, a mutation that impairs an adjacent PBX1/PREP1 (pre-B cell leukemia transcription factor 1-PBX/knotted-1 homeobox-1) binding site does not alter activin A-stimulated promoter activity in homologous cells.
MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.
Guadalajara, Mexico. In J Exp Clin Cancer Res, 2010
RESULTS: Here we show increased expression of MEIS1, MEIS2, and PREP1 genes in leukemia-derived cell lines compared with blood normal cells.
Regulation of CCL2 expression by an upstream TALE homeodomain protein-binding site that synergizes with the site created by the A-2578G SNP.
Baltimore, United States. In Plos One, 2010
We previously demonstrated that the -2578 G polymorphism creates a TALE homeodomain protein binding site (TALE binding site) for PREP1/PBX2 transcription factors.
prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish.
Padova, Italy. In Dev Biol, 2010
As the paralogue gene prep1.1 is more important in hindbrain patterning and neural crest chondrogenesis, we provide evidence of a functional specialization of prep genes in zebrafish head segmentation and morphogenesis.
Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
GeneRIF
Milano, Italy. In Nucleic Acids Res, 2010
excess Prep1 increases the sensitivity of cells to genotoxic stress and the extent of the apoptosis directly correlates with the level of Prep1.
Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.
Boston, United States. In Genes Dev, 2010
Here, we identify the Prep1 (pKnox1) transcription factor as a critical dose-dependent upstream regulator of Pax6 expression during lens formation.
Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1.
GeneRIF
Milano, Italy. In Mol Oncol, 2010
Immunohistochemistry on tissue micrroarrays (TMA) generated from three distinct human cohorts comprising a total of some 1000 human tumors revealed that 70% of the tumors express no or extremely low levels of Prep1, unlike normal tissues.
A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome.
Orléans, France. In Hum Mol Genet, 2010
Expression analysis pinpoints several genes, such as Ndufv3, Wdr4, Pknox1 and Cbs, as candidates whose overexpression in the hippocampus might facilitate learning and memory in Ts1Yah mice.
Characterization of the regulatory region of the zebrafish Prep1.1 gene: analogies to the promoter of the human PREP1.
GeneRIF
Milano, Italy. In Plos One, 2009
analysis of the regulatory region of the zebrafish Prep1.1 gene and the promoter of human PREP1
Two novel mitochondrial and chloroplastic targeting-peptide-degrading peptidasomes in A. thaliana, AtPreP1 and AtPreP2.
Review
GeneRIF
Stockholm, Sweden. In Biol Chem, 2006
AtPreP1 and AtPreP2 genes are differentially expressed in Arabidopsis
