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Pregnancy-associated plasma protein A, pappalysin 1
Pregnancy-Associated Plasma Protein-A, PAPP-A
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] (from
Tongsong et al., Chiang Mai, Thailand. In Int J Gynaecol Obstet, 2012
Ethnic group-specific median for PAPP-A should be incorporated during first-trimester screening for fetal Down syndrome; equation of best fit was predicted median PAPP-A level=28.767 - 0.781x(gestational age in days)+0.006x(gestational age in days)2.