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Pregnancy-associated plasma protein A, pappalysin 1

Pregnancy-Associated Plasma Protein-A, PAPP-A
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Pregnancy-Associated Plasma Protein-A antibodies
Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies
Ehetshami Sara et al., In ISRN Obstetrics and Gynecology, 2003
... In all studied participants, serum PAPP-A (IBL kit, Germany) and PP13 ...
Papers on Pregnancy-Associated Plasma Protein-A
High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naïve patients.
Krebsová et al., Praha, Czech Republic. In J Thromb Thrombolysis, 2012
High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naive patients
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women.
Tongsong et al., Chiang Mai, Thailand. In Int J Gynaecol Obstet, 2012
Ethnic group-specific median for PAPP-A should be incorporated during first-trimester screening for fetal Down syndrome; equation of best fit was predicted median PAPP-A level=28.767 - 0.781x(gestational age in days)+0.006x(gestational age in days)2.
Early first-trimester free-β-hCG and PAPP-A serum distributions in monochorionic and dichorionic twins.
Comas et al., Barcelona, Spain. In Prenat Diagn, 2012
Pregnancy-associated plasma protein A and free-beta-hCG values are gestational age specific.
Determinants of circulating matrix metalloproteinase-2 and pregnancy-associated plasma protein-A in patients with chronic kidney disease.
Tesar et al., Praha, Czech Republic. In Clin Lab, 2011
Serum MMP-2 and PAPP-A were independent correlates of proteinuria, albumin, and other examined parameters in patients with chronic kidney disease.
Temporal effect of Afro-Caribbean race on serum pregnancy-associated plasma protein-a at 9-13 weeks' gestation in screening for aneuploidies.
Nicolaides et al., Plymouth, United Kingdom. In Fetal Diagn Ther, 2011
Serum-free beta-hCG and PAPP-A concentrations at 9-13 weeks' gestation are affected by several pregnancy characteristics in Afro-Caribbean women.
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