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Pregnancy-associated plasma protein A, pappalysin 1

Pregnancy-Associated Plasma Protein-A, PAPP-A
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: AGE, HCG, HAD, CAN, Insulin
Papers using Pregnancy-Associated Plasma Protein-A antibodies
Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies
Ehetshami Sara et al., In ISRN Obstetrics and Gynecology, 2003
... In all studied participants, serum PAPP-A (IBL kit, Germany) and PP13 ...
Papers on Pregnancy-Associated Plasma Protein-A
Screening for trisomies by cell-free DNA testing of maternal blood: consequences of failed result.
Nicolaides et al., Gillingham, United Kingdom. In Ultrasound Obstet Gynecol, Feb 2016
RESULTS: Fetal fraction decreased with increasing body mass index and maternal age, was lower in women of South Asian racial origin than in Caucasians and in assisted than natural conceptions, and increased with fetal crown-rump length, serum PAPP-A and free β-hCG.
First trimester combined screening test in pregnancies derived from blastocyst transfer.
Candiani et al., Milano, Italy. In Eur J Obstet Gynecol Reprod Biol, Jan 2016
All cases underwent ultrasound assessment at 11(+0)-13(+6) weeks with measurements of crown rump length, nuchal translucency, free β-hCG and PAPP-A concentrations.
First trimester pregnancy-associated plasma protein-A and birth weight.
Jelliffe-Pawlowski et al., Richmond, United States. In Eur J Obstet Gynecol Reprod Biol, Jan 2016
OBJECTIVE: To evaluate first trimester pregnancy-associated plasma protein-A (PAPP-A) and birth weight percentile.
BMP-1 participates in the selection and dominance of buffalo follicles by regulating the proliferation and apoptosis of granulosa cells.
Shi et al., Nanning, China. In Theriogenology, Dec 2015
It also upregulated the expression of PAPP-A, IGF system, and VEGF, and so forth, which play important roles in the selection and dominance of growth follicles.
Use of biochemical tests of placental function for improving pregnancy outcome.
Thornton et al., Manchester, United Kingdom. In Cochrane Database Syst Rev, 2014
There are many other placental products that could be employed as surrogates of placental function, including: placental growth factor (PlGF), human chorionic gonadotrophin (hCG), plasma protein A (PAPP-A), placental protein 13 (PP-13), pregnancy-specific glycoproteins and progesterone metabolites and further studies should be encouraged to investigate these other placental products.
Associations of pregnancy-associated plasma protein-A level with essential hypertension and hypertensive disorders in pregnancy in Chinese population: a meta-analysis of 20 research studies involving 3332 individuals.
Fu et al., Changzhou, China. In Bmj Open, 2014
OBJECTIVE: To explore the associations between serum pregnancy-associated plasma protein-A (PAPP-A) level, and essential hypertension (EH) and hypertensive disorders in pregnancy (HDP) in Chinese population.
Pehlivanov et al., In Akush Ginekol (sofiia), 2014
Among multiple studied markers the most promising seam to be Doppler velosimetry of uterine arteries, PIGF, sFlt-1, sEndoglin, PAPP-A, PP-13.
Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis.
Duvekot et al., Rotterdam, Netherlands. In Int J Mol Sci, 2014
We found low predictive values using individual biomarkers which included a disintegrin and metalloprotease 12 (ADAM-12), inhibin-A, pregnancy associated plasma protein A (PAPP-A), placental growth factor (PlGF) and placental protein 13 (PP-13).
First trimester serum tests for Down's syndrome screening.
Alfirevic et al., Liverpool, United Kingdom. In Cochrane Database Syst Rev, 2014
We evaluated 78 test combinations formed from combinations of 18 different tests, with or without maternal age; ADAM12 (a disintegrin and metalloprotease), AFP (alpha-fetoprotein), inhibin, PAPP-A (pregnancy-associated plasma protein A, ITA (invasive trophoblast antigen), free βhCG (beta human chorionic gonadotrophin), PlGF (placental growth factor), SP1 (Schwangerschafts protein 1), total hCG, progesterone, uE3 (unconjugated oestriol), GHBP (growth hormone binding protein), PGH (placental growth hormone), hyperglycosylated hCG, ProMBP (proform of eosinophil major basic protein), hPL (human placental lactogen), (free αhCG, and free ßhCG to AFP ratio.
Serum pregnancy-associated plasma protein A correlates with inflammation and malnutrition in patients treated with maintenance hemodialysis.
Kuśnierz-Cabala et al., Kraków, Poland. In Folia Med Cracov, 2014
One of the biomarkers associated with inflammation and cardiovascular events is pregnancy-associated plasma protein A (PAPP-A).
High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naïve patients.
Krebsová et al., Praha, Czech Republic. In J Thromb Thrombolysis, 2012
High positive predictive value of PAPP-A for acute coronary syndrome diagnosis in heparin-naive patients
Median levels of serum biomarkers of fetal Down syndrome detected during the first trimester among pregnant Thai women.
Tongsong et al., Chiang Mai, Thailand. In Int J Gynaecol Obstet, 2012
Ethnic group-specific median for PAPP-A should be incorporated during first-trimester screening for fetal Down syndrome; equation of best fit was predicted median PAPP-A level=28.767 - 0.781x(gestational age in days)+0.006x(gestational age in days)2.
Early first-trimester free-β-hCG and PAPP-A serum distributions in monochorionic and dichorionic twins.
Comas et al., Barcelona, Spain. In Prenat Diagn, 2012
Pregnancy-associated plasma protein A and free-beta-hCG values are gestational age specific.
Temporal effect of Afro-Caribbean race on serum pregnancy-associated plasma protein-a at 9-13 weeks' gestation in screening for aneuploidies.
Nicolaides et al., Plymouth, United Kingdom. In Fetal Diagn Ther, 2011
Serum-free beta-hCG and PAPP-A concentrations at 9-13 weeks' gestation are affected by several pregnancy characteristics in Afro-Caribbean women.
Determinants of circulating matrix metalloproteinase-2 and pregnancy-associated plasma protein-A in patients with chronic kidney disease.
Tesar et al., Praha, Czech Republic. In Clin Lab, 2011
Serum MMP-2 and PAPP-A were independent correlates of proteinuria, albumin, and other examined parameters in patients with chronic kidney disease.
First-trimester or second-trimester screening, or both, for Down's syndrome.
First- and Second-Trimester Evaluation of Risk (FASTER) Research Consortium et al., New York City, United States. In N Engl J Med, 2005
METHODS: Women with singleton pregnancies underwent first-trimester combined screening (measurement of nuchal translucency, pregnancy-associated plasma protein A [PAPP-A], and the free beta subunit of human chorionic gonadotropin at 10 weeks 3 days through 13 weeks 6 days of gestation) and second-trimester quadruple screening (measurement of alpha-fetoprotein, total human chorionic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 weeks of gestation).
First-trimester placentation and the risk of antepartum stillbirth.
Dobbie et al., Cambridge, United Kingdom. In Jama, 2004
RESULTS: There were 8 stillbirths among the 400 women with levels of pregnancy-associated plasma protein A (PAPP-A) in the lowest fifth percentile compared with 17 among the remaining 7534 women (incidence rate per 10,000 women per week of gestation: 13.4 vs 1.4, respectively; hazard ratio [HR], 9.2 [95% confidence interval [CI], 4.0-21.4];
First-trimester screening for trisomies 21 and 18.
First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group et al., Philadelphia, United States. In N Engl J Med, 2003
METHODS: We conducted a multicenter study of screening for trisomies 21 and 18 among patients with pregnancies between 74 and 97 days of gestation, based on maternal age, maternal levels of free beta human chorionic gonadotropin and pregnancy-associated plasma protein A, and ultrasonographic measurement of fetal nuchal translucency.
Pregnancy-associated plasma protein A as a marker of acute coronary syndromes.
Schwartz et al., Rochester, United States. In N Engl J Med, 2001
We evaluated pregnancy-associated plasma protein A (PAPP-A), a potentially proatherosclerotic metalloproteinase, as a marker of acute coronary syndromes.
Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters.
Hackshaw et al., London, United Kingdom. In N Engl J Med, 1999
The first-trimester screening consisted of measurement of serum pregnancy-associated plasma protein A in 77 pregnancies affected by Down's syndrome and 383 unaffected pregnancies and measurements of nuchal translucency obtained by ultrasonography in 326 affected and 95,476 unaffected pregnancies.
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