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Transthyretin

Prealbumin, transthyretin, TTR
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, fibrillin-1, AGE, ACID
Papers using Prealbumin antibodies
Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles
Supplier
Mourton-Gilles Chantal et al., In BMC Veterinary Research, 2006
... 6: healthy ARR/ARR sheep; border line control "Ctl": 100 ng of Recombinant full length Human Prealbumin, amino acids 21-147, 13,8 kDa abcam n°92931) ...
Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
Supplier
Bernstein Carol et al., In Clinical and Experimental Gastroenterology, 2005
All wells contained the TransMessenger Transfection Reagent (TTR) from QIAGEN.
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Supplier
Deng Chu-Xia et al., In International Journal of Biological Sciences, 1992
... TTR-Cre transgenic mice (X.Y ...
Papers on Prealbumin
Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats.
New
Lee et al., Lexington, United States. In Respir Physiol Neurobiol, 09 May 2015
Our results showed: 1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats.
Characterization of little skate (Leucoraja erinacea) recombinant transthyretin zinc-dependent 3,3',5-triiodo-L-thyronine binding.
New
Yamauchi et al., Shizuoka, Japan. In Gen Comp Endocrinol, 08 May 2015
UNASSIGNED: Transthyretin (TTR) diverged from an ancestral 5-hydroxyisourate hydrolase (HIUHase) by gene duplication at some early stage of chordate evolution.
Extracellular remodeling in patients with wild-type amyloidosis consuming epigallocatechin-3-gallate: preliminary results of T1 mapping by cardiac magnetic resonance imaging in a small single center study.
New
Kristen et al., Heidelberg, Germany. In Clin Res Cardiol, 18 Mar 2015
Wild-type transthyretin amyloidosis (WT-ATTR) is characterized by extracellular amyloid deposition in the heart.
Effects of titanium dioxide nanoparticles on lead bioconcentration and toxicity on thyroid endocrine system and neuronal development in zebrafish larvae.
Review
New
Wu et al., Wuhan, China. In Aquat Toxicol, 07 Mar 2015
The significant up-regulation of tshβ gene and the down-regulation of TTR gene expression in the hypothalamic-pituitary-thyroid were observed in Pb with or without nano-TiO2 treatment groups.
A new prion disease: relationship with central and peripheral amyloidoses.
Review
New
Reilly et al., London, United Kingdom. In Nat Rev Neurol, Feb 2015
The chronic symptoms of this disorder, termed PrP systemic amyloidosis, can be very disabling, and are comparable to familial amyloid polyneuropathy (FAP) caused by transthyretin mutations.
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway.
New
Impact
Hilliard et al., Brisbane, Australia. In Nature, Feb 2015
PSR-1 functions cell-autonomously in the regrowing neuron and, instead of acting in its canonical signalling pathway, acts in a parallel phagocytic pathway that includes the transthyretin protein TTR-52, as well as CED-7, NRF-5 and CED-6 (refs 9, 10, 11, 12).
The amyloidogenic V122I transthyretin variant in elderly black Americans.
New
Impact
Solomon et al., Houston, United States. In N Engl J Med, Feb 2015
METHODS: We determined genotype status for the transthyretin gene (TTR) in 3856 black participants in the Atherosclerosis Risk in Communities study and assessed clinical profiles, mortality, and the risk of incident heart failure in V122I TTR variant carriers (124 participants [3%]) versus noncarriers (3732 participants).
Transport of thyroid hormones via the choroid plexus into the brain: the roles of transthyretin and thyroid hormone transmembrane transporters.
Review
New
Van Herck et al., Australia. In Front Neurosci, Dec 2014
In reptiles, birds and mammals, the main protein synthesized and secreted by the choroid plexus is a thyroid hormone distributor protein: transthyretin.
Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study.
New
Melse-Boonstra et al., In Bmc Med, Dec 2014
Proxy markers for vitamin A deficiency were serum concentrations of retinol binding protein (RBP), transthyretin, retinol measured by fluorometry and RBP:transthyretin molar ratio.
Amyloid fibrils nucleated and organized by DNA origami constructions.
New
Impact
Seeman et al., New York City, United States. In Nat Nanotechnol, Jul 2014
The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105-115 of the amyloidogenic protein transthyretin and a DNA origami construct is used to form 20-helix DNA nanotubes with sufficient space for the fibrils inside.
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
Impact
Diflunisal Trial Consortium et al., Umeå, Sweden. In Jama, 2014
IMPORTANCE: Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability.
Tweaking the structure to radically change the function: the evolution of transthyretin from 5-hydroxyisourate hydrolase to triiodothyronine distributor to thyroxine distributor.
Review
Richardson, Australia. In Front Endocrinol (lausanne), 2013
The TTR gene possibly arose as a duplication of the transthyretin-like protein (TLP) gene, around the stage of the agnathans.
Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction.
Review
Judge et al., Baltimore, United States. In Clin Med Insights Cardiol, 2013
Transthyretin (TTR) amyloidosis causes heart failure from cardiac deposition of TTR amyloid fibrils, the by-product of TTR homotetramer disassembly.
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
Impact
Suhr et al., Porto, Portugal. In N Engl J Med, 2013
BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart.
Transthyretin (TTR) cardiac amyloidosis.
GeneRIF
Berk et al., Boston, United States. In Circulation, 2012
Transthyretin cardiac amyloidosis is an underappreciated contributor to heart failure in elderly patients.
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
GeneRIF
Kai et al., Kumamoto, Japan. In Mol Cell, 2012
Data show that prolonged transthyretin (TTR) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation.
Identification of beta-amyloid-binding sites on transthyretin.
GeneRIF
Murphy et al., Madison, United States. In Protein Eng Des Sel, 2012
Strong binding of beta-amyloid peptide to TIAALLSPYSYS (residues 106-117) was detected, corresponding to strand G on the inner beta-sheet of TTR.
The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients.
GeneRIF
Anderson et al., London, United Kingdom. In Am Heart J, 2012
Electrocardiographic voltages meet the criteria for LVH in one quarter of patients with ATTR V122I cardiac amyloidosis.
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension.
GeneRIF
Young et al., Los Angeles, United States. In Prev Med, 2012
Discusses TTR gene mutations in amyloidosis and if amyloidosis has a role in the aging process. Explores if treating amyloidosis increases human lifespan and increases quality of life in the oldest old.
Amyloid and the cardiovascular system: A review of pathogenesis and pathology with clinical correlations.
Young et al., Ottawa, Canada. In Cardiovasc Pathol, 1995
Perhaps no organ system better exemplifies this than the cardiovascular one in which amyloid may form from precursor proteins as varied as immunoglobulin light chains, serum amyloid-A protein, transthyretin and its variants, atrial natriuretic factor, β2-microglobulin, and others.
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