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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.


Prealbumin, transthyretin, TTR
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: CAN, fibrillin-1, HAD, AGE, Serum albumin
Papers using Prealbumin antibodies
Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles
Mourton-Gilles Chantal et al., In BMC Veterinary Research, 2006
... 6: healthy ARR/ARR sheep; border line control "Ctl": 100 ng of Recombinant full length Human Prealbumin, amino acids 21-147, 13,8 kDa abcam n°92931) ...
Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
Bernstein Carol et al., In Clinical and Experimental Gastroenterology, 2005
All wells contained the TransMessenger Transfection Reagent (TTR) from QIAGEN.
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Deng Chu-Xia et al., In International Journal of Biological Sciences, 1992
... TTR-Cre transgenic mice (X.Y ...
Papers on Prealbumin
Natural history and therapy of TTR-cardiac amyloidosis: emerging disease-modifying therapies from organ transplantation to stabilizer and silencer drugs.
Maurer et al., New York City, United States. In Heart Fail Rev, 19 Dec 2014
UNLABELLED: Transthyretin-cardiac amyloidoses (ATTR-CA) are an underdiagnosed but increasingly recognized cause of heart failure.
Tuning transthyretin amyloidosis inhibition properties of iododiflunisal by combinatorial engineering of the non-salicylic ring substitutions.
Valencia et al., In Acs Comb Sci, 13 Dec 2014
From a selected set of 77 non-iodinated and 77 iodinated diflunisal analogues a subset of good transthyretin amyloid inhibitors has been obtained with improved turbidimetry inhibition constants, high binding affinity to transthyretin and good selectivity against other thyroxine binding proteins.
Amyloidogenic and non-amyloidogenic transthyretin variants interact differently with human cardiomyocytes: insights into early events of non-fibrillar tissue damage.
Reixach et al., In Biosci Rep, 13 Dec 2014
UNLABELLED: The transthyretin amyloidoses are diseases characterized by aggregation and extracellular deposition of the normally soluble plasma protein transthyretin (TTR).
Biomarkers identified from serum proteomic analysis for the differential diagnosis of systemic lupus erythematosus.
Salimi et al., Zāhedān, Iran. In Lupus, 12 Dec 2014
These spots were identified by MALDI-TOF/TOF-MS and classified into three groups include keratins, apolipoproteins and albumin, and individual proteins such as transthyretin, haptoglobin and prothrombin.
Pathophysiology and treatment of cardiac amyloidosis.
Sher et al., Rochester, United States. In Nat Rev Cardiol, 14 Nov 2014
Mass spectroscopy can be used to determine the protein subunit and classify the disease as immunoglobulin light-chain amyloidosis or transthyretin-related amyloidosis associated with mutant or wild-type TTR (formerly known as familial amyloid cardiomyopathy and senile cardiac amyloidosis, respectively).
Amyloid fibrils nucleated and organized by DNA origami constructions.
Seeman et al., New York City, United States. In Nat Nanotechnol, Jul 2014
The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105-115 of the amyloidogenic protein transthyretin and a DNA origami construct is used to form 20-helix DNA nanotubes with sufficient space for the fibrils inside.
[Transthyretin-related amyloidotic cardiomyopathy: looking for the etiological treatment].
Rapezzi et al., In G Ital Cardiol (rome), May 2014
Transthyretin (TTR)-related amyloidosis is a disease caused by the deposition of insoluble fibrils deriving from the misfolding of TTR, a protein mainly produced by the liver.
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
Diflunisal Trial Consortium et al., Umeå, Sweden. In Jama, Jan 2014
IMPORTANCE: Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability.
Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.
Turner et al., Leeds, United Kingdom. In Front Aging Neurosci, Dec 2013
We have also observed that another amyloid-clearing protein, namely transthyretin (TTR), is also regulated in the neuronal cell by a mechanism similar to NEP.
Recent advances in transthyretin amyloidosis therapy.
Ando et al., Kumamoto, Japan. In Transl Neurodegener, Dec 2013
Mutant (MT) forms of transthyretin (TTR) cause the most common type of autosomal-dominant hereditary systemic amyloidosis-familial amyloidotic polyneuropathy (FAP).
Transport of thyroid hormone in brain.
Köhrle et al., Berlin, Germany. In Front Endocrinol (lausanne), Dec 2013
One of these proteins, transthyretin is also present in the cerebrospinal fluid (CSF) after being secreted by the choroid plexus.
Proteomic Analysis in Type 2 Diabetes Patients before and after a Very Low Calorie Diet Reveals Potential Disease State and Intervention Specific Biomarkers.
Van Dijk et al., Leiden, Netherlands. In Plos One, Dec 2013
Targeted MRM analysis revealed differences in several proteins, which could be divided in diabetes-associated (fibrinogen, transthyretin), obesity-associated (complement C3), and diet-associated markers (apolipoproteins, especially apolipoprotein A-IV).
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
Suhr et al., Porto, Portugal. In N Engl J Med, Sep 2013
BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart.
Robust circadian oscillations in growing cyanobacteria require transcriptional feedback.
O'Shea et al., Cambridge, United States. In Science, Jun 2013
Layered on top of the PTR is transcriptional-translational feedback regulation (TTR), common to all circadian systems, consisting of a negative feedback loop in which KaiC regulates its own production.
Transthyretin (TTR) cardiac amyloidosis.
Berk et al., Boston, United States. In Circulation, 2012
Transthyretin cardiac amyloidosis is an underappreciated contributor to heart failure in elderly patients.
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
Kai et al., Kumamoto, Japan. In Mol Cell, 2012
Data show that prolonged transthyretin (TTR) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation.
Identification of beta-amyloid-binding sites on transthyretin.
Murphy et al., Madison, United States. In Protein Eng Des Sel, 2012
Strong binding of beta-amyloid peptide to TIAALLSPYSYS (residues 106-117) was detected, corresponding to strand G on the inner beta-sheet of TTR.
The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients.
Anderson et al., London, United Kingdom. In Am Heart J, 2012
Electrocardiographic voltages meet the criteria for LVH in one quarter of patients with ATTR V122I cardiac amyloidosis.
Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study.
Engert et al., Houston, United States. In J Clin Oncol, 2012
Secondary end points included ORR by independent central review, time to response (TTR), duration of response (DOR), progression-free survival (PFS), overall survival, and safety.
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension.
Young et al., Los Angeles, United States. In Prev Med, 2012
Discusses TTR gene mutations in amyloidosis and if amyloidosis has a role in the aging process. Explores if treating amyloidosis increases human lifespan and increases quality of life in the oldest old.
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