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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.


Prealbumin, transthyretin, TTR
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, fibrillin-1, ACID
Papers using Prealbumin antibodies
Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles
Mourton-Gilles Chantal et al., In BMC Veterinary Research, 2006
... 6: healthy ARR/ARR sheep; border line control "Ctl": 100 ng of Recombinant full length Human Prealbumin, amino acids 21-147, 13,8 kDa abcam n°92931) ...
Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
Bernstein Carol et al., In Clinical and Experimental Gastroenterology, 2005
All wells contained the TransMessenger Transfection Reagent (TTR) from QIAGEN.
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Deng Chu-Xia et al., In International Journal of Biological Sciences, 1992
... TTR-Cre transgenic mice (X.Y ...
Papers on Prealbumin
Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos.
Liu et al., Nanchang, China. In Sci Total Environ, 07 Dec 2015
In addition, the majority of the HPT axis-related genes examined, including CRH, TSHβ, TTR, UGT1ab, Pax8, Dio2 and TRα, were significantly upregulated in the presence of BF.
A differential protein solubility approach for the depletion of highly abundant proteins in plasma using ammonium sulfate.
Thiede et al., Oslo, Norway. In Analyst, 06 Dec 2015
Serum albumin, serotransferrin, alpha-1-antitrypsin and transthyretin were the abundant proteins that were highly enriched in 55% ammonium sulfate fractions.
Transthyretin as a new transporter of nanoparticles for receptor-mediated transcytosis in rat brain microvessels.
Kim et al., South Korea. In Colloids Surf B Biointerfaces, 04 Dec 2015
Eleven proteins, including transthyretin (Ttr), and creatine kinase-muscle type (CKM), were identified as being capable of penetrating the endothelial cell layer by RMT.
Inherited defects of thyroxine-binding proteins.
Refetoff et al., Chicago, United States. In Best Pract Res Clin Endocrinol Metab, 31 Oct 2015
Thyroid hormones (TH) are bound to three major serum transport proteins, thyroxine-binding globulin (TBG), transthyretin (TTR) and human serum albumin (HSA).
Plasma Transthyretin as a Biomarker of Lean Body Mass and Catabolic States.
Bernstein et al., Strasbourg, France. In Adv Nutr, Sep 2015
Plasma transthyretin (TTR) is a plasma protein secreted by the liver that circulates bound to retinol-binding protein 4 (RBP4) and its retinol ligand.
EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway.
Hilliard et al., Brisbane, Australia. In Nature, Feb 2015
PSR-1 functions cell-autonomously in the regrowing neuron and, instead of acting in its canonical signalling pathway, acts in a parallel phagocytic pathway that includes the transthyretin protein TTR-52, as well as CED-7, NRF-5 and CED-6 (refs 9, 10, 11, 12).
The amyloidogenic V122I transthyretin variant in elderly black Americans.
Solomon et al., Houston, United States. In N Engl J Med, Feb 2015
METHODS: We determined genotype status for the transthyretin gene (TTR) in 3856 black participants in the Atherosclerosis Risk in Communities study and assessed clinical profiles, mortality, and the risk of incident heart failure in V122I TTR variant carriers (124 participants [3%]) versus noncarriers (3732 participants).
An Enzyme from Aristolochia indica Destabilizes Fibrin-β Amyloid Co-Aggregate: Implication in Cerebrovascular Diseases.
Bhattacharyya et al., Calcutta, India. In Plos One, Dec 2014
The potency of the plant enzyme in degrading fibrin and fibrin-plasma protein (Aβ, human serum albumin, lysozyme, transthyretin and fibronectin) co-aggregates was demonstrated by atomic force microscopy, scanning electron microscopy and confocal microscopy that showed better potency of the plant enzyme as compared to plasmin.
Therapeutic Oligonucleotides Targeting Liver Disease: TTR Amyloidosis.
Schmidt et al., Münster, Germany. In Molecules, Dec 2014
Mutations of the gene encoding transthyretin (TTR), expressed in vast amounts by the liver, result in a complex degenerative disease, termed familial amyloid polyneuropathy (FAP).
Biomarkers in immunonutrition programme, is there still a need for new ones? A brief review.
De Kock et al., Brussels, Belgium. In Ecancermedicalscience, Dec 2014
Serum markers, such as albumin, transthyretin, white blood cells counts, and C-reactive protein are not more specific.
Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review.
Murta et al., Coimbra, Portugal. In Biomed Res Int, Dec 2014
FAP results from mutation of the transthyretin gene, with Val30Met being the most frequent substitution.
The Effect of Acute and Chronic Social Stress on the Hippocampal Transcriptome in Mice.
Juszczak et al., Poland. In Plos One, Dec 2014
Such contamination would result in a consistent up- or down-regulation of genes, such as Ttr, Igf2, Igfbp2, Prlr, Enpp2, Sostdc1, 1500015O10RIK (Ecrg4), Kl, Clic6, Kcne2, F5, Slc4a5, and Aqp1.
Amyloid fibrils nucleated and organized by DNA origami constructions.
Seeman et al., New York City, United States. In Nat Nanotechnol, Jul 2014
The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105-115 of the amyloidogenic protein transthyretin and a DNA origami construct is used to form 20-helix DNA nanotubes with sufficient space for the fibrils inside.
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
Diflunisal Trial Consortium et al., Umeå, Sweden. In Jama, 2014
IMPORTANCE: Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability.
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
Suhr et al., Porto, Portugal. In N Engl J Med, 2013
BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart.
Transthyretin (TTR) cardiac amyloidosis.
Berk et al., Boston, United States. In Circulation, 2012
Transthyretin cardiac amyloidosis is an underappreciated contributor to heart failure in elderly patients.
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
Kai et al., Kumamoto, Japan. In Mol Cell, 2012
Data show that prolonged transthyretin (TTR) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation.
Identification of beta-amyloid-binding sites on transthyretin.
Murphy et al., Madison, United States. In Protein Eng Des Sel, 2012
Strong binding of beta-amyloid peptide to TIAALLSPYSYS (residues 106-117) was detected, corresponding to strand G on the inner beta-sheet of TTR.
The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients.
Anderson et al., London, United Kingdom. In Am Heart J, 2012
Electrocardiographic voltages meet the criteria for LVH in one quarter of patients with ATTR V122I cardiac amyloidosis.
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension.
Young et al., Los Angeles, United States. In Prev Med, 2012
Discusses TTR gene mutations in amyloidosis and if amyloidosis has a role in the aging process. Explores if treating amyloidosis increases human lifespan and increases quality of life in the oldest old.
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