Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats.
Lexington, United States. In Respir Physiol Neurobiol, 09 May 2015
Our results showed: 1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats.
The amyloidogenic V122I transthyretin variant in elderly black Americans.
Houston, United States. In N Engl J Med, Feb 2015
METHODS: We determined genotype status for the transthyretin gene (TTR) in 3856 black participants in the Atherosclerosis Risk in Communities study and assessed clinical profiles, mortality, and the risk of incident heart failure in V122I TTR variant carriers (124 participants [3%]) versus noncarriers (3732 participants).
Amyloid fibrils nucleated and organized by DNA origami constructions.
New York City, United States. In Nat Nanotechnol, Jul 2014
The fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105-115 of the amyloidogenic protein transthyretin and a DNA origami construct is used to form 20-helix DNA nanotubes with sufficient space for the fibrils inside.