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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Transthyretin

Prealbumin, transthyretin, TTR
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: fibrillin-1, CAN, HAD, AGE, ACID
Papers using Prealbumin antibodies
Oral Transmissibility of Prion Disease Is Enhanced by Binding to Soil Particles
Supplier
Mourton-Gilles Chantal et al., In BMC Veterinary Research, 2006
... 6: healthy ARR/ARR sheep; border line control "Ctl": 100 ng of Recombinant full length Human Prealbumin, amino acids 21-147, 13,8 kDa abcam n°92931) ...
Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
Supplier
Bernstein Carol et al., In Clinical and Experimental Gastroenterology, 2005
All wells contained the TransMessenger Transfection Reagent (TTR) from QIAGEN.
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Supplier
Deng Chu-Xia et al., In International Journal of Biological Sciences, 1992
... TTR-Cre transgenic mice (X.Y ...
Papers on Prealbumin
Exome analysis of connective tissue dysplasia: death and rebirth of clinical genetics?
New
Wilson, Dallas, United States. In Am J Med Genet A, May 2014
Patient 1 had mutations in transthyretin (TTR), fibrillin (FBN1), and a calcium channel (CACNA1A) gene suggesting diagnoses of transthyretin amyloidosis, Marfan syndrome, and familial hemiplegic migraines, respectively.
Membrane carbonic anhydrase IX expression and relapse risk in resected stage I-II non-small-cell lung cancer.
New
Wistuba et al., Ottawa, Canada. In J Thorac Oncol, May 2014
To determine which patients need adjuvant chemotherapy, we assessed factors associated with time to relapse (TTR).
Quantification of transthyretin kinetic stability in human plasma using subunit exchange.
New
Kelly et al., Los Angeles, United States. In Biochemistry, May 2014
The transthyretin (TTR) amyloidoses are a group of degenerative diseases caused by TTR aggregation, requiring rate-limiting tetramer dissociation.
Mass spectrometry-based serum peptide profiling in hepatocellular carcinoma with bone metastasis.
New
Yang et al., Shanghai, China. In World J Gastroenterol, Apr 2014
These seven peptides were derived from alpha-fetoprotein, prothrombin, serglycin, isoform 2 of inter-alpha-trypsin inhibitor heavy chain H4, isoform 1 of autophagy-related protein 16-2, and transthyretin and fibrinogen beta chains, respectively.
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
New
Impact
Diflunisal Trial Consortium et al., Umeå, Sweden. In Jama, Jan 2014
IMPORTANCE: Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability.
Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP).
New
Li et al., Beijing, China. In Plos One, Dec 2013
However, the genes encoding proteins involved in TH transport (transthyretin, TTR) was transcriptionally significantly down-regulated after exposure to MEHP.
Safety and efficacy of RNAi therapy for transthyretin amyloidosis.
New
Impact
Suhr et al., Porto, Portugal. In N Engl J Med, Sep 2013
BACKGROUND: Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived transthyretin amyloid in peripheral nerves and the heart.
[Cerebral amyloid angiopathy with familial transthyretin-derived oculoleptomeningeal amyloidosis].
Review
New
Ikeda, Japan. In Brain Nerve, Jul 2013
Many variant forms of transthyretin (TTR) with a single amino acid substitution have been identified as causative amyloid precursor proteins in FAP.
Robust circadian oscillations in growing cyanobacteria require transcriptional feedback.
New
Impact
O'Shea et al., Cambridge, United States. In Science, Jun 2013
Layered on top of the PTR is transcriptional-translational feedback regulation (TTR), common to all circadian systems, consisting of a negative feedback loop in which KaiC regulates its own production.
NF90 in posttranscriptional gene regulation and microRNA biogenesis.
Review
Imoto et al., Tokushima, Japan. In Int J Mol Sci, 2012
Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs).
[Thyroid hormones and their precursors I. Biochemical properties].
Review
Noszál et al., Budapest, Hungary. In Acta Pharm Hung, 2012
In the blood more than 99% of the circulating thyroid hormone is bound to plasma proteins among which the thyroxine-binding globulin and transthyretin are crucial.
Imaging in systemic amyloidosis.
Review
Wechalekar et al., London, United Kingdom. In Br Med Bull, 2012
Bone-seeking tracers like 99mTc-DPD and pyrophosphate are beginning to have a role in imaging transthyretin cardiac amyloidosis.
Transthyretin (TTR) cardiac amyloidosis.
GeneRIF
Berk et al., Boston, United States. In Circulation, 2012
Transthyretin cardiac amyloidosis is an underappreciated contributor to heart failure in elderly patients.
STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.
GeneRIF
Kai et al., Kumamoto, Japan. In Mol Cell, 2012
Data show that prolonged transthyretin (TTR) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation.
Identification of beta-amyloid-binding sites on transthyretin.
GeneRIF
Murphy et al., Madison, United States. In Protein Eng Des Sel, 2012
Strong binding of beta-amyloid peptide to TIAALLSPYSYS (residues 106-117) was detected, corresponding to strand G on the inner beta-sheet of TTR.
The electrocardiographic features associated with cardiac amyloidosis of variant transthyretin isoleucine 122 type in Afro-Caribbean patients.
GeneRIF
Anderson et al., London, United Kingdom. In Am Heart J, 2012
Electrocardiographic voltages meet the criteria for LVH in one quarter of patients with ATTR V122I cardiac amyloidosis.
Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study.
Impact
Engert et al., Houston, United States. In J Clin Oncol, 2012
Secondary end points included ORR by independent central review, time to response (TTR), duration of response (DOR), progression-free survival (PFS), overall survival, and safety.
Supercentenarians and transthyretin amyloidosis: the next frontier of human life extension.
GeneRIF
Young et al., Los Angeles, United States. In Prev Med, 2012
Discusses TTR gene mutations in amyloidosis and if amyloidosis has a role in the aging process. Explores if treating amyloidosis increases human lifespan and increases quality of life in the oldest old.
Tafamidis.
Impact
Kirkpatrick et al., In Nat Rev Drug Discov, 2012
In November 2011, tafamidis (Vyndaqel; Pfizer), a small molecule that inhibits the dissociation of transthyretin tetramers, was granted marketing authorization by the European Commission for the treatment of transthyretin amyloidosis in adult patients with stage 1 symptomatic polyneuropathy to delay peripheral neurological impairment.
Acute phase reactants as novel predictors of cardiovascular disease.
Review
Meng et al., Saskatoon, Canada. In Isrn Inflamm, 2011
Cardiovascular disease is also accompanied by the reduction of negative acute phase reactants such as albumin, transferrin, transthyretin, retinol-binding protein, antithrombin, and transcortin.
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