The role of peroxiredoxin 4 in inflammatory response and aging.
Dallas, United States. In Biochim Biophys Acta, Feb 2016
In prior studies, we determined that the moderate overexpression of the Drosophila endoplasmic reticulum (ER)-localized peroxiredoxin (Prx), dPrx4, reduced oxidative damage and conferred beneficial effects on life span, while a high-level expression increased the incidence of tissue-specific apoptosis and dramatically shortened longevity.
Redoxins in peripheral neurons after sciatic nerve injury.
Frankfurt am Main, Germany. In Free Radic Biol Med, Dec 2015
The expression and localization of Glrx, Txn and Txnrd proteins was not affected by sciatic nerve injury but peroxiredoxins were upregulated in the DRGs, Prdx1 and Prdx6 mainly in non-neuronal cells and Prdx4 and Prdx5 in DRG neurons, the latter associated with an increase of respective mRNAs and protein accumulation in peripheral and/or central fibers.
Physiological and pathological views of peroxiredoxin 4.
Yamagata, Japan. In Free Radic Biol Med, Jun 2015
Among six PRDX members in mammalian cells, PRDX4 uniquely possesses a hydrophobic signal peptide at the amino terminus, and, hence, it undergoes either secretion or retention by the endoplasmic reticulum (ER) lumen.
The role of ascorbate in protein folding.
Budapest, Hungary. In Protoplasma, 2014
However, very recently, low tissue ascorbate levels and a noncanonical scurvy were observed in endoplasmic reticulum thiol oxidase- and peroxiredoxin 4-compromised mice.