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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PR domain containing 14

Prdm14
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Blimp-1, PGC, CAN, FATE, Nanog
Papers on Prdm14
NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.
New
Impact
Azim Surani et al., Kōbe, Japan. In Nature, Feb 2016
Consequently, bone morphogenetic protein 4 (BMP4), or ectopic expression of key germline transcription factors Prdm1, Prdm14 and Tfap2c, directly induce PGC-like cells (PGCLCs) in EpiLCs, but not in ES cells.
Spermatogonial stem cells specific marker identification in channel catfish, Ictalurus punctatus and blue catfish, I. furcatus.
New
Dunham et al., Auburn, United States. In Fish Physiol Biochem, Dec 2015
Oct4, Id4, Gfrα2, Pum2 and Prdm14 genes showed different expression patterns in the testicular germ cells of channel and blue catfish.
ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.
New
Wysocka et al., Stanford, United States. In Elife, Dec 2015
UNASSIGNED: Prdm14 is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation.
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
New
Okazaki et al., Saitama, Japan. In Stem Cells, Dec 2015
We further show that JARID2 physically interacts with ESRRB, SALL4A, and PRDM14, and that these JARID2-associated proteins synergistically and robustly facilitate iPSC reprogramming in a JARID2-dependent manner.
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia.
New
Farrar et al., Minneapolis, United States. In Oncogene, Nov 2015
High-throughput sequencing approaches were used to identify genes frequently targeted by the T2/Onc transposon; these included Sos1 (74%), Kdm2a (35%), Jak1 (26%), Bmi1 (19%), Prdm14 or Ncoa2 (13%), Cdkn2a (10%), Ikzf1 (8%), Caap1 (6%) and Klf3 (6%).
PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.
New
Seki et al., Sanda, Japan. In Biochem Biophys Res Commun, Nov 2015
PR-domain containing transcriptional regulator 14 (PRDM14), is essential for maintenance of ESC self-renewal when the cells are cultured in serum plus LIF, but not in 2i medium plus LIF.
Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy.
Review
New
Yang et al., Taipei, Taiwan. In J Chin Med Assoc, Aug 2015
Several EMT regulators including Snail, Zeb1, Zeb2, and Twist in solid tumor and Sox4, distal-less homeobox gene 4 (DLX4), Prdm14, Bmi1, and the forkhead box family in hematological malignancy are reviewed with regard to their signaling pathways, regulatory mechanisms, and clinical interactions.
Primordial germ cell specification: a context-dependent cellular differentiation event [corrected].
Review
Surani et al., Reykjavík, Iceland. In Philos Trans R Soc Lond B Biol Sci, 2015
While the majority of epiblast cells undergo differentiation towards somatic cell lineages, PGCs initiate a unique cellular programme driven by the cooperation of the transcription factors BLIMP1, PRDM14 and AP2γ.
Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.
Donohoe et al., New York City, United States. In Plos One, 2014
Here, we show that the H3K27-specific demethylase Utx regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist.
Dynamic expression of chromatin modifiers during developmental transitions in mouse preimplantation embryos.
Peters et al., Basel, Switzerland. In Sci Rep, 2014
We also detected lineage-specific expression of several modifiers, including Ezh1, Prdm14, Scmh1 and Tet1 underscoring possible roles in cell fate decisions.
PRDM14: a unique regulator for pluripotency and epigenetic reprogramming.
Review
Saitou et al., Kyoto, Japan. In Trends Biochem Sci, 2014
PRDM14 belongs to the PR domain-containing (PRDM) transcriptional regulators.
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells.
Impact
Ng et al., Singapore, Singapore. In Nat Cell Biol, 2013
Importantly, we confirmed that SON regulates the proper splicing of transcripts encoding for pluripotency regulators such as OCT4, PRDM14, E4F1 and MED24.
Induction of mouse germ-cell fate by transcription factors in vitro.
Impact
Saitou et al., Kyoto, Japan. In Nature, 2013
Here we show that, without cytokines, simultaneous overexpression of three transcription factors, Blimp1 (also known as Prdm1), Prdm14 and Tfap2c (also known as AP2γ), directs EpiLCs, but not embryonic stem cells, swiftly and efficiently into a PGC state.
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency.
Impact
Reik et al., Cambridge, United Kingdom. In Cell Stem Cell, 2013
We identify a Prdm14- and Nanog-binding cis-acting regulatory region in Dnmt3b that is highly responsive to signaling.
A tripartite transcription factor network regulates primordial germ cell specification in mice.
Impact
Azim Surani et al., Cambridge, United Kingdom. In Nat Cell Biol, 2013
BLIMP1, the key regulator of primordial germ cell (PGC) specification, apparently acts together with PRDM14 and AP2γ.
Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors.
GeneRIF
Justice et al., Houston, United States. In Oncogene, 2011
data provide the first direct evidence for the association of Prdm14 with cancer initiation in an in vivo mouse model and in human lymphoid malignancies, while suggesting mechanisms for Prdm14's mode of action
Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.
GeneRIF
Wysocka et al., Stanford, United States. In Nat Struct Mol Biol, 2011
Prdm14 safeguards mouse embryonic stem cells maintenance by preventing induction of extraembryonic endoderm fates.
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.
Impact
GeneRIF
Ng et al., Singapore, Singapore. In Nature, 2010
novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells
[Relationship between the expression of PRDM14 in non-small cell lung cancer and the clinicopathologic characteristics].
GeneRIF
Cui et al., Shenyang, China. In Zhongguo Fei Ai Za Zhi, 2010
The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type.
The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32.
GeneRIF
Justice et al., Houston, United States. In Plos One, 2007
study implicates Prdm14 as a proto-oncogene involved in lymphoblastic lymphoma formation
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