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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

PR domain containing 14

Prdm14
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011] (from NCBI)
Papers on Prdm14
Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors.
GeneRIF
Justice et al., Houston, United States. In Oncogene, 2011
data provide the first direct evidence for the association of Prdm14 with cancer initiation in an in vivo mouse model and in human lymphoid malignancies, while suggesting mechanisms for Prdm14's mode of action
Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates.
GeneRIF
Wysocka et al., Stanford, United States. In Nat Struct Mol Biol, 2011
Prdm14 safeguards mouse embryonic stem cells maintenance by preventing induction of extraembryonic endoderm fates.
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.
Impact
GeneRIF
Ng et al., Singapore, Singapore. In Nature, 2010
novel hESC regulators wherein PRDM14 exemplifies a key transcription factor required for the maintenance of hESC identity and the reacquisition of pluripotency in human somatic cells
[Relationship between the expression of PRDM14 in non-small cell lung cancer and the clinicopathologic characteristics].
GeneRIF
Cui et al., Shenyang, China. In Zhongguo Fei Ai Za Zhi, 2010
The high expression of PRDM14 in non-small cell lung cancer is associated with differentiation and histological type.
The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32.
GeneRIF
Justice et al., Houston, United States. In Plos One, 2007
study implicates Prdm14 as a proto-oncogene involved in lymphoblastic lymphoma formation
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