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Cadherin-related family member 1

prCAD, PCDH21, protocadherin-21, KIAA1775, Photoreceptor cadherin
This gene is a member of the cadherin superfamily of calcium-dependent cell-cell adhesion molecules. This non-classical cadherin appears to be exclusively expressed in the mitral and tufted cells in the main and accessory olfactory bulbs of the brain, suggesting a possible role in the formation and maintenance of neuronal networks. Alternatively spliced transcript variants encoding different isoform have been identified. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: Protocadherin, ROD, PCDH15, POLYMERASE, Peripherin
Papers using prCAD antibodies
Ashcroft Gillian S et al., In Genome Biology, 2002
... CA, USA), JCMC (rabbit polyclonal anti-Dsc1), anti-K16, anti-ARG1 (Santa Cruz Biotechnology, Santa Cruz, CA, USA), anti-PCDH21 or anti-SERPINB13 (Abcam, Cambridge, UK) and the ...
Papers on prCAD
Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment.
Futter et al., London, United Kingdom. In Proc Natl Acad Sci U S A, Jan 2016
Here we use immuno-electron microscopy and electron tomography to show that rhodopsin is transported from the inner to the outer segment via the ciliary plasma membrane, subsequently forming successive evaginations that "zipper" up proximally, but at their leading edges are free to make junctions containing the protocadherin, PCDH21, with the inner segment plasma membrane.
Analysis of cell surface markers specific for transplantable rod photoreceptors.
Ader et al., Dresden, Germany. In Mol Vis, 2012
Reverse transcriptase polymerase chain reaction identified Atp8a2, Cacna2d4, Cadm2, Cnga1, Kcnv2, and Pcdh21 as expressed in the retina and only a few additional tissues.
Non-clustered protocadherin.
Kim et al., Seoul, South Korea. In Cell Adh Migr, 2011
The phylogenetic analysis with full sequences of non-clustered PCDHs enabled them to be further classified into three subgroups: δ1 (PCDH1, PCDH7, PCDH9, PCDH11 and PCDH20), δ2 (PCDH8, PCDH10, PCDH12, PCDH17, PCDH18 and PCDH19) and ε (PCDH15, PCDH16, PCDH21 and MUCDHL).
A novel MERTK deletion is a common founder mutation in the Faroe Islands and is responsible for a high proportion of retinitis pigmentosa cases.
Rosenberg et al., Copenhagen, Denmark. In Mol Vis, 2010
The 91-kb deletion encompassing exons 1-7 of MERTK is a common founder mutation in the Faroe Islands, responsible for around 30% of RP, and together with mutations in protocadherin 21 (PCDH21) accounts for more than half of the retinal dystrophy cases.
Mutations in PCDH21 cause autosomal recessive cone-rod dystrophy.
Rosenberg et al., Copenhagen, Denmark. In J Med Genet, 2010
To our knowledge, this is the first report of mutations in PCDH21 as a cause of human disease, autosomal recessive cone-rod dystrophy.
Structure of the N terminus of cadherin 23 reveals a new adhesion mechanism for a subset of cadherin superfamily members.
Müller et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2010
PCDH21 and PCDH24 contain similarly charged N termini, suggesting that a subset of cadherins share a common interaction mechanism that differs from the strand-swap binding mode of classical cadherins.
Novel mutations in MERTK associated with childhood onset rod-cone dystrophy.
Moore et al., London, United Kingdom. In Mol Vis, 2009
The positional candidate genes protocadherin 21 (PCDH21), retinal G protein-coupled receptor (RGR), and MERTK were polymerase chain reaction (PCR) amplified and sequenced.
Biallelic mutation of protocadherin-21 (PCDH21) causes retinal degeneration in humans.
Webster et al., London, United Kingdom. In Mol Vis, 2009
Biallelic mutations in the photoreceptor-specific gene PCDH21 cause recessive retinal degeneration in humans.
Study of gene expression profile during cord blood-associated megakaryopoiesis.
Sun et al., Singapore, Singapore. In Eur J Haematol, 2008
Moreover, some genes that have not been reported to be associated with CB-derived megakaryopoiesis, such as Cbl-interacting proteins Sts-1, protocadherin 21, etc., are found to be highly expressed in the CD41(+) cells from this study.
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice.
Zhang et al., Salt Lake City, United States. In J Clin Invest, 2008
Immunoprecipitation studies showed that PROM1 interacted with protocadherin 21 (PCDH21), a photoreceptor-specific cadherin, and with actin filaments, both of which play critical roles in disk membrane morphogenesis.
Transgenic expression of Cre recombinase in mitral/tufted cells of the olfactory bulb.
Yokoi et al., Kyoto, Japan. In Genesis, 2005
Protocadherin 21 (Pcdh21) expression is highly restricted to M/T cells.
Protocadherin-21 (PCDH21), a candidate gene for human retinal dystrophies.
Gal et al., Köln, Germany. In Mol Vis, 2004
PCDH21 mutations are not a major cause of the retinal diseases investigated herein, and the corresponding human phenotype remains to be determined.
Proteolytic shedding of the extracellular domain of photoreceptor cadherin. Implications for outer segment assembly.
Nathans et al., Baltimore, United States. In J Biol Chem, 2004
prCAD ectodomain cleavage is an integral part of the outer segment assembly process, and outer segment assembly might be driven, at least in part, by the near irreversibility of proteolysis.
Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors.
de Keyzer et al., Paris, France. In J Clin Endocrinol Metab, 2002
In ACTH+, beside the expected POMC gene, we identified cFos, and KIAA1775, a large expressed sequence tag encoding a putative protocadherin-related protein.
A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival.
Nathans et al., Baltimore, United States. In Neuron, 2002
A cadherin family member, prCAD, was identified in retina cDNA by subtractive hybridization and high throughput sequencing.
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