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Protein regulator of cytokinesis 1

This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012] (from NCBI)
Top mentioned proteins: Polycomb, Histone, Bmi-1, CAN, H2A
Papers using PRC1 antibodies
PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone
Margolis Robert L. et al., In The Journal of Cell Biology, 2000
... Using a BamHI internal site, PRC1 cDNA, including the 5′ untranslated region (UTR) up to nucleotide 1836, was subcloned into the EcoRI-BamHI sites of the pEGFP-N1 vector (CLONTECH Laboratories, Inc.) ...
Papers on PRC1
Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins.
Lin et al., New Haven, United States. In Nat Genet, Feb 2016
Here we report that Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germline cells to regulate ovarian germline stem cells and oogenesis.
Non-canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis.
Schuringa et al., Groningen, Netherlands. In Cell Rep, Feb 2016
Here, we find that the non-canonical PRC1.1 complex, as identified by mass-spectrometry-based proteomics, is critically important for human leukemic stem cells.
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
Pasini et al., Milano, Italy. In Cell Stem Cell, Feb 2016
PRC1, which plays a dominant role in this context, executes its functions via multiple subcomplexes, which all contribute to H2AK119 mono-ubiquitination (H2Aubq).
The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function.
Wang et al., Birmingham, United States. In Proc Natl Acad Sci U S A, Feb 2016
Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are critical for both normal and pathological hematopoiesis; however, it is unclear which of the several counteracting H2A deubiquitinases functions along with PRC1 to control H2A ubiquitination (ubH2A) level and regulates hematopoiesis in vivo.
The evolutionary landscape of PRC1 core components in green lineage.
Shen et al., Changsha, China. In Planta, Feb 2016
MAIN CONCLUSION: The origin and evolution of plant PRC1 core components.
Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements.
Zhang et al., Shanghai, China. In Plos Genet, Jan 2016
We show that CURLY LEAF (CLF), a major catalytic subunit of PRC2, coordinates with different members of PRC1 in suppression of distinct plant developmental programs.
Complementary activities of TELOMERE REPEAT BINDING proteins and Polycomb Group complexes in transcriptional regulation of target genes.
Turck et al., Köln, Germany. In Plant Cell, Jan 2016
LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) is the only known plant PRC1 component that directly binds to H3K27me3, the histone modification set by PRC2, and also associates genome-wide with H3K27me3.
Polycomb repressor complex 1 promotes gene silencing through H2AK119 mono-ubiquitination in acinar-to-ductal metaplasia and pancreatic cancer cells.
Kleeff et al., München, Germany. In Oncotarget, Jan 2016
Here, we analyzed whether elevated levels of the polycomb repressor complex 1 (PRC1) components Bmi1 and Ring1b and their catalyzed histone modification H2AK119ub in ADMs and tumor cells, are responsible for the mediation of acinar gene silencing.
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores.
Tolić et al., Dresden, Germany. In Nat Commun, Dec 2015
We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules.
Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
Klose et al., Oxford, United Kingdom. In Nat Rev Mol Cell Biol, Nov 2015
Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.
PRC1 proteins orchestrate three-dimensional genome architecture.
Cavalli, Montpellier, France. In Nat Genet, Oct 2015
Now, a new study uncovers a major role for Polycomb components of the PRC1 complex in organizing physical networks of genes that are co-repressed to maintain pluripotency.
Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms.
Di Croce et al., Barcelona, Spain. In Cell Stem Cell, Oct 2015
Polycomb complexes (PRC1 and PRC2) are essential regulators of epigenetic gene silencing in embryonic and adult stem cells.
PcG and trxG in plants - friends or foes.
Sung et al., Berkeley, United States. In Trends Genet, May 2015
Recent progress in Arabidopsis research challenges the dominant model of PRC2-dependent recruitment of PRC1 to target genes.
A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response.
Tang et al., Hamilton, Canada. In Biomolecules, 2014
Mechanistically, BMI1 is a subunit of the Polycomb repressive complex 1 (PRC1), and binds the catalytic RING2/RING1b subunit to form a functional E3 ubiquitin ligase.
Epigenetic modifiers in normal and malignant hematopoiesis.
Bernt et al., Aurora, United States. In Epigenomics, 2014
In this review, we aim to compare the role of several key DNA or histone modifying enzymes and complexes in normal development and hematopoietic malignancies, including DNMT3A, TET2, IDH1, IDH2, MLL1, MLL4, DOT1L, PRC1/2 and WSHC1/NSD2/MMSET.
A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription.
Angrand et al., Villeneuve-d'Ascq, France. In Epigenetics, 2012
Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex.
PRC1 controls spindle polarization and recruitment of cytokinetic factors during monopolar cytokinesis.
Shuster et al., Las Cruces, United States. In Mol Biol Cell, 2012
Cells depleted of PRC1 failed to form a polarized microtubule array or ectopic furrows following mitotic exit, and recruitment of Aurora B kinase, male germ cell Rac GTPase-activating protein, and RhoA to the cortex was impaired.
Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.
Kapoor et al., New York City, United States. In Cell, 2010
PRC1's microtubule binding is mediated by a structured domain with a spectrin-fold and an unstructured Lys/Arg-rich domain.
Cleaved bovine prolactin-related protein-I stimulates vascular endothelial cell proliferation.
Hashizume et al., Tsukuba, Japan. In Mol Cell Endocrinol, 2010
Data show that cleaved PRP1 proliferates endothelial cells in vitro, and suggest that endothelial cell proliferation activity of cleaved PRP1 may be shared in specific bovine placentomal angiogenesis.
[Molecular mechanism of radiosensitizing effect of paclitaxel].
Hong et al., Suzhou, China. In Ai Zheng, 2009
The radiosensitizing effect of paclitaxel on KB cells may be due to the down-regulated expression of PRC1 and cyclin B2.
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