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proteins. Page last changed on 08 Dec 2016.
MAP kinase-activated protein kinase 5
PRAK, MK5, MAPK-activated protein kinase 5, MAPKAPK5, p38-regulated/activated protein kinase
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from
Sun et al., Los Angeles, United States. In Mol Cell Biol, 2012
It was shown that the tumor-suppressing and tumor-promoting functions of the p38-PRAK pathway are temporally and spatially separated during cancer development in vivo, relying on the stimulus, and the tissue type and the stage of cancer development.