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MAP kinase-activated protein kinase 5

PRAK, MK5, MAPK-activated protein kinase 5, MAPKAPK5, p38-regulated/activated protein kinase
The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using PRAK antibodies
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
Supplier
Moens Ugo et al., In Cellular and Molecular Life Sciences, 2005
... Activated PRAK was from Millipore Upstate (Billerica, MA), while purified PKA was from Promega Corporation (Madison, WI) ...
Papers on PRAK
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology.
GeneRIF
Kotlyarov et al., Hannover, Germany. In Mol Cell Biol, 2012
the regulation of neuronal morphogenesis is proposed as the first physiological function of the ERK3/MK5 signaling module
PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway.
GeneRIF
Sun et al., Los Angeles, United States. In Mol Cancer Res, 2012
Results suggest that PRAK may function as a tumor suppressor in multiple types of cancers.
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.
GeneRIF
Sun et al., Los Angeles, United States. In Mol Cell Biol, 2012
It was shown that the tumor-suppressing and tumor-promoting functions of the p38-PRAK pathway are temporally and spatially separated during cancer development in vivo, relying on the stimulus, and the tissue type and the stage of cancer development.
IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.
GeneRIF
Hüttelmaier et al., Halle, Germany. In Genes Dev, 2012
IGF2BP1 promotes the velocity and directionality of tumor-derived cell migration by determining the cytoplasmic fate of two novel target mRNAs: MAPK4 and PTEN
Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Impact
GeneRIF
Han et al., Xiamen, China. In Nat Cell Biol, 2011
Rheb inactivation by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
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