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Praja1, RING-H2 motif containing

Praja1, PJA1
This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
Papers on Praja1
Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates.
GeneRIF
Strickler et al., United States. In Cell Biochem Biophys, 2011
Data provide clues into novel aspects of Praja1 function.
PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
GeneRIF
Ciechanover et al., Haifa, Israel. In Biochem Biophys Res Commun, 2011
these results suggest a role for PRAJA1 in regulating the level of PRC2 by targeting its free subunits for Ub-mediated proteasomal degradation.
A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
GeneRIF
Watanabe et al., Ōbu, Japan. In J Biol Chem, 2002
A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.
GeneRIF
Cai et al., Frederick, United States. In Genomics, 2002
Involved in protein ubiquitination in the brain. Candidate gene for X-linked mental retardation.
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