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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein phosphatase 4, catalytic subunit

PPX, PP4, PPH3, PP4C
one of five classes of protein serine-threonine phosphatase catalytic subunits; includes subunits 1, 2A, 2B (calcineurin), 2C in addition to Pp4c [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: PP2A, ACID, CAN, HAD, fibrillin-1
Papers using PPX antibodies
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation
Supplier
Hirotsune Shinji et al., In The Journal of Cell Biology, 2001
... ), and PP4c by Bac-to-Bac baculo-system (Invitrogen) using SF-9 or High Five insect cells (BD Biosciences).
Papers on PPX
Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress.
New
Wurtele et al., Montréal, Canada. In Nucleic Acids Res, Feb 2016
Our results further reveal that in the presence of constitutive H3K56ac, the Slx4 scaffolding protein and PP4 phosphatase complex play essential roles in preventing hyperactivation of the DNA damage-response kinase Rad53 in response to spontaneous DNA damage caused by reactive oxygen species.
Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts.
New
Yang et al., Hangzhou, China. In Development, Feb 2016
On the basis of these results, a two-step process for the basal localization of Mira during NB division is revealed: cortical association of Mira mediated by the PTPA-PP4 complex is followed by apical aPKC-mediated basal restriction.
Inhibition of hippocampal plasticity in rats performing contrafreeloading for water under repeated administrations of pramipexole.
New
Nencini et al., Roma, Italy. In Psychopharmacology (berl), Dec 2015
RATIONALE: Compulsive symptoms develop in patients exposed to pramipexole (PPX), a dopaminergic agonist with high selectivity for the D3 receptor.
G protein-coupled estrogen receptor 1 (GPER 1) mediates estrogen-induced, proliferation of leiomyoma cells.
New
Jun et al., Hangzhou, China. In Gynecol Endocrinol, Nov 2015
We studied cell proliferation with 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide, and, mitotic activity with phosphohistone H3 (PPH3) expression in leiomyoma, and, matched, normal, smooth muscle tissues using standard immunohistochemistry. Downregulation of GPER-1 expression with siGPR30 partially attenuated the E2-activated MAPK signaling pathway (p < 0.01).
The effects of long-term dopaminergic treatment on locomotor behavior in rats.
Tulio de Mello et al., São Paulo, Brazil. In Sleep Sci, 2014
The rats were divided into control (CTRL) and drug (Pramipexole-PPX) groups that received daily saline vehicle and PPX treatments, respectively, for 71 days.
Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues.
Review
Jonassen et al., Stavanger, Norway. In Plant Cell Environ, 2014
The three closely related groups of serine/threonine protein phosphatases PP2A, PP4 and PP6 are conserved throughout eukaryotes.
TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response.
Kong et al., Duarte, United States. In Plos One, 2014
Here we show that Tip41-like protein (TIPRL), an evolutionarily conserved binding protein for PP2A-family phosphatases, is a negative regulator of protein phosphatase 4 (PP4).
Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance.
Li et al., Beijing, China. In Sci Rep, 2014
Protein phosphatase 4 (PP4) was shown to participate in multiple cellular processes, including DNA damage response, cell cycle and embryo development.
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.
Impact
Passegué et al., San Francisco, United States. In Nature, 2014
Moreover, once old HSCs re-establish quiescence, residual replication stress on ribosomal DNA (rDNA) genes leads to the formation of nucleolar-associated γH2AX signals, which persist owing to ineffective H2AX dephosphorylation by mislocalized PP4c phosphatase rather than ongoing DNA damage.
The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.
Impact
Aifantis et al., New York City, United States. In Immunity, 2012
The NF-κB signaling pathway is important in the regulation of physiological and malignant hematopoiesis.
A PP4 holoenzyme balances physiological and oncogenic nuclear factor-kappa B signaling in T lymphocytes.
Impact
Arnold et al., Heidelberg, Germany. In Immunity, 2012
PP4R1 formed part of a distinct PP4 holoenzyme and bridged the inhibitor of NF-κB kinase (IKK) complex and the phosphatase PP4c, thereby directing PP4c activity to dephosphorylate and inactivate the IKK complex.
Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
GeneRIF
Chowdhury et al., Boston, United States. In Embo J, 2012
The authors devised a novel proteomic strategy for systematic identification of proteins dephosphorylated by PP4C and identified KRAB-domain-associated protein 1 (KAP-1) as a substrate.
[Progress in polyphosphate and related metabolizing enzymes].
Review
Xie et al., Chongqing, China. In Sheng Li Ke Xue Jin Zhan, 2011
A thorough analysis of the mycobacterium tuberculosis PPX protein homologs and their biochemical activity is presented.
Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.
GeneRIF
Koo et al., South Korea. In Proc Natl Acad Sci U S A, 2010
Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2.
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
GeneRIF
Chowdhury et al., Boston, United States. In Nat Struct Mol Biol, 2010
PP4R2, a regulatory subunit of PP4, mediates the DNA damage-dependent association between RPA2 and the PP4C catalytic subunit.
Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.
GeneRIF
Williams et al., United Kingdom. In Leuk Res, 2009
PP4 activity significantly affects the mutation rate in leukemic T-cells, indicating that PP4 dysfunction may be important in the development and progression of leukemia
Proliferation is the strongest prognosticator in node-negative breast cancer: significance, error sources, alternatives and comparison with molecular prognostic markers.
Review
Zur Hausen et al., Stavanger, Norway. In Breast Cancer Res Treat, 2009
PPH3 counts are prognostically stronger than the MAI, and markers such as Cyclin-B and E2FR are promising, but must be validated.
PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.
GeneRIF
Durocher et al., Toronto, Canada. In Embo Rep, 2008
An evolutionarily conserved gamma histone 2AX phosphatase active on both DNA-damaged and undamaged chromatin.
[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].
Review
Hirotsune, Ōsaka, Japan. In Brain Nerve, 2008
Ndell is also involved in the regulation of microtubule organization, and becomes the target of various kinases and phosphatases, including CDK5/CDK1, Aurora-A and PP4.
KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis.
Review
Bozik et al., Pittsburgh, United States. In Cns Neurosci Ther, 2007
In cell-based assays, both RPPX and PPX reduce the production of reactive oxygen species (ROS), attenuate the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins.
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