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Protein phosphatase 2, regulatory subunit B, gamma
PPP2R2C, PR52
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
PP2A, ACID, V1a, CAN, PIF
Papers on
PPP2R2C
Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function.
New
Beijing, China. In Am J Physiol Renal Physiol, Feb 2016
The PP2A catalytic subunit and regulatory subunit PPP2R2C coimmunoprecipitated with the D2R.
Dissecting the mechanism of colorectal tumorigenesis based on RNA-sequencing data.
New
Qingdao, China. In Exp Mol Pathol, Apr 2015
Additionally, COL1A1-PPP2R2C and EXPH5-COL1A2 were observed fusion genes in cancer tissue.
The association between Salt-inducible kinase 2 (SIK2) and gamma isoform of the regulatory subunit B55 of PP2A (B55gamma) contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K.
Shanghai, China. In Cancer Cell Int, 2014
BACKGROUND: PPP2R2C encodes a gamma isoform of the regulatory subunit B55 subfamily consisting PP2A heterotrimeric with A and C subunits.
Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.
Shanghai, China. In Febs Lett, 2014
PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A).
PreImplantation factor (PIF*) promotes embryotrophic and neuroprotective decidual genes: effect negated by epidermal growth factor.
New Haven, United States. In J Neurodev Disord, 2013
In FTDC, PIF promotes bone morphogenetic protein pathway (SMAD1, 53-fold) and axonal guidance genes (EPH5) while inhibiting PPP2R2C, negative cell-growth regulator, involved in Alzheimer's and amyotrophic lateral sclerosis.
Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.
Toronto, Canada. In Bmc Med Genet, 2013
RESULTS: Although no genome-wide significant markers were identified, the combined GWAS findings have pointed to several genes of interest that support GWAS findings for BD from other groups or consortia, such as at SYNE1 on 6q25, PPP2R2C on 4p16.1,
PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.
Seattle, United States. In Mol Cancer Res, 2013
Of these, 14 were downregulated in primary and metastatic prostate cancer, including two subunits of the protein phosphatase 2 (PP2A) holoenzyme complex: PPP2R1A, a structural subunit with known tumor-suppressor properties in several tumor types; and PPP2R2C, a PP2A substrate-binding regulatory subunit that has not been previously identified as a tumor suppressor.
A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis.
Bradford, United Kingdom. In Peerj, 2012
When these were linked to so-called 'melanoma driver' genes involved in MAPK, Ca(2+), and WNT signaling pathways we were able to produce a new 12-gene diagnostic biomarker signature for melanoma (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4).
PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.
Würzburg, Germany. In Atten Defic Hyperact Disord, 2012
One of the most promising candidate genes in this region is protein phosphatase 2, regulatory subunit B, gamma (PPP2R2C), which, however, thus far has not been assessed for a potential association with ADHD.
Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua.
Cherry Hill, United States. In Reprod Biol Endocrinol, 2011
In contrast, anti-proliferative phosphatases PTPRZ1 and PPP2R2C expression increased.
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Rockville, United States. In Mol Psychiatry, 2011
Moreover, the susceptibility gene for bipolar disorder, PPP2R2C, was found to be associated with the number of perineuronal oligodendrocytes.
PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.
GeneRIF
Leuven, Belgium. In Eur J Med Genet, 2010
encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity
Molecular correlates of laminar differences in the macaque dorsal lateral geniculate nucleus.
Davis, United States. In J Neurosci, 2008
Cellular localization of gene expression revealed 11 new layer-specific markers, of which 10 were enriched in magnocellular layers (BRD4, CAV1, EEF1A2, FAM108A1, INalpha, KCNA1, NEFH, NEFL, PPP2R2C, and SFRP2) and one was enriched in parvocellular and koniocellular layers (TCF7L2).
RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection.
Philadelphia, United States. In Mol Ther, 2008
The best candidate siRNA targeted the PPP2R2C gene and produced a 65% increase in luminescence from lipofection, with a quantitative PCR-validated knockdown of approximately 76%.
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
GeneRIF
Amsterdam, Netherlands. In Plos Genet, 2007
novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4.
London, United Kingdom. In Genes Chromosomes Cancer, 2007
We identified a minimally deleted region encompassing six genes including two candidate tumor suppressor genes, CRMP1 a lung cancer metastasis-suppressing gene and PPP2R2C a gene for a regulatory subunit of the PP2 complex known to suppress tumorigenesis, particularly viral induced transformation.
Identification of specific PP2A complexes involved in human cell transformation.
Impact
GeneRIF
Boston, United States. In Cancer Cell, 2004
specific PP2A complexes involved in human cell transformation
Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.
GeneRIF
Chicago, United States. In J Biol Chem, 2003
PP2A has a role in glucose-regulated EF-2 phosphorylation and protein translation in rat cells
Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade.
GeneRIF
Iowa City, United States. In J Biol Chem, 2002
PP2A/Bgamma is a positive regulator of MAP kinase signaling in neurons.
