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Protein phosphatase 2, regulatory subunit B, gamma
PPP2R2C, PR52
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
PPP2R2C
Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.
New
Shanghai, China. In Febs Lett, 11 Jan 2014
PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A).
Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.
New
Toronto, Canada. In Bmc Med Genet, Dec 2013
RESULTS: Although no genome-wide significant markers were identified, the combined GWAS findings have pointed to several genes of interest that support GWAS findings for BD from other groups or consortia, such as at SYNE1 on 6q25, PPP2R2C on 4p16.1,
PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality.
New
Seattle, United States. In Mol Cancer Res, Jun 2013
Of these, 14 were downregulated in primary and metastatic prostate cancer, including two subunits of the protein phosphatase 2 (PP2A) holoenzyme complex: PPP2R1A, a structural subunit with known tumor-suppressor properties in several tumor types; and PPP2R2C, a PP2A substrate-binding regulatory subunit that has not been previously identified as a tumor suppressor.
A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis.
Bradford, United Kingdom. In Peerj, 2012
When these were linked to so-called 'melanoma driver' genes involved in MAPK, Ca(2+), and WNT signaling pathways we were able to produce a new 12-gene diagnostic biomarker signature for melanoma (i.e., EGFR, FGFR2, FGFR3, IL8, PTPRF, TNC, CXCL13, COL11A1, CHP2, SHC4, PPP2R2C, and WNT4).
PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD.
Würzburg, Germany. In Atten Defic Hyperact Disord, 2012
One of the most promising candidate genes in this region is protein phosphatase 2, regulatory subunit B, gamma (PPP2R2C), which, however, thus far has not been assessed for a potential association with ADHD.
Preimplantation factor (PIF) promoting role in embryo implantation: increases endometrial integrin-α2β3, amphiregulin and epiregulin while reducing betacellulin expression via MAPK in decidua.
Cherry Hill, United States. In Reprod Biol Endocrinol, 2011
In contrast, anti-proliferative phosphatases PTPRZ1 and PPP2R2C expression increased.
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.
Rockville, United States. In Mol Psychiatry, 2011
Moreover, the susceptibility gene for bipolar disorder, PPP2R2C, was found to be associated with the number of perineuronal oligodendrocytes.
PPP2R2C, a gene disrupted in autosomal dominant intellectual disability.
GeneRIF
Leuven, Belgium. In Eur J Med Genet, 2010
encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity
Molecular correlates of laminar differences in the macaque dorsal lateral geniculate nucleus.
Davis, United States. In J Neurosci, 2008
Cellular localization of gene expression revealed 11 new layer-specific markers, of which 10 were enriched in magnocellular layers (BRD4, CAV1, EEF1A2, FAM108A1, INalpha, KCNA1, NEFH, NEFL, PPP2R2C, and SFRP2) and one was enriched in parvocellular and koniocellular layers (TCF7L2).
RNA interference screen to identify pathways that enhance or reduce nonviral gene transfer during lipofection.
Philadelphia, United States. In Mol Ther, 2008
The best candidate siRNA targeted the PPP2R2C gene and produced a 65% increase in luminescence from lipofection, with a quantitative PCR-validated knockdown of approximately 76%.
A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC.
GeneRIF
Amsterdam, Netherlands. In Plos Genet, 2007
novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
Clonal divergence in lung cancer development is associated with allelic loss on chromosome 4.
London, United Kingdom. In Genes Chromosomes Cancer, 2007
We identified a minimally deleted region encompassing six genes including two candidate tumor suppressor genes, CRMP1 a lung cancer metastasis-suppressing gene and PPP2R2C a gene for a regulatory subunit of the PP2 complex known to suppress tumorigenesis, particularly viral induced transformation.
PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.
Antibes, France. In Pharmacogenomics J, 2007
In this region, the PPP2R2C gene encodes the Bgamma-regulatory subunit of the protein phosphatase 2A (PP2A-Bgamma).
Identification of specific PP2A complexes involved in human cell transformation.
Impact
GeneRIF
Boston, United States. In Cancer Cell, 2004
specific PP2A complexes involved in human cell transformation
In vitro cellular and humoral responses to Schistosoma mansoni vaccine candidate antigens.
Cairo, Egypt. In Acta Trop, 2003
The panel consisted of four recombinant antigens (Sm62-Irv5, Sm37-G3PDH, Sm28-GST and Sm14-FABP), one full-length native protein (Sm97-paramyosin), two synthetic peptides (MAP3 and MAP4) and three unpublished antigens (PR52-filamin, PL45-phosphoglycerate kinase, PN18-cyclophilin).
Fine mapping a quantitative trait locus affecting ovulation rate in swine on chromosome 8.
United States. In J Anim Sci, 2003
Large insert swine genomic libraries were screened, clones were isolated and then screened for microsatellite repeats, and informative microsatellite markers were developed for seven genes (GNRHR, IDUA, MAN2B2, MSX1, PDE6B, PPP2R2C, and RGS12).
Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.
GeneRIF
Chicago, United States. In J Biol Chem, 2003
PP2A has a role in glucose-regulated EF-2 phosphorylation and protein translation in rat cells
Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade.
GeneRIF
Iowa City, United States. In J Biol Chem, 2002
PP2A/Bgamma is a positive regulator of MAP kinase signaling in neurons.
Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.
Shanghai, China. In Genomics, 2000
The putative protein shares 81 and 85% identity with B1alpha (PPP2R2A) and B1beta (PPP2R2B), respectively, and was named PPP2R2C for its high level of homology to the other two isoforms.
