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PPM2 Ppm2p

PPM2, TYW4, LCMT2
The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STEP, CAN, YPL207w, fibrillin-1, FSH
Papers on PPM2
Ancestral and more recently acquired syntenic relationships of MADS-box genes uncovered by the Physcomitrella patens pseudochromosomal genome assembly.
New
Ashton et al., Regina, Canada. In Plant Cell Rep, Dec 2015
Furthermore, this early segmental duplication spawned two chromosomal lineages: one with a MIKC (C) gene, belonging to the PPM2 clade, in close proximity to one or a pair of MIKC* genes and another with a MIKC (C) gene, belonging to the PpMADS-S clade, characterised by greater separation from syntenic MIKC* genes.
KR-POK interacts with p53 and represses its ability to activate transcription of p21WAF1/CDKN1A.
GeneRIF
Hur et al., Seoul, South Korea. In Cancer Res, 2012
Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A.
Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
GeneRIF
Nureki et al., Yokohama, Japan. In Nucleic Acids Res, 2009
This paper reports crystal structures of a yeast homolog, TYW4.
The MADS-domain protein PPM2 preferentially occurs in gametangia and sporophytes of the moss Physcomitrella patens.
Münster et al., Köln, Germany. In Gene, 2007
In our study we analyzed PPM2, a classical MIKC-type MADS-box gene from the moss Physcomitrella patens, taking advantage of the unique technical properties Physcomitrella offers in terms of efficient homologous recombination.
Independent and complementary methods for large-scale structural analysis of mammalian chromatin.
Kingston et al., Boston, United States. In Genome Res, 2007
We validated these assays using the known positions of nucleosomes on the mouse mammary tumor virus LTR, and additionally, we characterized the previously unreported chromatin structure of the LCMT2 gene.
p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1.
GeneRIF
Choi et al., Ch'ŏngju, South Korea. In Biochem Biophys Res Commun, 2006
In conclusion, we report that the transcription factor Sp1 involved in the p38MAPK-mediated control of p21WAF1 regulation on VSMC in response to BITC has now been identified.
Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor.
GeneRIF
Wu et al., Harbin, China. In World J Gastroenterol, 2006
p21WAF1 and Bax may be used as the markers in the assessment of GIST malignant potential.
The X-ray crystal structures of human alpha-phosphomannomutase 1 reveal the structural basis of congenital disorder of glycosylation type 1a.
Allen et al., Boston, United States. In J Biol Chem, 2006
It is caused by mutations in alpha-phosphomannomutase (of which there are two isozymes, alpha-PMM1 and alpha-PPM2).
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.
Suzuki et al., Tokyo, Japan. In Embo J, 2006
Four genes YPL207w, YML005w, YGL050w and YOL141w (named TYW1, TYW2, TYW3 and TYW4, respectively) were essential for yW synthesis.
Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis.
Suzuki et al., Tokyo, Japan. In Nucleic Acids Symp Ser (oxf), 2005
We found four new genes YPL207w, YML005w, YOL141w and YGL050w (named TYW1, TYW2, TYW3 and TYW4, respectively) to be responsible for wybutosine (yW) synthesis.
Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.
GeneRIF
Oshimi et al., Tokyo, Japan. In Eur J Haematol, 2005
Inacativaton of this cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders.
Disruption of Cg-Ppm1, a polyprenyl monophosphomannose synthase, and the generation of lipoglycan-less mutants in Corynebacterium glutamicum.
Besra et al., Birmingham, United Kingdom. In J Biol Chem, 2003
In the present study, we demonstrate that the corynebacterial synthase is composed of two distinct domains; a catalytic domain (Cg-ppm1) and a membrane domain (Cg-ppm2).
Distribution of deoxynivalenol in wheat, wheat flour, bran, and gluten, and variability associated with the test procedure.
Castillo et al., Buenos Aires, Argentina. In J Aoac Int, 2003
The total variance combined sampling, sample preparation, and analytical variances were 0.188, 0.033, 0.42, and 0.0014 ppm2 for wheat, 1.93; flour, 0.99; bran, 4.68; and gluten, 0.29, respectively.
Reduced polyspermic fertilization of porcine oocytes utilizing elevated bicarbonate and reduced calcium concentrations in a single-medium system.
Krisher et al., West Lafayette, United States. In Reprod Fertil Dev, 2002
Embryonic development (cleavage and blastocyst stages) was assessed after culture in PPM1 and PPM2.
Two ancient classes of MIKC-type MADS-box genes are present in the moss Physcomitrella patens.
Theissen et al., Köln, Germany. In Mol Biol Evol, 2002
Phylogeny reconstructions and comparison of exon-intron structures revealed that the genes described here represent two different classes of homologous, yet distinct, MIKC-type MADS-box genes, termed MIKC(c)-type genes-"(c)" stands for "classic"-(PPM1, PPM2, PpMADS1) and MIKC(*)-type genes (PPM3, PPM4, PpMADS2, PpMADS3).
Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast.
Clarke et al., Los Angeles, United States. In Arch Biochem Biophys, 2001
The recent characterization of a mammalian PP2A carboxyl methyltransferase has led to the identification of two ORFs in Saccharomyces cerevisiae as potential orthologues of the mammalian PP2A methyltransferase: protein phosphatase methyltransferase 1 (PPM1) and protein phosphatase methyltransferase 2 (PPM2).
Dimethyl propionate ester heme-containing cytochrome b5: structure and stability.
Turano et al., Florence, Italy. In J Biol Inorg Chem, 2001
ppm2.
Methapyrilene effects on initiation and promotion of gamma-glutamyl-transpeptidase positive foci in rat liver.
Milks et al., In Res Commun Chem Pathol Pharmacol, 1982
Subsequently, the animals were promoted with 500 ppm2 phenobarbital or 200 ppm methapyrilene in drinking water for eight weeks.
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