The structure of human argonaute-2 in complex with miR-20a.
United States. In Cell, 2012
Study reports the structure of human Ago2 bound to a physiologically relevant microRNA, microRNA-20a, at 2.2 A resolution; the miRNA is anchored at both ends by the Mid and PAZ domains and makes several kinks and turns along the binding groove and miRNA binding confers remarkable stability on hAgo2.
The crystal structure of human Argonaute2.
Los Angeles, United States. In Science, 2012
2.3 angstrom resolution crystal structure of Ago2 reveals a bilobed molecule with a central cleft for binding guide and target RNAs; nucleotides 2 to 6 of a heterogeneous mixture of guide RNAs are positioned in an A-form conformation for base pairing with target messenger RNAs