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WNT1 inducible signaling pathway protein 3

PPD
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, IFN-gamma, AGE, CD4
Papers using PPD antibodies
Using ELISPOT to expose false positive skin test conversion in tuberculosis contacts.
Supplier
Myer Landon, In PLoS ONE, 2006
... sample taken for ELISPOT and HIV test, followed by a Mantoux test (2 Tuberculin Units [TU], PPD RT23 Statens Serum Institut, ...
Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis.
Supplier
Tyagi Anil Kumar, In PLoS ONE, 2005
... PPD, which according to the manufacturer reacts with related mycobacterial species (BP2027B, Acris Germany) ...
Reliability of tuberculin skin test measurement
Supplier
Hopewell Philip, In PLoS Medicine, 1996
... Immediately afterwards they underwent a TST (2 Tuberculin Units [TU], PPD RT23, Statens Serum Institut, ...
Papers on PPD
para-Phenylenediamine induces apoptosis through activation of reactive oxygen species-mediated mitochondrial pathway, and inhibition of the NF-κB, mTOR, and Wnt pathways in human urothelial cells.
New
Chye et al., Kuala Lumpur, Malaysia. In Environ Toxicol, Feb 2016
UNASSIGNED: para-Phenylenediamine (PPD) has long been used in two-thirds of permanent oxidative hair dye formulations.
Immunotherapy using purified protein derivative in the treatment of warts: An open uncontrolled trial.
New
Bhat et al., Wardha, India. In Indian J Dermatol Venereol Leprol, Jan 2016
Purified protein derivative (PPD) of tuberculin bacilli has been used as a non-specific stimulant of CMI to achieve this outcome.
Clinical manifestations and outcome of tuberculous sclerokeratitis.
New
Tabbara et al., Riyadh, Saudi Arabia. In Br J Ophthalmol, Jan 2016
Tuberculin skin test was done with purified protein derivative (PPD) on all patients.
Paraphenylene diamine exacerbates platelet aggregation and thrombus formation in response to a low dose of collagen.
New
Bagri et al., Montréal, Canada. In J Toxicol Sci, Dec 2015
Paraphenylene daimine (PPD) is an aromatic amine that is widely used in several industrial products; however, its toxicity has been reported in several cases of cardiac arrests.
The role of reproductive hormones in postpartum depression.
Review
New
Rubinow et al., Chapel Hill, United States. In Cns Spectr, Feb 2015
Despite decades of research aimed at identifying the causes of postpartum depression (PPD), PPD remains common, and the causes are poorly understood.
Does an Electronic Health Record Improve Completeness of Prenatal Studies?
Zlatnik et al., Livermore, United States. In Appl Clin Inform, 2014
OBJECTIVE: To determine whether implementation of an electronic health record (EHR) would increase the rate of prenatal Human Immunodeficiency Virus (HIV) and purified protein derivative (PPD) testing.
In search of neural endophenotypes of postpartum psychopathology and disrupted maternal caregiving.
Review
Swain et al., Pittsburgh, United States. In J Neuroendocrinol, 2014
Executive network and default mode connectivity abnormalities have been described in postpartum depression (PPD), although studies are very limited in these domains.
Allopregnanolone as a mediator of affective switching in reproductive mood disorders.
Review
Rubinow et al., Chapel Hill, United States. In Psychopharmacology (berl), 2014
RATIONALE: Reproductive mood disorders, including premenstrual dysphoria (PMD) and postpartum depression (PPD), are characterized by affective dysregulation that occurs during specific reproductive states.
The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle.
Review
Waters et al., Ames, United States. In Vet Immunol Immunopathol, 2014
In vitro, γδ T cells proliferate and produce robust amounts of IFNγ in response to complex, protein and non-protein mycobacterial antigens including M. bovis purified protein derivative (PPD), heat shock proteins and cell wall components such as mycolylarabinogalactan peptidoglycan (mAGP).
Pharmacotherapy of postpartum depression: an update.
Review
Wisner et al., Philadelphia, United States. In Expert Opin Pharmacother, 2014
INTRODUCTION: Postpartum depression (PPD) is a common and serious illness that affects up to 14% of women in the first month after childbirth.
APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10.
GeneRIF
Zhang et al., Guangzhou, China. In J Biol Chem, 2012
APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10
The structure of human argonaute-2 in complex with miR-20a.
Impact
GeneRIF
Joshua-Tor et al., United States. In Cell, 2012
Study reports the structure of human Ago2 bound to a physiologically relevant microRNA, microRNA-20a, at 2.2 A resolution; the miRNA is anchored at both ends by the Mid and PAZ domains and makes several kinks and turns along the binding groove and miRNA binding confers remarkable stability on hAgo2.
Confirmation of the recurrent ACVR1 617G>A mutation in South Africans with fibrodysplasia ossificans progressiva.
GeneRIF
Beighton et al., Cape Town, South Africa. In S Afr Med J, 2012
Confirmation of the presence of this recurrent mutation facilitates diagnostic accuracy in affected persons in South Africa, and allows researchers to narrow the search for molecular targets for rational intervention to the ACVR1/ALK2 domain.
The crystal structure of human Argonaute2.
Impact
GeneRIF
MacRae et al., Los Angeles, United States. In Science, 2012
2.3 angstrom resolution crystal structure of Ago2 reveals a bilobed molecule with a central cleft for binding guide and target RNAs; nucleotides 2 to 6 of a heterogeneous mixture of guide RNAs are positioned in an A-form conformation for base pairing with target messenger RNAs
Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development.
GeneRIF
Kaartinen et al., Ann Arbor, United States. In Plos One, 2011
Signaling via Alk2 is required for appropriate aortic valve development in utero, and that defects in this process lead to indirect secondary complications later in life.
Prolonged survival after complete resection of disseminated melanoma and active immunotherapy with a therapeutic cancer vaccine.
Impact
Morton et al., Santa Monica, United States. In J Clin Oncol, 2003
There was a significant delayed-type hypersensitivity (DTH) response to adjuvant vaccine therapy (P =.0001), and OS was significantly correlated with DTH to vaccine (P =.0001) but not with DTH to purified protein derivative (PPD), a control antigen.
BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies.
Impact
Dockrell et al., Karonga, Malawi. In Lancet, 2002
METHODS: 483 adolescents and young adults in Malawi and 180 adolescents in the UK were tested for interferon-gamma (IFN-gamma) response to M tuberculosis purified protein derivative (PPD) in a whole blood assay, and for delayed type hypersensitivity (DTH) skin test response to tuberculin PPD, before and 1 year after receiving BCG (Glaxo 1077) vaccination or placebo or no vaccine.
Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells.
Impact
Hill et al., Oxford, United Kingdom. In Lancet, 2001
The current method, the tuberculin skin test (TST), has poor specificity because of the antigenic cross-reactivity of purified protein derivative (PPD) with M bovis BCG vaccine and environmental mycobacteria.
Risk of infection with Mycobacterium tuberculosis in travellers to areas of high tuberculosis endemicity.
Impact
Mensen et al., Amsterdam, Netherlands. In Lancet, 2000
METHODS: In a multicentre, prospective cohort study based in travel and tuberculosis clinics in the Netherlands, 1072 BCG-naive immunocompetent travellers to countries with an estimated annual risk of M. tuberculosis infection of at least 1% were skin tested before departure with 1 tuberculin unit purified protein derivative (PPD) of M. tuberculosis in Tween-80.
Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire.
Impact
Ashwell et al., Bethesda, United States. In Immunity, 2000
TKO mice responded normally to the complex antigen PPD but were proliferative nonresponders to pigeon cytochrome c 81-104 (PCC), having a large decrease in the frequency of PCC-responsive CD4+ T cells.
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