GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Peroxisome proliferator-activated receptor gamma
PPARgamma
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers on
PPARgamma
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with MS detection.
New
Pavia, Italy. In J Chromatogr A, 16 Mar 2013
For this purpose the ligand binding domain of PPARα receptor was immobilized onto the surface of open tubular capillaries to create new PPAR-alpha-OT columns to be used in parallel with PPAR-gamma-OT columns.
Comparison of the anti-inflammatory and therapeutic actions of PPAR-gamma agonists rosiglitazone and troglitazone in experimental colitis.
New
Lublin, Poland. In J Physiol Pharmacol, Dec 2012
Non-specific inflammatory bowel diseases, including ulcerative colitis and Crohn`s disease, are chronic non-infectious diseases that showed an increase in prevalence in recent years, particularly in the developed countries.
Identification of PPARgamma Partial Agonists of Natural Origin (II): In Silico Prediction in Natural Extracts with Known Antidiabetic Activity.
New
Tarragona, Spain. In Plos One, Dec 2012
BACKGROUND: Natural extracts have played an important role in the prevention and treatment of diseases and are important sources for drug discovery.
PAX8-PPARgamma oncogene in follicular thyroid tumors: RT-PCR and immunohistochemical analyses.
New
Osijek, Croatia. In Coll Antropol, Nov 2012
A potentially useful marker for this differentiation is the PAX8-PPARgamma rearrangement, identified in follicular thyroid carcinomas, but not in follicular adenomas or other types of thyroid tumors.
[Effects of SREBP-1 over-expression on fatty acid metabolism related genes expression in goats].
New
China. In Sheng Wu Gong Cheng Xue Bao, Nov 2012
The expression level of Peroxisome proliferator activated receptorgamma (PPARgamma) increased by 1.5 times.
Thiazolidinedione safety.
Review
New
Boston, United States. In Expert Opin Drug Saf, Jul 2012
However, the development of highly targeted selective PPAR gamma modulators (SPPARγMs) and dual PPAR gamma/alpha agonists is on the horizon.
[Endothelial progenitor cells and vascular health: effects of lifestyle's modifications].
Review
New
Florence, Italy. In Monaldi Arch Chest Dis, Jun 2012
In addition to some pharmacological treatment such as statins, erythropoietin, PPAR-gamma agonists and angiotensin-II receptor antagonists, the effects of healthy lifestyle, via mobilization and functional improvement of EPC, is increasingly recognized.
How to diagnose a lipodystrophy syndrome.
Review
New
Lille, France. In Ann Endocrinol (paris), Jun 2012
Gene mutations encoding for PPAR-gamma, Akt2, CIDEC, perilipin and the ZMPSTE 24 enzyme are much more rare.
Mice with cardiac overexpression of peroxisome proliferator-activated receptor γ have impaired repolarization and spontaneous fatal ventricular arrhythmias.
GeneRIF
New York City, United States. In Circulation, 2012
Our findings support an important link between PPARgamma activation, cardiomyocyte lipid accumulation, ion channel remodeling, and increased cardiac mortality.
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.
GeneRIF
London, United Kingdom. In J Clin Invest, 2011
Deletion of Ikk2 in initiated pre-malignant epithelial cells downregulates the classical Notch target genes Hes1 & Hey1. Hes1 suppresses expression of Pparg.
Increased body mass index but not common vitamin D receptor, peroxisome proliferator-activated receptor γ, or cytokine polymorphisms confers predisposition to posttransplant diabetes.
GeneRIF
Houston, United States. In Arch Pathol Lab Med, 2011
Increased body mass index but not common vitamin D receptor, peroxisome proliferator-activated receptor gamma, or cytokine polymorphisms confers predisposition to posttransplant diabetes.
Sex-specific differences in Type 2 Diabetes Mellitus and dyslipidemia therapy: PPAR agonists.
Review
Berlin, Germany. In Handb Exp Pharmacol, 2011
Ligands of peroxisome proliferator-activated receptors (PPARs) are used as oral antidiabetics (PPARgamma agonists: thiazolidinediones, TZDs), or for the treatment of dyslipidemia and cardiovascular diseases, due to their lipid-lowering properties (PPARalpha agonists: fibrates), as PPARs control transcription of a set of genes involved in the regulation of lipid and carbohydrate metabolism.
[The endocannabinoid system and its role in regulation of metabolism in peripheral tissues].
Review
Warsaw, Poland. In Postepy Biochem, 2011
Activation of CB1 receptor leads to: (i) increase in the activity of transcription factors which regulate gene expression involved in lipid synthesis (SREBP-1c, PPARgamma), (ii) inhibition of AMP-activated protein kinase and (iii) decrease in fatty acid oxidation.
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity.
Impact
GeneRIF
San Diego, United States. In Cell, 2011
PPARgamma response genes were upregulated in adipose tissue from adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout mice and CDK5-mediated PPARgamma ser-273 phosphorylation was reduced, creating a constitutively active PPARgamma state.
Troglitazone induced apoptosis via PPARγ activated POX-induced ROS formation in HT29 cells.
GeneRIF
Beijing, China. In Biomed Environ Sci, 2011
The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation, at least partly, via PPARgamma activation.
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Impact
San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Impact
Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Impact
GeneRIF
Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Impact
Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Impact
Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
