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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Peroxisome proliferator-activated receptor gamma

PPARgamma
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PPAR, Insulin, ACID, CAN, V1a
Papers on PPARgamma
Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: Targeting PPARγ and GLT-1 pathways.
New
Ekavali et al., Chandīgarh, India. In Pharmacol Rep, Feb 2016
BACKGROUND: The relation between glutamate homeostasis and PPAR gamma has got tremendous importance in nerve trauma and pain.
Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells.
New
Sen et al., India. In Cytokine, Jan 2016
IFNγ induced PPAR gamma coactivator-1 alpha (PGC-1α) positively regulated RIG-I; with PRMT-1 and G9a affecting PGC-1α in a counter-regulatory manner.
Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia.
New
Xie et al., In Invest Ophthalmol Vis Sci, Jan 2016
Furthermore, the application of NPFF rescued the activation of SIRT1 and PPAR-gamma, and downregulated the expression of PTEN and Rb in diabetic TG neurons.
Analysis for Carom complex, signaling and function by database mining.
New
Wang et al., In Front Biosci, Dec 2015
Using GEO database, we discovered that four conditions (hypoxia, endometriosis, PPARgamma deletion and iPSC reprogramming) altered Carom/partner expression in endothelial cells.
Fatty acids, eicosanoids and PPAR gamma.
New
Ghosh et al., Rouen, France. In Eur J Pharmacol, Dec 2015
UNASSIGNED: Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine.
The role of PPAR-gamma receptor in pruritus.
Review
New
Dehpour et al., Tehrān, Iran. In Eur J Pharmacol, Oct 2015
Recent studies have clarified the novel mediators and neuronal pathways involved in itch transmission, which might result in introduction of new therapies for management of pruritus in the near future.
PPAR gamma gene--a review.
Review
Ranjitha Kumari et al., India. In Diabetes Metab Syndr, 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes.
A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: increasing glutamate uptake with PPARγ agonists.
Review
Kaye et al., Melbourne, Australia. In J Clin Neurosci, 2015
PPAR gamma agonists are known to upregulate functional EAAT2 expression in astrocytes and prevent excitotoxicity caused by glutamate excess.
Capsaicin may have important potential for promoting vascular and metabolic health.
Review
O'Keefe et al., Encinitas, United States. In Open Heart, 2014
TRPV1 activation induces calcium influx, and in certain tissues this is associated with increased activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXRα.
Features of intestinal lesions in the clinical course of inflammatory bowel diseases.
Review
Sferra et al., In Ital J Anat Embryol, 2013
Increased evidence indicate that a number of molecules are involved in the development of the disease and a crosstalk between TGFbeta/Smads pathway and alphavbeta6 integrin, mTOR and PPARgamma could play a crucial role in the development of intestinal fibrosis.
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
GeneRIF
Randolph et al., New York City, United States. In J Immunol, 2012
A key role is uncovered for macrophage PPARgamma in promoting resolution of inflammation and maintaining functionality in lung macrophages, where it regulates and supports pulmonary host defense.
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis.
GeneRIF
Chen et al., Ann Arbor, United States. In Circulation, 2012
In a mouse model deficient in peroxisome proliferator-activated receptor-gamma in smooth muscle cells (SMPG KO mice), complete absence of perivascular adipose tissue was likely caused by PPAR-gamma deletion in the perivascular adipocyte precursor cells.
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
GeneRIF
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Impact
GeneRIF
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer.
GeneRIF
Walter et al., Erlangen, Germany. In Anticancer Res, 2012
study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Impact
Glass et al., San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Impact
Lees et al., Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Impact
GeneRIF
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Impact
Wan et al., Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Impact
Lazar et al., Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
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