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Peroxisome proliferator-activated receptor gamma

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PPAR, Insulin, ACID, CAN, V1a
Papers on PPARgamma
Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish.
Moyes et al., Kingston, Canada. In Comp Biochem Physiol B Biochem Mol Biol, 19 Oct 2015
UNASSIGNED: Remodeling the muscle metabolic machinery in mammals in response to energetic challenges depends on the energy sensor AMP-activated protein kinase (AMPK) and its ability to phosphorylate PPAR gamma coactivator 1 α (PGC1α), which in turn coactivates metabolic genes through direct and indirect association with DNA-binding proteins such as the nuclear respiratory factor 1 (NRF1) (Wu et al. 1999).
Telmisartan to reduce cardiovascular risk in older HIV-infected adults: a pilot study.
Currier et al., In Hiv Clin Trials, 11 Oct 2015
Telmisartan is an angiotensin receptor blocker (ARB) and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist that improves endothelial function and cardiovascular mortality in HIV-uninfected populations.
Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis.
Jang et al., Seoul, South Korea. In Atherosclerosis, 04 Oct 2015
OBJECTIVE: The ligand-activated transcription factor peroxisome proliferator-activated receptor gamma (PPARγ) is a key factor in adipogenesis, insulin sensitivity, and cell cycle regulation.
Involvement of resveratrol in crosstalk between adipokine adiponectin and hepatokine fetuin-A in vivo and in vitro.
Yang et al., Kwangju, South Korea. In J Nutr Biochem, 17 Aug 2015
In epididymal fat depots, RSV increased adiponectin, peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, sirtuin1 and AMP-activated protein kinase (AMPK).
[R-value comprehensive evaluation of effect of three methods for lung-kidney comprehensive evaluation study on R value of three methods for regulating and invigorating lung and kidney in regulating lung inflammation signaling pathways in COPD rats].
Li et al., In Zhongguo Zhong Yao Za Zhi, Apr 2015
Specifically, (1) Linking JAK/STAT signaling pathway: JAK2 mRNA, and protein expressions of STAT-1, STAT-3, STAT-5, JAK-2; (2) NF-kappaB signaling pathway: Smad2 mRNA and protein expressions of I-kappaB, NF-kappaB, TGF-beta1; (3) PPARgamma and antioxidant signaling pathway: SOD, PGE mRNA, PPARgamma protein.
Capsaicin may have important potential for promoting vascular and metabolic health.
O'Keefe et al., Encinitas, United States. In Open Heart, Dec 2014
TRPV1 activation induces calcium influx, and in certain tissues this is associated with increased activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXRα.
Nutritional factors in transdifferentiation of scheletal muscles to adipocytes.
Mocanu et al., In Rev Med Chir Soc Med Nat Iasi, Jul 2014
The molecular mechanisms mediating the adipogenic action of thiazolidinediones and fatty acids in myoblasts could involve peroxisome proliferators-activated receptor-gamma (PPARgamma and CCAAT-enhancer-binding protein C/EBP.
[Progress of berberine for treatment of type 2 diabetes].
Xie et al., In Zhongguo Zhong Yao Za Zhi, Apr 2014
The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway.
Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction.
Hébert et al., Meaux, France. In Front Physiol, 2013
PPAR gamma plays a major role in both glucose and lipid metabolisms and presents circadian properties which coordinate the interplay between metabolism and CRs.
Cross-talk between heme oxygenase and peroxisome proliferator-activated receptors in the regulation of physiological functions.
Ndisang, Saskatoon, Canada. In Front Biosci, 2013
The isoforms of PPAR include PPAR alpha, PPAR gamma and PPAR delta (also known as PPAR beta).
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
Randolph et al., New York City, United States. In J Immunol, 2012
A key role is uncovered for macrophage PPARgamma in promoting resolution of inflammation and maintaining functionality in lung macrophages, where it regulates and supports pulmonary host defense.
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis.
Chen et al., Ann Arbor, United States. In Circulation, 2012
In a mouse model deficient in peroxisome proliferator-activated receptor-gamma in smooth muscle cells (SMPG KO mice), complete absence of perivascular adipose tissue was likely caused by PPAR-gamma deletion in the perivascular adipocyte precursor cells.
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer.
Walter et al., Erlangen, Germany. In Anticancer Res, 2012
study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Glass et al., San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Lees et al., Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Wan et al., Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Lazar et al., Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
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