[Effect of apigenin on protein expressions of PPARs in livertissues of rats with nonalcoholic steatohepatitis].
Hangzhou, China. In Zhonghua Gan Zang Bing Za Zhi, Mar 2015
After13 weeks of treatment,changes in insulin sensitivity from pre-treatment baseline were assessed by measuring the alanine aminotransferase (ALT), aspartate aminotransferase (AST),total cholesterol (TC),triglycerides (TG),low-density and high-density lipoprotein cholesterol (LDL-C and HDL-C),fasting blood glucose (FBG) and fasting insulin (FINS).The liverindex and HOMA-Irwere also calculated.Protein and gene expression of PPARa and PPARgamma in livertissue were assessed by immunohistochemistry and RT-PCR.Statistical analysis was performed by the LSD test and Games-Howell test.
Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats.
Tirupati, India. In Bmc Complement Altern Med, Dec 2014
Changes in body weight, body composition, blood glucose, insulin, tissue and serum lipid profiles, atherogenic index, liver markers, and expression of adipogenesis-related genes such as leptin, adiponectin, FAS, PPARgamma, AMPK-1alpha and SREBP-1c, were studied in experimental rats.
[Progress of berberine for treatment of type 2 diabetes].
In Zhongguo Zhong Yao Za Zhi, Apr 2014
The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway.
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Fingered for a fat fate.
Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.