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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Peroxisome proliferator-activated receptor gamma

PPARgamma
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PPAR, Insulin, CAN, ACID, V1a
Papers on PPARgamma
Anti-pruritic activity of pioglitazone on serotonin-induced scratching in mice: Possible involvement of PPAR-gamma receptor and nitric oxide.
New
Dehpour et al., Tehrān, Iran. In Eur J Pharmacol, 10 Nov 2014
UNLABELLED: Pioglitazone is a member of peroxisome proliferator-activated receptor gamma (PPARγ) agonists, particularly used in management of type II diabetes.
Fisetin Upregulates the Expression of Adiponectin in 3T3-L1 Adipocytes via the Activation of SIRT1-Deacetylase and PPARs.
New
Chung et al., In J Agric Food Chem, 06 Nov 2014
Fisetin also promoted deacetylation of PPAR gamma co-activator 1, PGC-1 and its interaction with PPARs.
Long-term globular adiponectin administration improves adipose tissue dysmetabolism in high-fat diet-fed Wistar rats.
New
Seiça et al., Coimbra, Portugal. In Arch Physiol Biochem, 31 Oct 2014
More, adiponectin was able to increase IkappaBalpha and PPARgamma levels and to prevent high-fat diet-induced impairment of insulin signalling, especially in epididymal adipose tissue.
Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.
New
Bender et al., Cambridge, United Kingdom. In Mol Biosyst, 25 Oct 2014
Lastly, (iii) the thiazolidinediones drug cluster predicted peroxisome proliferator activated receptor (PPAR) PPAR-alpha, PPAR-gamma, acyl CoA desaturase and significant differential expression of genes ANGPTL4, FABP4 and PRKCD.
Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a.
New
Ji et al., Shanghai, China. In Tumour Biol, 21 Sep 2014
At the molecular level, we found that TUT1 could inhibit the expression levels of PPARgamma and SREBP-1c, two key regulators in lipogenesis, through upregulation of microRNA-24 and microRNA-29a.
[Progress of berberine for treatment of type 2 diabetes].
Review
New
Xie et al., In Zhongguo Zhong Yao Za Zhi, Apr 2014
The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway.
The impact of dietary fatty acids on macrophage cholesterol homeostasis.
Review
New
Lottenberg et al., São Paulo, Brazil. In J Nutr Biochem, Feb 2014
As isomers of conjugated linoleic acid (CLAs) are strong PPAR gamma ligands, they induce cluster of differentiation (CD36) expression, increasing intracellular cholesterol content.
Regulation of energy metabolism by long-chain fatty acids.
Review
New
Loor et al., Urbana, United States. In Prog Lipid Res, Jan 2014
Genes targeted by PPAR-gamma in adipocytes suggest that PPAR-gamma senses incoming non-esterified LCFAs and induces the pathways to store LCFAs as triglycerides.
[Regulation of differentiation of mesenchymal stem cells by the Hippo pathway effectors TAZ/YAP].
Review
New
Teng et al., Harbin, China. In Yi Chuan, Nov 2013
It has been reported that the lineage-specific transcriptional factors including Runt related transcription factor 2 (RUNX2), Peroxisome proliferator-activator receptor gamma (PPARgamma) and Myogenic differentiation 1 (MyoD) may play key regulatory roles among the differentiation of MSCs.
[Concept and clinical characteristics of diabetes mellitus in the elderly].
Review
New
Yokono, Quito, Ecuador. In Nihon Rinsho, Nov 2013
Exercise seems to improve insulin resistance through mitochondrial function by activating AMP-activated protein kinase(AMPK) and PPARgamma coactivator-1alpha (PGC-1alpha).
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
GeneRIF
Randolph et al., New York City, United States. In J Immunol, 2012
A key role is uncovered for macrophage PPARgamma in promoting resolution of inflammation and maintaining functionality in lung macrophages, where it regulates and supports pulmonary host defense.
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis.
GeneRIF
Chen et al., Ann Arbor, United States. In Circulation, 2012
In a mouse model deficient in peroxisome proliferator-activated receptor-gamma in smooth muscle cells (SMPG KO mice), complete absence of perivascular adipose tissue was likely caused by PPAR-gamma deletion in the perivascular adipocyte precursor cells.
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
GeneRIF
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Impact
GeneRIF
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer.
GeneRIF
Walter et al., Erlangen, Germany. In Anticancer Res, 2012
study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Impact
Glass et al., San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Impact
Lees et al., Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Impact
GeneRIF
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Impact
Wan et al., Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Impact
Lazar et al., Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
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