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Peroxisome proliferator-activated receptor gamma

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PPAR, Insulin, CAN, ACID, HAD
Papers on PPARgamma
Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue.
Wright et al., Guelph, Canada. In J Appl Physiol, 27 Apr 2014
Exercise training (4 weeks of treadmill running, 1 hr/day, 5 days/wk) increased markers of skeletal muscle mitochondrial content and the induction of PPAR gamma co-activator 1 alpha in epididymal adipose tissue.
Evodiamine inhibition of TGF-beta1-induced epithelial-mesenchymal transition in NRK52E cells via Smad and PPAR-gamma pathway.
Yuan et al., Haikou, China. In Cell Biol Int, 07 Apr 2014
Phosphorylation of Smad proteins and PPAR-gamma activation are required for the process of TGF-beta1-induced EMT.
[Effect of Bushen Huatan Recipe on the Akt signal pathway in polycystic ovarian syndrome model rats with insulin resistance: an experimental research].
Wu et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, 28 Feb 2014
The expression of insulin receptor substrate 1 (IRS-1), glycogen synthetase kinase-3beta (GSK-3beta), glucose transporter 4 (GLUT-4), and peroxisome proliferator activated receptor (PPAR-gamma) mRNA were detected by RT-PCR.
Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates.
Emborg et al., In Neurol Res, Jan 2014
UNLABELLED: Objective: To characterize the distribution of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in the substantia nigra of normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated hemiparkinsonian monkeys, in order to validate PPAR-gamma as a target for neuroprotection.
9-cis-Retinoic Acid and Troglitazone Impacts Cellular Adhesion, Proliferation, and Integrin Expression in K562 Cells.
Kelley et al., Conway, United States. In Plos One, Dec 2013
Recently, troglitazone, a PPAR gamma agonist, has been demonstrated to have anti-inflammatory effects.
[Concept and clinical characteristics of diabetes mellitus in the elderly].
Yokono, Quito, Ecuador. In Nihon Rinsho, Nov 2013
Exercise seems to improve insulin resistance through mitochondrial function by activating AMP-activated protein kinase(AMPK) and PPARgamma coactivator-1alpha (PGC-1alpha).
The mitochondrial H(+)-ATP synthase and the lipogenic switch: new core components of metabolic reprogramming in induced pluripotent stem (iPS) cells.
Menendez et al., Girona, Spain. In Cell Cycle, Feb 2013
Importantly, iPS cells exhibited a significant intracellular accumulation of neutral lipid bodies; however, these bodies may be a reflection of intense lysosomal/autophagocytic activity rather than bona fide lipid droplet formation in iPS cells, as they were largely unresponsive to pharmacological modulation of PPARgamma and FASN activities.
PPARgamma-Dependent Control of Renin Expression: Molecular Mechanisms and Pathophysiological Relevance.
Todorov, Dresden, Germany. In Ppar Res, 2012
During the last years accumulating evidence demonstrated that the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) regulates the expression of renin gene and thus the overall renin production.
[Peroxisome proliferator-activated receptors-gamma and hypertension: lessons of the history of researches].
Rasin, In Ter Arkh, 2012
The paper analyzes data from the clinical use of thiazolidinediones, human genetic observations and experiments with peroxisome proliferator-activated receptor (PPAR-gamma) gene removal, and also those on the role of PPAR-alpha and -gamma in the function of the vascular endothelium, sympathetic autonomic nervous system, and renal sodium reabsorption.
[The role of TLR4 receptor in development of inflammation and carcinogenesis in ulcerative colitis and pharmacotherapy of this disorder].
Okopień et al., In Wiad Lek, 2012
On the other hand, this reaction is inhibited by anti-inflammatory agents, such as prostaglandin 15d-PGJ2, and peroxisome proliferator activated receptor type gamma (PPARgamma).
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
Randolph et al., New York City, United States. In J Immunol, 2012
A key role is uncovered for macrophage PPARgamma in promoting resolution of inflammation and maintaining functionality in lung macrophages, where it regulates and supports pulmonary host defense.
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis.
Chen et al., Ann Arbor, United States. In Circulation, 2012
In a mouse model deficient in peroxisome proliferator-activated receptor-gamma in smooth muscle cells (SMPG KO mice), complete absence of perivascular adipose tissue was likely caused by PPAR-gamma deletion in the perivascular adipocyte precursor cells.
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer.
Walter et al., Erlangen, Germany. In Anticancer Res, 2012
study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Glass et al., San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Lees et al., Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Wan et al., Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Lazar et al., Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
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