Pomegranate vinegar attenuates adiposity in obese rats through coordinated control of AMPK signaling in the liver and adipose tissue.
In Lipids Health Dis, 02 Dec 2013
RESULTS: Compared to control, PV supplementation increased phosphorylation of AMP-activated protein kinase (AMPK), leading to changes in mRNA expressions: increases for hormone sensitive lipase and mitochondrial uncoupling protein 2 and decreases for sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptorgamma (PPARgamma) in adipose tissue; increases for PPARalpha and carnitinepalmitoyltransferase-1a (CPT-1a) and decrease for SREBP-1c in the liver.
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Fingered for a fat fate.
Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.