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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Peroxisome proliferator-activated receptor gamma

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PPAR, Insulin, ACID, CAN, V1a
Papers on PPARgamma
Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer's Disease.
Camins et al., Barcelona, Spain. In Mol Neurobiol, 12 Dec 2015
In addition, protein levels of PPAR gamma coactivator-1α (PGC-1α), a molecule involved in mitochondrial biogenesis and energy homeostasis, were decreased in 9-month-old APPswe/PS1dE9 mice but not in APPswe/PS1dE9/jnk1+/- animals.
Decreased Endothelial NOS Expression and Function Contributes to Impaired Mitochondrial Biogenesis and Oxidative Stress in Fetal Lambs with PPHN.
G Konduri et al., Sinŭiju, North Korea. In Am J Physiol Lung Cell Mol Physiol, 30 Nov 2015
Phosphorylation of AMP-activated kinase (AMPK) and levels of PPAR gamma coactivator 1-alpha (PGC-1α) and sirtuin1, which facilitate mitochondrial biogenesis, were decreased in PPHN.
Training-induced anti-atherosclerotic effects are associated with increased vascular PPARgamma expression in apolipoprotein E deficient mice.
Laurant et al., Besançon, France. In Acta Physiol (oxf), 15 Nov 2015
AIM: Physical exercise prevents cardiovascular risk and atherosclerosis lesions.
PPAR gamma gene--a review.
Ranjitha Kumari et al., India. In Diabetes Metab Syndr, Jan 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes.
Capsaicin may have important potential for promoting vascular and metabolic health.
O'Keefe et al., Encinitas, United States. In Open Heart, Dec 2014
TRPV1 activation induces calcium influx, and in certain tissues this is associated with increased activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXRα.
Macrophage polarisation by fatty acids is PPARgamma-dependent.
Griffiths et al., United Kingdom. In Free Radic Biol Med, Oct 2014
This increases mitochondrial superoxide production, reduces dependency on oxidative phosphorylation through ceramide-dependent inhibition of PPARgamma activity and increases TNFa production, again via a mechanism that requires ceramide production.
Body energy metabolism and oxidative stress in mice supplemented with conjugated linoleic acid (CLA) associated to oleic acid.
Alberici et al., Ribeirão Preto, Brazil. In Free Radic Biol Med, Oct 2014
Oleic acid partially reversed the lower lipid accumulation increasing PPARgamma content, reversed the higher ROS generation by liver mitochondria and improved liver oxidative status.
Nutritional factors in transdifferentiation of scheletal muscles to adipocytes.
Mocanu et al., In Rev Med Chir Soc Med Nat Iasi, Jul 2014
The molecular mechanisms mediating the adipogenic action of thiazolidinediones and fatty acids in myoblasts could involve peroxisome proliferators-activated receptor-gamma (PPARgamma and CCAAT-enhancer-binding protein C/EBP.
[Progress of berberine for treatment of type 2 diabetes].
Xie et al., In Zhongguo Zhong Yao Za Zhi, Apr 2014
The mechanisms of berberine in diabetes include: improving the function of beta-cell; prompting insulin secretion and islets regeneration, lowing lipid level, regulating glucose and lipid metabolic by influence transcriptional factors expression such as PPARgamma, C/EBPalpha, SREBP-1c, LXR, having the activities of anti-oxidation and inhibiting reductase to repress oxidative stress state and regulate metabolic signal pathway.
Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction.
Hébert et al., Meaux, France. In Front Physiol, 2013
PPAR gamma plays a major role in both glucose and lipid metabolisms and presents circadian properties which coordinate the interplay between metabolism and CRs.
Systemic analysis of PPARγ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity.
Randolph et al., New York City, United States. In J Immunol, 2012
A key role is uncovered for macrophage PPARgamma in promoting resolution of inflammation and maintaining functionality in lung macrophages, where it regulates and supports pulmonary host defense.
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis.
Chen et al., Ann Arbor, United States. In Circulation, 2012
In a mouse model deficient in peroxisome proliferator-activated receptor-gamma in smooth muscle cells (SMPG KO mice), complete absence of perivascular adipose tissue was likely caused by PPAR-gamma deletion in the perivascular adipocyte precursor cells.
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Kim et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2012
the MGAT1 pathway induced by hepatic PPARgamma is critically important in the development of hepatic steatosis during diet-induced obesity
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Accili et al., New York City, United States. In Cell, 2012
Study reports that SirT1-dependent Ppargamma deacetylation promotes browning of subcutaneous white adipose by regulating ligand-dependent coactivator/corepressor exchange at the Ppargamma transcriptional complex.
Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-γ) in advanced prostate cancer.
Walter et al., Erlangen, Germany. In Anticancer Res, 2012
study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
A new role for cyclic phosphatidic acid as a PPARgamma antagonist.
Glass et al., San Diego, United States. In Cell Metab, 2010
A recent study in Molecular Cell (Tsukahara et al., 2010) identifies cyclic phosphatidic acid (CPA) as a naturally occurring PPARgamma antagonist that can be generated from lysophospholipids by signal-dependent activation of phospholipase D2.
Rb regulates fate choice and lineage commitment in vivo.
Lees et al., Cambridge, United States. In Nature, 2010
In contrast, pRb acts with E2F to suppress peroxisome proliferator-activated receptor gamma subunit (PPAR-gamma), the master activator of adipogenesis.
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.
Spiegelman et al., Boston, United States. In Nature, 2010
findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.
Wan et al., Dallas, United States. In Cell Metab, 2010
Long-term usage of rosiglitazone, a synthetic PPARgamma agonist, increases fracture rates among diabetic patients.
Fingered for a fat fate.
Lazar et al., Philadelphia, United States. In Cell Metab, 2010
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage.
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