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Peroxisome proliferator-activated receptor delta

PPARdelta, PPARbeta
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: PPAR, PPARgamma, ACID, Insulin, CAN
Papers on PPARdelta
Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease.
New
Souza-Mello, Rio de Janeiro, Brazil. In World J Hepatol, Jun 2015
PPAR-beta/delta is crucial to the regulation of forkhead box-containing protein O subfamily-1 expression and, hence, the modulation of enzymes that trigger hepatic gluconeogenesis.
Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice.
New
Souza-Mello et al., Rio de Janeiro, Brazil. In Mol Cell Endocrinol, Mar 2015
Treated groups demonstrated active UCP-1 beige cell clusters within sWAT, confirmed through higher gene expression of PPARalpha, PPARbeta, PGC1alpha, BMP8B, UCP-1, PRDM16 and irisin in treated groups.
Capsaicin may have important potential for promoting vascular and metabolic health.
Review
O'Keefe et al., Encinitas, United States. In Open Heart, 2014
TRPV1 activation induces calcium influx, and in certain tissues this is associated with increased activation or expression of key proteins such as endothelial nitric oxide synthase (eNOS), uncoupling protein 2 (UCP2), KLF2, PPARdelta, PPARgamma, and LXRα.
Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions.
Peijnenburg et al., Wageningen, Netherlands. In Bmc Genomics, 2014
Furthermore, only in WT-PCLS, CDCA upregulated a subset of known FXR-target genes as well as the regulator of inflammation and mitochondrial functions peroxisome proliferator- activated receptor delta (Ppar delta).
Association of peroxisome proliferator-activated receptor-delta polymorphisms with sugar metabolism indices and tumor necrosis factor alpha level.
Jin et al., Dalian, China. In Genet Mol Res, 2013
The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TNFα, and PPAR delta -87T/C of 286 patients with type 2 diabetes mellitus (T2DM) and 158 subjects with normal fasting glucose (NFG) were measured in a Dalian population.
PPAR-alpha and PPAR-beta expression changes in the hippocampus of rats undergoing global cerebral ischemia/reperfusion due to PPAR-gamma status.
Yang et al., Chongqing, China. In Behav Brain Funct, 2013
BACKGROUND: Peroxisome proliferator-activated receptors (PPARs, including alpha, beta and gamma subtypes) and their agonists have a protective role in treatment of central nervous system (CNS) diseases.
Cross-talk between heme oxygenase and peroxisome proliferator-activated receptors in the regulation of physiological functions.
Review
Ndisang, Saskatoon, Canada. In Front Biosci, 2013
The isoforms of PPAR include PPAR alpha, PPAR gamma and PPAR delta (also known as PPAR beta).
Peroxisome proliferator-activated receptor gamma as modulator of inflammation in pulmonary sarcoidosis.
Review
Jeftović-Stoimenov et al., Niš, Serbia. In Srp Arh Celok Lek, 2013
There are three subtypes of PPARs: PPARalpha (also known as NR1C3), PPARgamma (known as NR1C1) and PPARdelta (known as PPARbeta or NR1C2).
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Impact
GeneRIF
Pandolfi et al., Boston, United States. In Nat Med, 2012
A PML-PPAR-delta pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
GeneRIF
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity.
GeneRIF
Kambadur et al., Singapore, Singapore. In J Biol Chem, 2012
PPARbeta/delta is a positive regulator of skeletal muscle myogenesis, which functions through negatively modulating myostatin activity via a mechanism involving Gasp-1.
Associations of type 2 diabetes with common variants in PPARD and the modifying effect of vitamin D among middle-aged and elderly Chinese.
GeneRIF
Lin et al., Shanghai, China. In Plos One, 2011
common variants in PPARD contribute to the risk of type 2 diabetes in Chinese Hans, and provided suggestive evidence of interaction between 25(OH)D levels and PPARD-rs6902123 on HbA1c
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
GeneRIF
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
two residues (Val312 and Ile328) in the buried hormone binding pocket play special roles in PPARdelta selective binding
Endurance exercise mimetics in skeletal muscle.
Review
Narkar et al., Houston, United States. In Curr Sports Med Rep, 2010
In this article, we describe recent advances in the understanding of the key components of this circuitry [namely peroxisome proliferator activator receptor delta (PPARdelta), adenosine monophosphate (AMP)-activated protein kinase (AMPK), silent information regulator two protein 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)] that govern aerobic transformation of the skeletal muscles.
PPAR receptor activation: Experimental studies on cardiac structure and function.
Review
Bishop-Bailey, London, United Kingdom. In Curr Opin Investig Drugs, 2010
The PPARs are a family of three ligand-activated nuclear receptors: PPARalpha, PPARbeta/delta and PPARgamma.
Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta.
Review
Impact
GeneRIF
Krook et al., Stockholm, Sweden. In Pharmacol Rev, 2009
REVIEW: current status regarding the regulation, and the metabolic effects, of PPARdelta in skeletal muscle
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.
Impact
Semenkovich et al., Saint Louis, United States. In Cell, 2009
Interaction of 16:0/18:1-GPC with the PPARalpha ligand-binding domain and coactivator peptide motifs was comparable to PPARalpha agonists, but interactions with PPARdelta were weak and none were detected with PPARgamma.
Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.
Impact
Wang et al., Worcester, United States. In Cell, 2009
Interestingly, the nuclear receptor PPARdelta not only mediates the actions of PGC-1alpha but also regulates twist-1 expression, suggesting a negative-feedback regulatory mechanism.
AMPK and PPARdelta agonists are exercise mimetics.
Impact
Evans et al., Los Angeles, United States. In Cell, 2008
We found that PPARbeta/delta agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice.
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance.
Impact
GeneRIF
Chawla et al., Stanford, United States. In Cell Metab, 2008
in response to the Th2 cytokine IL-4, PPARdelta directs expression of the alternative phenotype in Kupffer cells and adipose tissue macrophages of lean mice
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