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Peroxisome proliferator activated receptor alpha

PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, V1a, CAN, HAD
Papers using PPAR antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-PPARγ polyclonal antibody was purchased from Cell Signaling Technology (Danvers, Mass); anti- ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Supplier
Yang James Y. et al., In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
Supplier
Chen Nai-hong et al., In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Supplier
Chuu Jiunn-Jye et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Supplier
Vázquez-Carrera Manuel et al., In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
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Papers on PPAR
Gut carbohydrate metabolism instead of fat metabolism regulated by gut microbes mediates high-fat diet-induced obesity.
New
Xie et al., Beijing, China. In Benef Microbes, 30 Sep 2014
Expressions of peroxisome proliferator-activated receptor gamma 2 and CCAAT/enhancer binding protein-β in visceral adipose tissues were significantly downregulated in lean mice as compared with obese mice.
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
New
Ruan et al., Wuhan, China. In Exp Mol Pathol, Jun 2014
RESULTS: PTX3 overexpression not only promoted oxLDL uptake but also significantly reduced cholesterol efflux to apoA-I; it also significantly decreased the expression of peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor alpha (LXRα) and ATP-binding membrane cassette transporter A-1 (ABCA1), which was increased with PTX3 silencing.
Modulation of adiponectin as a potential therapeutic strategy.
Review
New
Koh et al., Seoul, South Korea. In Atherosclerosis, Apr 2014
Intensive lifestyle modifications and pharmacologic agents, including peroxisome proliferator-activated receptor-γ or α agonists, some statins, renin-angiotensin-aldosterone system blockers, some calcium channel blockers, mineralocorticoid receptor blockers, new β-blockers, and several natural compounds can increase adiponectin levels and suppress or prevent disease initiation or progression, respectively, in cardiovascular and metabolic disorders.
Targeting inflammation: new therapeutic approaches in chronic kidney disease (CKD).
Review
New
Cuzzocrea et al., Messina, Italy. In Pharmacol Res, Mar 2014
Instead, palmitoylethanolamide (PEA) a member of the fatty acid ethanolamine family, is a novel non-steroidal, kidney friendly anti-inflammatory and anti-fibrotic agent with a well-documented safety profile, that may represent a potential candidate in treating CKD probably by a combination of pharmacological properties, including some activity at the peroxisome proliferator activated receptor alpha (PPAR-α).
A160: role of interleukin-1 in abnormal monocyte phenotype in systemic onset juvenile idiopathic arthritis.
New
Mellins et al., Stanford, United States. In Arthritis Rheumatol, Mar 2014
We used real time PCR to measure M1 associated genes: Interferon Regulatory factor (IRF) family IRF5, STAT1; M2 associated genes IRF4, STAT6, Kruppel-Like Factor 4 (KLF4) and peroxisome proliferator-activated receptor-γ (PPAR-γ); IL-1 secretion related genes: RAB39, RAB27A, RAB27B, P2RX7, and IL-1β.
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos.
New
Impact
Sha et al., Kunming, China. In Cell, Mar 2014
We also show that this system enables simultaneous disruption of two target genes (Ppar-γ and Rag1) in one step, and no off-target mutagenesis was detected by comprehensive analysis.
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.
New
Impact
Gerszten et al., Boston, United States. In Cell Metab, Feb 2014
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise.
New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy.
Review
New
Zhang et al., Nanjing, China. In Ppar Res, Dec 2013
Thiazolidinediones (TZDs), the synthetic exogenous ligands of nuclear receptor peroxisome proliferator-activated receptor- γ (PPAR γ ), had been thought to be a promising candidate for strengthening the therapy of DN.
Roles of FGFs as Adipokines in Adipose Tissue Development, Remodeling, and Metabolism.
Review
New
Itoh et al., Kyoto, Japan. In Front Endocrinol (lausanne), Dec 2013
The peroxisome proliferator-activated receptor γ-FGF1 axis is critical for energy homeostasis.
Biological Rationale for the Use of PPARγ Agonists in Glioblastoma.
Review
New
Kurian et al., Bristol, United Kingdom. In Front Oncol, Dec 2013
There has been interesting preliminary evidence suggesting that diabetic patients receiving peroxisome proliferator-activated receptor gamma (PPARγ) agonists, a group of anti-diabetic, thiazolidinedione drugs, have an increased median survival for glioblastoma.
Aerobic interval training attenuates mitochondrial dysfunction in rats post-myocardial infarction: roles of mitochondrial network dynamics.
New
Zang et al., Xi'an, China. In Int J Mol Sci, Dec 2013
Mitochondrial respiratory functions (as measured by the respiratory control ratio (RCR) and the ratio of ADP to oxygen consumption (P/O)); complex activities; dynamic proteins (mitofusin (mfn) 1/2, type 1 optic atrophy (OPA1) and dynamin-related protein1 (DRP1)); nuclear peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α); and the oxidative signaling of extracellular signal-regulated kinase (ERK) 1/2, c-Jun NH2-terminal protein kinase (JNK) and P53 were observed.
p53 induces skin aging by depleting Blimp1+ sebaceous gland cells.
New
Xu et al., Los Angeles, United States. In Cell Death Dis, Dec 2013
The reduction in the fat layer may result from the decrease of mammalian TOR complex 1 (mTORC1) activity accompanied by elevated expression of energy expenditure genes, and possibly as compensatory effects, leading to the elevation of peroxisome proliferator-activated receptor (PPAR)γ, an inducer of sebocyte differentiation.
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.
New
Impact
Kadowaki et al., Tokyo, Japan. In Nature, Dec 2013
Adiponectin secreted from adipocytes binds to adiponectin receptors AdipoR1 and AdipoR2, and exerts antidiabetic effects via activation of AMPK and PPAR-α pathways, respectively.
Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons.
New
Impact
Liao et al., Memphis, United States. In Cell Metab, Jun 2013
The BACE1 promoter contains multiple PPAR-RXR sites, and direct interactions among SIRT1-PPARγ-PGC-1 at these sites were enhanced with fasting.
PPARγ signaling and metabolism: the good, the bad and the future.
Review
New
Impact
Evans et al., Los Angeles, United States. In Nat Med, May 2013
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes.
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
GeneRIF
Gonzalez et al., Bethesda, United States. In J Lipid Res, 2012
is an essential regulator of bile acid biosynthesis, transport, and secretion
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
GeneRIF
Moynagh et al., Ireland. In J Biol Chem, 2012
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-beta expression via peroxisome proliferator-activated receptor-alpha.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
GeneRIF
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Impact
GeneRIF
Mathis et al., Boston, United States. In Nature, 2012
identification of peroxisome proliferator-activated receptor (PPAR)-gamma, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of visceral adipose tissue Treg cell accumulation, phenotype and function
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
GeneRIF
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) gamma activators and pan-PPAR partial agonists.
More papers using PPAR antibodies
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
Sitter Thomas et al., In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Supplier
Fantus I. George et al., In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Supplier
Wilkins Alastair et al., In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Supplier
Adams Sean H. et al., In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Supplier
Stewart LaMonica V. et al., In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Supplier
Noy Noa et al., In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Supplier
Subbaramaiah Kotha et al., In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Supplier
Li Defa et al., In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Supplier
Rosenfield Robert L. et al., In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Supplier
Travers Jeffrey B. et al., In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
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