Effects of Concurrent Training on Oxidative Capacity in Rat Gastrocnemius Muscle.
Amsterdam, Netherlands. In Med Sci Sports Exerc, 07 Apr 2013
SDH activity, mRNA expression of SDH, peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), receptor-interacting protein 140 (RIP140) and BCL2/adenovirus E1B 19 kd-interacting protein 3 (BNIP3) as well as PGC-1αprotein levels were analyzed in the low and high oxidative region of the GM.
Expression and Function of PPARs in Placenta.
Nara, Japan. In Ppar Res, Dec 2012
Peroxisome proliferator-activated receptors (PPAR) are members of the superfamily of nuclear hormone receptors involved in embryonic development and differentiation of several tissues including placenta, which respond to specific ligands such as polyunsaturated fatty acids by altering gene expression.
Novel antiinflammatory therapies for COPD.
Hartford, United States. In Chest, Nov 2012
Agents that have been approved for a non-COPD indication but that have potential for inhibiting COPD inflammation include the statins, some phosphodiesterase inhibitors, some long-acting β agonists, tiotropium bromide, the peroxisome proliferator-activated receptor-γ agonist rosiglitazone, and various monoclonal antibodies.
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
United States. In Pharmacol Rev, Oct 2012
The importance of the cytoprotective Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1/nuclear factor (erythroid-derived 2)-like 2/antioxidant response element (Keap1/Nrf2/ARE) pathway as a mechanism of action is explained, but interactions with peroxisome proliferator-activated receptor γ (PARPγ), inhibitor of nuclear factor-κB kinase complex (IKK), janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT), human epidermal growth factor receptor 2 (HER2)/ErbB2/neu, phosphatase and tensin homolog (PTEN), the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, mammalian target of rapamycin (mTOR), and the thiol proteome are also described.
Multigenerational epigenetic adaptation of the hepatic wound-healing response.
Newcastle upon Tyne, United Kingdom. In Nat Med, Sep 2012
Underlying this adaptation was less generation of liver myofibroblasts, higher hepatic expression of the antifibrogenic factor peroxisome proliferator-activated receptor γ (PPAR-γ) and lower expression of the profibrogenic factor transforming growth factor β1 (TGF-β1) compared to rats without this adaptation.
[Metabolic and regulatory function of fatty acid synthase].
More papers using
Gdańsk, Poland. In Postepy Biochem, 2011
Moreover, this review presents the recently postulated role of FAS in: a) synthesis of natural ligands of PPARalpha; b) feeding behavior; c) endothelial NO production; d) protection of cardiomiocytes from pathological calcium influx; and e) diet induced atherosclerosis.