Impact of targeted PPARγ disruption on bone remodeling.
Grand Forks, United States. In Mol Cell Endocrinol, 06 Mar 2015
UNASSIGNED: Peroxisome proliferator-activated receptor gamma (PPARγ), known as the master regulator of adipogenesis, has been regarded as a promising target for new anti-osteoporosis therapy due to its role in regulating bone marrow mesenchymal stem/progenitor cell (BMSC) lineage commitment.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
Boston, United States. In Nature, 15 Feb 2015
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity.
Pisa, Italy. In Ppar Res, Dec 2014
Peroxisome proliferator-activated receptor- (PPAR-) γ expression has been shown in thyroid tissue from patients with thyroiditis or Graves' disease and furthermore in the orbital tissue of patients with Graves' ophthalmopathy (GO), such as in extraocular muscle cells.
Neuroinflammation in Alzheimer's disease.
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Guangzhou, China. In Neuropsychiatr Dis Treat, Dec 2014
In addition, we summarize and discuss the role of intracellular signaling pathways involved in inflammatory responses in astrocytes and microglia, including the mitogen-activated protein kinase pathways, nuclear factor-kappa B cascade, and peroxisome proliferator-activated receptor-gamma transcription factors.