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Peroxisome proliferator activated receptor alpha

PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, Insulin, CAN, HAD
Papers using PPAR antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-PPARγ polyclonal antibody was purchased from Cell Signaling Technology (Danvers, Mass); anti- ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Supplier
Yang James Y. et al., In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
Supplier
Chen Nai-hong et al., In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Supplier
Chuu Jiunn-Jye et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Supplier
Vázquez-Carrera Manuel et al., In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
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Papers on PPAR
Analysis of Clinical Indexes and RUNX3, TBKBP1, PPARGC1B Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis.
New
Wang et al., Tianjin, China. In Genet Test Mol Biomarkers, 10 Jan 2015
Runt-related transcription factor 3 (RUNX3), tumor necrosis factor family member-associated NF-κB activator binding kinase 1 binding protein (TBKBP1), and peroxisome proliferator-activated receptor-gamma coactivator 1 beta (PPARGC1B) have recently been found to be associated with susceptibility to AS in patients of Western European descent.
Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis.
New
van Horssen et al., In Acta Neuropathol Commun, 10 Jan 2015
In this study, we explored the distribution and role of the mitochondrial antioxidants peroxiredoxin-3 and thioredoxin-2 as well as their regulator peroxisome proliferator-activated receptor gamma coactivator1-alpha (PGC-1¿) in MS pathogenesis.Immunohistochemical analysis of a large cohort of MS patients revealed a striking upregulation of PGC-1¿ and downstream mitochondrial antioxidants in active demyelinating MS lesions.
Stimulatory effect of plasma samples from fattening cattle on adipogenesis-related gene expression in preadipocyte cells.
New
Aso et al., Sendai, Japan. In Anim Sci J, 09 Jan 2015
The mRNA expressions of stearoyl-CoA desaturase, adipocyte Protein 2, peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein 1 in BIP cells were significantly higher following treatment with those plasma samples collected from the cattle with the highest diaphragmatic unsaturated fatty acids to saturated fatty acids ratio (US/S).
Nutrient-sensing nuclear receptors coordinate autophagy.
New
Impact
Moore et al., Houston, United States. In Nature, 04 Jan 2015
This response is lost in PPARα knockout (Ppara(-/-), also known as Nr1c1(-/-)) mice, which are partially defective in the induction of autophagy by fasting.
Biological evaluation and structural insights for design of subtype-selective peroxisome proliferator activated receptor-α (PPAR-α) agonists.
New
Sangamwar et al., India. In Bioorg Med Chem Lett, 26 Dec 2014
UNLABELLED: Peroxisome proliferator activated receptors-α (PPAR-α) control the expression of several genes involved in diseases like diabetes, hyperlipidaemia, and inflammatory disorders.
A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: Increasing glutamate uptake with PPARγ agonists.
Review
New
Kaye et al., Melbourne, Australia. In J Clin Neurosci, 22 Dec 2014
UNLABELLED: The established role of glutamate in the pathogenesis of glioma-associated seizures (GAS) led us to investigate a novel treatment method using an established drug class, peroxisome proliferator activated receptor (PPAR) gamma agonists.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
New
Impact
Spiegelman et al., Boston, United States. In Nature, 17 Dec 2014
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Botanical compounds and their regulation of nuclear receptor action: The case of traditional Chinese medicine.
Review
New
Laudet et al., Lyon, France. In Mol Cell Endocrinol, 06 Dec 2014
We exemplified well-characterized TCM action mediated by NR such as steroid receptors (ER, GR, AR), metabolic receptors (PPAR, LXR, FXR, PXR, CAR) and RXR.
Molecular Mechanism of PPARα Action and its Impact on Lipid Metabolism, Inflammation and Fibrosis in Non-Alcoholic Fatty Liver Disease.
Review
New
Staels et al., Lille, France. In J Hepatol, 01 Dec 2014
UNLABELLED: Peroxisome Proliferator-Activated Receptor α (PPARα) is a ligand-activated transcription factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor subfamily.
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.
New
Impact
Kopf et al., Zürich, Switzerland. In Nat Immunol, 30 Nov 2014
We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs).
PPAR gamma gene - A review.
Review
New
Ranjitha Kumari et al., India. In Diabetes Metab Syndr, 13 Nov 2014
UNLABELLED: Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
New
Impact
Kalluri et al., Houston, United States. In Nat Cell Biol, Oct 2014
Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.
Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
New
Impact
Ruas et al., Stockholm, Sweden. In Cell, Oct 2014
This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1α1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.
Circadian rhythms, Wnt/beta-catenin pathway and PPAR alpha/gamma profiles in diseases with primary or secondary cardiac dysfunction.
Review
New
Hébert et al., Meaux, France. In Front Physiol, Dec 2013
Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta, and gamma) play a key role in metabolic regulatory processes, particularly in heart muscle.
Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity.
New
Radak et al., Budapest, Hungary. In Plos One, Dec 2013
LCR-T had significantly higher levels of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1α), decreased levels of reactive oxygen species and increased acetylated p53 compared to LCR-C, while training produced no significant changes for these measures in HCR rats.
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
GeneRIF
Gonzalez et al., Bethesda, United States. In J Lipid Res, 2012
is an essential regulator of bile acid biosynthesis, transport, and secretion
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
GeneRIF
Moynagh et al., Ireland. In J Biol Chem, 2012
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-beta expression via peroxisome proliferator-activated receptor-alpha.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
GeneRIF
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Impact
GeneRIF
Mathis et al., Boston, United States. In Nature, 2012
identification of peroxisome proliferator-activated receptor (PPAR)-gamma, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of visceral adipose tissue Treg cell accumulation, phenotype and function
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
GeneRIF
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) gamma activators and pan-PPAR partial agonists.
More papers using PPAR antibodies
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
Sitter Thomas et al., In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Supplier
Fantus I. George et al., In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Supplier
Wilkins Alastair et al., In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Supplier
Adams Sean H. et al., In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Supplier
Stewart LaMonica V. et al., In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Supplier
Noy Noa et al., In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Supplier
Subbaramaiah Kotha et al., In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Supplier
Li Defa et al., In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Supplier
Rosenfield Robert L. et al., In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Supplier
Travers Jeffrey B. et al., In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
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