Crystal structures of the human adiponectin receptors.
Yokohama, Japan. In Nature, 08 May 2015
UNASSIGNED: Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids.
Melbourne, Australia. In J Nutr Biochem, 26 Mar 2015
The complex actions of EPA include increased G-protein-receptor-mediated release of glucagon-like peptide 1 (GLP-1) from enteroendocrine L-cells in the intestine, up-regulation of the apelin pathway and down-regulation of other control pathways to promote insulin secretion by the pancreatic β-cells, together with suppression of inflammatory responses to adipokines, inhibition of peroxisome proliferator-activated receptor α actions and prevention of decreased insulin-like growth factor-1 secretion to improve peripheral insulin responses.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
Boston, United States. In Nature, Feb 2015
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin.
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Tehrān, Iran. In Int J Endocrinol Metab, Oct 2014
RESULTS: Curcumin can reduce blood glucose level by reducing the hepatic glucose production, suppression of hyperglycemia-induced inflammatory state, stimulation of glucose uptake by up-regulation of GLUT4, GLUT2 and GLUT3 genes expressions, activation of AMP kinase, promoting the PPAR ligand-binding activity, stimulation of insulin secretion from pancreatic tissues, improvement in pancreatic cell function, and reduction of insulin resistance.