Effects of dietary phosphate on glucose and lipid metabolism.
Tokushima, Japan. In Am J Physiol Endocrinol Metab, Feb 2016
On the other hand, uncoupling protein 1 (UCP1) and peroxisome proliferator-activated receptor gamma coactivator alpha (PGC1α) expression were significantly increased in the brown adipose tissue (BAT) of HP group.
Caloric restriction and exercise "mimetics'': Ready for prime time?
Basel, Switzerland. In Pharmacol Res, Jan 2016
Interestingly, many of these compounds activate related signaling pathways, most often postulated to act on the common downstream effector peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in skeletal muscle.
Crystal structures of the human adiponectin receptors.
Yokohama, Japan. In Nature, May 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Biomarkers in Diabetic Retinopathy.
More papers using
Sydney, Australia. In Rev Diabet Stud, 2014
Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics.