NCoR negatively regulates adipogenic differentiation of mesenchymal stem cells.
Jinan, China. In In Vitro Cell Dev Biol Anim, 28 Jun 2015
It further proved that small interfering RNA (siRNA)-mediated knockdown of NCoR could promote cell viability and differentiation and enhance messenger RNA (mRNA) expression of lipoprotein lipase (LPL) and protein expression of CCAAT/enhancer binding protein-α (C/EBPα) and peroxisome proliferator-activated receptor-γ (PPARγ).
PPARγ Inhibits Hypoxia-induced Store-operated Calcium Entry by Suppressing Caveolin-1.
Baltimore, United States. In Am J Respir Cell Mol Biol, 28 Jun 2015
RATIONALE: Our previous publication demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) inhibits the pathogenesis of chronic hypoxia-induced pulmonary hypertension (CHPH) by targeting store-operated calcium entry (SOCE) in rat distal pulmonary arterial smooth muscle cells (PASMCs).
The emerging role of Nrf2 in mitochondrial function.
Dundee, United Kingdom. In Free Radic Biol Med, 11 Jun 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased ROS production in mitochondria by transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Crystal structures of the human adiponectin receptors.
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Yokohama, Japan. In Nature, 16 May 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.