Interaction Between Pro12Ala Polymorphism of PPARγ2 and Diet on Adiposity Phenotypes.
Napoli, Italy. In Curr Atheroscler Rep, 31 Dec 2014
UNLABELLED: The aim of this report is to perform a systematic review and qualitative synthesis of the literature to address whether, and to what extent, diet modulates the effects of the Pro12Ala polymorphism of peroxisome proliferator-activated receptor gamma 2 (PPARγ2) on body weight and other measures of adiposity.
Role of adiponectin system in insulin resistance.
Pisa, Italy. In Mol Genet Metab, 16 Oct 2014
Adiponectin exerts insulin-sensitizing effects through binding to its receptors, leading to activation of AMPK, PPAR-α, and potentially other unknown molecular pathways.
A20--an omnipotent protein in the liver: prometheus myth resolved?
In Adv Exp Med Biol, Dec 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
Apoptosis, Fibrosis and Senescence.
Charlottesville, United States. In Nephron Clin Pract, Dec 2013
Furthermore, increased expression of nuclear peroxisome proliferator-activated receptor-α in proximal tubules can directly reduce increased expression of transforming growth factor-β1 and interstitial inflammation in models of renal fibrosis, which suggests preservation of proximal tubule cell metabolism and integrity represents an important new therapeutic target.
Mitochondrial Biogenesis in the Acutely Injured Kidney.
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Boston, United States. In Nephron Clin Pract, Dec 2013
Emerging literature suggests that a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor-γ-coactivator-1α (PGC-1α), is highly expressed in the tubular epithelium of the healthy kidney, and its induction during the post-injury period may contribute to functional recovery from acute kidney injury.