GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Peroxisome proliferator activated receptor alpha
PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
PPAR
antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
In Pulmonary Medicine, 2010
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Supplier
In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Supplier
In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
more suppliersSupplier
In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Papers on
PPAR
Review: Endocrine disrupting chemicals and immune responses: a focus on bisphenol-A and its potential mechanisms.
Review
New
Calgary, Canada. In Mol Immunol, 30 Apr 2013
Finally, we consider that these immunological activities of BPA may be mediated through estrogen receptor signaling, arylhydrocarbon receptor, and the peroxisome proliferator-activated receptor family of nuclear receptors.
Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of HIF-1 and Upregulation of PPARα
New
Newark, United States. In Circ Res, 08 Apr 2013
Hypoxia-inducible factor-1α (HIF-1α) was downregulated while peroxisome proliferator-activated receptor-alpha (PPARα was upregulated in Tg-DN-Nox mice.
Effects of Concurrent Training on Oxidative Capacity in Rat Gastrocnemius Muscle.
New
Amsterdam, Netherlands. In Med Sci Sports Exerc, 07 Apr 2013
SDH activity, mRNA expression of SDH, peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), receptor-interacting protein 140 (RIP140) and BCL2/adenovirus E1B 19 kd-interacting protein 3 (BNIP3) as well as PGC-1αprotein levels were analyzed in the low and high oxidative region of the GM.
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs.
New
Impact
Los Angeles, United States. In Nature, 07 Mar 2013
Here we show that induction of adult-like metabolic energetics from an embryonic/glycolytic state and abnormal peroxisome proliferator-activated receptor gamma (PPAR-γ) activation underlie the pathogenesis of ARVD/C.
PPAR γ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid.
New
Matsumoto, Japan. In J Lipids, Dec 2012
These LPL-related responses are mediated by cell surface G-protein-coupled receptors and also intracellular receptor peroxisome proliferator-activated receptor gamma (PPAR ).
Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs.
New
Australia. In Ppar Res, Dec 2012
PPAR mediated gene activation is ultimately involved in maintenance of cellular homeostasis through the transcriptional regulation of metabolic enzymes and transporters that target the activating ligand.
Expression and Function of PPARs in Placenta.
New
Nara, Japan. In Ppar Res, Dec 2012
Peroxisome proliferator-activated receptors (PPAR) are members of the superfamily of nuclear hormone receptors involved in embryonic development and differentiation of several tissues including placenta, which respond to specific ligands such as polyunsaturated fatty acids by altering gene expression.
Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects.
Review
New
New York City, United States. In Am Heart J, Nov 2012
Dual-peroxisome proliferator-activated receptor (PPAR) α/γ agonists may offer opportunities to lower macrovascular and microvascular complications of type 2 diabetes mellitus beyond the reductions achieved with conventional risk-factor modification.
Novel antiinflammatory therapies for COPD.
Review
New
Hartford, United States. In Chest, Nov 2012
Agents that have been approved for a non-COPD indication but that have potential for inhibiting COPD inflammation include the statins, some phosphodiesterase inhibitors, some long-acting β agonists, tiotropium bromide, the peroxisome proliferator-activated receptor-γ agonist rosiglitazone, and various monoclonal antibodies.
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.
New
Impact
Iowa City, United States. In Cell Metab, Nov 2012
Dominant-negative (DN) mutations in the nuclear hormone receptor peroxisome proliferator-activated receptor-γ (PPARγ) cause hypertension by an unknown mechanism.
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.
Review
New
Impact
United States. In Pharmacol Rev, Oct 2012
The importance of the cytoprotective Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1/nuclear factor (erythroid-derived 2)-like 2/antioxidant response element (Keap1/Nrf2/ARE) pathway as a mechanism of action is explained, but interactions with peroxisome proliferator-activated receptor γ (PARPγ), inhibitor of nuclear factor-κB kinase complex (IKK), janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT), human epidermal growth factor receptor 2 (HER2)/ErbB2/neu, phosphatase and tensin homolog (PTEN), the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway, mammalian target of rapamycin (mTOR), and the thiol proteome are also described.
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
New
Impact
Boston, United States. In Nat Med, Sep 2012
Here we identify a previously unknown promyelocytic leukemia (PML)–peroxisome proliferator-activated receptor δ (PPAR-δ)–fatty-acid oxidation (FAO) pathway for the maintenance of hematopoietic stem cells (HSCs).
Multigenerational epigenetic adaptation of the hepatic wound-healing response.
New
Impact
Newcastle upon Tyne, United Kingdom. In Nat Med, Sep 2012
Underlying this adaptation was less generation of liver myofibroblasts, higher hepatic expression of the antifibrogenic factor peroxisome proliferator-activated receptor γ (PPAR-γ) and lower expression of the profibrogenic factor transforming growth factor β1 (TGF-β1) compared to rats without this adaptation.
[Endothelial progenitor cells and vascular health: effects of lifestyle's modifications].
Review
New
Florence, Italy. In Monaldi Arch Chest Dis, Jun 2012
In addition to some pharmacological treatment such as statins, erythropoietin, PPAR-gamma agonists and angiotensin-II receptor antagonists, the effects of healthy lifestyle, via mobilization and functional improvement of EPC, is increasingly recognized.
[Metabolic and regulatory function of fatty acid synthase].
Review
Gdańsk, Poland. In Postepy Biochem, 2011
Moreover, this review presents the recently postulated role of FAS in: a) synthesis of natural ligands of PPARalpha; b) feeding behavior; c) endothelial NO production; d) protection of cardiomiocytes from pathological calcium influx; and e) diet induced atherosclerosis.
Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α.
GeneRIF
Ann Arbor, United States. In J Biol Chem, 2011
CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalpha
Menin prevents liver steatosis through co-activation of peroxisome proliferator-activated receptor alpha.
GeneRIF
Shanghai, China. In Febs Lett, 2011
menin acts synergistically with the nuclear receptor PPARalpha to control gene expression of fatty acid oxidation
Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways.
GeneRIF
Uji, Japan. In Am J Physiol Endocrinol Metab, 2011
Farnesol could improve metabolic abnormalities in mice via both PPARalpha-dependent and -independent pathways and that the activation of FXR by farnesol might contribute partially to the PPARalpha-independent hepatic triglyceride content-lowering effect.
Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.
GeneRIF
New York City, United States. In J Biol Chem, 2011
Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction.
[All signs of metabolic syndrome in the hypertensive ISIAH rats are associated with increased activity of transcription factors PPAR, LXR, PXR, and CAR in the liver].
More papers using
PPAR
antibodies
GeneRIF
In Biomed Khim, 2011
Integrated investigation of PPAR, LXR, PXR, CAR regulatory mechanisms, signal transduction and transcriptional targets will provide insights into the pathogenesis of MS and offer valuable information for designing of drugs for MS treatment.
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Supplier
In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Supplier
In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1α and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
Supplier
In PPAR Research, 2004
... ], PPAR-γ (Rosiglitozone; 10 μM, Cayman Chemical) [ ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Supplier
In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Supplier
In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Supplier
In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Supplier
In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Supplier
In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Supplier
In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Supplier
In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Supplier
In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
