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Peroxisome proliferator activated receptor alpha

PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, V1a, CAN, HAD
Papers using PPAR antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-PPARγ polyclonal antibody was purchased from Cell Signaling Technology (Danvers, Mass); anti- ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Yang James Y. et al., In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
Chen Nai-hong et al., In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Chuu Jiunn-Jye et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Vázquez-Carrera Manuel et al., In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
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Papers on PPAR
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.
Kopf et al., Zürich, Switzerland. In Nat Immunol, 30 Nov 2014
We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs).
Carrot juice fermented with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats.
Xie et al., In J Agric Food Chem, 22 Nov 2014
In addition, NCU and FCJ had restored the antioxidant capacity, morphology of pancreas and kidney, and up regulated mRNA of low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (CYP7A1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ).
PGC-1α Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons.
Cowell et al., Birmingham, United States. In J Neurosci, 22 Nov 2014
Accumulating evidence strongly implicates the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in the pathophysiology of multiple neurological disorders, but the downstream gene targets of PGC-1α in the brain have remained enigmatic.
PPAR-γ promotes endothelial cell migration By inducing the expression of Sema3g.
Wang et al., Beijing, China. In J Cell Biochem, 21 Nov 2014
UNLABELLED: In addition to regulating lipid and glucose metabolism, the nuclear receptor PPAR-γ has emerged as a potentially relevant player in regulating endothelial cell function.
In Utero Exposure to Pre-Pregnancy Maternal Obesity and Post-weaning High Fat Diet Impairs Regulators of Mitochondrial Dynamics in Rat Placenta and Offspring.
Shankar et al., United States. In Physiol Genomics, 21 Nov 2014
Putative transcriptional regulators of mitochondrial dynamics were reduced in rat placenta and offspring liver and skeletal muscle (peroxisome proliferator-activated receptor gamma co-activator (PGC1)α, PGC1β, and estrogen-related receptor (ERR)α), consistent with indirect calorimetry findings revealing reduced energy expenditure and impaired fat utilization.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
Kalluri et al., Houston, United States. In Nat Cell Biol, 31 Oct 2014
Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression.
Ruas et al., Stockholm, Sweden. In Cell, 25 Oct 2014
This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1α1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.
The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation.
Panati et al., Cuddapah, India. In Int Immunopharmacol, 17 Oct 2014
The aim of the study was to collect all the literature on NFAs and its interactions with peroxisome proliferator-activated receptor gamma (PPAR-γ) and review in detail the anti-inflammatory properties of PPAR-γ interceded by NFAs.
Role of adiponectin system in insulin resistance.
Caselli, Pisa, Italy. In Mol Genet Metab, 16 Oct 2014
Adiponectin exerts insulin-sensitizing effects through binding to its receptors, leading to activation of AMPK, PPAR-α, and potentially other unknown molecular pathways.
Insulin resistance in Alzheimer's disease.
Denner et al., Galveston, United States. In Neurobiol Dis, 16 Oct 2014
Of note are human and animal model studies geared toward improving insulin resistance that have led to the identification of the nuclear receptor and transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ) as an intervention tool for early AD.
The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.
Davis et al., Worcester, United States. In Cell Metab, 02 Oct 2014
Here, we demonstrate that hepatic JNK potently represses the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα).
Physiological functions of peroxisome proliferator-activated receptor β.
Grimaldi et al., Nice, France. In Physiol Rev, Jul 2014
The physiological functions of PPARβ remained for a while less investigated, but the finding that specific synthetic agonists exert beneficial actions in obese subjects uplifted the studies aimed to elucidate the roles of this PPAR isoform.
[Modern methods of correction of systemic inflammation and insulin resistance by patients with coronary heart disease and diabetes mellitus type 2].
Shaenko et al., In Lik Sprava, Mar 2014
Debate the use of "submaximal" double and triple agonist PPAR.
Oxidized Low-Density Lipoprotein Suppresses Expression of Prostaglandin E Receptor Subtype EP3 in Human THP-1 Macrophages.
Huang et al., Shantou, China. In Plos One, Dec 2013
Moreover, oxLDL inhibited nuclear factor-κB (NF-κB)-dependent transcription of the EP3 gene by the activation of peroxisome proliferator-activated receptor-γ (PPAR-γ).
Role of PPAR γ in the Differentiation and Function of Neurons.
Cabezas-Opazo et al., Santiago, Chile. In Ppar Res, Dec 2013
Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases.
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
Gonzalez et al., Bethesda, United States. In J Lipid Res, 2012
is an essential regulator of bile acid biosynthesis, transport, and secretion
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
Moynagh et al., Ireland. In J Biol Chem, 2012
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-beta expression via peroxisome proliferator-activated receptor-alpha.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Mathis et al., Boston, United States. In Nature, 2012
identification of peroxisome proliferator-activated receptor (PPAR)-gamma, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of visceral adipose tissue Treg cell accumulation, phenotype and function
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) gamma activators and pan-PPAR partial agonists.
More papers using PPAR antibodies
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Sitter Thomas et al., In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
Lipid peroxidation and redox-sensitive signaling pathways
Santanam Nalini et al., In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Fantus I. George et al., In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Wilkins Alastair et al., In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Adams Sean H. et al., In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Stewart LaMonica V. et al., In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Noy Noa et al., In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Subbaramaiah Kotha et al., In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Li Defa et al., In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Rosenfield Robert L. et al., In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Travers Jeffrey B. et al., In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
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