Analytes and Metabolites Associated With Muscle Quality in Young, Healthy Adults.
Boston, United States. In Med Sci Sports Exerc, 19 Dec 2014
RESULTS: Metabolites or analytes related to dietary protein intake (albumin, branched chain amino acids (BCAAs)) and excitation-contraction coupling (calcium, magnesium) were positively associated, whereas metabolites related to gut bacterial metabolism (cinamoylglycine, hydrocinnamate, hippurate, indolepropionate) and peroxisome proliferator activated receptor-alpha (PPAR-α) (methylglutarylcarnintine, cinnamoylglycine) activation were negatively associated with LP/Lean.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
Boston, United States. In Nature, 17 Dec 2014
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver.
Ube, Japan. In World J Gastroenterol, 28 Nov 2014
Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form of nicotinamide adenine dinucleotide in hepatocytes; increasing hepatic sterol regulatory element-binding protein (SREBP)-1, plasminogen activator inhibitor (PAI)-1, and early growth response-1 activity; and decreasing hepatic peroxisome proliferator-activated receptor-α activity.
Role of adiponectin system in insulin resistance.
Pisa, Italy. In Mol Genet Metab, 16 Oct 2014
Adiponectin exerts insulin-sensitizing effects through binding to its receptors, leading to activation of AMPK, PPAR-α, and potentially other unknown molecular pathways.
A20--an omnipotent protein in the liver: prometheus myth resolved?
In Adv Exp Med Biol, Dec 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
Identification of Creb3l4 as an essential negative regulator of adipogenesis.
More papers using
Seoul, South Korea. In Cell Death Dis, Dec 2013
In 3T3-L1 preadipocytes, Creb3l4 knockdown resulted in increased expression of peroxisome proliferator-activated receptor γ (PPARγ2) and CCAAT/enhancer binding protein (C/EBPα), either by increasing the protein stability of C/EBPβ or by decreasing the expression of GATA3, a negative regulator of PPARγ2 expression.