Long Term Metabolic Alterations in a Febrile Seizure Model.
Wuhan, China. In Int J Neurosci, 22 Jun 2015
These changes were accompanied by increased mRNA expression of genes such as phosphoenolpyruvate carboxykinase (PEPCK) and carnitine palmitoyl transferase-1 (CPT-1), but not peroxisome proliferator-activated receptor α (PPARα).
The emerging role of Nrf2 in mitochondrial function.
Dundee, United Kingdom. In Free Radic Biol Med, 11 Jun 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased ROS production in mitochondria by transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Crystal structures of the human adiponectin receptors.
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Yokohama, Japan. In Nature, 16 May 2015
Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.