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Peroxisome proliferator activated receptor alpha

PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, Insulin, CAN, HAD
Papers using PPAR antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-PPARγ polyclonal antibody was purchased from Cell Signaling Technology (Danvers, Mass); anti- ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Supplier
Yang James Y. et al., In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
Supplier
Chen Nai-hong et al., In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Supplier
Chuu Jiunn-Jye et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Supplier
Vázquez-Carrera Manuel et al., In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
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Papers on PPAR
Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity and type 2 diabetes in humans and mice.
New
Holvoet et al., Leuven, Belgium. In Int J Obes (lond), 14 May 2015
We investigated the effect of caloric restriction and PPAR agonist treatment on Cox in obese diabetic mice, and that of diet-induced insulin resistance in Streptozotocin-treated mice.
Hikiamides A-C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456.
New
Igarashi et al., Toyama, Japan. In J Nat Prod, 14 May 2015
They also induced PPAR-γ-dependent gene expression at a concentration from 0.63 to 10 μM in a gene reporter assay.
New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.
New
Abdalla et al., São Paulo, Brazil. In Vascul Pharmacol, 10 May 2015
UNASSIGNED: Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ (PPARγ■) agonists that improve insulin-mediated glucose uptake and possess beneficial vasculoprotective actions.
Crystal structures of the human adiponectin receptors.
New
Impact
Yokoyama et al., Yokohama, Japan. In Nature, 08 May 2015
UNASSIGNED: Adiponectin stimulation of its receptors, AdipoR1 and AdipoR2, increases the activities of 5' AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR), respectively, thereby contributing to healthy longevity as key anti-diabetic molecules.
Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.
New
Impact
Mitro et al., Milano, Italy. In Cell Metab, 07 May 2015
These metabolic alterations are the result of local accumulation of two endogenous peroxisome proliferator-activated receptor-α (Pparα) ligands, 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphatidylcholine and 1-stearoyl-2-oleyl-sn-glycerol-3-phosphatidylcholine.
Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control.
Review
New
Paquot et al., Liège, Belgium. In Diabetes Metab, 17 Apr 2015
Most studies have used metformin, an AMP-activated protein kinase (AMPK) activator, and thiazolidinediones (TZDs), which act as peroxisome proliferator-activated receptor-gamma (PPARγ) agonists.
A step ahead of PPARγ full agonists to PPARγ partial agonists: therapeutic perspectives in the management of diabetic insulin resistance.
Review
New
Balakumar et al., Bedung, Malaysia. In Eur J Pharmacol, 04 Apr 2015
PPARs bind natural or synthetic PPAR ligands do function as cellular sensors to regulate the gene transcription.
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
New
Impact
Kallies et al., Australia. In Nat Immunol, 31 Mar 2015
Their development depends on the transcription factor PPAR-γ; however, the environmental cues required for their differentiation are unknown.
Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids.
Review
New
Brown et al., Melbourne, Australia. In J Nutr Biochem, 26 Mar 2015
The complex actions of EPA include increased G-protein-receptor-mediated release of glucagon-like peptide 1 (GLP-1) from enteroendocrine L-cells in the intestine, up-regulation of the apelin pathway and down-regulation of other control pathways to promote insulin secretion by the pancreatic β-cells, together with suppression of inflammatory responses to adipokines, inhibition of peroxisome proliferator-activated receptor α actions and prevention of decreased insulin-like growth factor-1 secretion to improve peripheral insulin responses.
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.
New
Impact
Spiegelman et al., Boston, United States. In Nature, Feb 2015
Previous work has shown that phosphorylation of PPARγ (peroxisome proliferator-activated receptor γ) at serine 273 by cyclin-dependent kinase 5 (Cdk5) stimulates diabetogenic gene expression in adipose tissues.
Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection.
New
Impact
Gallo et al., San Diego, United States. In Science, Feb 2015
Impaired adipogenesis resulted in increased infection as seen in Zfp423(nur12) mice or in mice given inhibitors of peroxisome proliferator-activated receptor γ.
Breaking the mold: transcription factors in the anucleate platelet and platelet-derived microparticles.
Review
New
Phipps et al., Rochester, United States. In Front Immunol, Dec 2014
Our lab and others have discovered the presence and non-genomic roles of transcription factors in platelets, such as the nuclear factor kappa β (NFκB) family of proteins and peroxisome proliferator-activated receptor gamma (PPARγ).
PPARD +294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between PPARD +294T/C polymorphism and serum lipid profiles.
New
Peng et al., In Lipids Health Dis, Dec 2014
BACKGROUND: The +294T/C polymorphism in the peroxisome proliferator-activated receptor delta (PPARD) gene is associated with hyperlipidemia in several younger populations, but results are still inconsistence across ethnic groups and its possible impact on the lipid profiles of long-lived individuals remains unexploited.
The Effect of Baicalin as A PPAR Activator on Erythroid Differentiation of CD133(+)Hematopoietic Stem Cells in Umbilical Cord Blood.
New
Ejtehadifar et al., Tabrīz, Iran. In Cell J, Dec 2014
OBJECTIVE: The peroxisome proliferator-activated receptors (PPARs) are a group of nu- clear receptor proteins whose functions as transcription factors regulate gene expres- sions.
Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin.
Review
New
Mirmiran et al., Tehrān, Iran. In Int J Endocrinol Metab, Oct 2014
RESULTS: Curcumin can reduce blood glucose level by reducing the hepatic glucose production, suppression of hyperglycemia-induced inflammatory state, stimulation of glucose uptake by up-regulation of GLUT4, GLUT2 and GLUT3 genes expressions, activation of AMP kinase, promoting the PPAR ligand-binding activity, stimulation of insulin secretion from pancreatic tissues, improvement in pancreatic cell function, and reduction of insulin resistance.
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
GeneRIF
Gonzalez et al., Bethesda, United States. In J Lipid Res, 2012
is an essential regulator of bile acid biosynthesis, transport, and secretion
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
GeneRIF
Moynagh et al., Ireland. In J Biol Chem, 2012
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-beta expression via peroxisome proliferator-activated receptor-alpha.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
GeneRIF
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Impact
GeneRIF
Mathis et al., Boston, United States. In Nature, 2012
identification of peroxisome proliferator-activated receptor (PPAR)-gamma, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of visceral adipose tissue Treg cell accumulation, phenotype and function
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
GeneRIF
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) gamma activators and pan-PPAR partial agonists.
More papers using PPAR antibodies
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
Sitter Thomas et al., In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Supplier
Fantus I. George et al., In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Supplier
Wilkins Alastair et al., In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Supplier
Adams Sean H. et al., In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Supplier
Stewart LaMonica V. et al., In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Supplier
Noy Noa et al., In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Supplier
Subbaramaiah Kotha et al., In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Supplier
Li Defa et al., In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Supplier
Rosenfield Robert L. et al., In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Supplier
Travers Jeffrey B. et al., In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
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