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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Peroxisome proliferator activated receptor alpha

PPAR, PPARalpha, peroxisome proliferator-activated receptor
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, V1a, CAN, HAD
Papers using PPAR antibodies
Association of hepatocyte growth factor promoter polymorphism with severity of interstitial lung disease in Japanese patients with systemic sclerosis
Supplier
Silver Richard M. et al., In Pulmonary Medicine, 2010
... Anti-PPARγ polyclonal antibody was purchased from Cell Signaling Technology (Danvers, Mass); anti- ...
Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease
Supplier
Yang James Y. et al., In Experimental Diabetes Research, 2009
... were obtained from the following vendors, respectively: ERK1/2 and phospho-ERK1/2 (#9100), Cell Signaling (Beverly, Mass); PPARα (sc9000) and AR (sc17735), Santa Cruz Biotechnology Inc ...
Sub-chronic administration of the 11β-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity
Supplier
Chen Nai-hong et al., In Experimental Diabetes Research, 2007
... -HSD1 primary antibody and PPAR-γ primary antibody for western blot were from Abcam Biotechnology (England) ...
Electrolytes and Na+-K+-ATPase: potential risk factors for the development of diabetic nephropathy
Supplier
Chuu Jiunn-Jye et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... Mouse monoclonal antibodies-PPARγ and HRP anti-mouse IgG were from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
Supplier
Vázquez-Carrera Manuel et al., In Diabetes, 2007
... The PPAR-δ ligand GW501516 was obtained from Biomol Research Laboratories (Plymouth Meeting, ...
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Papers on PPAR
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.
New
Impact
Kopf et al., Zürich, Switzerland. In Nat Immunol, 30 Nov 2014
We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs).
Gallic Acid Regulates Body Weight and Glucose Homeostasis Through AMPK Activation.
New
Kim et al., Wŏnju, South Korea. In Endocrinology, 30 Nov 2014
Here we report that GA plays its role through the activation of AMP-activated protein kinase (AMPK) and by regulating mitochondrial function via the activation of peroxisome proliferator-activated receptor-γ coactivator1α (PGC1α).
Ethanol and liver: Recent insights into the mechanisms of ethanol-induced fatty liver.
New
Liu, Ube, Japan. In World J Gastroenterol, 28 Nov 2014
Alcohol induces fatty liver by increasing the ratio of reduced form of nicotinamide adenine dinucleotide to oxidized form of nicotinamide adenine dinucleotide in hepatocytes; increasing hepatic sterol regulatory element-binding protein (SREBP)-1, plasminogen activator inhibitor (PAI)-1, and early growth response-1 activity; and decreasing hepatic peroxisome proliferator-activated receptor-α activity.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.
New
Impact
Kalluri et al., Houston, United States. In Nat Cell Biol, 31 Oct 2014
Invasive cancer cells use the transcription coactivator peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A, also known as PGC-1α) to enhance oxidative phosphorylation, mitochondrial biogenesis and the oxygen consumption rate.
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression.
New
Impact
Ruas et al., Stockholm, Sweden. In Cell, 25 Oct 2014
This study opens therapeutic avenues for the treatment of depression by targeting the PGC-1α1-PPAR axis in skeletal muscle, without the need to cross the blood-brain barrier.
The role of nitrated fatty acids and peroxisome proliferator-activated receptor gamma in modulating inflammation.
Review
New
Panati et al., Cuddapah, India. In Int Immunopharmacol, 17 Oct 2014
The aim of the study was to collect all the literature on NFAs and its interactions with peroxisome proliferator-activated receptor gamma (PPAR-γ) and review in detail the anti-inflammatory properties of PPAR-γ interceded by NFAs.
Role of adiponectin system in insulin resistance.
Review
New
Caselli, Pisa, Italy. In Mol Genet Metab, 16 Oct 2014
Adiponectin exerts insulin-sensitizing effects through binding to its receptors, leading to activation of AMPK, PPAR-α, and potentially other unknown molecular pathways.
The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.
New
Impact
Davis et al., Worcester, United States. In Cell Metab, 02 Oct 2014
Here, we demonstrate that hepatic JNK potently represses the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα).
Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity.
New
Russell et al., Ann Arbor, United States. In Ann Clin Transl Neurol, Aug 2014
Hyperphosphorylated tau was accumulated within mitochondria and peroxisome proliferator-activated receptor-gamma coactivator 1α, the NAD(+)-dependent protein deacetylase sirtuin 1, and mitochondrial transcription factor A were downregulated in the aged LCR rat hippocampus.
Physiological functions of peroxisome proliferator-activated receptor β.
Review
New
Impact
Grimaldi et al., Nice, France. In Physiol Rev, Jul 2014
The physiological functions of PPARβ remained for a while less investigated, but the finding that specific synthetic agonists exert beneficial actions in obese subjects uplifted the studies aimed to elucidate the roles of this PPAR isoform.
[Modern methods of correction of systemic inflammation and insulin resistance by patients with coronary heart disease and diabetes mellitus type 2].
Review
New
Shaenko et al., In Lik Sprava, Mar 2014
Debate the use of "submaximal" double and triple agonist PPAR.
The regulation of catalase activity by PPAR γ is affected by α-synuclein.
New
Sharon et al., Jerusalem, Israel. In Ann Clin Transl Neurol, Mar 2014
Moreover, we found that α-Syn expression downregulate the peroxisome proliferator-activated receptor (PPAR)γ, which controls catalase transcription.
Effect of Coptidis Rhizoma extracts in a water-based solution on insulin resistance in 3T3-L1 adipocytes.
New
Wang et al., Shanghai, China. In Biomed Res, Dec 2013
Potential roles of CRE in glucose consumption, mRNA expression of peroxisome proliferators activated receptor (PPAR-γ), expression of insulin receptor substrate-1 (IRS-1) protein, and phosphorylation of IRS-1 Ser307 were also investigated in the present study.
Role of PPAR γ in the Differentiation and Function of Neurons.
Review
New
Cabezas-Opazo et al., Santiago, Chile. In Ppar Res, Dec 2013
Neuronal processes (neurites and axons) have an important role in brain cells communication and, generally, they are damaged in neurodegenerative diseases.
A20--an omnipotent protein in the liver: prometheus myth resolved?
Review
New
Ferran et al., In Adv Exp Med Biol, Dec 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.
GeneRIF
Gonzalez et al., Bethesda, United States. In J Lipid Res, 2012
is an essential regulator of bile acid biosynthesis, transport, and secretion
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
GeneRIF
Moynagh et al., Ireland. In J Biol Chem, 2012
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-beta expression via peroxisome proliferator-activated receptor-alpha.
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply.
GeneRIF
Granneman et al., Detroit, United States. In J Biol Chem, 2012
lipolytic products can activate PPARalpha and PPARdelta in brown adipocytes, thereby expanding the oxidative capacity to match enhanced fatty acid supply.
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells.
Impact
GeneRIF
Mathis et al., Boston, United States. In Nature, 2012
identification of peroxisome proliferator-activated receptor (PPAR)-gamma, the 'master regulator' of adipocyte differentiation, as a crucial molecular orchestrator of visceral adipose tissue Treg cell accumulation, phenotype and function
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) γ activators and pan-PPAR partial agonists.
GeneRIF
Polikarpov et al., São Carlos, Brazil. In Plos One, 2011
Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) gamma activators and pan-PPAR partial agonists.
More papers using PPAR antibodies
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
Supplier
Sitter Thomas et al., In Mediators of Inflammation, 2006
... Antibody against PPAR-γ was from Santa Cruz Biotechnology (Santa Cruz, California, USA) ...
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... PPARα antagonist (MK886) was obtained from Cayman (Ann Arbor, MI) ...
Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-κB activation
Supplier
Fantus I. George et al., In Experimental Diabetes Research, 2006
... and VEGF, and monoclonal antibodies against PPARγ were obtained from Santa Cruz Biotechnology, Inc ...
15d-Prostaglandin J2 activates peroxisome proliferator-activated receptor-gamma, promotes expression of catalase, and reduces inflammation, behavioral dysfunction, and neuronal loss after intracerebral hemorrhage in rats
Supplier
Wilkins Alastair et al., In Journal of Neuroinflammation, 2005
... The PPAR-γ agonist, pioglitazone was purchased from Cayman Chemical (Ann Arbor, Michigan, ...
Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism
Supplier
Adams Sean H. et al., In PPAR Research, 2004
... acetylated-histone H3 (K9), acetylated-histone H4 (pan) were purchased from Upstate Biotechnology, and the antibody against PPARγ was from Abcam.
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells
Supplier
Stewart LaMonica V. et al., In PPAR Research, 2003
... The PPARγ antagonist GW9662 was purchased from Cayman Chemicals ...
Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus
Supplier
Noy Noa et al., In PPAR Research, 2003
... Antibodies against RXR (sc-774) and PPAR-β/δ (sc-7197), rabbit IgG (sc-2027), and protein A/G agarose (sc-2003) were purchased from Santa Cruz Biotechnology Inc ...
A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: The RESP model
Supplier
Subbaramaiah Kotha et al., In Journal of Medicinal Chemistry, 2001
... Bovine antichicken IgY-HRP secondary antibody and isoform specific PPAR antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Regulation of E2F1 activity by acetylation.
Supplier
Vanacker Jean-Marc, In PLoS ONE, 1999
... Polyclonal anti-PPAR-γ antibodies were purchased from Acris Antibodies GmbH, Germany ...
Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
Supplier
Li Defa et al., In Lipids in Health and Disease, 1998
... Antibodies for hypoxia inducible factor-2 alpha (HIF-2α), peroxisome proliferator-activated receptor alpha (PPARα) and secondary antibody coupled to horse radish peroxidase (HRP) were purchased from Abcam (Cambridge, MA) ...
Mechanisms of androgen induction of sebocyte differentiation
Supplier
Rosenfield Robert L. et al., In Journal of Nutrition and Metabolism, 1997
... ] and the noncompetitive PPARγ binding pocket antagonist GW9662 [20] that were kindly provided by GlaxoSmith-Kline and Merck, courtesy of Drs ...
Prostaglandin E2 gel improvement of psoriatic lesions
Supplier
Travers Jeffrey B. et al., In PPAR Research, 1985
... The specific PPARγ antagonist, GW9662, was obtained from Cayman Chemical (Ann Arbor, MI) ...
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