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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 24 Oct 2014.

Protein phosphatase, Mg2+/Mn2+ dependent, 1G

PP2Cgamma, PPM1G, FIN13, protein phosphatase 1gamma, protein phosphatase 1 G
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: ACID, PP1, V1a, PP2A, CAN
Papers using PP2Cgamma antibodies
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
Supplier
Gruss Oliver J. et al., In The Journal of Cell Biology, 2005
... PPM1G expression constructsHis-hPPM1G and His-xPPM1G were cloned into pQE32 (SphI–KpnI; QIAGEN).
Papers on PP2Cgamma
WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.
New
Maddika et al., Hyderābād, India. In Mol Cell Biol, 01 Nov 2014
Further, we identified phosphatase PPM1G as a functional switch that controls the balance between monomeric WWP2 and a WWP2/WWP1 heterodimeric state in the cell.
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
New
D'Orso et al., Dallas, United States. In Cell Rep, Jan 2014
We demonstrate that Tat recruits PPM1G/PP2Cγ to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop.
Nuclear phosphatase PPM1G in cellular survival and neural development.
New
Wang et al., Los Angeles, United States. In Dev Dyn, Sep 2013
BACKGROUND: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage.
Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1).
New
Gao et al., Lexington, United States. In J Biol Chem, Sep 2013
Here, we report the identification of PPM1G as the phosphatase of 4E-BP1.
Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
Sun et al., Jinan, China. In Sci Rep, 2012
By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G.
Identification and characterization of protein phosphatase 2C activation by ceramide.
Hannun et al., Charleston, United States. In J Lipid Res, 2012
Proteomic analysis of this fraction revealed the identity of the phosphatase to be PP2Cγ/PPM1G.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Choudhary et al., Copenhagen, Denmark. In Mol Cell, 2012
We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions.
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
GeneRIF
Dianov et al., Oxford, United Kingdom. In Mol Cell, 2012
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Takai et al., Nagoya, Japan. In Bioorg Med Chem, 2010
Protein phosphatase 1gamma, a serine/threonine phosphatase, is a metalloprotein that coordinates two Mn(2+) in the active site when expressed in Escherichia coli in a buffer containing MnCl(2).
Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling.
GeneRIF
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2009
PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway.
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
Hebert et al., Jackson, United States. In J Cell Sci, 2009
mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs.
Cell stress gives a red light to the mitochondrial cell death pathway.
Gores et al., Rochester, United States. In Sci Signal, 2007
In this case, protein phosphatase 1gamma (PP1gamma) regulated the phosphorylation status of the Bcl-2/Bcl-X(L)-associated death promoter (BAD).
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.
GeneRIF
Gruss et al., Heidelberg, Germany. In J Cell Biol, 2007
an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.
GeneRIF
Krainer et al., New York City, United States. In Nat Struct Mol Biol, 2007
PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1.
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.
Vaughan et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2007
Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking.
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
GeneRIF
Okawa et al., Kyoto, Japan. In J Cell Biol, 2006
Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.
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