GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 21 May 2016.
Protein phosphatase, Mg2+/Mn2+ dependent, 1G
PP2Cgamma, PPM1G, FIN13, protein phosphatase 1gamma, protein phosphatase 1 G
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] (from
D'Orso et al., Dallas, United States. In Mol Cell Biol, Nov 2015
Here we report that the PPM1G phosphatase (inducibly recruited by nuclear factor κB [NF-κB] to target promoters) directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.