GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Protein phosphatase, Mg2+/Mn2+ dependent, 1G
PP2Cgamma, PPM1G, FIN13, protein phosphatase 1gamma, protein phosphatase 1 G
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] (from
NCBI)
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Papers using
PP2Cgamma
antibodies
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
Supplier
In The Journal of Cell Biology, 2005
... PPM1G expression constructsHis-hPPM1G and His-xPPM1G were cloned into pQE32 (SphI–KpnI; QIAGEN).
Papers on
PP2Cgamma
Identification and characterization of protein phosphatase 2C activation by ceramide.
New
Charleston, United States. In J Lipid Res, Aug 2012
Proteomic analysis of this fraction revealed the identity of the phosphatase to be PP2Cγ/PPM1G.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
New
Copenhagen, Denmark. In Mol Cell, May 2012
We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions.
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
New
Oxford, United Kingdom. In Mol Cell, Apr 2012
After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53.
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Nagoya, Japan. In Bioorg Med Chem, 2010
Protein phosphatase 1gamma, a serine/threonine phosphatase, is a metalloprotein that coordinates two Mn(2+) in the active site when expressed in Escherichia coli in a buffer containing MnCl(2).
Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling.
GeneRIF
Seoul, South Korea. In Biochem Biophys Res Commun, 2009
PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway.
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
Jackson, United States. In J Cell Sci, 2009
mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs.
Cell stress gives a red light to the mitochondrial cell death pathway.
Rochester, United States. In Sci Signal, 2007
In this case, protein phosphatase 1gamma (PP1gamma) regulated the phosphorylation status of the Bcl-2/Bcl-X(L)-associated death promoter (BAD).
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.
GeneRIF
Heidelberg, Germany. In J Cell Biol, 2007
an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.
GeneRIF
New York City, United States. In Nat Struct Mol Biol, 2007
PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1.
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.
Bethesda, United States. In Proc Natl Acad Sci U S A, 2007
Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking.
PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).
GeneRIF
South Korea. In Febs Lett, 2006
The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner.
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
GeneRIF
Kyoto, Japan. In J Cell Biol, 2006
Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.
Regulation of protein phosphatase 1gamma activity in hypoxia through increased interaction with NIPP1: implications for cellular metabolism.
Dublin, Ireland. In J Cell Physiol, 2006
Eukaryotic cells sense decreased oxygen levels and respond by altering their metabolic strategy to sustain non-respiratory ATP production through glycolysis, and thus promote cell survival in a hypoxic environment.
Regulation of catalase enzyme activity by cell signaling molecules.
Ponce, Puerto Rico. In Mol Cell Biochem, 2002
Among PKC isozymes examined, PKCzeta was the most effective modulator followed by PKCgamma, and protein phosphatase 1gamma and 2A decreased the catalase activity.
The NDUFS4 nuclear gene of complex I of mitochondria and the cAMP cascade.
Bari, Italy. In Biochim Biophys Acta, 2002
In the mitochondrial inner membrane a PP2Cgamma-type phosphatase has also been immunodetected, which dephosphorylates the 18 kDa subunit, phosphorylated by PKA.
