GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 20 Feb 2014.
Protein phosphatase, Mg2+/Mn2+ dependent, 1G
PP2Cgamma, PPM1G, FIN13, protein phosphatase 1gamma, protein phosphatase 1 G
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] (from
NCBI)
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Papers using
PP2Cgamma
antibodies
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
Supplier
In The Journal of Cell Biology, 2005
... PPM1G expression constructsHis-hPPM1G and His-xPPM1G were cloned into pQE32 (SphI–KpnI; QIAGEN).
Papers on
PP2Cgamma
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
New
Dallas, United States. In Cell Rep, 12 Jan 2014
We demonstrate that Tat recruits PPM1G/PP2Cγ to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop.
Nuclear phosphatase PPM1G in cellular survival and neural development.
New
Los Angeles, United States. In Dev Dyn, Sep 2013
BACKGROUND: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage.
Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1).
New
Lexington, United States. In J Biol Chem, Sep 2013
Here, we report the identification of PPM1G as the phosphatase of 4E-BP1.
Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
Jinan, China. In Sci Rep, 2012
By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G.
Identification and characterization of protein phosphatase 2C activation by ceramide.
Charleston, United States. In J Lipid Res, 2012
Proteomic analysis of this fraction revealed the identity of the phosphatase to be PP2Cγ/PPM1G.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Copenhagen, Denmark. In Mol Cell, 2012
We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions.
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
Oxford, United Kingdom. In Mol Cell, 2012
After ionizing radiation, dephosphorylation of USP7S by the ATM-dependent protein phosphatase PPM1G leads to USP7S downregulation, followed by Mdm2 downregulation and accumulation of p53.
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Nagoya, Japan. In Bioorg Med Chem, 2010
Protein phosphatase 1gamma, a serine/threonine phosphatase, is a metalloprotein that coordinates two Mn(2+) in the active site when expressed in Escherichia coli in a buffer containing MnCl(2).
Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling.
GeneRIF
Seoul, South Korea. In Biochem Biophys Res Commun, 2009
PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway.
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
Jackson, United States. In J Cell Sci, 2009
mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs.
Cell stress gives a red light to the mitochondrial cell death pathway.
Rochester, United States. In Sci Signal, 2007
In this case, protein phosphatase 1gamma (PP1gamma) regulated the phosphorylation status of the Bcl-2/Bcl-X(L)-associated death promoter (BAD).
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.
GeneRIF
Heidelberg, Germany. In J Cell Biol, 2007
an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.
GeneRIF
New York City, United States. In Nat Struct Mol Biol, 2007
PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1.
Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.
Bethesda, United States. In Proc Natl Acad Sci U S A, 2007
Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking.
PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1).
GeneRIF
South Korea. In Febs Lett, 2006
The degradation of p21(WAF1/CIP1) induced by PP2Cgamma was mediated in a proteasome-dependent manner.
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
GeneRIF
Kyoto, Japan. In J Cell Biol, 2006
Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.
