GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Protein phosphatase, Mg2+/Mn2+ dependent, 1G
PP2Cgamma, PPM1G, FIN13, protein phosphatase 1gamma, protein phosphatase 1 G
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010] (from
NCBI)
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Top mentioned proteins:
ACID, PP1, Inactive, V1a, HAD
Papers using
PP2Cgamma
antibodies
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
Supplier
In The Journal of Cell Biology, 2005
... PPM1G expression constructsHis-hPPM1G and His-xPPM1G were cloned into pQE32 (SphI–KpnI; QIAGEN).
Papers on
PP2Cgamma
PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
New
Dallas, United States. In Mol Cell Biol, Nov 2015
Here we report that the PPM1G phosphatase (inducibly recruited by nuclear factor κB [NF-κB] to target promoters) directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.
Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.
New
London, United Kingdom. In Am J Psychiatry, Jun 2015
RESULTS: Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder.
Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.
New
Ann Arbor, United States. In Arthritis Rheumatol, May 2015
In addition, we identified candidate susceptibility genes with suggestive levels of association (P < 1 × 10(-5)) with Takayasu arteritis, including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B.
The catalytically inactive tyrosine phosphatase HD-PTP/PTPN23 is a novel regulator of SMN complex localization.
New
Heidelberg, Germany. In Mol Biol Cell, Feb 2015
Several phosphatases had been implicated in the regulation of SMN, including the nuclear phosphatases PPM1G and PP1γ.
WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels.
Hyderābād, India. In Mol Cell Biol, 2014
Further, we identified phosphatase PPM1G as a functional switch that controls the balance between monomeric WWP2 and a WWP2/WWP1 heterodimeric state in the cell.
Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
Dallas, United States. In Cell Rep, 2014
We demonstrate that Tat recruits PPM1G/PP2Cγ to locally disassemble P-TEFb from the 7SK snRNP at the HIV promoter via dephosphorylation of the kinase T loop.
Nuclear phosphatase PPM1G in cellular survival and neural development.
Los Angeles, United States. In Dev Dyn, 2013
BACKGROUND: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage.
Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1).
Lexington, United States. In J Biol Chem, 2013
Here, we report the identification of PPM1G as the phosphatase of 4E-BP1.
Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site.
Jinan, China. In Sci Rep, 2012
By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G.
Identification and characterization of protein phosphatase 2C activation by ceramide.
Charleston, United States. In J Lipid Res, 2012
Proteomic analysis of this fraction revealed the identity of the phosphatase to be PP2Cγ/PPM1G.
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
Copenhagen, Denmark. In Mol Cell, 2012
We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions.
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
GeneRIF
Oxford, United Kingdom. In Mol Cell, 2012
ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Nagoya, Japan. In Bioorg Med Chem, 2010
Protein phosphatase 1gamma, a serine/threonine phosphatase, is a metalloprotein that coordinates two Mn(2+) in the active site when expressed in Escherichia coli in a buffer containing MnCl(2).
Protein phosphatase 2Cgamma regulates the level of p21Cip1/WAF1 by Akt signaling.
GeneRIF
Seoul, South Korea. In Biochem Biophys Res Commun, 2009
PP2Cgamma is a novel regulator of p21(Cip1/WAF1) protein stability via the Akt signaling pathway.
Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines.
Jackson, United States. In J Cell Sci, 2009
mRNA levels of the nuclear phosphatase PPM1G are significantly reduced in primary cells and expression of PPM1G in primary cells induces CBs.
Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.
GeneRIF
Heidelberg, Germany. In J Cell Biol, 2007
an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex
Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1.
GeneRIF
New York City, United States. In Nat Struct Mol Biol, 2007
PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1.
A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B.
GeneRIF
Kyoto, Japan. In J Cell Biol, 2006
Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.
