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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protamine 2

PP2B, protamine 2, PRM2
Top mentioned proteins: PP2A, ACID, PP1, CAN, HAD
Papers on PP2B
Protein phosphatase role in adenosine A1 receptor-induced AMPA receptor trafficking and rat hippocampal neuronal damage in hypoxia/reperfusion injury.
New
Cayabyab et al., Saskatoon, Canada. In Neuropharmacology, Mar 2016
This study further investigates the mechanism of A1R-mediated AMPAR internalization and hippocampal slice neuronal damage through activation of protein phosphatase 1 (PP1), 2A (PP2A), and 2B (PP2B) using electrophysiological, biochemical and imaging techniques.
Role of protein phosphatases in the run-down of guinea-pig cardiac Cav1.2 Ca2+ channels.
New
Kameyama et al., China. In Am J Physiol Cell Physiol, Feb 2016
But protein phosphatase type 2B (PP2B, calcineurin) inhibitor, cyclosporine A together with cyclophilin A had no effect on the channel run-down.
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines.
New
Zákány et al., Debrecen, Hungary. In Int J Oncol, Jan 2016
The amount of HA was reduced upon the inhibition of calcineurin with cyclosporine A (CsA), while the inhibition of ERK1/2 with PD098059 elevated it in both cell lines.
Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells.
New
Chauhan et al., In Reprod Fertil Dev, Dec 2015
Quantitative polymerase chain reaction analysis revealed that 20%-40% CCM induced the highest expression of primordial germ cell-specific (deleted in Azoospermia- like (Dazl), dead (Asp-Glu-Ala-Asp) box polypeptide 4 (Vasa also known as DDX4) and promyelocytic leukemia zinc finger protein (Plzf)); meiotic (synaptonemal complex protein 3 (Sycp3), mutl homolog I (Mlh1), transition protein 1/2 (Tnp1/2) and protamine 2 (Prm2); spermatocyte-specific boule-like RNA binding protein (Boule) and tektin 1 (Tekt1)) and oocyte-specific growth differentiation factor 9 (Gdf9) and zona pellucida 2 /3 (Zp2/3)) genes over 8-14 days in culture.
Comparison of Protamine 1 to Protamine 2 mRNA Ratio and YBX2 gene mRNA Content in Testicular Tissue of Fertile and Azoospermic Men.
New
Hashjin et al., Qazvīn, Iran. In Int J Fertil Steril, Oct 2015
BACKGROUND: Although aberrant protamine (PRM) ratios have been observed in infertile men, the mechanisms that implicit the uncoupling of PRM1 and PRM2 expression remain unclear.
Focused library with a core structure extracted from natural products and modified: application to phosphatase inhibitors and several biochemical findings.
New
Impact
Sodeoka et al., Wako, Japan. In Acc Chem Res, Jun 2015
From the resulting focused library, we identified a highly selective PP2B inhibitor, NCA-01.
Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder.
Review
Scott et al., Seattle, United States. In Front Pharmacol, 2014
Accordingly, numerous AKAPs bind phosphatases such as protein phosphatase 1 (PP1), calcineurin (PP2B), and PP2A.
Ser/Thr-phosphoprotein phosphatases in chondrogenesis: neglected components of a two-player game.
Review
Zákány et al., Debrecen, Hungary. In Cell Signal, 2014
Of the main Ser/Thr PPs, some of the functions of PP1, PP2A and PP2B have been characterised in the context of chondrogenesis.
Aberrant protamine content in sperm and consequential implications for infertility treatment.
Review
Coward et al., Oxford, United Kingdom. In Hum Fertil (camb), 2014
Human sperm express two types of protamine: protamine 1 (P1) and the family of protamine 2 (P2) proteins, with P1 and P2 normally existing in a ratio of approximately 1:1.
The developmental stages of synaptic plasticity.
Review
Kessels et al., Amsterdam, Netherlands. In J Physiol, 2014
First we summarize the current data on the structure of synapses and the developmental expression patterns of the key molecular players of synaptic plasticity, N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, as well as pivotal kinases (Ca(2+)/calmodulin-dependent protein kinase II, protein kinase A, protein kinase C) and phosphatases (PP1, PP2A, PP2B).
Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease.
Review
Xu et al., Los Angeles, United States. In Mol Neurodegener, 2013
Aβ-induced synaptic dysfunction is dependent on overstimulation of N-methyl-D-aspartate receptors (NMDARs) resulting in aberrant activation of redox-mediated events as well as elevation of cytoplasmic Ca2+, which in turn triggers downstream pathways involving phospho-tau (p-tau), caspases, Cdk5/dynamin-related protein 1 (Drp1), calcineurin/PP2B, PP2A, Gsk-3β, Fyn, cofilin, and CaMKII and causes endocytosis of AMPA receptors (AMPARs) as well as NMDARs.
Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
GeneRIF
Dufau et al., Bethesda, United States. In J Biol Chem, 2012
Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
GeneRIF
Kume et al., Kumamoto, Japan. In J Neurosci, 2011
results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
Supramolecular assemblies and localized regulation of voltage-gated ion channels.
Review
Impact
Hell et al., Iowa City, United States. In Physiol Rev, 2009
The type 2 ryanodine receptor as well as AMPA- and NMDA-type glutamate receptors are in close proximity to Cav1.2 in cardiomyocytes and neurons, respectively, yet independently anchor PKA, CaMKII, and the serine/threonine phosphatases PP1, PP2A, and PP2B, as is discussed in detail.
Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes.
GeneRIF
Lefèvre et al., Lyon, France. In Genomics, 2008
Study shows that protamine 1 and 2 mRNAs, which are specific to the round spermatid stage, are repressed at the two-pronuclei and two-cell stages postfertilization, respectively, in embryos created by round spermatid injection, by distinct mechanisms.
A network of control mediated by regulator of calcium/calmodulin-dependent signaling.
Impact
Greengard et al., New York City, United States. In Science, 2004
Phospho-RCS acted as a competitive inhibitor of CaM-dependent enzymes, including protein phosphatase 2B (PP2B, also called calcineurin).
Reciprocal regulation of the mouse protamine genes by the orphan nuclear receptor germ cell nuclear factor and CREMtau.
GeneRIF
Cooney et al., Houston, United States. In Mol Reprod Dev, 2004
Germ cell nuclear factor acts as a repressor of basal transcription on both the Protamine 1 and Protamine 2 promoters.
Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice.
GeneRIF
Eddy et al., Kwangju, South Korea. In Biol Reprod, 2003
direct correlation between the fraction of sperm with haploinsufficiency of PRM2 and the frequency of sperm with damaged DNA. Ultrastructural analysis revealed reduced compaction of the chromatin
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Impact
Eddy et al., United States. In Nat Genet, 2001
We disrupted the coding sequence of one allele of either Prm1 or Prm2 in embryonic stem (ES) cells derived from 129-strain mice, and injected them into blastocysts from C57BL/6-strain mice.
A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells.
Impact
Braun et al., Seattle, United States. In Nat Genet, 1999
Using immunohistological analysis, we determined that the endogenous Prm2 mRNA and a reporter mRNA carrying protamine 1 translational-control elements were translated in a mosaic pattern.
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