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Protein phosphatase 2A activator, regulatory subunit 4

PP2A, protein phosphatase 2A
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, Akt, CAN, PP1
Papers using PP2A antibodies
Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation.
Supplier
Finkelstein David, In PLoS ONE, 2007
... Louis, MO]; PP2A 2039 and pGSK-3β (Ser9) 9336 were from Cell Signaling Technology (Danvers, Massachusetts); human ...
A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Supplier
Chandra Dhyan, In PLoS ONE, 2006
... The TGFβRII, AKAP149, AKAP220 and PKA and PP2A catalytic subunit antibodies were obtained from Santa Cruz Biotechnology.
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
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Hannun Yusuf A. et al., In The Journal of Cell Biology, 2005
... PP2A (catalytic subunit α) antibody was from BD Biosciences.
Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis.
Supplier
Langsley Gordon, In PLoS ONE, 2004
... Polyclonal antibodies directed against PP2A-A (catalytic subunit of PP2A) and PP2A tyrosine phosphorylated at position 307 were from Santa Cruz Biotechnology, and those against integrin ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Supplier
Aguila Marcia B., In PLoS ONE, 2000
... (CAT#3662), p-STAT3 tyrosine 705 (CAT#4113), STAT3 (CAT#9132), p-hormone sensitive lipase (p-HSL) (Ser563) (CAT#4139), HSL (CAT#4107), PP2A (CAT# 2041) and LKB-1(CAT#3050) were from Cell Signaling (Danvers, MA) ...
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Papers on PP2A
HEK293 cells exposed to microcystin-LR show reduced protein phosphatase 2A activity and more stable cytoskeletal structure when overexpressing α4 protein.
New
Xu et al., Hangzhou, China. In Environ Toxicol, Feb 2016
The major mechanism of MC-LR toxicity has been attributed to its inhibition of protein phosphatases 1 (PP1) and 2A (PP2A).
Spatial Regulation of Greatwall by Cdk1 and PP2A-Tws in the Cell Cycle.
New
Archambault et al., Montréal, Canada. In Cell Cycle, Feb 2016
UNASSIGNED: Entry into mitosis requires the phosphorylation of multiple substrates by cyclin B-Cdk1, while exit from mitosis requires their dephosphorylation, which depends largely on the phosphatase PP2A in complex with its B55 regulatory subunit (Tws in Drosophila).
Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-κB pathway dependent repression of PP2Ac.
New
Li et al., Suzhou, China. In Cell Cycle, Feb 2016
UNASSIGNED: Previous studies have indicated that inflammatory stimulation represses protein phosphatase 2A (PP2A), a well-known tumor suppressor.
Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells.
New
Yi et al., Detroit, United States. In Mol Cell Endocrinol, Feb 2016
UNASSIGNED: Protein phosphatase 2A (PP2A) is one of the major serine/threonine phosphatases.
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
New
Planel et al., Québec, Canada. In Neurobiol Dis, Feb 2016
N-terminal kinase (JNK) and Protein Phosphatase 2A (PP2A) in 4-week-old db/db mice.
Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer.
New
Impact
Polyak et al., Boston, United States. In Nature, Feb 2016
Proteomic studies of resistant TNBC identify strong association with MED1 and hyper-phosphorylation of BRD4 attributable to decreased activity of PP2A, identified here as a principal BRD4 serine phosphatase.
All roads lead to PP2A: Exploiting the therapeutic potential of this phosphatase.
Review
New
Narla et al., New York City, United States. In Febs J, Nov 2015
UNASSIGNED: Protein phosphatase 2A is a serine/threonine phosphatase involved in the regulation of many cellular processes.
The αRep artificial repeat protein scaffold: a new tool for crystallization and live cell applications.
Review
New
Minard et al., Orsay, France. In Biochem Soc Trans, Nov 2015
We have designed a new family of artificial proteins, named αRep, based on HEAT (acronym for Huntingtin, elongation factor 3 (EF3), protein pphosphatase 2A (PP2A), yeast kinase Tor1) repeat proteins containing an α-helical repeated motif.
Vertebrate Reproduction.
Review
New
Fissore et al., Durham, United States. In Cold Spring Harb Perspect Biol, Oct 2015
Protein kinase and phosphatase signaling pathways involving Mos, CDK1, RSK, and PP2A regulate meiosis during maturation of the oocyte.
A PP1-PP2A phosphatase relay controls mitotic progression.
Impact
Hagan et al., Manchester, United Kingdom. In Nature, 2015
Although Cdc14 phosphatase drives this reversal in budding yeast, protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) activities have each been independently linked to mitotic exit control in other eukaryotes.
STRIPAK components determine mode of cancer cell migration and metastasis.
Impact
Sahai et al., London, United Kingdom. In Nat Cell Biol, 2015
We further show that FAM40B mutations found in human tumours uncouple it from PP2A and enable it to drive a contractile phenotype, which may underlie its role in human cancer.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
Impact
Cecconi et al., Copenhagen, Denmark. In Nat Cell Biol, 2015
We found that AMBRA1 favours the interaction between c-Myc and its phosphatase PP2A and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate.
Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder.
Review
Scott et al., Seattle, United States. In Front Pharmacol, 2014
Accordingly, numerous AKAPs bind phosphatases such as protein phosphatase 1 (PP1), calcineurin (PP2B), and PP2A.
Role of "oncogenic nexus" of CIP2A in breast oncogenesis: how does it work?
Review
Dey et al., Sioux Falls, United States. In Am J Cancer Res, 2014
OncoPrints (c-BioPortal) showed alterations (%) of regulatory subunits genes of PP2A (PPP2R1A and PPP2R1B) along with alterations of CIP2A in breast invasive carcinoma (TCGA, Nature 2012 & TCGA, Provisional).
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
Impact
Saurin et al., Utrecht, Netherlands. In Nat Cell Biol, 2014
Active SAC signalling recruits PP2A-B56 to kinetochores where it antagonizes Aurora B to promote PP1 recruitment.
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
GeneRIF
Kim et al., Seoul, South Korea. In Mol Cell Biochem, 2012
DUSP6 and PP2A participate in the regulation of melanogenesis
Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation.
GeneRIF
Wadzinski et al., Nashville, United States. In J Biol Chem, 2012
Data show MID1-dependent monoubiquitination of alpha4 triggers calpain-mediated cleavage and switches alpha4's activity from protective to destructive, resulting in increased Tau phosphorylation.
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.
GeneRIF
Sontag et al., Dallas, United States. In J Neurosci, 2012
These findings reveal a novel mechanism involving methylation-dependent pathways in L-dopa induces PP2A hypomethylation and increases Tau phosphorylation, which may be potentially detrimental to neuronal cells.
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism.
GeneRIF
Tsokos et al., Boston, United States. In J Immunol, 2012
Increased PP2Ac expression participates in SLE pathogenesis by promoting inflammation through unchecked IL-17 production.
PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing.
GeneRIF
Noteborn et al., Leiden, Netherlands. In Cell Death Dis, 2011
Knockdown of the ST-interacting PP2A-B56gamma subunit in normal fibroblasts mimicked the effect of nuclear ST expression, resulting in induction of apoptin phosphorylation.
More papers using PP2A antibodies
Apaf-1 is a transcriptional target for E2F and p53
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Bhat Manoj K et al., In Molecular Cancer, 2000
... pCdk5, Cdk5, p35, Bcl-2, cytochrome-C, PARP, COX-IV, β-Tubulin, β-Actin, HRP-linked secondary antibodies, Control, p53 and PP2A siRNAs were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.
Supplier
Buday Laszlo, In PLoS ONE, 1999
... MO); anti-PP1 catalytic subunit antibody: R&D System (Minneapolis, MN); anti-SLC9A3R1 antibody: Abgent (San Diego, CA); anti-PP2A B subunit (most specific for Bα) and anti-NHERF1(A310) antibodies, anti-rabbit IgG HRP-linked and anti-mouse IgG HRP-linked secondary antibodies: Cell Signaling Technology, Inc ...
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... Signaling Technology), PP1-β (rabbit A300-905A; Bethyl Laboratories, Inc.), PP1-γ (goat SC-6108; Santa Cruz Biotechnology, Inc.), PP2A (mouse 610555; BD), TPX2 (mouse ab32795; Abcam), Hec1 (mouse GTX70268; GeneTex, ...
Obesity-related overexpression of fatty-acid synthase gene in adipose tissue involves sterol regulatory element-binding protein transcription factors
Supplier
Hajduch Eric et al., In Diabetes, 1997
... synthase kinase 3α/β (GSK3α/β), and Thr410/403-PKCζ/λ were from Cell Signaling (New England Biolabs); and Tyr307-PP2A, PP2A A-subunit, PKCζ, and hemagglutinin (HA) were from Santa Cruz Biotechnology.
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