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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Protein phosphatase 1, catalytic subunit, alpha isozyme

pp1a, PPP1CA, PPI-A, PPP1A
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, PP1, NSP2, HAD
Papers using pp1a antibodies
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
Schneider-Stock Regine, In PLoS ONE, 2006
... Antibodies of FLAG (Sigma), Myc (Santa Cruz), PP1A (Epitomics), GST (Santa Cruz), YAP2 ...
Papers on pp1a
Ras regulates Rb via NORE1A.
Clark et al., Louisville, United States. In J Biol Chem, Jan 2016
We show that Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation.
Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus.
Guo et al., Wuhan, China. In Virus Res, Nov 2015
Coronavirus 3C-like protease (3CLpro) is responsible for the cleavage of coronaviral polyprotein 1a/1ab (pp1a/1ab) to produce the mature non-structural proteins (nsps) of nsp4-16.
MiR-125b promotes cell migration and invasion by targeting PPP1CA-Rb signal pathways in gastric cancer, resulting in a poor prognosis.
Zhou et al., Hangzhou, China. In Gastric Cancer, Oct 2015
RESULTS: MiR-125b was upregulated in gastric cancer tissues and cell lines, and significantly promoted cellular proliferation, migration, and invasion by downregulating the expression of PPP1CA and upregulating Rb phosphorylation.
Loss of the tumor suppressor spinophilin (PPP1R9B) increases the cancer stem cell population in breast tumors.
Carnero et al., Sevilla, Spain. In Oncogene, Oct 2015
A reduction of the levels of PPP1CA mimicked the cancer stem-like cell phenotype of Spn downregulation, suggesting that the mechanism of Spn involves PP1a.
Nuclear Protein Phosphatase 1 α (PP1A) Expression is Associated with Poor Prognosis in p53 Expressing Glioblastomas.
Santosh et al., Bengaluru, India. In Pathol Oncol Res, Sep 2015
BACKGROUND: Protein phosphatase 1 α (PP1A) is an enzyme intimately associated with cell cycle, the over expression of which has been demonstrated in glioblastoma (GBM).
The Screening of Genes Sensitive to Long-Term, Low-Level Microwave Exposure and Bioinformatic Analysis of Potential Correlations to Learning and Memory.
Huang et al., Beijing, China. In Biomed Environ Sci, Aug 2015
Construction of a protein interaction network identified several important regulatory genes including synbindin (sbdn), Crystallin (CryaB), PPP1CA, Ywhaq, Psap, Psmb1, Pcbp2, etc., which play important roles in the processes of learning and memorye.
PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction.
Guan et al., Shanghai, China. In Embo Rep, Aug 2015
PARD3 promotes the interaction between PP1A and LATS1 to induce LATS1 dephosphorylation and inactivation, therefore leading to dephosphorylation and activation of TAZ.
Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers.
Hyland et al., Bethesda, United States. In Int J Epidemiol, Aug 2015
Several suggestive eQTLs were also found in oesophageal (rs10898459 in EED), gastric cardia (rs7157322 in DICER1; rs8179271 in ASH1L), and gastric non-cardia (rs1790733 in PPP1CA) tissues.
Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase.
Fang et al., Brookings, United States. In Virus Res, May 2015
The porcine reproductive and respiratory syndrome virus (PRRSV) replicase polyproteins pp1a and pp1ab are proteolytically processed by four proteases encoded in ORF1a.
Characterization of an alphamesonivirus 3C-like protease defines a special group of nidovirus main proteases.
Ziebuhr et al., Gießen, Germany. In J Virol, 2014
The expression of these enzymes in virus-infected cells requires the extensive proteolytic processing of two large replicase polyproteins, pp1a and pp1ab, by the viral 3C-like protease (3CL(pro)).
Phosphoprotein phosphatase 1 complexes in spermatogenesis.
Fardilha et al., Aveiro, Portugal. In Curr Mol Pharmacol, 2013
Three genes, PPP1CA, PPP1CB and PPP1CC, encode four PPP1C isoforms, PPP1CA, PPP1CB, PPP1CC1, and PPP1CC2.
Spinophilin: a new tumor suppressor at 17q21.
Carnero, Sevilla, Spain. In Curr Mol Med, 2012
The scaffold protein spinophilin (SPN) is a regulatory subunit of phosphatase 1a (PP1a) located at 17q21.33.
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.
Welch et al., Cambridge, United Kingdom. In Biochem J, 2012
We have identified a novel mechanism for direct activation of P-Rex1 through PP1alpha-dependent dephosphorylation.
Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
Hannun et al., Charleston, United States. In J Biol Chem, 2012
a novel, acute mechanism of ERM regulation dependent on PP1alpha and plasma membrane ceramide.
Protein phosphatase 1α interacting proteins in the human brain.
da Cruz e Silva et al., Aveiro, Portugal. In Omics, 2012
Results identify specific protein phosphatase 1alpha-interacting proteins in human brain.
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137.
Diamond et al., Saint Louis, United States. In Plos One, 2011
Data show that knockdown of the catalytic subunit of PP1 (PP1Calpha), but not PP2A (PP2ACalpha), increased pS137-PFN1 levels.
Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.
Mansuy et al., Zürich, Switzerland. In Plos One, 2011
analysis of selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins.
Snijder et al., Brookings, United States. In Virus Res, 2010
For porcine reproductive and respiratory syndrome virus (PRRSV), based on bioinformatics predictions and experimental studies, a processing map for the pp1a and pp1ab replicase polyproteins has been developed.
The role of porcine reproductive and respiratory syndrome (PRRS) virus structural and non-structural proteins in virus pathogenesis.
Gagnon et al., Saint-Hyacinthe, Canada. In Anim Health Res Rev, 2010
The ORF1a and ORF1b replicase-associated genes encode the polyproteins pp1a and pp1ab, respectively.
[Helicobacter pylori infection and antimicrobial agents resistance].
de Korwin, Nancy, France. In Rev Med Interne, 2004
Metronidazole resistance reduces eradication rate of about 25%, leading to the use of metronidazole in second line therapy, in increasing the triple therapy duration at 14 days (PPI-A-M), or in combination with quadruple therapy (Bismuth-PPI-T-M).
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