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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Protein phosphatase 1, catalytic subunit, alpha isozyme

pp1a, PPP1CA, PPI-A, PPP1A
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using pp1a antibodies
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
Supplier
Schneider-Stock Regine, In PLoS ONE, 2006
... Antibodies of FLAG (Sigma), Myc (Santa Cruz), PP1A (Epitomics), GST (Santa Cruz), YAP2 ...
Papers on pp1a
The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.
GeneRIF
Welch et al., Cambridge, United Kingdom. In Biochem J, 2012
We have identified a novel mechanism for direct activation of P-Rex1 through PP1alpha-dependent dephosphorylation.
Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
GeneRIF
Hannun et al., Charleston, United States. In J Biol Chem, 2012
a novel, acute mechanism of ERM regulation dependent on PP1alpha and plasma membrane ceramide.
Protein phosphatase 1α interacting proteins in the human brain.
GeneRIF
da Cruz e Silva et al., Aveiro, Portugal. In Omics, 2012
Results identify specific protein phosphatase 1alpha-interacting proteins in human brain.
Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection.
GeneRIF
Mansuy et al., Zürich, Switzerland. In Plos One, 2011
analysis of selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137.
GeneRIF
Diamond et al., Saint Louis, United States. In Plos One, 2011
Data show that knockdown of the catalytic subunit of PP1 (PP1Calpha), but not PP2A (PP2ACalpha), increased pS137-PFN1 levels.
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