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POU domain, class 5, transcription factor 1

pou2, spg/pou2
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, FATE, PAX2, Wnt1, ACID
Papers on pou2
Medaka Oct4 is essential for pluripotency in blastula formation and ES cell derivation.
New
Hong et al., Singapore, Singapore. In Stem Cell Rev, Feb 2015
The transcription factor Oct4 or Pou5f1 identified in mouse features pluripotency expression and activity in the inner cell mass and embryonic stem (ES) cells.
The POU-er of gene nomenclature.
Brickman et al., Haifa, Israel. In Development, 2014
The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate.
Spermatogonial stem cell quest: nanos2, marker of a subpopulation of undifferentiated A spermatogonia in trout testis.
Le Gac et al., Rennes, France. In Biol Reprod, 2014
Trout homologues of SSC and/or immature progenitor markers in mammals-nanos2 and nanos3, pou2, plzf, and piwil2-were preferentially expressed in the prepubertal testis and in the undifferentiated A spermatogonia populations purified by centrifugal elutriation.
Characterization of spermatogonial markers in the mature testis of the dogfish (Scyliorhinus canicula L.).
Sourdaine et al., Caen, France. In Reproduction, 2014
Dogfish cDNA sequences have been identified and validated by phylogenetic analyses for gfrα1, plzf, pou2, as well as for high-mobility group box proteins 2 and 3 (hmgb2 and 3) and for mini-chromosome maintenance protein 6 (mcm6).
POU genes are expressed during the formation of individual ganglia of the cephalopod central nervous system.
Wanninger et al., Vienna, Austria. In Evodevo, 2013
RESULTS: POU2, POU3, POU4 and POU6 orthologs were identified in transcriptomes derived from developmental stages and adult brain tissue of I. notoides.
Early cell lineage specification in a marsupial: a case for diverse mechanisms among mammals.
Renfree et al., Melbourne, Australia. In Development, 2013
Pluriblast cells (equivalent to the ICM) became distinguishable from trophoblast cells by differential expression of POU5F1 and, to a greater extent, POU2, a paralogue of POU5F1.
Do not put all teleosts in one net: focus on the sox2 and pou2 genes.
Le Bail et al., Rennes, France. In Comp Biochem Physiol B Biochem Mol Biol, 2013
The Pou2 and Sox2 proteins are major transcription factors for development and cell differentiation.
oct4-EGFP reporter gene expression marks the stem cells in embryonic development and in adult gonads of transgenic medaka.
Gutzeit et al., Dresden, Germany. In Mol Reprod Dev, 2013
One of the key genes in this process is oct4, also referred to as pou5f1 in mammals and pou2 in teleosts.
On the origin of POU5F1.
Renfree et al., Melbourne, Australia. In Bmc Biol, 2012
POU5F1 and POU2 are the two principle members constituting the class V POU domain family of transcription factors, thought to have a conserved role in the regulation of pluripotency in vertebrates as well as germ cell maintenance and neural patterning.
Pou2, a class V POU-type transcription factor in zebrafish, regulates dorsoventral patterning and convergent extension movement at different blastula stages.
Yamasu et al., Saitama, Japan. In Mech Dev, 2012
Zebrafish pou2, which encodes a class V POU transcription factor considered to be an orthologue of mouse Oct-3/4, has been implicated by mutant analysis in dorsoventral (DV) patterning, gastrulation, and endoderm formation in early embryos and later in the regionalization of the neural plate.
Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis.
Yamasu et al., Saitama, Japan. In Dev Growth Differ, 2012
Zebrafish pou2, encoding the class V POU transcription factor orthologous to mouse Oct-3/4, has been implicated in different aspects of development, such as dorsoventral patterning, endoderm formation, and brain regionalization, by analyzing pou2 mutant embryos.
Identification of a pou2 ortholog in Chinese sturgeon, Acipenser sinensis and its expression patterns in tissues, immature individuals and during embryogenesis.
Li et al., Shanghai, China. In Fish Physiol Biochem, 2012
The class V POU family genes, including pou5f1 and pou2, encode transcription factors critical for the maintenance of pluripotency in embryonic stem cells (ESC) and germ line cells in vertebrates.
A regulatory program for excretory system regeneration in planarians.
Reddien et al., Cambridge, United States. In Development, 2011
Here, we identify a set of genes, Six1/2-2, POU2/3, hunchback, Eya and Sall, that encode transcription regulatory proteins that are required for planarian protonephridia regeneration.
Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.
GeneRIF
Onichtchouk et al., Freiburg, Germany. In Dev Biol, 2011
show that Pou5f1 binds to phylogenetically conserved Oct/Pou5f1 sites in the vox promoter, both in vivo and in vitro
Ontogenetic expression of maternal and zygotic genes in Atlantic cod embryos under ambient and thermally stressed conditions.
Hamre et al., Bergen, Norway. In Comp Biochem Physiol A Mol Integr Physiol, 2011
The purpose of the present study was to follow the ontogenetic expression of selected genes of maternal (pou2 and nanog) and zygotic origin (hsp70, hsp90α and stip1), in Atlantic cod embryos under ambient and thermally stressed conditions.
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.
GeneRIF
Eggenschwiler et al., Princeton, United States. In Proc Natl Acad Sci U S A, 2011
Data show that IFT122 controls the ciliary localization of Shh pathway regulators in different ways.
Embryonic stem cells isolated from Atlantic cod (Gadus morhua) and the developmental expression of a stage-specific transcription factor ac-Pou2.
Skjærven et al., Bergen, Norway. In Fish Physiol Biochem, 2010
The cod transcript, designated Atlantic cod-Pou2 (ac-Pou2), can be used as a genetic marker for cod blastula cells in vivo and in vitro.
Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene.
GeneRIF
Kuss et al., Berlin, Germany. In Am J Hum Genet, 2010
we found a homozygous missense mutation in the IFT122 (WDR10) gene that cosegregated with Sensenbrenner syndrome
Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development.
GeneRIF
Driever et al., Freiburg, Germany. In Mol Syst Biol, 2009
The temporospatial structure of the zebrafish Pou5f1 target networks may explain aspects of the evolution of the mammalian stem cell networks.
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