On the origin of POU5F1.
Melbourne, Australia. In Bmc Biol, 2012
POU5F1 and POU2 are the two principle members constituting the class V POU domain family of transcription factors, thought to have a conserved role in the regulation of pluripotency in vertebrates as well as germ cell maintenance and neural patterning.
Mesendoderm specification depends on the function of Pou2, the class V POU-type transcription factor, during zebrafish embryogenesis.
Saitama, Japan. In Dev Growth Differ, 2012
Zebrafish pou2, encoding the class V POU transcription factor orthologous to mouse Oct-3/4, has been implicated in different aspects of development, such as dorsoventral patterning, endoderm formation, and brain regionalization, by analyzing pou2 mutant embryos.