[Study on relationships between biomarkers in workers with low-level occupational lead exposure].
In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, Jun 2015
The blood samples of 233 workers with occupational lead exposure and 76 non-occupational lead exposure were collected to measure the blood lead (Pb-B) level using graphite furnace atomic absorption spectrometry (GFAAS), the zinc Protoporphyrin (ZPP) level with blood fluorescence assay, and the delta-aminolevulinic acid dehydratase (ALAD) concentration by a spectrophotometer, and to determine the gene polymorphism of ALAD with TaqMan real-time polymerase chain reaction.
Drugs and acute porphyrias: reasons for a hazardous relationship.
Reggio nell'Emilia, Italy. In Postgrad Med, 2014
In the acute porphyrias (acute intermittent porphyria, hereditary coproporphyria, variegate porphyria, and the very rare delta-aminolevulinic acid dehydratase ALAD-d porphyria), the characteristic severe neurovisceral involvement is mainly ascribed to a tissue accumulation of delta-aminolevulinic acid, a neurotoxic nonporphyrin precursor.
Allostery and the dynamic oligomerization of porphobilinogen synthase.
Philadelphia, United States. In Arch Biochem Biophys, 2012
The structural basis for allosteric regulation of porphobilinogen synthase (PBGS) is modulation of a quaternary structure equilibrium between octamer and hexamer (via dimers), which is represented schematically as 8mer ⇔ 2mer ⇔ 2mer∗⇔ 6mer∗.