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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

HEM12 Hem12p

Pop3, HEM12, Wat1, Pop3p, hem6
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008] (from NCBI)
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Top mentioned proteins: ACID, CAN, Tec, Rpp29, fibrillin-1
Papers on Pop3
A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions.
New
Serrano et al., Valencia, Spain. In J Exp Bot, Feb 2015
Concerning the latter effect, several mutants of Arabidopsis thaliana with improved capability for H(+) efflux (wat1-1D, overexpression of AKT1 and ost2-1D) are less sensitive to inhibition by ABA than the wild type.
The emerging role of human PYHIN proteins in innate immunity: implications for health and disease.
Bowie et al., Dublin, Ireland. In Biochem Pharmacol, 2015
There are five human PYHIN proteins; Absent in melanoma 2 (AIM2), IFN-γ inducible protein 16 (IFI16), Myeloid cell nuclear differentiation antigen (MNDA), Pyrin and HIN domain family member 1 (PYHIN1) and the recently identified Pyrin domain only protein 3 (POP3).
Hem12, an enzyme of heme biosynthesis pathway, is monoubiquitinated by Rsp5 ubiquitin ligase in yeast cells.
Zoladek et al., Warsaw, Poland. In Acta Biochim Pol, 2014
Heme biosynthesis pathway is conserved in yeast and humans and hem12 yeast mutants mimic porphyria cutanea tarda (PCT), a hereditary human disease caused by mutations in the UROD gene.
Exploring the water-binding pocket of the type II dehydroquinase enzyme in the structure-based design of inhibitors.
González-Bello et al., Santiago de Compostela, Spain. In J Med Chem, 2014
Structural and computational studies to explore the WAT1 binding pocket in the structure-based design of inhibitors against the type II dehydroquinase (DHQ2) enzyme are reported.
The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.
Impact
Stehlik et al., Chicago, United States. In Nat Immunol, 2014
Here we identified the PYRIN domain (PYD)-only protein POP3, which competes with ASC for recruitment to ALRs, as an inhibitor of DNA virus-induced activation of ALR inflammasomes in vivo.
Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe.
Ahmed et al., Lucknow, India. In Plos One, 2013
We have isolated a novel mutant allele of wat1, a WD repeat containing protein that exhibits conditional synthetic lethality with chk1 knock out.
A dominant-negative form of Arabidopsis AP-3 β-adaptin improves intracellular pH homeostasis.
Serrano et al., Valencia, Spain. In Plant J, 2013
The phenotypes of one identified mutant, weak acid-tolerant 1-1D (wat1-1D) are due to the expression of a truncated form of AP-3 β-adaptin (encoded by the PAT2 gene) that behaves as a as dominant-negative.
Arabidopsis wat1 (walls are thin1)-mediated resistance to the bacterial vascular pathogen, Ralstonia solanacearum, is accompanied by cross-regulation of salicylic acid and tryptophan metabolism.
Goffner et al., Toulouse, France. In Plant J, 2013
Inactivation of Arabidopsis WAT1 (Walls Are Thin1), a gene required for secondary cell-wall deposition, conferred broad-spectrum resistance to vascular pathogens, including the bacteria Ralstonia solanacearum and Xanthomonas campestris pv.
Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
Tamanoi et al., Los Angeles, United States. In J Cell Sci, 2013
The TORC1 components Pop3, Toc1 and Tco89, are dispensable for Psk1 regulation, but disruption of pop3(+) causes an increase in the sensitivity of TORC1 to rapamycin.
Pyrin- and CARD-only Proteins as Regulators of NLR Functions.
Review
Harton et al., Albany, United States. In Front Immunol, 2012
Although clear examples of pathogen encoded POPs are currently limited to members of the poxviridae, the human genome likely encodes three POPs (POP1, POP2, and a potential POP3), of which only POP2 is known to prevent NLR:ASC interaction, and three COPs (COP/Pseudo-ICE, INCA, and ICEBERG), initially described for their ability to inhibit caspase-1 activity.
Identification of novel transcription factors regulating secondary cell wall formation in Arabidopsis.
Grima-Pettenati et al., Toulouse, France. In Front Plant Sci, 2012
To this end, we have developed a post-genomic approach by combining four independent in-house SCW-related transcriptome datasets obtained from (1) the fiber cell wall-deficient wat1 Arabidopsis mutant, (2) Arabidopsis lines over-expressing either the master regulatory activator EgMYB2 or (3) the repressor EgMYB1 and finally (4) Arabidopsis orthologs of Eucalyptus xylem-expressed genes.
Single-cell-based system to monitor carrier driven cellular auxin homeostasis.
Kleine-Vehn et al., Gent, Belgium. In Bmc Plant Biol, 2012
CONCLUSIONS: This single-cell-based system is a useful tool by which the activity of putative auxin carriers, such as PINs, PILS and WALLS ARE THIN1 (WAT1), can be indirectly visualized in a medium-to-high throughput manner.
Arabidopsis WAT1 is a vacuolar auxin transport facilitator required for auxin homoeostasis.
Goffner et al., Toulouse, France. In Nat Commun, 2012
We demonstrate that WALLS ARE THIN1 (WAT1), a plant-specific protein that dictates secondary cell wall thickness of wood fibres, facilitates auxin export from isolated Arabidopsis vacuoles in yeast and in Xenopus oocytes.
Reduced Popdc3 expression correlates with high risk and poor survival in patients with gastric cancer.
GeneRIF
Luo et al., Kunming, China. In World J Gastroenterol, 2012
Reduced expression of Popdc3 may play a significant role in the carcinogenesis and progression of gastric cancer. Popdc3 may be an independent prognostic factor.
The genetic structure of Leishmania infantum populations in Brazil and its possible association with the transmission cycle of visceral leishmaniasis.
Cupolillo et al., Rio de Janeiro, Brazil. In Plos One, 2011
POP3 (31 strains) was less dispersed, and it was observed primarily in Mato Grosso do Sul (MS).
Frequent silencing of popeye domain-containing genes, BVES and POPDC3, is associated with promoter hypermethylation in gastric cancer.
GeneRIF
Kim et al., Taejŏn, South Korea. In Carcinogenesis, 2010
Frequent silencing of POPDC3 is associated with promoter hypermethylation in gastric cancer.
Self-sterility in Arabidopsis due to defective pollen tube guidance.
Impact
Preuss et al., Chicago, United States. In Science, 1996
Two Arabidopsis genes, POP2 and POP3, were found that mediate pollen tube guidance and are critical for self-fertility in diploid reproductive cells.
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