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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RuvB-like 1

Pontin, TIP49, Reptin, TIP48, RUVBL1, TIP49a
nuclear DNA helicase that binds TBP; involved in recombination and transcription [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ATPase, CAN, c-Myc, Histone, fibrillin-1
Papers on Pontin
A novel interaction of ECD protein with R2TP complex component RUVBL1 is required for the functional role of ECD in cell cycle progression.
New
Band et al., Omaha, United States. In Mol Cell Biol, Jan 2016
Further biochemical analyses demonstrated that an additional phosphorylation-independent interaction of ECD with the RUVBL1 component of the R2TP complex, and this interaction is essential for ECD's cell cycle progression function.
WNT-associated gene expression in human mesenchymal stromal cells under hypoxic stress.
New
Buravkova et al., Moscow, Russia. In Dokl Biochem Biophys, Nov 2015
FZD1, FZD3, SFRP1, and SFRP4 genes were up-regulated after short-term hypoxic stress (0.1% O2), whereas the expression of LEF-1 and RUVBL1 genes was significantly inhibited (down-regulated).
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
New
Sherman et al., Boston, United States. In Embo J, Oct 2015
We performed an siRNA screen for proteins involved in aggresome formation and identified novel mammalian AAA+ protein disaggregases RuvbL1 and RuvbL2.
Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients.
Paradowska-Dogan et al., Gießen, Germany. In Clin Epigenetics, 2014
Depletion of binding sites for H4K12ac was observed within the following developmentally important promoters: AFF4, EP300, LRP5, RUVBL1, USP9X, NCOA6, NSD1, and POU2F1.
The value of transcranial Doppler derived pulsatility index for diagnosing cerebral small-vessel disease.
Shemshaki et al., Eşfahān, Iran. In Adv Biomed Res, 2014
Based on MRI findings, patients were categorized into five subgroups of preventricular hyperintensity (PVH), deep white matter hyperintensity (DWMH), lacunar, pontin hyperintensity (PH), and PVH+DWMH+lacunar.
Substrate recognition and function of the R2TP complex in response to cellular stress.
Review
Macurek et al., Praha, Czech Republic. In Front Genet, 2014
The R2TP complex is a HSP90 co-chaperone, which consists of four subunits: PIH1D1, RPAP3, RUVBL1, and RUVBL2.
Chromosome Missegregation Associated with RUVBL1 Deficiency.
Ferrari et al., Zürich, Switzerland. In Plos One, 2014
RUVBL1 (RuvB-like1) and RUVBL2 (RuvB-like 2) are integral components of multisubunit protein complexes involved in processes ranging from cellular metabolism, transcription and chromatin remodeling to DNA repair.
[Central pontin myelinolysis].
Review
Dornonville de la Cour, Svendborg, Denmark. In Ugeskr Laeger, 2013
Initially central pontin myelinolysis was associated with alcoholism and later with hyponatraemia and particularly the correction rate.
RUVBL2 is a novel repressor of ARF transcription.
GeneRIF
Mei et al., Hefei, China. In Febs Lett, 2012
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.
Review
Ohno et al., Yokohama, Japan. In Nucleus, 2012
Recently, ATPase associated diverse cellular activities (AAA+) proteins RUVBL1 and RUVBL2 (RUVBL1/2) have been shown to be common regulators of PIKKs.
Structural and functional insights into a dodecameric molecular machine - the RuvBL1/RuvBL2 complex.
GeneRIF
Carrondo et al., Lisbon, Portugal. In J Struct Biol, 2011
truncation of domain II led to a substantial increase in ATP consumption of RuvBL1, RuvBL2 and their complex. In addition, we present evidence that DNA unwinding of the human RuvBL proteins can be auto-inhibited by domain II
Genetic and physical interactions between Tel2 and the Med15 Mediator subunit in Saccharomyces cerevisiae.
GeneRIF
Charbonneau et al., Lyon, France. In Plos One, 2011
Existence of a novel role for Tel2, namely in transcription, possibly in cooperation with Rvb2 and involving the existence of physical interactions with the Med15/Gal11 Mediator subunit.
Hypoxia-induced methylation of a pontin chromatin remodeling factor.
GeneRIF
Baek et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, 2011
Pontin is methylated by G9a/GLP methyltransferases in hypoxic condition and potentiates HIF-1alpha-mediated activation by increasing the recruitment of p300 coactivator to a subset of HIF-1alpha target promoters.
RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer.
GeneRIF
Young et al., Dublin, Ireland. In Febs Lett, 2011
data firmly implicate RuvBl2 in Ets2 mediated regulation of hTERT in colon cancer which has functional and clinical consequences
RVB1/RVB2: running rings around molecular biology.
Review
GeneRIF
Dutta et al., Charlottesville, United States. In Mol Cell, 2009
RVB1 and RVB2 function within multiple protein complexes is reviewed.
Pontin and reptin, two related ATPases with multiple roles in cancer.
Review
Rosenbaum et al., Berlin, Germany. In Cancer Res, 2008
Studies in model organisms or cultured human cells suggest potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin.
Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2008
Study identifies the ATPases pontin and reptin as telomerase components through affinity purification of TERT from human cells.
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.
Impact
GeneRIF
Baek et al., Seoul, South Korea. In Nat Cell Biol, 2006
sumoylation status of reptin modulates the invasive activity of cancer cells with metastatic potential
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Impact
Baek et al., Seoul, South Korea. In Nature, 2005
Here we report that the downregulation of a metastasis suppressor gene, KAI1, in prostate cancer cells involves the inhibitory actions of beta-catenin, along with a reptin chromatin remodelling complex.
Reptin and pontin antagonistically regulate heart growth in zebrafish embryos.
Impact
GeneRIF
Fishman et al., Boston, United States. In Cell, 2002
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway
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