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Paraoxonase 3

PON3, paraoxonase 3
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: paraoxonase, PON2, HDL, CAN, HAD
Papers using PON3 antibodies
Enhancement of NF-κB expression and activity upon differentiation of human embryonic stem cell line SNUhES3
Horke Sven et al., In Journal of Lipids, 2006
... Human PON2 or PON3 cDNA was subcloned into pDsRed-Express-N1 or pEGFP-N1 plasmids (Clontech).
Papers on PON3
Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3.
Ludewig et al., Iowa City, United States. In Environ Sci Pollut Res Int, Feb 2016
Our results demonstrate that (i) the non-dioxin-like PCB154, PCB155, and PCB184 significantly reduced liver and serum PON1 activities, but only in male rats; (ii) the non-dioxin-like PCB153, the most abundant PCB in many matrices, did not affect PON1 messenger RNA (mRNA) level in the liver but significantly decreased serum PON1 activity in male rats; (iii) PCB126, an AhR ligand and dioxin-like PCB, increased both PON1 activities and gene expression; and (iv) even though three tested AhR ligands induced CYP1A in several tissues to a similar extent, they displayed differential effects on the three PONs and AhR, i.e., PCB126 was an efficacious inducer of PON1, PON2, PON3, and AhR in the liver, while 3-methylcholantrene induced liver AhR and lung PON3, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent AhR agonist, increased only PON3 in the lung, at the doses and exposure times used in these studies.
Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.
Chung et al., Seoul, South Korea. In J Mol Neurosci, Nov 2015
The human paraoxonase (PON) gene family includes three members: PON1, PON2, and PON3.
Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis.
DCCT/EDIC Research Group et al., Los Angeles, United States. In J Proteome Res, Jun 2015
In each population, paraoxonase-3 (PON3), a potent antioxidant protein, was depleted from the HDL of patients with subclinical atherosclerosis.
Paraoxonase activity as a marker of exposure to xenobiotics in tobacco smoke.
Socha et al., Wrocław, Poland. In Int J Toxicol, May 2015
The paraoxonase (PON) family is composed of 3 proteins (PON1, PON2, and PON3), each of which plays a crucial role in the body, displaying antioxidant, anti-inflammatory, and antiatherosclerotic properties.
An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity.
Manco et al., Napoli, Italy. In Plos One, 2014
The human paraoxonase 2 (PON2) has been described as a highly specific lactonase hydrolysing the quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone (3OC12-HSL) and having secondary esterase but not phosphotriesterase activity, in contrast with the related enzymes PON1 and PON3.
Review: The role of paraoxonase in cardiovascular diseases.
Milnerowicz et al., Wrocław, Poland. In Ann Clin Lab Sci, 2014
Paraoxonase (PON) is a group of proteins present in three forms (PON1, PON2, PON3) encoded by genes PON1, PON2, and PON3.
Immunohistochemical analysis of paraoxonases and chemokines in arteries of patients with peripheral artery disease.
Camps et al., Reus, Spain. In Int J Mol Sci, 2014
The paraoxonases (PON) are a group of antioxidant enzymes, termed PON1, PON2, and PON3 that protect lipoproteins and cells from peroxidation and, as such, may be involved in protection against the atherosclerosis process.
Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus.
Lu et al., Shanghai, China. In Cardiovasc Diabetol, 2014
METHODS: Relative intensity of apoA-I glycation and activities of high-density lipoprotein (HDL)-associated PON1 and PON3 were determined in 205 consecutive T2DM patients with stable angina with (n = 144) or without (n = 61) significant CAD (luminal diameter stenosis ≥ 70 %).
Characterization of the paraoxonase system in follicular fluid of women subjected to an ovarian stimulation cycle.
Ruiz-Larrea et al., Spain. In Free Radic Biol Med, 2014
The objective of this work was a) to characterize the paraoxonase system in follicular fluid of women undergoing a controlled ovarian stimulation cycle, analysing the associated PON1, PON2, and PON3 activities, and b) to study the possible involvement of the PON system in follicular maturation.
Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection.
Furlong et al., Seattle, United States. In Neurotoxicology, 2014
Paraoxonase 2 (PON2) is a member of a gene family which also includes the more studied PON1, as well as PON3.
Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants.
Gupta et al., Louisville, United States. In Toxicol Rep, 2014
Serum and liver activities of the antioxidant enzymes, PON1 and PON3, and AhR transcription were also significantly increased by PCB126.
Association between paraoxonases gene expression and oxidative stress in hepatotoxicity induced by CCl4.
Sayed-Ahmed et al., Riyadh, Saudi Arabia. In Oxid Med Cell Longev, 2013
CCl4 group showed significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), thiobarbituric acid reactive substances (TBAR), hydrogen peroxide (H2O2), and lipid profile and a significant decrease in glutathione peroxidase (GPx), glutathione S transferase (GST), catalase (CAT), paraoxonase-1 (PON-1), paraoxonase-3 (PON-3), peroxisome proliferator activated receptor delta (PPAR-δ), and ATP-binding cassette transporter 1 (ABAC1) genes expression levels.
Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review.
Joven et al., Reus, Spain. In Int J Mol Sci, 2013
Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism's antioxidant system; alterations in which are associated with diseases involving oxidative stress.
Inflammation, infection, cancer and all that…the role of paraoxonases.
Reddy et al., Los Angeles, United States. In Adv Exp Med Biol, 2013
The paraoxonase (PON) gene family consists of three members, PON1, PON2 and PON3.
Effect of PON1 gene polymorphisms in Turkish patients with hepatocellular carcinoma.
Çınar et al., Adana, Turkey. In Meta Gene, 2013
Human serum paraoxonases (PON1, PON2 and PON3) play a role in antioxidant defense and protect the cell against ROS.
Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease.
Camps et al., Reus, Spain. In Atherosclerosis, 2012
Increased serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease.
Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice.
Smith et al., Cambridge, United Kingdom. In Am J Physiol Endocrinol Metab, 2012
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
Serum paraoxonase-3 concentration in HIV-infected patients. Evidence for a protective role against oxidation.
Camps et al., Reus, Spain. In J Lipid Res, 2012
This study reports for the first time an important increase in serum PON3 concentrations in HIV-infected patients that is associated with their oxidative status and their treatment with NNRTI.
Measurement of serum PON-3 concentration: method evaluation, reference values, and influence of genotypes in a population-based study.
Camps et al., Spain. In J Lipid Res, 2011
Serum PON3 concentrations showed a moderate influence (about 10% variation) by PON3 promoter polymorphisms.
Continuous reduction of plasma paraoxonase activity with increasing dialysis vintage in hemodialysis patients.
Tepel et al., Bochum, Germany. In Ther Apher Dial, 2010
in hemodialysis patients, frequency distribution of PON ratio showed 3 PON phenotypes: 74% oshowed PON1, 21% PON2, and 5% PON3. Compared to hemodialysis patients with PON1, patients with PON2 or 3 showed higher conversion rates for 4-nitrophenylacetate
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