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Polymeric immunoglobulin receptor

polymeric immunoglobulin receptor, Secretory component, poly-Ig receptor
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: IgA, IgM, CAN, HAD, ACID
Papers on polymeric immunoglobulin receptor
Secretory component mediates Candida albicans binding to epithelial cells.
Cannon et al., Dunedin, New Zealand. In Oral Dis, Jan 2016
RESULTS: Three of the polypeptides bound by C. albicans cells were identified as components of secretory IgA, including secretory component.
Pulmonary but Not Subcutaneous Delivery of BCG Vaccine Confers Protection to Tuberculosis-Susceptible Mice by an Interleukin 17-Dependent Mechanism.
Martin et al., Madrid, Spain. In J Infect Dis, Nov 2015
Thus, IL-17A neutralization in vivo reduces protection and abrogates M. tuberculosis-specific immunoglobulin A (IgA) secretion to respiratory airways and lung expression of polymeric immunoglobulin receptor induced following intranasal vaccination.
Proteomic investigation of whole saliva in Wilson's disease.
Messana et al., Monserrato, Italy. In J Proteomics, Nov 2015
Wilson's disease patient saliva showed high levels of two new fragments of the polymeric immunoglobulin receptor, and of α-defensins 2 and 4. Overall, the salivary proteome of Wilson's disease patients reflected oxidative stress and inflammatory conditions characteristic of the pathology, highlighting differences that could be useful clues of disease exacerbation.
Secretory leukocyte protease inhibitor inhibits expression of polymeric immunoglobulin receptor via the NF-κB signaling pathway.
Komiyama et al., Tokyo, Japan. In Mol Immunol, Oct 2015
Polymeric immunoglobulin receptor (pIgR) plays an important role in mucosal immune systems.
Cooperativity among secretory IgA, the polymeric immunoglobulin receptor, and the gut microbiota promotes host-microbial mutualism.
Kaetzel, Lexington, United States. In Immunol Lett, 2014
SIgA is transported into external secretions by the polymeric immunoglobulin receptor (pIgR).
The mucosal immune system: From dentistry to vaccine development.
Azegami et al., Tokyo, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2014
At effector sites, PP-originated antigen-specific IgA B cells become plasma cells to produce polymeric IgA and form secretory IgA by binding to poly-Ig receptor expressed on epithelial cells for protective immunity.
Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus faecium from the Intestinal Epithelium.
Willems et al., Utrecht, Netherlands. In Mbio, 2014
E. faecium agglutinates intraluminally in an extracellular matrix consisting of secretory IgA (sIgA), polymeric immunoglobulin receptor (pIgR), and epithelial cadherin (E-cadherin) proteins, thereby maintaining spatial segregation of E. faecium from the intestinal wall.
Putting J chain back on the map: how might its expression define plasma cell development?
Flajnik et al., Baltimore, United States. In J Immunol, 2014
J chain also is required for poly-Ig receptor-mediated transport of these Ig classes across the mucosal epithelium.
Stress modulates intestinal secretory immunoglobulin A.
Drago-Serrano et al., Mexico. In Front Integr Neurosci, 2012
SIgA is a protein complex formed by dimeric (dIgA) or polymeric IgA (pIgA) and the secretory component (SC), a peptide derived from the polymeric immunoglobulin receptor (pIgR).
Loss of polymeric immunoglobulin receptor expression is associated with lung tumourigenesis.
Massion et al., Nashville, United States. In Eur Respir J, 2012
Polymeric immunoglobulin receptor (PIGR)expression was lost in most lung cancers and pre-invasive bronchial lesions, suggesting that PIGR downregulation is an early event in lung tumourigenesis. PIGR overexpression inhibited cell proliferation.
Sputum proteomics identifies elevated PIGR levels in smokers and mild-to-moderate COPD.
Kinnula et al., Oulu, Finland. In J Proteome Res, 2012
The comparison of nonsmokers, smokers, and smokers with moderate COPD revealed 15 changed proteins with the majority, including polymeric immunoglobulin receptor (PIGR), being elevated in smokers and subjects with COPD.
The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.
Geng et al., Shanghai, China. In J Natl Cancer Inst, 2011
Results identify pIgR as a potential link between hepatitis B virus-derived hepatitis and HCC metastasis and provide evidence in support of pIgR as a prognostic biomarker for HCC and a potential therapeutic target.
Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity.
Kaetzel et al., Oslo, Norway. In Mucosal Immunol, 2011
The polymeric immunoglobulin receptor (pIgR) has the dual role of transporting locally produced dimeric IgA across mucosal epithelia, and serving as the precursor of secretory component, a glycoprotein that enhances the immune functions of SIgA.
Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores.
Hammerschmidt et al., Greifswald, Germany. In J Biol Chem, 2011
Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores.
Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH.
Dolk et al., Utrecht, Netherlands. In Plos One, 2010
Both native and phage-bound variable domain of camelid derived heavy chain only antibodies, were only able to get across polarized MDCK cells that express the human pIgR gene in a basolateral to apical fashion.
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2010
Polymeric immunoglobulin A (pIgA) transcytosis, mediated by the polymeric immunoglobulin receptor (pIgR), is a central component of mucosal immunity and a model for regulation of polarized epithelial membrane traffic.
Functional architecture of the retromer cargo-recognition complex.
Hurley et al., Bethesda, United States. In Nature, 2007
The retromer complex is required for the sorting of acid hydrolases to lysosomes, transcytosis of the polymeric immunoglobulin receptor, Wnt gradient formation, iron transporter recycling and processing of the amyloid precursor protein.
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor.
Mostov et al., San Francisco, United States. In Nat Cell Biol, 2004
The polymeric immunoglobulin receptor (pIgR) transcytoses polymeric IgA (pIgA) from the basolateral to the apical surface of epithelial cells and hepatocytes.
Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc.
Bjorkman et al., Pasadena, United States. In Nature, 2003
The FcalphaRI-binding site on IgA1 overlaps the reported polymeric immunoglobulin receptor (pIgR)-binding site, which might explain why secretory IgA cannot initiate phagocytosis or bind to FcalphaRI-expressing cells in the absence of an integrin co-receptor.
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo.
Corthésy et al., France. In Immunity, 2002
It is composed of at least two monomeric IgA molecules, covalently linked through the J chain, and secretory component (SC).
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