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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Chromobox homolog 2

Polycomb, M33, N33
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, CAN, EZH2, PRC1, V1a
Papers on Polycomb
Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins.
New
Impact
Lin et al., New Haven, United States. In Nat Genet, Feb 2016
Here we report that Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germline cells to regulate ovarian germline stem cells and oogenesis.
Polycomb-dependent epigenetic landscape in adult T-cell leukemia.
New
Watanabe et al., Tokyo, Japan. In Blood, Feb 2016
We found that polycomb repressive complex 2 (PRC2)-mediated tri-methylation at histone H3Lys27 (H3K27me3) was significantly and frequently reprogrammed at half of genes in ATL cells.
Super-resolution imaging reveals distinct chromatin folding for different epigenetic states.
New
Impact
Zhuang et al., Cambridge, United States. In Nature, Feb 2016
We classified genomic domains in Drosophila cells into transcriptionally active, inactive or Polycomb-repressed states, and observed distinct chromatin organizations for each state.
Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.
New
Impact
van Lohuizen et al., Amsterdam, Netherlands. In Cancer Cell, Feb 2016
Polycomb repressive complexes (PRC) are frequently implicated in human cancer, acting either as oncogenes or tumor suppressors.
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.
New
Jernberg-Wiklund et al., Uppsala, Sweden. In Oncotarget, Feb 2016
Taken together, these data suggest an important role for the Polycomb repressive complex 2 (PRC2) in MM, and highlights the PRC2 component EZH2 as a potential therapeutic target in MM.
MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53.
New
Dobbelstein et al., Göttingen, Germany. In Mol Cell, Feb 2016
Most of the MDM2-controlled genes also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic component EZH2.
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
New
Impact
Pasini et al., Milano, Italy. In Cell Stem Cell, Feb 2016
Polycomb repressive complexes (PRCs) are among the most important gatekeepers of establishing and maintaining cell identity in metazoans.
The evolutionary landscape of PRC1 core components in green lineage.
Review
New
Shen et al., Changsha, China. In Planta, Feb 2016
Polycomb repressive complex1 (PRC1) plays critical roles in epigenetic silencing of homeotic genes and determination of cell fate.
Polycomb in Transcriptional Phase Transition of Developmental Genes.
Review
New
Koseki et al., Yokohama, Japan. In Trends Biochem Sci, Jan 2016
Developmental regulatory gene expression, mostly regulated by the Polycomb/Trithorax group of chromatin regulators, is often temporally and spatially specific, and sometimes changes repeatedly within the same cell lineage.
Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements.
New
Zhang et al., Shanghai, China. In Plos Genet, Jan 2016
Polycomb repressive complexes (PRCs) play crucial roles in transcriptional repression and developmental regulation in both plants and animals.
Integrated genomic characterization of IDH1-mutant glioma malignant progression.
New
Impact
Günel et al., New Haven, United States. In Nat Genet, Jan 2016
These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
The Emerging Role of Epigenetics in the Regulation of Female Puberty.
Review
New
Ojeda et al., In Endocr Dev, Dec 2015
The Polycomb group (PcG) of transcriptional silencers appears to be a major component of the repressive arm of this mechanism.
Epigenetic Regulation.
Review
New
Niller et al., Szeged, Hungary. In Adv Exp Med Biol, Dec 2015
Proteins that build up Polycomb group (PcG) and Trithorax group (TrxG) protein complexes may also modify histones.
Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the Kidney.
Review
New
Crean et al., Dublin, Ireland. In J Clin Med, Dec 2015
Here we discuss the latest findings that delineate new and novel interactions between this transcriptional regulatory network and highlight a hitherto poorly recognized role for the Polycomb Repressive Complex (PRC2) in the regulation of renal cell plasticity.
Chromatin topology is coupled to Polycomb group protein subnuclear organization.
New
Francis et al., Boston, United States. In Nat Commun, Dec 2015
Many proteins that regulate genome architecture, including Polycomb group (PcG) proteins, form subnuclear structures.
A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription.
GeneRIF
Angrand et al., Villeneuve-d'Ascq, France. In Epigenetics, 2012
Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 protein complex.
Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
GeneRIF
Morohashi et al., Ōbu, Japan. In Endocrinology, 2012
This study implicates Cbx2 in testis differentiation through regulating Sry gene expression.
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.
GeneRIF
Liang et al., Beijing, China. In J Biol Chem, 2012
CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin
A novel nonsense mutation in TUSC3 is responsible for non-syndromic autosomal recessive mental retardation in a consanguineous Iranian family.
GeneRIF
Kuss et al., Berlin, Germany. In Am J Med Genet A, 2011
A novel nonsense mutation in TUSC3 is responsible for non-syndromic autosomal recessive mental retardation
Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.
GeneRIF
Burlingame et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2011
Data show that Polycomb repressive complex 2 is necessary to maintain normal levels of OGT and for the correct cellular distribution of O-GlcNAc.
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