Integrated genomic characterization of IDH1-mutant glioma malignant progression.
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These include activation of the MYC and RTK-RAS-PI3K pathways and upregulation of the FOXM1- and E2F2-mediated cell cycle transitions, as well as epigenetic silencing of developmental transcription factor genes bound by Polycomb repressive complex 2 in human embryonic stem cells.
Szeged, Hungary. In Adv Exp Med Biol, Dec 2015
Proteins that build up Polycomb group (PcG) and Trithorax group (TrxG) protein complexes may also modify histones.