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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Intraflagellar transport 88 homolog

Polaris, Tg737, IFT88, DAF-19
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, CD55, fibrillin-1, V1a
Papers on Polaris
Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain.
New
Blaess et al., Bonn, Germany. In Dev Biol, Feb 2016
We analyzed mutant mouse lines deficient in the intraflagellar transport protein IFT88, which is critical for primary cilia function.
Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes.
New
Sun et al., United States. In Osteoarthritis Cartilage, Jan 2016
Abolishing primary cilia through knockdown of intraflagellar transport protein (IFT88) attenuated CITED2 gene expression and decreased protein levels.
[Dynamic changes and effect of primary cilia on adipogenesis during 3T3-L1 cell differentiation into adipocytes].
New
Xiong et al., Guangzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Nov 2015
The expression levels of primary cilia key proteins like kinesin family member 3a (Kif3a), intraflagellar transport protein 88 (IFT88), acetylated α-tubulin (acAT) and adipogenic key protein peroxisome proliferator activated receptor γ (PPARγ) were detected by Western blotting.
IFT88 influences chondrocyte actin organization and biomechanics.
New
Knight et al., London, United Kingdom. In Osteoarthritis Cartilage, Nov 2015
METHODS: The study used an established chondrocyte cell line with and without hypomorphic mutation of IFT88 (IFT88(orpk)).
A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome.
New
Saito et al., Tokyo, Japan. In Nephron Extra, May 2015
A multicenter prospective study, POLARIS (Prospective Observational Survey on the Long-Term Effects of LDL Apheresis on Drug-Resistant Nephrotic Syndrome), was conducted to evaluate its clinical efficacy with high-level evidence.
Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges.
Review
Szlosarek et al., London, United Kingdom. In Cancer Res Treat, 2013
Clinical trials of several arginine depletors are ongoing, including pegylated arginine deiminase (ADI-PEG20, Polaris Group) and bioengineered forms of human arginase.
Hormonal crosstalk for root development: a combined experimental and modeling perspective.
Review
Lindsey et al., Durham, United Kingdom. In Front Plant Sci, 2013
In this review, we discuss the experimental evidence showing that the POLARIS peptide of Arabidopsis plays an important role in hormonal crosstalk and root growth, and review the crosstalk between auxin and other hormones for root growth with and without osmotic stress.
Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.
Impact
GeneRIF
Martens et al., Ann Arbor, United States. In Nat Med, 2012
A mutation in IFT88 causes a hitherto unknown human ciliopathy.
BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.
GeneRIF
Sheffield et al., Iowa City, United States. In Hum Mol Genet, 2012
Knockout of Bbs7 combined with a hypomorphic Ift88 allele (orpk as a model for Shh dysfuction) results in embryonic lethality with e12.5 embryos having exencephaly, pericardial edema, cleft palate and abnormal limb development.
Role of epidermal primary cilia in the homeostasis of skin and hair follicles.
GeneRIF
Yoder et al., Birmingham, United States. In Development, 2011
Epidermal cilia function was analyzed using conditional alleles of the ciliogenic genes Ift88 and Kif3a.
The cilia protein IFT88 is required for spindle orientation in mitosis.
Impact
GeneRIF
Doxsey et al., Worcester, United States. In Nat Cell Biol, 2011
Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos.
GMAP210 and IFT88 are present in the spermatid golgi apparatus and participate in the development of the acrosome-acroplaxome complex, head-tail coupling apparatus and tail.
GeneRIF
Rios et al., New York City, United States. In Dev Dyn, 2011
Data show that IFT88 is present in the Golgi of spermatids, that the microtubule-associated golgin GMAP210 and IFT88 participate in acrosome, HTCA, and tail biogenesis.
RPGR: role in the photoreceptor cilium, human retinal disease, and gene therapy.
Review
Stieger et al., Gießen, Germany. In Ophthalmic Genet, 2011
The Retinitis Pigmentosa GTPase Regulator (RPGR), which is located in the CC, participates in the IFT and interacts with a variety of proteins, including RPGRIP-1, CEP290, NPM, SMC1 and 3 and IFT88.
In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells.
Impact
Götz et al., München, Germany. In Cell Stem Cell, 2011
Inducible deletion of the ciliary protein IFT88 in aNSCs validates the role of ciliary function in aNSCs.
Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.
Impact
Baldari et al., Siena, Italy. In Nat Cell Biol, 2009
Moreover, IFT20 was required for the inducible assembly of a complex with other IFT components (IFT57 and IFT88) and the TCR.
FGF signalling during embryo development regulates cilia length in diverse epithelia.
Impact
Yost et al., Salt Lake City, United States. In Nature, 2009
Abrogation of Fgfr1 signalling downregulates expression of two ciliogenic transcription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polaris), indicating that FGF signalling mediates cilia length through an Fgf8/Fgf24-Fgfr1-intraflagellar transport pathway.
Primary cilia and signaling pathways in mammalian development, health and disease.
Review
Christensen et al., Copenhagen, Denmark. In Nephron Physiol, 2008
Indeed, hypomorphic mutations in the mouse ift88 (previously called Tg737) gene, which encodes a ciliogenic intraflagellar transport protein, result in malformation of primary cilia, and in the collecting ducts of kidney tubules this is accompanied by development of autosomal recessive polycystic kidney disease (PKD).
Lilliputians get into the limelight: novel class of small peptide genes in morphogenesis.
Review
Kageyama et al., Okazaki, Japan. In Dev Growth Differ, 2008
POLARIS, ROTUNDIFOLIA4, and Enod40 are plant peptides that are involved, respectively, in root formation, leaf shape control, and cortical cell division during nodule formation.
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