Novel roles for O-linked glycans in protein folding.
Stony Brook, United States. In Glycoconj J, 2014
Pofut2, a related enzyme that modifies Thrombospondin type I repeats (TSRs), has also been hypothesized to play a role in the folding and quality control of TSR-containing proteins.
O-fucosylation is required for ADAMTS13 secretion.
Saint Louis, United States. In J Biol Chem, 2007
When the expression of protein O-fucosyltransferase 2 (POFUT2), the enzyme that transfers fucose to serines in TSRs, was reduced using siRNA, the secretion of ADAMTS13 decreased.