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proteins. Page last changed on 19 Dec 2016.
Patatin-like phospholipase domain containing 5
This gene is a member of the patatin-like phospholipase family; its encoded protein has been shown to inhibit transacylation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] (from
Rich et al., Charlottesville, United States. In Curr Opin Lipidol, Apr 2015
Exome sequencing promises to identify genes with protein-coding variants with a large impact on lipids, as shown for LDL-cholesterol levels associated with novel (PNPLA5) and known (LDLR, PCSK9, APOB) genes.
NHLBI Grand Opportunity Exome Sequencing Project et al., Chapel Hill, United States. In Am J Hum Genet, 2014
We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previously unidentified variants in PCSK9, LDLR and APOB, three known lipid-related genes.
Brown et al., Ithaca, United States. In Plos One, 2012
Transient transfection of truncated versions of human adipose triglyceride lipase (ATGL, also known as PNPLA2), PNPLA3/adiponutrin, or PNPLA5 (GS2-like) fused to GFP revealed that the C-terminal third of these proteins contains sequences that are sufficient for targeting to LDs.