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Purine nucleoside phosphorylase

PNP, purine nucleoside phosphorylase
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, fibrillin-1
Papers using PNP antibodies
Jak2 FERM Domain Interaction with the Erythropoietin Receptor Regulates Jak2 Kinase Activity.
Supplier
Lau Andy T. Y., In PLoS ONE, 2007
... Staurosporine and AMP-PNP were obtained from BioMol and Roche respectively ...
Papers on PNP
A Combined Approach Employing Chlorotoxin-Nanovectors and Low Dose Radiation to Reach Infiltrating Tumor Niches in Glioblastoma.
New
Matteoli et al., In Acs Nano, Feb 2016
We used poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PNP) conjugated to chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells.
Long period fiber grating based sensor for the detection of triacylglycerides.
New
Sharma et al., New Delhi, India. In Biosens Bioelectron, Jan 2016
The stability is confirmed by lipase p-nitrophenyl palmitate (PNP) assay.
6-Methylpurine derived sugar modified nucleosides: Synthesis and evaluation of their substrate activity with purine nucleoside phosphorylases.
New
Secrist et al., Birmingham, United States. In Bioorg Chem, Jan 2016
UNASSIGNED: 6-Methylpurine (MeP) is cytotoxic adenine analog that does not exhibit selectivity when administered systemically, and could be very useful in a gene therapy approach to cancer treatment involving Escherichia coli PNP.
A continuous spectrophotometric enzyme-coupled assay for deoxynucleoside triphosphate triphosphohydrolases.
New
Hochkoeppler et al., United States. In Anal Biochem, Jan 2016
In particular, using Escherichia coli deoxynucleoside triphosphohydrolase (Dgt), which hydrolyzes dGTP to deoxyguanosine and tripolyphosphate (PPPi), as the enzyme to be tested, we devised a procedure relying on purine nucleoside phosphorylase (PNPase) and xanthine oxidase (XOD) as the auxiliary enzymes.
6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.
New
Secrist et al., Birmingham, United States. In Eur J Med Chem, Jan 2016
UNASSIGNED: Impressive antitumor activity has been observed with fludarabine phosphate against tumors that express Escherichia coli purine nucleoside phosphorylase (PNP) due to the liberation of 2-fluoroadenine in the tumor tissue.
The new nanophysiology: regulation of ionic flow in neuronal subcompartments.
Review
New
Impact
Yuste et al., Paris, France. In Nat Rev Neurosci, Nov 2015
Here we discuss a broader theory that uses the Poisson-Nernst-Planck (PNP) approximation and electrodiffusion to more accurately model the constraints that neuronal nanostructures place on electrical current flow.
Hydrogenation and dehydrogenation iron pincer catalysts capable of metal-ligand cooperation by aromatization/dearomatization.
New
Impact
Milstein et al., Israel. In Acc Chem Res, Aug 2015
More specifically, we have studied complexes of various transition metals (Ru, Fe, Co, Rh, Ir, Ni, Pd, Pt, and Re) bearing pyridine- and bipyridine-based PNP and PNN pincer ligands, which have slightly acidic methylene protons.
New medications in development for the treatment of hyperuricemia of gout.
Review
New
Perez-Ruiz et al., Madrid, Spain. In Curr Opin Rheumatol, Mar 2015
An inhibitor of purine nucleoside phosphorylase, Ulodesine, is in development in combination with allopurinol.
Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations.
Wielgus-Kutrowska et al., Olsztyn, Poland. In Molecules, 2014
Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides.
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.
Review
Yegutkin, Turku, Finland. In Crit Rev Biochem Mol Biol, 2014
The duration and magnitude of purinergic signaling is governed by a network of ectoenzymes, including the enzymes of the nucleoside triphosphate diphosphohydrolase (NTPDase) family, the nucleotide pyrophosphatase/phosphodiesterase (NPP) family, ecto-5'-nucleotidase/CD73, tissue-nonspecific alkaline phosphatase (TNAP), prostatic acid phosphatase (PAP) and other alkaline and acid phosphatases, adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP).
AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility.
Review
Cowden et al., United States. In Environ Res, 2014
The genes we examined were arsenic (+3) methyltransferase (AS3MT), glutathione-s-transferase omega (GSTO), and purine nucleoside phosphorylase (PNP).
Thirteen years experience with selective screening for disorders in purine and pyrimidine metabolism.
Review
Ugarte et al., Madrid, Spain. In Nucleosides Nucleotides Nucleic Acids, 2013
In the last thirteen years, we have studied urine/plasma specimens from about 1600 patients and we have identified 35 patients: eight patients with adenylosuccinate lyase deficiency, eight patients with hypoxanthine-guanine phosphoribosyltransferase deficiency, one patient with purine nucleoside phosphorylase deficiency, ten patients with xanthine dehydrogenase deficiency, six patients with molybdenum cofactor deficiency and two patients with dihydropyrimidine dehydrogenase deficiency.
Structure of AMP-PNP-bound vitamin B12 transporter BtuCD-F.
Impact
Locher et al., Zürich, Switzerland. In Nature, 2012
Here we report the 3.5 Å crystal structure of the transporter-binding protein complex BtuCD-BtuF (BtuCD-F) trapped in an β-γ-imidoadenosine 5'-phosphate (AMP-PNP)-bound intermediate state.
T- and B-cell defects in a novel purine nucleoside phosphorylase mutation.
GeneRIF
Etzioni et al., In J Allergy Clin Immunol, 2012
Complete lack of PNP triggers accumulation of deoxyguanosine, thereby disrupting B-cell development, the consequence of which is more profound with time, as was found in the older sister.
Human pancreatic polypeptide in a phospholipid-based micellar formulation.
GeneRIF
Onyuksel et al., Chicago, United States. In Pharm Res, 2012
Self-association of PPY with phospholipid micelles addressed the delivery issues of the peptide for diabetes treatment.
A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.
GeneRIF
Murphy et al., London, United Kingdom. In Endocrinology, 2011
investigated the role of metalloendopeptidases in PYY(3-36) degradation and determined whether modulation of these enzymes enhanced PYY(3-36) plasma levels and bioactivity in vivo.
Purine nucleoside phosphorylase deficiency: a mutation update.
GeneRIF
Marinaki et al., London, United Kingdom. In Nucleosides Nucleotides Nucleic Acids, 2011
Biochemical and genetic data on a cohort of seven patients from six families identified as PNPase deficient, is reported.
Effects of purine nucleoside phosphorylase deficiency on thymocyte development.
GeneRIF
Grunebaum et al., Toronto, Canada. In J Allergy Clin Immunol, 2011
PNP is important for the survival of DP thymocytes. Accumulation of dGuo in cases of PNP deficiency leads to mitochondria-initiated apoptosis of DP thymocytes, which can be prevented by restoring PNP activity in the cells.
Late metal carbene complexes generated by multiple C-H activations: examining the continuum of M=C bond reactivity.
Impact
Grubbs et al., Pasadena, United States. In Acc Chem Res, 2009
Using these reports as a backdrop, we focus on the double C-H activation of ethers and amines at iridium complexes supported by Ozerov's amidophosphine PNP ligand (PNP = [N(2-P(i)Pr(2)-4-Me-C(6)H(3))(2)](-)), allowing isolation of unusual square-planar iridium(I) carbenes.
Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.
Impact
Kim et al., New York City, United States. In Nat Med, 2008
Plasmodium species have a unique streamlined purine pathway in which the dual specificity enzyme purine nucleoside phosphorylase (PNP) functions in both purine recycling and purine salvage.
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