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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pregnancy upregulated non-ubiquitously expressed CaM kinase

Pnck, CaMKIbeta2, mCaMKIbeta, CaMK1beta, mCaMKIbeta2, CaMKIbeta
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CaM, EGFR, CaM kinase, HAD, V1a
Papers on Pnck
Pnck overexpression in HER-2 gene-amplified breast cancer causes Trastuzumab resistance through a paradoxical PTEN-mediated process.
New
Johnson et al., Washington, D.C., United States. In Breast Cancer Res Treat, Apr 2015
The gene for Pregnancy Up-regulated Non-ubiquitous Calmodulin Kinase (Pnck), a novel calmodulin kinase, is expressed in roughly one-third of human breast tumors, but not in adjoining normal tissues.
Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells.
Lovrečić et al., Ljubljana, Slovenia. In Plos One, 2014
Among these there were genes that have previously not been reported in human somatic follicular cells, like prokineticin 2 (PROK2), higher expressed in GC, and pregnancy up-regulated nonubiquitous CaM kinase (PNCK), higher expressed in CC.
PTEN-mediated ERK1/2 inhibition and paradoxical cellular proliferation following Pnck overexpression.
Johnson et al., Washington, D.C., United States. In Cell Cycle, 2013
Pregnancy upregulated non-ubiquitous calmodulin kinase (Pnck), a novel calmodulin kinase, is significantly overexpressed in breast and renal cancers.
A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.
Innis et al., Ann Arbor, United States. In Plos Genet, 2012
In addition, we refined the Ppd genetic interval and discovered a novel ETnII-β early transposon insertion between the genes for Dusp9 and Pnck.
Increased expression of pregnancy up-regulated non-ubiquitous calmodulin kinase is associated with poor prognosis in clear cell renal cell carcinoma.
Wang et al., Guangzhou, China. In Plos One, 2012
PURPOSE: The aims of this study were to evaluate the clinical significance and potential prognostic value of pregnancy up-regulated non-ubiquitous calmodulin kinase (PNCK) in clear cell renal cell carcinoma (ccRCC) patients.
Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex.
GeneRIF
Johnson et al., Washington, D.C., United States. In Am J Physiol Cell Physiol, 2011
Pnck induces epidermal growth factor receptor degradation, most likely through perturbation of Hsp90 chaperone activity due to Hsp90 phosphorylation. Epidermal growth factor receptor degradation is coupled to proteasomal degradation of Pnck.
RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.
Fardel et al., Rennes, France. In Plos One, 2010
Interestingly, four of them are able to bind calmodulin among which the IP3 kinase A (ITPKA) and pregnancy up-regulated non-ubiquitously expressed CaM kinase (PNCK, also named CaMKIβ).
Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma.
Zhang et al., Shenzhen, China. In Plos One, 2009
In addition to confirming that canonical cancer genes and miRNAs (including VEGFA, DUSP9 and ERBB4; miR-210, miR-184 and miR-206) play pivotal roles in ccRCC development, promising novel candidates (such as PNCK and miR-122) without previous annotation in ccRCC carcinogenesis were also discovered in this study.
Calmodulin-dependent kinase 1beta is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro.
Jemtland et al., Oslo, Norway. In Bone, 2008
In situ hybridization was used to determine the spatial and temporal expression of CaMK1beta during endochondral bone development in mouse embryos and newborn pups.
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
GeneRIF
Johnson et al., Washington, D.C., United States. In Am J Physiol Cell Physiol, 2008
Pnck induces ligand-independent EGFR degradation, and it may represent an attractive therapeutic target in EGFR-regulated oncogenesis.
Expression of Ca2+/calmodulin-dependent protein kinase (CaMK) Ibeta2 in developing rat CNS.
Terashima et al., Kōbe, Japan. In Neuroscience, 2001
We observed the onset time and distribution pattern of beta2 isoform of Ca2+/calmodulin-dependent protein kinase I (CaMKIbeta2) in the CNS of the rat during the embryonic period until birth using an immunohistochemical method.
Distribution of Ca(2+)/calmodulin-dependent protein kinase I beta 2 in the central nervous system of the rat.
Terashima et al., Kōbe, Japan. In Brain Res, 2001
Recently, we reported the mRNA localization of Ca(2+)/calmodulin-dependent protein kinase I beta 2 isoform (CaMKIbeta2) in the mouse nervous system.
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
Chodosh et al., Philadelphia, United States. In Cancer Res, 2000
While screening for protein kinases expressed in the murine mammary gland, we identified previously a Ca2+/calmodulin-dependent kinase, Pnck, that is most closely related to CaMKI.
Cloning, characterization, and chromosomal localization of Pnck, a Ca(2+)/calmodulin-dependent protein kinase.
Chodosh et al., Philadelphia, United States. In Genomics, 2000
In the course of a degenerate RT-PCR protein kinase screen, we identified a novel serine/threonine kinase, Pnck.
Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase Ibeta2 in the nervous system.
Minami et al., Kōbe, Japan. In J Neurochem, 1999
We report here the identification and expression of mouse CaMKIbeta (mCaMKIbeta), in particular mCaMKIbeta2, an isoform of mCaMKIbeta.
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