gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Sodium channel, voltage-gated, type IX, alpha subunit

PN1, Nav1.7, Gdn, SCN9A, SERPINE2
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, Plasminogen
Papers on PN1
Protease nexin-1 regulates retinal vascular development.
New
Arocas et al., Paris, France. In Cell Mol Life Sci, 25 Jul 2015
UNASSIGNED: We recently identified protease nexin-1 (PN-1) or serpinE2, as a possibly underestimated player in maintaining angiogenic balance.
Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.
New
Miranda et al., Thousand Oaks, United States. In Bioorg Med Chem Lett, 16 Jul 2015
UNASSIGNED: Many efforts are underway to develop selective inhibitors of the voltage-gated sodium channel NaV1.7 as new analgesics.
[American Academy of Neurology, Washington, 18-25 April 2015].
Review
New
Pierrot-Deseilligny et al., Bordeaux, France. In Rev Neurol (paris), 21 Jun 2015
Patients with painful small fiber neuropathy have a high rate of mutations in the SCN9A gene, coding for Nav1.7 voltage-gated sodium-channels.
A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis.
New
Impact
Knott et al., New York City, United States. In Nature, May 2015
Those clones that efficiently enter the vasculature express two secreted proteins, Serpine2 and Slpi, which were necessary and sufficient to program these cells for vascular mimicry.
Metastatic lymph node ratio successfully predicts prognosis in western gastric cancer patients.
Review
New
Dissanaike et al., United States. In Surg Oncol, Apr 2015
AJCC 7th edition nodal staging (N0: 0, N1:1-2, N2:3-6, N3:≥7 positive lymph nodes) and LNR positive nodal staging (PN0: 0%, PN1: 1-20%, PN2: 21-50%, PN3: 51-100% of examined nodes positive) were compared as respects seven year survivorship.
Painful peripheral neuropathy and sodium channel mutations.
Review
New
Waxman et al., Maastricht, Netherlands. In Neurosci Lett, Jan 2015
Voltage-gated sodium channels NaV1.7,
Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
New
Wang et al., Shenzhen, China. In Plos One, Dec 2014
To gain mechanistic insights into action of anti-arrhythmics, we characterized biophysical properties of Nav1.5 and Nav1.7 channels stably expressed in HEK293 cells and compared their use-dependent block in response to mexiletine and lidocaine using whole-cell patch clamp recordings.
Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels.
Review
New
Abriel et al., Taza, Morocco. In Front Physiol, Dec 2014
The p.I141V mutation in SCN4A and SCN5A, as well as its homologous p.I136V mutation in SCN9A, are interesting examples of mutations that have been linked to inherited hyperexcitability myotonia, exercise-induced polymorphic ventricular arrhythmias and erythromelalgia, respectively.
Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula.
New
Rash et al., Australia. In Toxins (basel), Dec 2014
We isolated three novel peptides, μ-TRTX-Phlo1a, -Phlo1b and -Phlo2a, that inhibit human NaV1.7 (hNaV1.7).
Temporal dynamics of anxiety phenotypes in a dental pulp injury model.
New
Li et al., Shanghai, China. In Mol Pain, Dec 2014
Moreover, oral administration of an anti-inflammatory drug, ibuprofen, or an analgesic agent, ProTx-II, which is a selective inhibitor of NaV1.7 sodium channels, both significantly alleviated DPI-induced avoidance in mice.
Sodium channel genes in pain-related disorders: phenotype-genotype associations and recommendations for clinical use.
Review
New
Impact
Faber et al., New Haven, United States. In Lancet Neurol, Nov 2014
Missense substitutions of SCN9A, the gene encoding sodium channel NaV1.7,
A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief.
New
Impact
Lee et al., Durham, United States. In Cell, Jul 2014
Here, we present a monoclonal antibody that targets the voltage-sensor paddle of NaV1.7, the subtype critical for pain sensation.
Painful and painless channelopathies.
Review
New
Impact
Woods et al., Cambridge, United Kingdom. In Lancet Neurol, Jun 2014
For example, the voltage-gated sodium ion channel Nav1.7 is expressed selectively in sensory and autonomic neurons; inactivating mutations in SCN9A, which encodes Nav1.7, result in congenital insensitivity to pain, whereas gain-of-function mutations in this gene produce distinct pain syndromes such as inherited erythromelalgia, paroxysmal extreme pain disorder, and small-fibre neuropathy.
Voltage-gated sodium channels in the mammalian heart.
Review
Blechschmidt et al., Jena, Germany. In Glob Cardiol Sci Pract, 2013
Nav1.7).
Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.
Impact
Zakon et al., Austin, United States. In Science, 2013
Bark scorpion venom induces pain in many mammals (house mice, rats, humans) by activating the voltage-gated Na(+) channel Nav1.7, but has no effect on Nav1.8.
Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo.
GeneRIF
Djamgoz et al., İstanbul, Turkey. In Cancer Lett, 2012
the involvement of functional voltage-gated sodium channels expression as a potentiating factor in metastatic prostate cancer has been confirmed in vivo for the first time
Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.
GeneRIF
Waxman et al., New Haven, United States. In J Neurosci, 2012
The results of this study suggested that Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury.
Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
GeneRIF
Huntington et al., Cambridge, United Kingdom. In Blood, 2012
crystal structures of PN1 in complex with heparin and catalytically inert thrombin suggest a unique 2-step mechanism of thrombin recognition involving rapid electrostatics-driven association
Nav1.7-related small fiber neuropathy: impaired slow-inactivation and DRG neuron hyperexcitability.
GeneRIF
Waxman et al., New Haven, United States. In Neurology, 2012
The I739V Nav1.7 variant in a patient with biopsy-confirmed idiopathic small fiber neuropathy impairs slow-inactivation within dorsal root ganglion neurons and increases their excitability.
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons.
GeneRIF
Wood et al., London, United Kingdom. In Nat Commun, 2011
Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.
share on facebooktweetadd +1mail to friends