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Postmeiotic segregation increased 2

PMS2, DNA mismatch repair
This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MLH1, MSH2, MSH6, CAN, HAD
Papers using PMS2 antibodies
A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast.
Supplier
Broberg Karin et al., In Environmental Health Perspectives, 2009
... (mutL homolog 1) gene, a component of the DNA mismatch repair pathway.Commercially available kits (Qiagen) were used to measure ...
The reliability of immunohistochemistry as a prescreening method for the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) – results of an international collaborative study
Supplier
Kam Lee Suk et al., In The Indian Journal of Medical Research, 2000
... No.610919) at 1/50 dilution and PMS2 ((BD Biosciences Pharmingen, USA, Cat ...
Papers on PMS2
Constitutional MLH1 methylation presenting with colonic polyposis syndrome and not Lynch syndrome.
New
Terdiman et al., San Francisco, United States. In Fam Cancer, Feb 2016
Immunohistochemistry (IHC) of multiple tumors showed absent MLH1 and PMS2 expression, though germline testing with Sanger sequencing and multiplex ligation-dependent probe amplification of these mismatch repair genes (MMR) genes was negative.
Visualizing the Path of DNA through Proteins Using DREEM Imaging.
New
Erie et al., Chapel Hill, United States. In Mol Cell, Feb 2016
Imaging of nucleosomes and DNA mismatch repair complexes demonstrates that DREEM can reveal both the path of the DNA wrapping around histones and the path of DNA as it passes through both single proteins and multiprotein complexes.
Impact of DNA mismatch repair system alterations on human fertility and related treatments.
New
Jin et al., Hangzhou, China. In J Zhejiang Univ Sci B, Jan 2016
DNA mismatch repair (MMR) is one of the biological pathways, which plays a critical role in DNA homeostasis, primarily by repairing base-pair mismatches and insertion/deletion loops that occur during DNA replication.
Acute lymphoblastic leukemia and lymphoma in the context of constitutional mismatch repair deficiency syndrome.
New
Schlegelberger et al., Hannover, Germany. In Eur J Med Genet, Jan 2016
Causative mutations are found in DNA mismatch repair genes PMS2, MSH6, MSH2 or MLH1 that are well known in the context of Lynch syndrome.
An intact Pms2 ATPase domain is not essential for male fertility.
New
Liskay et al., Portland, United States. In Dna Repair (amst), Jan 2016
UNASSIGNED: The DNA mismatch repair (MMR) machinery in mammals plays critical roles in both mutation avoidance and spermatogenesis.
Visualization of mismatch repair complexes using fluorescence microscopy.
Review
New
Hombauer et al., Heidelberg, Germany. In Dna Repair (amst), Jan 2016
UNASSIGNED: DNA mismatch repair (MMR) is a surveillance mechanism present in most living organisms, which repairs errors introduced by DNA polymerases.
Disease-associated repeat instability and mismatch repair.
Review
New
Pearson et al., Toronto, Canada. In Dna Repair (amst), Jan 2016
DNA repair, in particular mismatch repair (MMR), is the major driving force of disease-associated repeat expansions.
Review: Clinical aspects of hereditary DNA Mismatch repair gene mutations.
Review
New
Hofstra et al., Groningen, Netherlands. In Dna Repair (amst), Jan 2016
UNASSIGNED: Inherited mutations of the DNA Mismatch repair genes MLH1, MSH2, MSH6 and PMS2 can result in two hereditary tumor syndromes: the adult-onset autosomal dominant Lynch syndrome, previously referred to as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) and the childhood-onset autosomal recessive Constitutional Mismatch Repair Deficiency syndrome.
Germline Mutations in Predisposition Genes in Pediatric Cancer.
New
Impact
Downing et al., Memphis, United States. In N Engl J Med, Jan 2016
The most commonly mutated genes in the affected patients were TP53 (in 50 patients), APC (in 6), BRCA2 (in 6), NF1 (in 4), PMS2 (in 4), RB1 (in 3), and RUNX1 (in 3).
Protein-protein interactions in DNA mismatch repair.
Review
New
Gotthardt et al., Gießen, Germany. In Dna Repair (amst), Jan 2016
UNASSIGNED: The principal DNA mismatch repair proteins MutS and MutL are versatile enzymes that couple DNA mismatch or damage recognition to other cellular processes.
Mismatch repair and homeologous recombination.
Review
New
Lebbink et al., Rotterdam, Netherlands. In Dna Repair (amst), Jan 2016
UNASSIGNED: DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences.
Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.
New
Impact
Steidl et al., United States. In Nat Med, Oct 2015
Heterozygous deletion of an enhancer of PU.1, which resulted in a 35% reduction of PU.1 expression, was sufficient to induce myeloid-biased preleukemic stem cells and their subsequent transformation to AML in a DNA mismatch repair-deficient background.
N6-methyldeoxyadenosine marks active transcription start sites in chlamydomonas.
New
Impact
He et al., Chicago, United States. In Cell, Jun 2015
It is widespread in bacteria and functions in DNA mismatch repair, chromosome segregation, and virulence regulation.
Differential DNA mismatch repair underlies mutation rate variation across the human genome.
New
Impact
Lehner et al., Barcelona, Spain. In Nature, Jun 2015
Here we identify variable DNA mismatch repair (MMR) as the basis of this variation.
DNA triplet repeat expansion and mismatch repair.
Review
Impact
Wells et al., West Chester, United States. In Annu Rev Biochem, 2014
DNA mismatch repair is a conserved antimutagenic pathway that maintains genomic stability through rectification of DNA replication errors and attenuation of chromosomal rearrangements.
Insertion of an SVA element, a nonautonomous retrotransposon, in PMS2 intron 7 as a novel cause of Lynch syndrome.
GeneRIF
Wijnen et al., Leiden, Netherlands. In Hum Mutat, 2012
Insertion of an SVA element, a nonautonomous retrotransposon, in PMS2 intron 7 as a novel cause of Lynch syndrome.
Expression of mismatch repair gene PMS2 in nasopharyngeal carcinoma and regulation by glycogen synthase kinase-3β in vivo and in vitro.
GeneRIF
Li et al., Beijing, China. In Auris Nasus Larynx, 2012
Inactivation of GSK-3beta might be important for nasopharyngeal carcinoma tumorgenesis through negatively regulating PMS2 production
Mismatch repair genes expression defects & association with clinicopathological characteristics in colorectal carcinoma.
GeneRIF
Kam et al., George Town, Malaysia. In Indian J Med Res, 2011
About 15 per cent colorectal tumors demonstrated absent MSH2, MSH6 and PMS2 protein expression in isolation or in combination with other MMR genes, which often predicts a germline mutation.
Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes.
GeneRIF
Jenkins et al., Melbourne, Australia. In Br J Cancer, 2011
Germline mutations in PMS2 gene is associated with colorectal cancer.
Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids.
GeneRIF
Webb et al., Southampton, United Kingdom. In Plos One, 2010
Down-regulation of PMS2 is associated with initiation and growth of neuroblastoma and brain tumour multicellular spheroids.
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